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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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PTPN1

Gene Name PTPN1 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 2F71
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsPTPN1 PTP1B
Protein NameTyrosine-protein phosphatase non-receptor type 1
Alternative Name(s)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Ensembl Gene IDENSG00000196396
EntrezGene ID5770
UniProt AC (Human)P18031 (protein sequence)
Enzyme ClassEC 3.1.3.48 (BRENDA )
Molecular Weight49967
Protein Length435
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 1 (CATH: 3.90.190.10)Historical ClassPTPs >> Class I Cys-based PTPs >> Classical PTPs >> Non-receptor type PTPs (NRPTPs)
Localization cytoplasm; endoplasmic reticulum (PubMed: 2546149, 1739967, 7935344 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: May play an important role in CKII- and p60c-src-induced signal transduction cascades (By similarity).
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Protein Sequence
MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE PPPEHIPPPP RPPKRILEPH NGKCREFFPN HQWVKEETQE DKDCPIKEEK GSPLNAAPYG IESMSQDTEV RSRVVGGSLR GAQAASPAKG EPSLPEKDED HALSYWKPFL VNMCVATVLT AGAYLCYRFL FNSNT
ELM motif
N/A
Gene Ontology
GO:0007596blood coagulation
GO:0005829cytosol
GO:0005789endoplasmic reticulum membrane
GO:0060333interferon-gamma-mediated signaling pathway
GO:0046627negative regulation of insulin receptor signaling pathway
GO:0004725protein tyrosine phosphatase activity
GO:0060334regulation of interferon-gamma-mediated signaling pathway
GO:0060338regulation of type I interferon-mediated signaling pathway
GO:0060337type I interferon-mediated signaling pathway
GO:0008270zinc ion binding

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