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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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PPAP2A

Gene Name PPAP2A (QuickGO)SynonymsPPAP2A LPP1
Protein NameLipid phosphate phosphohydrolase 1
Alternative name(s)
Lipid phosphate phosphohydrolase 1 (EC 3.1.3.4) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a)
Ensembl Gene IDENSG00000067113EntrezGene ID8611
UniProt AC (Human)O14494 (protein sequence)Enzyme ClassEC 3.1.3.4 (BRENDA )
Molecular Weight32156Protein Length284
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 12 (CATH: 1.20.144.10)Historical ClassPhosphatidic acid phosphatase (PAP)
Localization cytosol; plasma membrane (PubMed: 9705349 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
Protein Sequence
MFDKTRLPYV ALDVLCVLLA GLPFAILTSR HTPFQRGVFC NDESIKYPYK EDTIPYALLG GIIIPFSIIV IILGETLSVY CNLLHSNSFI RNNYIATIYK AIGTFLFGAA ASQSLTDIAK YSIGRLRPHF LDVCDPDWSK INCSDGYIEY YICRGNAERV KEGRLSFYSG HSSFSMYCML FVALYLQARM KGDWARLLRP TLQFGLVAVS IYVGLSRVSD YKHHWSDVLT GLIQGALVAI LVAVYVSDFF KERTSFKERK EEDSHTTLHE TPTTGNHYPS NHQP
ELM motif
N/A
Gene Ontology
GO:0007205activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0030521androgen receptor signaling pathway
GO:0008354germ cell migration
GO:0005887integral to plasma membrane
GO:0005624membrane fraction
GO:0008285negative regulation of cell proliferation
GO:0008195phosphatidate phosphatase activity
GO:0046839phospholipid dephosphorylation
GO:0019216regulation of lipid metabolic process
GO:0006665sphingolipid metabolic process
GO:0042392sphingosine-1-phosphate phosphatase activity

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