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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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GHR

Gene Name GHR (QuickGO)

PDB ID: 1A22
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SynonymsGHR
Protein NameGHR
Alternative Name(s)
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Protein FamilyType I cytokine receptor family, Type 1 subfamily
EntrezGene ID2690
UniProt AC (Human)P10912 (protein sequence)
Enzyme ClassN/A
Molecular Weight71500
Protein Length638
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Localization (UniProt annotation)Cell membrane; Single-pass type I membrane protein. Secreted.
Gene ExpressionGene Expression Atlas Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).; FUNCTION: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.; FUNCTION: Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.
Catalytic Activity (UniProt annotation)
N/A
Protein Sequence
MDLWQLLLTL ALAGSSDAFS GSEATAAILS RAPWSLQSVN PGLKTNSSKE PKFTKCRSPE RETFSCHWTD EVHHGTKNLG PIQLFYTRRN TQEWTQEWKE CPDYVSAGEN SCYFNSSFTS IWIPYCIKLT SNGGTVDEKC FSVDEIVQPD PPIALNWTLL NVSLTGIHAD IQVRWEAPRN ADIQKGWMVL EYELQYKEVN ETKWKMMDPI LTTSVPVYSL KVDKEYEVRV RSKQRNSGNY GEFSEVLYVT LPQMSQFTCE EDFYFPWLLI IIFGIFGLTV MLFVFLFSKQ QRIKMLILPP VPVPKIKGID PDLLKEGKLE EVNTILAIHD SYKPEFHSDD SWVEFIELDI DEPDEKTEES DTDRLLSSDH EKSHSNLGVK DGDSGRTSCC EPDILETDFN ANDIHEGTSE VAQPQRLKGE ADLLCLDQKN QNNSPYHDAC PATQQPSVIQ AEKNKPQPLP TEGAESTHQA AHIQLSNPSS LSNIDFYAQV SDITPAGSVV LSPGQKNKAG MSQCDMHPEM VSLCQENFLM DNAYFCEADA KKCIPVAPHI KVESHIQPSL NQEDIYITTE SLTTAAGRPG TGEHVPGSEM PVPDYTSIHI VQSPQGLILN ATALPLPDKE FLSSCGYVST DQLNKIMP
ELM motif
LIG_SH2_STAT5STAT5 Src Homology 2 (SH2) domain binding motif.
Gene Ontology
GO:00061032-oxoglutarate metabolic process
GO:0007259JAK-STAT cascade
GO:0042977activation of JAK2 kinase activity
GO:0000187activation of MAPK activity
GO:0000255allantoin metabolic process
GO:0009986cell surface
GO:0006101citrate metabolic process
GO:0006600creatine metabolic process
GO:0046449creatinine metabolic process
GO:0006897endocytosis
GO:0005615extracellular space
GO:0006631fatty acid metabolic process
GO:0019838growth factor binding
GO:0070195growth hormone receptor complex
GO:0060396growth hormone receptor signaling pathway
GO:0048009insulin-like growth factor receptor signaling pathway
GO:0005887integral to plasma membrane
GO:0006549isoleucine metabolic process
GO:0044236multicellular organismal metabolic process
GO:0006107oxaloacetate metabolic process
GO:0017046peptide hormone binding
GO:0040018positive regulation of multicellular organism growth
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0070064proline-rich region binding
GO:0042803protein homodimerization activity
GO:0019901protein kinase binding
GO:0031623receptor internalization
GO:0046898response to cycloheximide
GO:0032355response to estradiol stimulus
GO:0006105succinate metabolic process
GO:0019530taurine metabolic process
GO:0006573valine metabolic process

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