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Human Phosphatases
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Statistics

241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
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336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
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299 KEGG pathways;
876 Reactome pathways;
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last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023

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IMPAD1

Basic Information
Substrates
Pathway
Interacting Proteins
Phosphorylating Kinases

Gene Name	IMPAD1 (QuickGO)	Interactive visualization IMPAD1 structures (A quick tutorial to explore the interctive visulaization)
Synonyms	IMPAD1, IMPA3
Protein Name	IMPAD1
Alternative Name(s)	Inositol monophosphatase 3;IMP 3;IMPase 3;3.1.3.25;3.1.3.7;Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase;Golgi-resident PAP phosphatase;gPAPP;Inositol monophosphatase domain-containing protein 1;Inositol-1(or 4)-monophosphatase 3;Myo-inositol monophosphatase A3;
EntrezGene ID	54928 (Comparitive Toxicogenomics)
UniProt AC (Human)	Q9NX62 (protein sequence)
Enzyme Class	EC 3.1.3.25 3.1.3.7 (BRENDA )
Molecular Weight	38681 Dalton
Protein Length	359 amino acids (AA)
Genome Browsers	NCBI \| ENSG00000104331 (Ensembl) \| UCSC
Crosslinking annotations	Query our ID-mapping table
Orthologues	Quest For Orthologues (QFO) \| GeneTree
Classification	Superfamily: adenosine_fructose_inositol-x-phosphatases (AFIxP) \| Historic class: Inositol monophosphatase \| CATH ID: 3.30.540.10, 3.40.190.80 \| SCOP Fold: CP
Phosphatase activity	active \| Catalytic signature motif: unknown

Domain organization, Expression, Diseases

Localization, Function, Catalytic activity and Sequence

Motif information from Eukaryotic Linear Motif atlas (ELM)

Gene Ontology (P: Process; F: Function and C: Component terms)

KEGG Pathway
Reactome Pathway

Pathway ID	Pathway Name	Pathway Description (KEGG)
hsa00562	Inositol phosphate metabolism
hsa00920	Sulfur metabolism	Sulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in sulfate to -2 in sulfide (H2S). Sulfate reduction can occur in both an energy consuming assimilatory pathway and an energy producing dissimilatory pathway. The assimilatory pathway, which is found in a wide range of organisms, produces reduced sulfur compounds for the biosynthesis of S-containing amino acids and does not lead to direct excretion of sulfide. In the dissimilatory pathway, which is restricted to obligatory anaerobic bacterial and archaeal lineages, sulfate (or sulfur) is the terminal electron acceptor of the respiratory chain producing large quantities of inorganic sulfide. Both pathways start from the activation of sulfate by reaction with ATP to form adenylyl sulfate (APS). In the assimilatory pathway [MD:M00176] APS is converted to 3'-phosphoadenylyl sulfate (PAPS) and then reduced to sulfite, and sulfite is further reduced to sulfide by the assimilatory sulfite reductase. In the dissimilatory pathway [MD:M00596] APS is directly reduced to sulfite, and sulfite is further reduced to sulfide by the dissimilatory sulfite reductase. The capacity for oxidation of sulfur is quite widespread among bacteria and archaea, comprising phototrophs and chemolithoautotrophs. The SOX (sulfur-oxidation) system [MD:M00595] is a well-known sulfur oxidation pathway and is found in both photosynthetic and non-photosynthetic sulfur-oxidizing bacteria. Green sulfur bacteria and purple sulfur bacteria carry out anoxygenic photosynthesis with reduced sulfur compounds such as sulfide and elemental sulfur, as well as thiosulfate (in some species with the SOX system), as the electron donor for photoautotrophic growth. In some chemolithoautotrophic sulfur oxidizers (such as Thiobacillus denitrificans), it has been suggested that dissimilatory sulfur reduction enzymes operate in the reverse direction, forming a sulfur oxidation pathway from sulfite to APS and then to sulfate.
hsa01100	Metabolic pathways
hsa04070	Phosphatidylinositol signaling system