spacer
Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
--------------------------------
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
--------------------------------
last update: 18 Feb, 2016

spacer

PTPN12

Gene Name PTPN12 (QuickGO)SynonymsPTPN12
Protein NameTyrosine-protein phosphatase non-receptor type 12
Alternative name(s)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Ensembl Gene IDENSG00000127947EntrezGene ID5782
UniProt AC (Human)Q05209 (protein sequence)Enzyme ClassEC 3.1.3.48 (BRENDA )
Molecular Weight88106Protein Length780
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 1 (CATH: 3.90.190.10)Historical ClassPTPs >> Class I Cys-based PTPs >> Classical PTPs >> Non-receptor type PTPs (NRPTPs)
Localization cytoplasm (PubMed: 11337490, 8887669 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesChEMBL
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
N/A
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Protein Sequence
MEQVEILRKF IQRVQAMKSP DHNGEDNFAR DFMRLRRLST KYRTEKIYPT ATGEKEENVK KNRYKDILPF DHSRVKLTLK TPSQDSDYIN ANFIKGVYGP KAYVATQGPL ANTVIDFWRM IWEYNVVIIV MACREFEMGR KKCERYWPLY GEDPITFAPF KISCEDEQAR TDYFIRTLLL EFQNESRRLY QFHYVNWPDH DVPSSFDSIL DMISLMRKYQ EHEDVPICIH CSAGCGRTGA ICAIDYTWNL LKAGKIPEEF NVFNLIQEMR TQRHSAVQTK EQYELVHRAI AQLFEKQLQL YEIHGAQKIA DGVNEINTEN MVSSIEPEKQ DSPPPKPPRT RSCLVEGDAK EEILQPPEPH PVPPILTPSP PSAFPTVTTV WQDNDRYHPK PVLHMVSSEQ HSADLNRNYS KSTELPGKNE STIEQIDKKL ERNLSFEIKK VPLQEGPKSF DGNTLLNRGH AIKIKSASPC IADKISKPQE LSSDLNVGDT SQNSCVDCSV TQSNKVSVTP PEESQNSDTP PRPDRLPLDE KGHVTWSFHG PENAIPIPDL SEGNSSDINY QTRKTVSLTP SPTTQVETPD LVDHDNTSPL FRTPLSFTNP LHSDDSDSDE RNSDGAVTQN KTNISTASAT VSAATSTESI STRKVLPMSI ARHNIAGTTH SGAEKDVDVS EDSPPPLPER TPESFVLASE HNTPVRSEWS ELQSQERSEQ KKSEGLITSE NEKCDHPAGG IHYEMCIECP PTFSDKREQI SENPTEATDI GFGNRCGKPK GPRDPPSEWT
ELM motif
N/A
Gene Ontology
GO:0017124SH3 domain binding
GO:0004726non-membrane spanning protein tyrosine phosphatase activity
GO:0005625soluble fraction

spacer
spacer