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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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PPP5C

Gene Name PPP5C (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 3H63
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsPPP5C PPP5
Protein NameSerine/threonine-protein phosphatase 5
Alternative Name(s)
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Ensembl Gene IDENSG00000011485
EntrezGene ID5536
UniProt AC (Human)P53041 (protein sequence)
Enzyme ClassEC 3.1.3.16 (BRENDA )
Molecular Weight56879
Protein Length499
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 5 (CATH: 3.60.21.10)Historical ClassPSTPs >> PPP >> PP5
Localization cytoplasm; nucleus; plasma membrane (PubMed: 15383005, 7925273, 10400612, 12176367 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
Protein Sequence
MAMAEGERTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK LEDGKVTISF MKELMQWYKD QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSISKR GVSCQFGPDV TKAFLEENNL DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP HPNVKPMAYA NTLLQLGMM
ELM motif
N/A
Gene Ontology
GO:0005794Golgi apparatus
GO:0046872metal ion binding
GO:0007067mitosis
GO:0005634nucleus
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0005515protein binding
GO:0006470protein dephosphorylation
GO:0004722protein serine/threonine phosphatase activity
GO:0004871signal transducer activity
GO:0006351transcription, DNA-dependent

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