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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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IMPA2

Gene Name IMPA2 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 2CZH
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsIMPA2 IMP.18P
Protein NameInositol monophosphatase 2
Alternative Name(s)
Inositol monophosphatase 2 (IMP 2) (IMPase 2) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2)
Ensembl Gene IDENSG00000141401
EntrezGene ID3613
UniProt AC (Human)O14732 (protein sequence)
Enzyme ClassEC 3.1.3.25 (BRENDA )
Molecular Weight31321
Protein Length288
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 10 (CATH: 3.30.540.10, 3.40.190.80)Historical ClassInositol monophosphatase
Localization N/A
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
Protein Sequence
MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK
ELM motif
N/A
Gene Ontology
GO:0005737cytoplasm
GO:0008934inositol monophosphate phosphatase activity
GO:0046855inositol phosphate dephosphorylation
GO:0046872metal ion binding
GO:0042803protein homodimerization activity
GO:0007165signal transduction

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