spacer
Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
--------------------------------
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
--------------------------------
last update: 18 Feb, 2016

spacer

PTPN11

Gene Name PTPN11 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 3O5X
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsPTPN11 PTP2C SHPTP2
Protein NameTyrosine-protein phosphatase non-receptor type 11
Alternative Name(s)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Ensembl Gene IDENSG00000179295
EntrezGene ID5781
UniProt AC (Human)Q06124 (protein sequence)
Enzyme ClassEC 3.1.3.48 (BRENDA )
Molecular Weight68436
Protein Length597
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 1 (CATH: 3.90.190.10)Historical ClassPTPs >> Class I Cys-based PTPs >> Classical PTPs >> Non-receptor type PTPs (NRPTPs)
Localization cytoplasm; cytosol; plasma membrane (PubMed: 10940933, 10734310, 14560030, 14665621, 15574420, 9054388 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Protein Sequence
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIRCQELKYD VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQAL LQGNTERTVW QYHFRTWPDH GVPSDPGGVL DFLEEVHHKQ ESIMDAGPVV VHCSAGIGRT GTFIVIDILI DIIREKGVDC DIDVPKTIQM VRSQRSGMVQ TEAQYRFIYM AVQHYIETLQ RRIEEEQKSK RKGHEYTNIK YSLADQTSGD QSPLPPCTPT PPCAEMREDS ARVYENVGLM QQQKSFR
ELM motif
LIG_SH2_GRB2GRB2-like Src Homology 2 (SH2) domains binding motif.
Gene Ontology
GO:0031295T cell costimulation
GO:0007411axon guidance
GO:0034329cell junction assembly
GO:0005829cytosol
GO:0048013ephrin receptor signaling pathway
GO:0007173epidermal growth factor receptor signaling pathway
GO:0008543fibroblast growth factor receptor signaling pathway
GO:0008286insulin receptor signaling pathway
GO:0060333interferon-gamma-mediated signaling pathway
GO:0050900leukocyte migration
GO:0004726non-membrane spanning protein tyrosine phosphatase activity
GO:0030168platelet activation
GO:0005515protein binding
GO:0033628regulation of cell adhesion mediated by integrin
GO:0060334regulation of interferon-gamma-mediated signaling pathway
GO:0060338regulation of type I interferon-mediated signaling pathway
GO:0060337type I interferon-mediated signaling pathway

spacer
spacer