Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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MINPP1
Gene Name  | MINPP1 (QuickGO) | (A quick tutorial to explore the interctive visulaization) |
| Synonyms | MINPP1, MIPP, UNQ900/PRO1917 | |
| Protein Name | MINPP1 |
|
| Alternative Name(s) |
Multiple inositol polyphosphate phosphatase 1;3.1.3.62;2,3-bisphosphoglycerate 3-phosphatase;2,3-BPG phosphatase;3.1.3.80;Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase;Ins(1,3,4,5)P(4) 3-phosphatase; | |
| EntrezGene ID | 9562 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | Q9UNW1 (protein sequence) | |
| Enzyme Class | EC 3.1.3.62 3.1.3.80 (BRENDA ) | |
| Molecular Weight | 55051 Dalton | |
| Protein Length | 487 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000107789 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | |
| Classification | Superfamily: histidine phosphatase (HP) | Historic class: Multiple inositol-polyphosphate phosphatase | CATH ID: 3.40.50.1240 | SCOP Fold: HP | |
| Phosphatase activity | active | Catalytic signature motif: unknown | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam) | No Pfam domain found | ||
| Catalytic Site | Mechanism and Catalytic Site Atlas | ||
| Gene Expression | Gene Expression Atlas | Diseases | OMIM | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus | ||
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Endoplasmic reticulum lumen | |||
| Function (UniProt annotation) | |||
| Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositolpentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6)Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediatingthe dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) toproduce phospho-D-glycerate without formation of 3-phosphoglycerate May play a role in bone development(endochondral ossification) May play a role in the transition ofchondrocytes from proliferation to hypertrophy (By similarity) | |||
| Catalytic Activity (UniProt annotation) | |||
| Myo-inositol hexakisphosphate + H(2)O = myo-inositol pentakisphosphate (mixed isomers) + phosphate 2,3-bisphospho-D-glycerate + H(2)O = 2-phospho-D-glycerate + phosphate | |||
| Protein Sequence | |||
| MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTP VQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALR LASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVE KNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNADLIQVAFFTCSFDLAIKGVKSPWCDVFDIDDAKVLEYLNDLK QYWKRGYGYTINSRSSCTLFQDIFQHLDKAVEQKQRSQPISSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNYKKQMH RKFRSGLIVPYASNLIFVLYHCENAKTPKEQFRVQMLLNEKVLPLAYSQETVSFYEDLKNHYKDILQSCQTSEECELARA NSTSDEL |
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
ELM Motif | Motif Instance | Description | Motif Regex |
| NA | NA | NA | NA |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0001503 | P:ossification |
| GO:0003993 | F:acid phosphatase activity |
| GO:0005783 | C:endoplasmic reticulum |
| GO:0005788 | C:endoplasmic reticulum lumen |
| GO:0006797 | P:polyphosphate metabolic process |
| GO:0030282 | P:bone mineralization |
| GO:0030351 | F:inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity |
| GO:0034417 | F:bisphosphoglycerate 3-phosphatase activity |
| GO:0043647 | P:inositol phosphate metabolic process |
| GO:0051717 | F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity |
| GO:0052745 | F:inositol phosphate phosphatase activity |
| GO:0052826 | F:inositol hexakisphosphate 2-phosphatase activity |
| GO:0070062 | C:extracellular exosome |
| GO:0101006 | F:protein histidine phosphatase activity |
