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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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INPP5E

Gene Name INPP5E (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 2XSW
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SynonymsINPP5E
Protein Name72 kDa inositol polyphosphate 5-phosphatase
Alternative Name(s)
72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol polyphosphate 5-phosphatase type IV) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase)
Ensembl Gene IDENSG00000148384
EntrezGene ID56623
UniProt AC (Human)Q9NRR6 (protein sequence)
Enzyme ClassEC 3.1.3.36 (BRENDA )
Molecular Weight70205
Protein Length644
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 11 (CATH: 3.60.10.10)Historical ClassInositol-1,4,5-trisphosphate 5-phosphatase
Localization cytoplasm; cytoskeleton; golgi apparatus (PubMed: 10806194, 19668215, 19668216 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Converts phosphatidylinositol-3,4,5-triphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Protein Sequence
MPSKAENLRP SEPAPQPPEG RTLQGQLPGA PPAQRAGSPP DAPGSESPAL ACSTPATPSG EDPPARAAPI APRPPARPRL ERALSLDDKG WRRRRFRGSQ EDLEARNGTS PSRGSVQSEG PGAPAHSCSP PCLSTSLQEI PKSRGVLSSE RGSPSSGGNP LSGVASSSPN LPHRDAAVAG SSPRLPSLLP PRPPPALSLD IASDSLRTAN KVDSDLADYK LRAQPLLVRA HSSLGPGRPR SPLACDDCSL RSAKSSFSLL APIRSKDVRS RSYLEGSLLA SGALLGADEL ARYFPDRNVA LFVATWNMQG QKELPPSLDE FLLPAEADYA QDLYVIGVQE GCSDRREWET RLQETLGPHY VLLSSAAHGV LYMSLFIRRD LIWFCSEVEC STVTTRIVSQ IKTKGALGIS FTFFGTSFLF ITSHFTSGDG KVAERLLDYT RTVQALVLPR NVPDTNPYRS SAADVTTRFD EVFWFGDFNF RLSGGRTVVD ALLCQGLVVD VPALLQHDQL IREMRKGSIF KGFQEPDIHF LPSYKFDIGK DTYDSTSKQR TPSYTDRVLY RSRHKGDICP VSYSSCPGIK TSDHRPVYGL FRVKVRPGRD NIPLAAGKFD RELYLLGIKR RISKEIQRQQ ALQSQNSSTI CSVS
ELM motif
N/A
Gene Ontology
GO:0032580Golgi cisterna membrane
GO:0035085cilium axoneme
GO:0005856cytoskeleton
GO:0004445inositol-polyphosphate 5-phosphatase activity
GO:0004439phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

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