spacer
Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
--------------------------------
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
--------------------------------
last update: 18 Feb, 2016

spacer

PPM1L

Gene Name PPM1L (QuickGO)SynonymsPPM1L PP2CE
Protein NameProtein phosphatase 1L
Alternative name(s)
Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon)
Ensembl Gene IDENSG00000163590EntrezGene ID151742
UniProt AC (Human)Q5SGD2 (protein sequence)Enzyme ClassEC 3.1.3.16 (BRENDA )
Molecular Weight41053Protein Length360
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 6 (CATH: 3.60.40.10)Historical ClassPSTPs >> PPM >> PP2C
Localization N/A
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
Protein Sequence
MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK SSRDAVKMVK GKVAEIMQND RLGGLDVLEA EFSKTWEFKN HNVAVYSIQG RRDHMEDRFE VLTDLANKTH PSIFGIFDGH GGETAAEYVK SRLPEALKQH LQDYEKDKEN SVLSYQTILE QQILSIDREM LEKLTVSYDE AGTTCLIALL SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK RIKRAGGFIS FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA SDGLWDAFSN EEAVRFIKER LDEPHFGAKS IVLQSFYRGC PDNITVMVVK FRNSSKTEEQ
ELM motif
N/A
Gene Ontology
GO:0005789endoplasmic reticulum membrane
GO:0016021integral to membrane
GO:0046872metal ion binding
GO:0006470protein dephosphorylation
GO:0004722protein serine/threonine phosphatase activity
GO:0008287protein serine/threonine phosphatase complex
GO:0006665sphingolipid metabolic process

spacer
spacer