DEPOD - human DEPhOsphorylation Database

Basic Information
Phosphatases
Pathway

Name	sn-glycerol 3-phosphate	Download: mol \| sdf
Synonyms	0(2r)-2,3-dihydroxypropyl dihydrogen phosphate; sn-glycerol 3-(dihydrogen phosphate); (r)-glycerol 1-phosphate; D-glycerol 1-phosphate; Glycerophosphoric acid; Phosphoric acid mono-((r)-2,3-dihydroxy-propyl) ester; Sn-glycerol 3-phosphate;
Definition	An sn-glycerol 3-phosphate having unsubstituted hydroxy groups.
Molecular Weight (Exact mass)	172.0737 (172.0137)
Molecular Formula	C3H9O6P
SMILES	OC[C@@H](O)COP(O)(O)=O
InChI	InChI=1S/C3H9O6P/c4-1-3(5)2-9-10(6,7)8/h3-5H,1-2H2,(H2,6,7,8)/t3-/m1/s1
InChI Key	AWUCVROLDVIAJX-GSVOUGTGSA-N
Crosslinking annotations	KEGG:C00093 \| 3DMET:B01157 \| CAS:17989-41-2 \| ChEBI:15978 \| ChEMBL:CHEMBL1232920 \| KNApSAcK:C00007288 \| NIKKAJI:J4.456C \| PDB-CCD:G3P \| PDB-CCD:GP9 \| PubChem:3393 \|

Pathway ID	Pathway Name	Pathway Description (KEGG)
map00561	Glycerolipid metabolism	NA
map00564	Glycerophospholipid metabolism	NA
map01100	Metabolic pathways	NA
map01110	Biosynthesis of secondary metabolites	NA
map02010	ABC transporters	The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
map05231	Choline metabolism in cancer	Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS and PI3K-AKT pathways, and transcription factors associated with oncogenesis such as hypoxia-inducible factor 1 (HIF1) mediate overexpression and activation of choline cycle enzymes, which causes increased levels of choline-containing precursors and breakdown products of membrane phospholipids. These products of choline phospholipid metabolism, such as phosphocholine (PCho), diacylglycerol (DAG) and phosphatidic acid, may function as second messengers that are essential for the mitogenic activity of growth factors, particularly in the activation of the ras-raf-1-MAPK cascade and protein kinase C pathway.

CHEBI:15978