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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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KEGG Pathway - Inositol phosphate metabolism

Phosphatases known in this pathway

NameSynonymsUniProt ACDephosphorylate substrates:
IMPA2 (QuickGO)IMP 2O14732adenosine 2'-phosphate alpha-D-glucose 1-phosphate beta-D-glucose 1-phosphate glycerol 2-phosphate Ins(1,4)P2 Ins(1)P1 Ins(2)P1 Ins(3)P1 Ins(4)P1 Ins(5)P1 Ins(6)P1 scyllo-inositol 1,4-bisphosphate
SYNJ2 (QuickGO)Synaptojanin-2O15056Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2
INPP4B (QuickGO)INPP4BO15327Ins(1,3,4)P3 Ins(1,4)P2 Ins(3,4)P2 PtdIns(3,4)P2
INPPL1 (QuickGO)SHIP2O15357Ins(1,2,3,4,5)P5 Ins(1,3,4,5)P4 Ins(1,4,5,6)P4 Ins(2,4,5,6)P4 PtdIns(3,4,5)P3 PtdIns(3,5)P2
SYNJ1 (QuickGO)Synaptojanin-1O43426Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2
IMPA1 (QuickGO)IMP 1P29218adenosine 2'-phosphate alpha-D-glucose 1-phosphate alpha-D-glucose 6-phosphate beta-D-glucose 1-phosphate beta-D-glucose 6-phosphate D-fructose 1-phosphate glycerol 2-phosphate Ins(1,4)P2 Ins(1)P1 Ins(2)P1 Ins(3)P1 Ins(4)P1 Ins(5)P1 Ins(6)P1 scyllo-inositol 1,3-bisphosphate scyllo-inositol 1,4-bisphosphate scyllo-inositol monophosphate
INPP5B (QuickGO)INPP5BP32019Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2
INPP1 (QuickGO)IPPaseP49441Ins(1,3,4)P3 Ins(1,4)P2
PTEN (QuickGO)PTENP60484CREB1 FAK Ins(1,3,4,5)P4 PDGFRB PtdIns(3,4,5)P3 PtdIns(3,4)P2 PtdIns(3,5)P2 PtdIns(3)P PTEN SHC1
OCRL (QuickGO)OCRL-1Q01968Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2
INPP5A (QuickGO)INPP5AQ14642Ins(1,3,4,5)P4 Ins(1,4,5)P3
INPP5J (QuickGO)INPP5JQ15735Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(4,5)P2
INPP4A (QuickGO)INPP4AQ96PE3Ins(1,3,4)P3 Ins(3,4)P2 PtdIns(3,4)P2
INPP5K (QuickGO)INPP5KQ9BT40Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2
INPP5E (QuickGO)INPP5EQ9NRR6Ins(1,3,4,5)P4 Ins(1,4,5)P3 PtdIns(3,4,5)P3 PtdIns(4,5)P2
MINPP1 (QuickGO)MINPP1Q9UNW12,3-bisphospho-D-glycerate Ins(1,3,4,5)P4 InsP6

