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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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G6PC2

Gene Name G6PC2 (QuickGO)SynonymsG6PC2 IGRP
Protein NameGlucose-6-phosphatase 2
Alternative name(s)
Glucose-6-phosphatase 2 (G-6-Pase 2) (G6Pase 2) (EC 3.1.3.9) (Islet-specific glucose-6-phosphatase catalytic subunit-related protein)
Ensembl Gene IDENSG00000152254EntrezGene ID57818
UniProt AC (Human)Q9NQR9 (protein sequence)Enzyme ClassEC 3.1.3.9 (BRENDA )
Molecular Weight40580Protein Length355
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 12 (CATH: 1.20.144.10)Historical ClassGlucose-6-phosphatase (Glc-6-Pase)
Localization endoplasmic reticulum (PubMed: 15044018 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: D-glucose 6-phosphate + H(2)O = D-glucose + phosphate.
Protein Sequence
MDFLHRNGVL IIQHLQKDYR AYYTFLNFMS NVGDPRNIFF IYFPLCFQFN QTVGTKMIWV AVIGDWLNLI FKWILFGHRP YWWVQETQIY PNHSSPCLEQ FPTTCETGPG SPSGHAMGAS CVWYVMVTAA LSHTVCGMDK FSITLHRLTW SFLWSVFWLI QISVCISRVF IATHFPHQVI LGVIGGMLVA EAFEHTPGIQ TASLGTYLKT NLFLFLFAVG FYLLLRVLNI DLLWSVPIAK KWCANPDWIH IDTTPFAGLV RNLGVLFGLG FAINSEMFLL SCRGGNNYTL SFRLLCALTS LTILQLYHFL QIPTHEEHLF YVLSFCKSAS IPLTVVAFIP YSVHMLMKQS GKKSQ
ELM motif
N/A
Gene Ontology
GO:0005789endoplasmic reticulum membrane
GO:0006094gluconeogenesis
GO:0042593glucose homeostasis
GO:0015758glucose transport
GO:0004346glucose-6-phosphatase activity
GO:0016021integral to membrane
GO:0050796regulation of insulin secretion
GO:0055085transmembrane transport

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