Collapse Statistics
226 human active and 11 inactive phosphatases in total;
194 phosphatases have substrate data;
305 protein substrates;
89 non-protein substrates;
1114 dephosphorylation interactions;
213 KEGG pathways;
206 NCI Nature PID pathways
560 Reactome pathways;
last update: 18 Feb, 2016


DEPOD - Substrate Search Result

Protein substrate

Name Gene namesProtein names
N-WASPWASLNeural Wiskott-Aldrich syndrome protein (N-WASP)
AXIN1AXIN1 AXINAxin-1 (Axis inhibition protein 1) (hAxin)
LATLATLinker for activation of T-cells family member 1 (36 kDa phospho-tyrosine adapter protein) (pp36) (p36-38)
PSTPIP1PSTPIP1 CD2BP1Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)
TONEBPNFAT5 KIAA0827 TONEBPNuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP)
c-MycMYC BHLHE39Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
PDHA1PDHA1 PHE1APyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC (PDHE1-A type I)
TAUMAPT MAPTL MTBT1 TAUMicrotubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
CD32FCGR2A CD32 FCG2 FCGR2A1 IGFR2Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)
E-cadherinCDH1 CDHE UVOCadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
EzrinEZR VIL2Ezrin (Cytovillin) (Villin-2) (p81)
RP-A p32RPA2 REPA2 RPA32 RPA34Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)
PLC-gamma-1PLCG1 PLC11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (EC (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
NucleolinNCLNucleolin (Protein C23)
CBLCBL CBL2 RNF55E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (Signal transduction protein CBL)
MSNMSNMoesin (Membrane-organizing extension spike protein)
SHC1SHC1 SHC SHCASHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
PDHA2PDHA2 PDHALPyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC (PDHE1-A type II)
IRS1IRS1Insulin receptor substrate 1 (IRS-1)
BRCA1BRCA1 RNF53Breast cancer type 1 susceptibility protein (EC 6.3.2.-) (RING finger protein 53)
WASpWAS IMD2Wiskott-Aldrich syndrome protein (WASp)
SHPS-1SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRPTyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
SMAD3SMAD3 MADH3Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
FKBP4FKBP4 FKBP52Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
NF-kappa-B p65RELA NFKB3Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
p190-BARHGAP5 RHOGAP5Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B)
SKP2SKP2 FBXL1S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
NFAT1NFATC2 NFAT1 NFATPNuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)
CortactinCTTN EMS1Src substrate cortactin (Amplaxin) (Oncogene EMS1)
POLD3POLD3 KIAA0039DNA polymerase delta subunit 3 (DNA polymerase delta subunit p66)
SMAD2SMAD2 MADH2 MADR2Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
SMAD1SMAD1 BSP1 MADH1 MADR1Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
RN-treUSP6NL KIAA0019USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre)
KAP3KIFAP3 KIF3AP SMAPKinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein)
C-Nap1CEP250 CEP2 CNAP1Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2)
Carma1CARD11 CARMA1Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)
RACGAP1RACGAP1 KIAA1478 MGCRACGAPRac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP)
p190 RhoGAPARHGAP35 GRF1 GRLF1 KIAA1722Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)
SK1SPHK1 SPHK SPKSphingosine kinase 1 (SK 1) (SPK 1) (EC
CERTCOL4A3BP CERT STARD11Collagen type IV alpha-3-binding protein (Ceramide transfer protein) (hCERT) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11)
PAGPAG1 CBP PAGPhosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)
mannose 6-phosphate glycoproteinsN/Amannose 6-phosphate glycoproteins
reduced carboxyamidomethylated and maleylated lysozyme (RCML)N/Areduced carboxyamidomethylated and maleylated lysozyme (RCML)