Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
MAP2K1	6840	COSM4166155,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A106T	Substitution - Missense	15:66436770-66436770,	PATHOGENIC	0.9965	24982505
MAP2K1	6840	COSM6931494,	breast	carcinoma	p.?	Unknown	15:66436745-66436745,	PATHOGENIC	0.9965	28481359
MAP2K1	6840	COSM6946330,	large_intestine	carcinoma	p.H100N	Substitution - Missense	15:66436752-66436752,	PATHOGENIC	0.99557	28481359
MAP2K1	6840	COSM1238027,	skin	malignant_melanoma	p.I111S	Substitution - Missense	15:66436786-66436786,	PATHOGENIC	0.99515	22588879
MAP2K1	6840	COSM1238027,	skin	malignant_melanoma	p.I111S	Substitution - Missense	15:66436786-66436786,	PATHOGENIC	0.99515	22588879
MAP2K1	6840	COSM1238027,	skin	malignant_melanoma	p.I111S	Substitution - Missense	15:66436786-66436786,	PATHOGENIC	0.99515	24463458
MAP2K1	6840	COSM1238027,	skin	malignant_melanoma	p.I111S	Substitution - Missense	15:66436786-66436786,	PATHOGENIC	0.99515	24463458
MAP2K1	6840	COSM1238027,	skin	malignant_melanoma	p.I111S	Substitution - Missense	15:66436786-66436786,	PATHOGENIC	0.99515	24463458
MAP2K1	6840	COSM6978597,	lung	carcinoma	p.?	Unknown	15:66443358-66443358,	PATHOGENIC	0.99488	28481359
MAP2K1	6840	COSM5546576,	skin	malignant_melanoma	p.G176S	Substitution - Missense	15:66444665-66444665,	PATHOGENIC	0.99445	24463458
MAP2K1	6840	COSM5546576,	skin	malignant_melanoma	p.G176S	Substitution - Missense	15:66444665-66444665,	PATHOGENIC	0.99445	24463458
MAP2K1	6840	COSM6984581,	endometrium	carcinoma	p.H184R	Substitution - Missense	15:66444690-66444690,	PATHOGENIC	0.99442	28481359
MAP2K1	6840	COSM3503332,	skin	malignant_melanoma	p.W247*	Substitution - Nonsense	15:66485036-66485036,	PATHOGENIC	0.99417	28481359
MAP2K1	6840	COSM1315829,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C121S	Substitution - Missense	15:66436816-66436816,	PATHOGENIC	0.99404	25899310
MAP2K1	6840	COSM1315829,	biliary_tract	carcinoma	p.C121S	Substitution - Missense	15:66436816-66436816,	PATHOGENIC	0.99404	28481359
MAP2K1	6840	COSM1315829,	NS	malignant_melanoma	p.C121S	Substitution - Missense	15:66436816-66436816,	PATHOGENIC	0.99404	21383288
MAP2K1	6840	COSM1517232,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.G128V	Substitution - Missense	15:66436837-66436837,	PATHOGENIC	0.99341	24982505
MAP2K1	6840	COSM1517232,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.G128V	Substitution - Missense	15:66436837-66436837,	PATHOGENIC	0.99341	27241017
MAP2K1	6840	COSM6921082,	large_intestine	carcinoma	p.G137V	Substitution - Missense	15:66436864-66436864,	PATHOGENIC	0.99341	28481359
MAP2K1	6840	COSM1517232,	lung	carcinoma	p.G128V	Substitution - Missense	15:66436837-66436837,	PATHOGENIC	0.99341	28481359
MAP2K1	6840	COSM1517232,	large_intestine	carcinoma	p.G128V	Substitution - Missense	15:66436837-66436837,	PATHOGENIC	0.99341	28481359
MAP2K1	6840	COSM1578965,	endometrium	carcinoma	p.R201H	Substitution - Missense	15:66481788-66481788,	PATHOGENIC	0.99319	21726664
MAP2K1	6840	COSM1578965,	large_intestine	carcinoma	p.R201H	Substitution - Missense	15:66481788-66481788,	PATHOGENIC	0.99319	18186519
MAP2K1	6840	COSM1374186,	large_intestine	carcinoma	p.G128D	Substitution - Missense	15:66436837-66436837,	PATHOGENIC	0.99253	24951259
MAP2K1	6840	COSM1374186,	skin	malignant_melanoma	p.G128D	Substitution - Missense	15:66436837-66436837,	PATHOGENIC	0.99253	25452114
MAP2K1	6840	COSM1374186,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.G128D	Substitution - Missense	15:66436837-66436837,	PATHOGENIC	0.99253	25899310
MAP2K1	6840	COSM1374186,	skin	malignant_melanoma	p.G128D	Substitution - Missense	15:66436837-66436837,	PATHOGENIC	0.99253	28481359
MAP2K1	6840	COSM1374186,	large_intestine	carcinoma	p.G128D	Substitution - Missense	15:66436837-66436837,	PATHOGENIC	0.99253	28481359
MAP2K1	6840	COSM1374186,	skin	malignant_melanoma	p.G128D	Substitution - Missense	15:66436837-66436837,	PATHOGENIC	0.99253	28481359
MAP2K1	6840	COSM5009261,	large_intestine	carcinoma	p.D136N	Substitution - Missense	15:66436860-66436860,	PATHOGENIC	0.99253	24951259
MAP2K1	6840	COSM6930195,	skin	malignant_melanoma	p.G213V	Substitution - Missense	15:66481824-66481824,	PATHOGENIC	0.99244	28481359
