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Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
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305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
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213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
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last update: 18 Feb, 2016

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PFKFB2

Gene Name PFKFB2 (QuickGO)SynonymsPFKFB2
Protein NameFructose-2,6-bisphosphatase
Alternative name(s)
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
Ensembl Gene IDENSG00000123836EntrezGene ID5208
UniProt AC (Human)O60825 (protein sequence)Enzyme ClassEC 3.1.3.46, 2.7.1.105 (BRENDA )
Molecular Weight58477Protein Length505
Phosphatase activityactive
Protein DomainInterPro | Pfam3D Structure * PDB | PDBe | DrugPort
* ModBase | SwissModel
Structure-based FamilyFamily 8 (CATH: 3.40.50.1240)Historical ClassPhosphoglycerate mutase
Localization cytosol; mitochondrion (PubMed: 7904197, 9464277 | Europe PMC)
Catalytic SiteCatalytic Site Atlas Target by Small MoleculesN/A
Gene ExpressionGene Expression Atlas

The Human Protein Atlas

Function and DiseaseOMIM
Protein-protein Interaction Database STRING | IntAct | MINT
Kinase Database Phospho.ELM | PhosphoSite | NetworKIN
Function (UniProt annotation)
FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate.
Catalytic Activity (UniProt annotation)
CATALYTIC ACTIVITY: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.; CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
Protein Sequence
MSGASSSEQN NNSYETKTPN LRMSEKKCSW ASYMTNSPTL IVMIGLPARG KTYVSKKLTR YLNWIGVPTK VFNLGVYRRE AVKSYKSYDF FRHDNEEAMK IRKQCALVAL EDVKAYLTEE NGQIAVFDAT NTTRERRDMI LNFAEQNSFK VFFVESVCDD PDVIAANILE VKVSSPDYPE RNRENVMEDF LKRIECYKVT YRPLDPDNYD KDLSFIKVIN VGQRFLVNRV QDYIQSKIVY YLMNIHVQPR TIYLCRHGES EFNLLGKIGG DSGLSVRGKQ FAQALRKFLE EQEITDLKVW TSQLKRTIQT AESLGVPYEQ WKILNEIDAG VCEEMTYAEI EKRYPEEFAL RDQEKYLYRY PGGESYQDLV QRLEPVIMEL ERQGNVLVIS HQAVMRCLLA YFLDKGADEL PYLRCPLHTI FKLTPVAYGC KVETIKLNVE AVNTHRDKPT NNFPKNQTPV RMRRNSFTPL SSSNTIRRPR NYSVGSRPLK PLSPLRAQDM QEGAD
ELM motif
N/A
Gene Ontology
GO:00038736-phosphofructo-2-kinase activity
GO:0005524ATP binding
GO:0005829cytosol
GO:0006003fructose 2,6-bisphosphate metabolic process
GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity
GO:0006096glycolysis

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