spacer
Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
--------------------------------
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
--------------------------------
last update: 18 Feb, 2016

spacer

ACP5

Gene Name ACP5 (QuickGO)
Structure of phosphatase catalytic domain

PDB ID: 1WAR
(LeftMouse - Rotate; Shift+Left - Scale; Ctrl+Left - Translate)
SynonymsACP5
Protein NameTartrate-resistant acid phosphatase type 5
Alternative Name(s)
Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase)
Ensembl Gene IDENSG00000102575
EntrezGene ID54
UniProt AC (Human)P13686 (protein sequence)
Enzyme ClassEC 3.1.3.2 (BRENDA )
Molecular Weight36599
Protein Length325
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 5 (CATH: 3.60.21.10)Historical ClassPurple acid phosphatase
Localization cytoplasm; cytosol; extracellular region; vacuole (PubMed: 12450668, 10639488, 2775236 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol + phosphate.
Protein Sequence
MDMWTALLIL QALLLPSLAD GATPALRFVA VGDWGGVPNA PFHTAREMAN AKEIARTVQI LGADFILSLG DNFYFTGVQD INDKRFQETF EDVFSDRSLR KVPWYVLAGN HDHLGNVSAQ IAYSKISKRW NFPSPFYRLH FKIPQTNVSV AIFMLDTVTL CGNSDDFLSQ QPERPRDVKL ARTQLSWLKK QLAAAREDYV LVAGHYPVWS IAEHGPTHCL VKQLRPLLAT YGVTAYLCGH DHNLQYLQDE NGVGYVLSGA GNFMDPSKRH QRKVPNGYLR FHYGTEDSLG GFAYVEISSK EMTVTYIEAS GKSLFKTRLP RRARP
ELM motif
N/A
Gene Ontology
GO:0003993acid phosphatase activity
GO:0005829cytosol
GO:0008199ferric iron binding
GO:0008198ferrous iron binding
GO:0016021integral to membrane
GO:0005764lysosome
GO:0006767water-soluble vitamin metabolic process

spacer
spacer