Substrates known in this pathway

NameSynonymsUniProt ACDephosphorylated by phosphatases:
PLC-gamma-11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)P19174PTP1B RPTPeta
PTENPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)P60484PTEN
Ins(1)P11D-myo-Inositol 1-monophosphate; 1D-myo-Inositol 1-phosphate; D-myo-Inositol 1-phosphate; Inositol 1-phosphate; Inositol 1-phosphate; Myoinositol 1-phosphate; Ins(1)P1N/AIMP 1 IMP 2
Ins(1,2,3,4,5)P5(1R,2S,3R,4S,5S,6R)-6-HYDROXYCYCLOHEXANE-1,2,3,4,5-PENTAYL PENTAKIS[DIHYDROGEN (PHOSPHATE)]; 1D-myo-Inositol 1,2,3,4,5-pentakisphosphate; 1L-myo-Inositol 1,2,3,4,5-pentakisphosphate; D-myo-Inositol 1,2,3,4,5-pentakisphosphate; Inositol 1,2,3,4,5-pentakisphosphate; L-myo-Inositol 1,2,3,4,5-pentakisphosphate; myo-Inositol 1,2,3,4,5-pentakisphosphate; Ins(1,2,3,4,5)P5N/ASHIP2
Ins(1,3)P21D-myo-Inositol 1,3-bisphosphate; D-myo-inositol 1,3-bisphosphate; D-myo-Inositol 1,3-bisphosphate; Inositol 1,3-bisphosphate; myo-Inositol 1,3-bisphosphate; PHOSPHORIC ACID MONO-(2,3,4,6-TETRAHYDROXY-5-PHOSPHONOOXY-CYCLOHEXYL) ESTER; Ins(1,3)P2N/AMTM1 MTMR2 MTMR7
Ins(1,3,4)P3(1S,3S,4S)-1,3,4-TRIPHOSPHO-MYO-INOSITOL; 1D-myo-inositol 1,3,4-trisphosphate; 1D-myo-Inositol 1,3,4-trisphosphate; D-myo-Inositol 1,3,4-trisphosphate; Inositol 1,3,4-trisphosphate; Ins(1,3,4)P3N/ABPNT1 INPP4A INPP4B IPPase
Ins(1,3,4,5)P41D-myo-inositol 1,3,4,5-tetrakisphosphate; 1D-myo-Inositol 1,3,4,5-tetrakisphosphate; D-myo-Inositol 1,3,4,5-tetrakisphosphate; Inositol 1,3,4,5-tetrakisphosphate; Ins(1,3,4,5)P4N/AINPP5A INPP5B INPP5E INPP5J INPP5K MINPP1 OCRL-1 PTEN SHIP1 SHIP2 Synaptojanin-1 Synaptojanin-2 TPIP
Ins(1,4)P21D-myo-Inositol 1,4-bisphosphate; D-myo-Inositol 1,4-bisphosphate; D-MYO-INOSITOL-1,4-BISPHOSPHATE; Inositol 1,4-bisphosphate; myo-inositol 1,4-bisphosphate; myo-Inositol 1,4-bisphosphate; Ins(1,4)P2N/ABPNT1 IMP 1 IMP 2 INPP4B IPPase
Ins(1,4,5)P31,4,5-Insp3; 1D-myo-Inositol 1,4,5-trisphosphate; D-myo-Inositol 1,4,5-trisphosphate; D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE; Inositol 1,4,5-trisphosphate; Ins(1,4,5)P3; InsP3; IP3N/AINPP5A INPP5B INPP5E INPP5J INPP5K OCRL-1 Synaptojanin-1 Synaptojanin-2
Ins(1,4,5,6)P41D-myo-Inositol 1,4,5,6-tetrakisphosphate; D-myo-Inositol 1,4,5,6-tetrakisphosphate; Inositol 1,4,5,6-tetrakisphosphate; Ins(1,4,5,6)P4N/ASHIP2
Ins(3)P11D-myo-Inositol 3-monophosphate; 1D-myo-Inositol 3-phosphate; 1L-myo-Inositol 1-phosphate; D-myo-Inositol 3-monophosphate; D-myo-Inositol 3-phosphate; Inositol 3-phosphate; L-myo-Inositol 1-phosphate; Myoinositol 3-phosphate; Ins(3)P1N/AIMP 1 IMP 2
Ins(3,4)P21D-myo-Inositol 3,4-bisphosphate; D-myo-Inositol 3,4-bisphosphate; Inositol 3,4-bisphosphate; Ins(3,4)P2N/AINPP4A INPP4B
Ins(4)P11D-myo-Inositol 4-monophosphate; 1D-myo-Inositol 4-phosphate; D-myo-Inositol 4-phosphate; Ins(4)P1N/AIMP 1 IMP 2
InsP61D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate; D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate; myo-inositol 1,2,3,4,5,6-hexakisphosphate; myo-Inositol hexakisphosphate; Phytate; Phytic acid; InsP6N/AMINPP1
PtdIns(3)P1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3'-phosphate); 1-Phosphatidyl-1D-myo-inositol 3-phosphate; Phosphatidylinositol 3-phosphate; PtdIns-3-P; PtdIns3P; PtdIns(3)P; PI3PN/AMTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 PTEN PTPS31 SAC1
PtdIns(3,4)P21-phosphatidyl-1D-myo-inositol 3,4-bisphosphate; 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate; 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate pentaanion; PtdIns(3,4)P2; PI(3,4)P2N/AINPP4A INPP4B PTEN PTPS31
PtdIns(3,4,5)P31,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate); 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate; 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate; Phosphatidylinositol-3,4,5-trisphosphate; PIP3; PtsIns(3,4,5)P3; PtsIns-3,4,5-P3; PtdIns(3,4,5)P3; PI(3,4,5)P3N/AC1-TEN FIG4 INPP5B INPP5E INPP5K OCRL-1 PTEN PTPS31 SAC2 SHIP1 SHIP2 Synaptojanin-1 Synaptojanin-2 TPIP
PtdIns(3,5)P21,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',5'-bisphosphate); 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate; 1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate; PtsIns(3,5)P2; PtsIns-3,5-P2; PtdIns(3,5)P2; PI(3,5)P2N/AFIG4 MTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR6 MTMR7 PTEN PTPS31 SHIP2 TPIP
PtdIns(4)P1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-4'-phosphate); 1-phosphatidyl-1D-myo-inositol 4-monophosphate; 1-Phosphatidyl-1D-myo-inositol 4-phosphate; Phosphatidylinositol 4-phosphate; PtdIns-4-P; PtdIns4P; PtdIns(4)P; PI4PN/APTPS31 SAC1
PtdIns(4,5)P21,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-4',5'-bisphosphate); 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate; 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate; 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate; 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate; Phosphatidyl-myo-inositol 4,5-bisphosphate; Phosphatidyl-myo-inositol 4,5-bisphosphate; Phosphatidylinositol-4,5-bisphosphate; Phosphatidylinositol-4,5-bisphosphate; PIP2; PIPP; PtsIns(4,5)P2; PtsIns-4,5-P2; PtdIns(4,5)P2; PI(4,5)P2N/AFIG4 INPP5B INPP5E INPP5J INPP5K OCRL-1 PRL-3 PTPS31 SAC2 Synaptojanin-1 Synaptojanin-2
PtdIns(5)P1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate); 1-phosphatidyl-1D-myo-inositol 5-phosphate; 1-Phosphatidyl-1D-myo-inositol 5-phosphate; PIP; PtdIns-5-P; PtdIns5P; PtdIns(5)P; PI5PN/APTPS31

Sorry, no phosphatase/substrate known in this pathway here!

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