DEPOD - human DEPhOsphorylation Database

Name	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate	Download: mol \| sdf
Synonyms	01,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',5'-bisphosphate); 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 2,3-bis(alkanoyloxy)propyl (1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonatooxy)cyclohexyl phosphate; Pi(3,5)p2; Pips; Ptdins(3,5)p2; Ptsins(3,5)p2; Ptsins-3,5-p2;
Definition	NA
Molecular Weight (Exact mass)	NA
Molecular Formula	C11H19O19P3R2
SMILES	[H][C@@](COC([])=O)(COP(O)(=O)O[C@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](O)[C@@H](OP(O)(O)=O)[C@H]1O)OC([])=O
InChI	InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2-,3-,4+,5-,6-/m0/s1
InChI Key	CIPFCGZLFXVXBG-CNWJWELYSA-N
Crosslinking annotations	KEGG:C11556 \| ChEBI:16851 \| PubChem:13723 \|

Pathway ID	Pathway Name	Pathway Description (KEGG)
map00562	Inositol phosphate metabolism	NA
map01100	Metabolic pathways	NA
map04070	Phosphatidylinositol signaling system	NA
map04144	Endocytosis	Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.

CHEBI:16851