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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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DUSP23

Gene Name DUSP23 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 2IMG
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsDUSP23 LDP3 VHZ
Protein NameDual specificity protein phosphatase 23
Alternative Name(s)
Dual specificity protein phosphatase 23 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z)
Ensembl Gene IDENSG00000158716
EntrezGene ID54935
UniProt AC (Human)Q9BVJ7 (protein sequence)
Enzyme ClassEC 3.1.3.16, 3.1.3.48 (BRENDA )
Molecular Weight16588
Protein Length150
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 1 (CATH: 3.90.190.10)Historical ClassPTPs >> Class I Cys-based PTPs >> VH1-like or dual-specificity phosphatases (DSPs) >> Atypical DSPs
Localization cytoplasm; cytosol; nucleus (PubMed: 15281913, 15201283, 15147733 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.; CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
Protein Sequence
MGVQPPNFSW VLPGRLAGLA LPRLPAHYQF LLDLGVRHLV SLTERGPPHS DSCPGLTLHR LRIPDFCPPA PDQIDRFVQI VDEANARGEA VGVHCALGFG RTGTMLACYL VKERGLAAGD AIAEIRRLRP GSIETYEQEK AVFQFYQRTK
ELM motif
N/A
Gene Ontology
GO:0005829cytosol
GO:0005634nucleus
GO:0004725protein tyrosine phosphatase activity
GO:0008138protein tyrosine/serine/threonine phosphatase activity

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