Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
last update: 18 Feb, 2016


KEGG Pathway - Endocytosis

Phosphatases known in this pathway

NameSynonymsUniProt ACDephosphorylate substrates:
DNAJC6 (QuickGO)auxilinO75061N/A

Substrates known in this pathway

NameSynonymsUniProt ACDephosphorylated by phosphatases:
DRP1Dynamin-1-like protein (EC (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1)O00429PP2Balpha PP2Bbeta PP2Bgamma
STAM2Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)O75886PTP1B
EGFREpidermal growth factor receptor (EC (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)P00533CDC25A LMW-PTP PTP-J PTP-MEG2 PTP1B RPTPeta RPTPkappa RPTPsigma SHP1 SHP2 STS-1 TCPTP VHR
Trk-AHigh affinity nerve growth factor receptor (EC (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (p140-TrkA) (Trk-A)P04629RPTPsigma RPTPzeta SHP1
RETProto-oncogene tyrosine-protein kinase receptor Ret (EC (Cadherin family member 12) (Proto-oncogene c-Ret)P07949RPTPeta
IGF1RInsulin-like growth factor 1 receptor (EC (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]P08069PTP1B
METHepatocyte growth factor receptor (HGF receptor) (EC (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)P08581LAR PTP1B RPTPbeta RPTPeta TCPTP
KITMast/stem cell growth factor receptor (SCFR) (EC (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)P10721SHP1
SRCProto-oncogene tyrosine-protein kinase Src (EC (Proto-oncogene c-Src) (pp60c-src) (p60-Src)P12931HD-PTP LMW-PTP PP2Aalpha PP2Abeta PTP-PEST PTP1B PTPD1 RPTPalpha RPTPepsilon RPTPeta SAP1 SHP1 SHP2 TCPTP
KGFRFibroblast growth factor receptor 2 (FGFR-2) (EC (K-sam) (Keratinocyte growth factor receptor) (CD antigen CD332)P21802VHR
CBLE3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (Signal transduction protein CBL)P22681RPTPeta STS-1
VEGFR-2Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)P35968LMW-PTP RPTPbeta RPTPeta SHP1 SHP2 TCPTP
PKC-lambdaProtein kinase C iota type (EC (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)P41743PP2Aalpha PP2Abeta
DYN2Dynamin-2 (EC PP2Bbeta PP2Bgamma
SMAD3Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)P84022MTMR4 PP2Aalpha PP2Abeta PP2Calpha SCP1 SCP2 SCP3
MDM2E3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (p53-binding protein Mdm2)Q00987PP2Aalpha PP2Abeta PP2Cdelta
Caveolin-1Caveolin-1Q03135PTP1B TCPTP
Dynamin-1Dynamin-1 (EC PP2Bbeta PP2Bgamma
ERBB4Receptor tyrosine-protein kinase erbB-4 (EC (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]Q15303ACPT
SMAD2Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)Q15796PP2Calpha SCP1 SCP2 SCP3
PAR-3Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)Q8TEW0PP1alpha
PtdIns(3)P1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3'-phosphate); 1-Phosphatidyl-1D-myo-inositol 3-phosphate; Phosphatidylinositol 3-phosphate; PtdIns-3-P; PtdIns3P; PtdIns(3)P; PI3PN/AMTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 PTEN PTPS31 SAC1
PtdIns(3,4,5)P31,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate); 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate; 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate; Phosphatidylinositol-3,4,5-trisphosphate; PIP3; PtsIns(3,4,5)P3; PtsIns-3,4,5-P3; PtdIns(3,4,5)P3; PI(3,4,5)P3N/AC1-TEN FIG4 INPP5B INPP5E INPP5K OCRL-1 PTEN PTPS31 SAC2 SHIP1 SHIP2 Synaptojanin-1 Synaptojanin-2 TPIP
PtdIns(4,5)P21,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-4',5'-bisphosphate); 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate; 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate; 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate; 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate; Phosphatidyl-myo-inositol 4,5-bisphosphate; Phosphatidyl-myo-inositol 4,5-bisphosphate; Phosphatidylinositol-4,5-bisphosphate; Phosphatidylinositol-4,5-bisphosphate; PIP2; PIPP; PtsIns(4,5)P2; PtsIns-4,5-P2; PtdIns(4,5)P2; PI(4,5)P2N/AFIG4 INPP5B INPP5E INPP5J INPP5K OCRL-1 PRL-3 PTPS31 SAC2 Synaptojanin-1 Synaptojanin-2

Sorry, no phosphatase/substrate known in this pathway here!