Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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SACM1L
Gene Name  | SACM1L (QuickGO) | (A quick tutorial to explore the interctive visulaization) |
| Synonyms | SACM1L, KIAA0851 | |
| Protein Name | SACM1L |
|
| Alternative Name(s) |
Phosphatidylinositide phosphatase SAC1;3.1.3.-;Suppressor of actin mutations 1-like protein; | |
| EntrezGene ID | 22908 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | Q9NTJ5 (protein sequence) | |
| Enzyme Class | N/A | |
| Molecular Weight | 66967 Dalton | |
| Protein Length | 587 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000211456 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | |
| Classification | Superfamily: SAC domain phosphatases | Historic class: SAC domain family | CATH ID: NA | SCOP Fold: CC1 | |
| Phosphatase activity | active | Catalytic signature motif: NCMDCLDR | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam) | No Pfam domain found | ||
| Catalytic Site | Mechanism and Catalytic Site Atlas | ||
| Gene Expression | Gene Expression Atlas | Diseases | OMIM | DisGeNet | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus | ||
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Endoplasmic reticulum membrane | |||
| Function (UniProt annotation) | |||
| Phosphoinositide phosphatase that hydrolyzesphosphatidylinositol 3-phosphate (PtdIns(3)P) andphosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621)Has low activity towards PtdIns(3,5)P2 (By similarity) | |||
| Catalytic Activity (UniProt annotation) | |||
| NA | |||
| Protein Sequence | |||
| MATAAYEQLKLHITPEKFYVEACDDGADDVLTIDRVSTEVTLAVKKDVPPSAVTRPIFGILGTIHLVAGNYLIVITKKIK VGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLSNTSPEFQEMSLLE RADQRFVWNGHLLRELSAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVET EQIVHYNGSKASFVQTRGSIPVFWSQRPNLKYKPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQT FATMVSSLGSGMMRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGQVVANQEGVFRSNCMDCLDRTNVIQ SLLARRSLQAQLQRLGVLHVGQKLEEQDEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIR YYKNNFSDGFRQDSIDLFLGNYSVDELESHSPLSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGVAS IGTFFIILYNGKDFVDAPRLVQKEKID |
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
ELM Motif | Motif Instance | Description | Motif Regex |
| NA | NA | NA | NA |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0000139 | C:Golgi membrane |
| GO:0004438 | F:phosphatidylinositol-3-phosphatase activity |
| GO:0005789 | C:endoplasmic reticulum membrane |
| GO:0005794 | C:Golgi apparatus |
| GO:0006661 | P:phosphatidylinositol biosynthetic process |
| GO:0016791 | F:phosphatase activity |
| GO:0030176 | C:integral component of endoplasmic reticulum membrane |
| GO:0032281 | C:AMPA glutamate receptor complex |
| GO:0034593 | F:phosphatidylinositol bisphosphate phosphatase activity |
| GO:0034596 | F:phosphatidylinositol phosphate 4-phosphatase activity |
| GO:0043812 | F:phosphatidylinositol-4-phosphate phosphatase activity |
| GO:0046856 | P:phosphatidylinositol dephosphorylation |
