Top ILKAP
Localization (UniProt annotation) Cytoplasm Function (UniProt annotation) Protein phosphatase that may play a role in regulationof cell cycle progression via dephosphorylation of its substrateswhose appropriate phosphorylation states might be crucial for cellproliferation Selectively associates with integrin linked kinase(ILK), to modulate cell adhesion and growth factor signalingInhibits the ILK-GSK3B signaling axis and may play an importantrole in inhibiting oncogenic transformation Catalytic Activity (UniProt annotation) [a protein]-serine/threonine phosphate + H(2)O= [a protein]-serine/threonine + phosphate Protein Sequence MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSGSLATSISQMVKTEGKGAKRK
TSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRAS
KFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAI
LCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRF
ILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRIGH
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source CDK9 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CEP19 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CERK Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct CFAP298 Affinity Capture-MS physical 26496610 , (Europe PMC )NA BioGRID CHEK1 Biochemical Activity physical 29371914 , (Europe PMC )NA BioGRID CHEK2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CHST15 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct CSK Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EGFR Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID EPHA2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID EPHA3 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB3 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB4 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID FBH1 Affinity Capture-MS physical 26496610 , (Europe PMC )NA BioGRID FGFR3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID GSK3B Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HGS Reconstituted Complex physical 19019082 , (Europe PMC )NA BioGRID IGF1R Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ILK Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 11331582 , (Europe PMC )0.51 BioGRID, IntAct KDR Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID KIT Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID LMTK2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID LTN1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MAEL Affinity Capture-Western physical 29371914 , (Europe PMC )NA BioGRID MAP2K7 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MAPK1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MAPK14 Biochemical Activity physical 29371914 , (Europe PMC )NA BioGRID MAPK3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MUSK Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID NDUFS6 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID OTUB1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26752685 , (Europe PMC )0.35 BioGRID, IntAct PAK1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PAK2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PDK1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct PRPF3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PRPF4 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PTK7 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ROR1 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ROR2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID RPS6KA1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RPS6KA3 Biochemical Activity physical 29371914 , (Europe PMC )NA BioGRID SMAD4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID SNRNP27 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID STAT5A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct TEK Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID TRIM25 Affinity Capture-RNA physical 29117863 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source CASQ1 pull down association 28330616 , (Europe PMC )0.35 IntAct CEP19 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CERK Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct CHST15 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct CUX1 pull down association 28330616 , (Europe PMC )0.35 IntAct DBN1 pull down association 28330616 , (Europe PMC )0.35 IntAct FBXO18 anti tag coimmunoprecipitation association 26496610 , (Europe PMC )0.35 IntAct ILK Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 11331582 , (Europe PMC )0.51 BioGRID, IntAct JUN anti bait coimmunoprecipitation association 25609649 , (Europe PMC )0.35 IntAct, MINT LTN1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MYO1B pull down association 28330616 , (Europe PMC )0.35 IntAct MYO1C pull down association 28330616 , (Europe PMC )0.35 IntAct OTUB1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26752685 , (Europe PMC )0.35 BioGRID, IntAct PDK1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct PPM1G pull down association 28330616 , (Europe PMC )0.35 IntAct PTPRB pull down association 28330616 , (Europe PMC )0.35 IntAct PTPRH pull down association 28330616 , (Europe PMC )0.35 IntAct RPS11 pull down association 28330616 , (Europe PMC )0.35 IntAct STAT5A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct TAF4B pull down association 28330616 , (Europe PMC )0.35 IntAct TPM4 pull down association 28330616 , (Europe PMC )0.35 IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source C21orf59 anti tag coimmunoprecipitation association 26496610 , (Europe PMC )0.35 IntAct CASQ1 pull down association 28330616 , (Europe PMC )0.35 IntAct CDK9 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CEP19 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CERK Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct CFAP298 Affinity Capture-MS physical 26496610 , (Europe PMC )NA BioGRID CHEK1 Biochemical Activity physical 29371914 , (Europe PMC )NA BioGRID CHEK2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CHST15 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct CSK Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CUX1 pull down association 28330616 , (Europe PMC )0.35 IntAct DBN1 pull down association 28330616 , (Europe PMC )0.35 IntAct EGFR Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID EPHA2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID EPHA3 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB3 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB4 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID FBH1 Affinity Capture-MS physical 26496610 , (Europe PMC )NA BioGRID FBXO18 anti tag coimmunoprecipitation association 26496610 , (Europe PMC )0.35 IntAct FGFR3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID GSK3B Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HGS Reconstituted Complex physical 19019082 , (Europe PMC )NA BioGRID IGF1R Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ILK Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 11331582 , (Europe PMC )0.51 BioGRID, IntAct JUN anti bait coimmunoprecipitation association 25609649 , (Europe PMC )0.35 IntAct, MINT KDR Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID KIT Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID LMTK2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID LTN1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MAEL Affinity Capture-Western physical 29371914 , (Europe PMC )NA BioGRID MAP2K7 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MAPK1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MAPK14 Biochemical Activity physical 29371914 , (Europe PMC )NA BioGRID MAPK3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MUSK Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID MYO1B pull down association 28330616 , (Europe PMC )0.35 IntAct MYO1C pull down association 28330616 , (Europe PMC )0.35 IntAct NDUFS6 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID OTUB1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26752685 , (Europe PMC )0.35 BioGRID, IntAct PAK1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PAK2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PDK1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct PPM1G pull down association 28330616 , (Europe PMC )0.35 IntAct PRPF3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PRPF4 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PTK7 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID PTPRB pull down association 28330616 , (Europe PMC )0.35 IntAct PTPRH pull down association 28330616 , (Europe PMC )0.35 IntAct ROR1 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ROR2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID RPS11 pull down association 28330616 , (Europe PMC )0.35 IntAct RPS6KA1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RPS6KA3 Biochemical Activity physical 29371914 , (Europe PMC )NA BioGRID SMAD4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID SNRNP27 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID STAT5A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct TAF4B pull down association 28330616 , (Europe PMC )0.35 IntAct TEK Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID TPM4 pull down association 28330616 , (Europe PMC )0.35 IntAct TRIM25 Affinity Capture-RNA physical 29117863 , (Europe PMC )NA BioGRID
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