Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last update: 11 Mar, 2019
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last update: 11 Mar, 2019
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REACTOME Pathway - Ub-specific processing proteases
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| CDC25A | P30304 | EGFR, RAF1, CDK1, CDK4, CDK2, MAPK3, MAPK1, CUX1, | Non-protein substrates of this phosphatase are not reported yet |
| PTEN | P60484 | PDGFRB, CREB1, SHC1, PTEN, PTK2, PTK6, | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate, 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, 1D-myo-inositol 1,3,4,5-tetrakisphosphate, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 3-phosphate, |
| TAB1 | Q15750 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| AXIN1 | O15169 | PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPM1A, |
| MAP3K7 | O43318 | PPP2CA, PPP2CB, PPM1B, PPM1L, PPP6C, |
| STAM2 | O75886 | PTPN1, |
| MYC | P01106 | PPP2CA, PPP2CB, CTDSP1, |
| TP53 | P04637 | CDC14A, CDC14B, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPM1D, DUSP26, |
| HIST1H2AG | P0C0S8 | ALPL, ALPI, PPM1G, |
| NFKBIA | P25963 | PTPN1, PTPN13, PPP3CB, PPP3CC, PPP2CB, PPP2CA, PPP3CA, |
| CDC25A | P30304 | CDC14A, CDC14B, |
| TGFBR1 | P36897 | PPP1CC, PPP1CA, PPP1CB, |
| PTEN | P60484 | PTEN, PPP2CA, |
| SMAD3 | P84022 | MTMR4, PPP2CA, PPP2CB, PPM1A, CTDSP1, CTDSP2, CTDSPL, |
| MDM2 | Q00987 | PPP2CA, PPP2CB, PPM1D, |
| TRAF2 | Q12933 | PPP2CA, PPP2CB, |
| SKP2 | Q13309 | CDC14B, |
| SMAD2 | Q15796 | PPM1A, CTDSP1, CTDSP2, CTDSPL, |
| SMAD1 | Q15797 | PDP1, PDP2, PPP2CA, PPP2CB, PPM1A, CTDSP1, CTDSP2, CTDSPL, |
| HIST1H2BM | Q99879 | PPM1G, |