MAP2K1	6840	COSM232755,	skin	malignant_melanoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	22197931
MAP2K1	6840	COSM232755,	skin	malignant_melanoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	26343386
MAP2K1	6840	COSM4253315,	endometrium	carcinoma	p.S212N	Substitution - Missense	15:66481821-66481821,	PATHOGENIC	0.99148	28481359
MAP2K1	6840	COSM232755,	NS	malignant_melanoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	28481359
MAP2K1	6840	COSM232755,	central_nervous_system	glioma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	28481359
MAP2K1	6840	COSM232755,	large_intestine	carcinoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	28481359
MAP2K1	6840	COSM232755,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	28481359
MAP2K1	6840	COSM232755,	skin	malignant_melanoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	28481359
MAP2K1	6840	COSM232755,	skin	malignant_melanoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	28481359
MAP2K1	6840	COSM232755,	skin	malignant_melanoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	28481359
MAP2K1	6840	COSM232755,	urinary_tract	carcinoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	28481359
MAP2K1	6840	COSM232755,	large_intestine	carcinoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	24951259
MAP2K1	6840	COSM232755,	lung	carcinoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	28481359
MAP2K1	6840	COSM232755,	large_intestine	carcinoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	18186519
MAP2K1	6840	COSM232755,	large_intestine	carcinoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	21726664
MAP2K1	6840	COSM232755,	skin	malignant_melanoma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	24463458
MAP2K1	6840	COSM232755,	central_nervous_system	glioma	p.E203K	Substitution - Missense	15:66481793-66481793,	PATHOGENIC	0.99148	28481359
MAP2K1	6840	COSM6904425,	upper_aerodigestive_tract	carcinoma	p.H188Y	Substitution - Missense	15:66444701-66444701,	PATHOGENIC	0.99119	27105424
MAP2K1	6840	COSM6968948,	small_intestine	carcinoma	p.A158V	Substitution - Missense	15:66443314-66443314,	PATHOGENIC	0.99091	28481359
MAP2K1	6840	COSM1196947,	lung	carcinoma	p.Y134C	Substitution - Missense	15:66436855-66436855,	PATHOGENIC	0.99058	18186519
MAP2K1	6840	COSM6950284,	lung	carcinoma	p.N122D	Substitution - Missense	15:66436818-66436818,	PATHOGENIC	0.99058	28481359
MAP2K1	6840	COSM4808464,	large_intestine	carcinoma	p.Y130C	Substitution - Missense	15:66436843-66436843,	PATHOGENIC	0.99058	28481359
MAP2K1	6840	COSM6949338,	urinary_tract	carcinoma	p.P264R	Substitution - Missense	15:66485087-66485087,	PATHOGENIC	0.99021	28481359
MAP2K1	6840	COSM1235482,	large_intestine	carcinoma	p.R49L	Substitution - Missense	15:66435092-66435092,	PATHOGENIC	0.99018	22327936
MAP2K1	6840	COSM5702509,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M94I	Substitution - Missense	15:66435228-66435228,	PATHOGENIC	0.99	26980021
MAP2K1	6840	COSM1678546,	small_intestine	carcinoma	p.D67N	Substitution - Missense	15:66435145-66435145,	PATHOGENIC	0.98984	28481359
MAP2K1	6840	COSM1678546,	large_intestine	carcinoma	p.D67N	Substitution - Missense	15:66435145-66435145,	PATHOGENIC	0.98984	19411838
MAP2K1	6840	COSM1678546,	ovary	carcinoma	p.D67N	Substitution - Missense	15:66435145-66435145,	PATHOGENIC	0.98984	18060073
MAP2K1	6840	COSM1678546,	salivary_gland	carcinoma	p.D67N	Substitution - Missense	15:66435145-66435145,	PATHOGENIC	0.98984	27334835
MAP2K1	6840	COSM1678546,	large_intestine	carcinoma	p.D67N	Substitution - Missense	15:66435145-66435145,	PATHOGENIC	0.98984	22327936
MAP2K1	6840	COSM1678546,	lung	carcinoma	p.D67N	Substitution - Missense	15:66435145-66435145,	PATHOGENIC	0.98984	23371856
MAP2K1	6840	COSM1678546,	endometrium	carcinoma	p.D67N	Substitution - Missense	15:66435145-66435145,	PATHOGENIC	0.98984	27159395
MAP2K1	6840	COSM1678546,	endometrium	carcinoma	p.D67N	Substitution - Missense	15:66435145-66435145,	PATHOGENIC	0.98984	27159395
MAP2K1	6840	COSM6986263,	skin	malignant_melanoma	p.P124R	Substitution - Missense	15:66436825-66436825,	PATHOGENIC	0.98979	28481359
MAP2K1	6840	COSM6927503,	lung	carcinoma	p.S194A	Substitution - Missense	15:66481766-66481766,	PATHOGENIC	0.9893	28481359
MAP2K1	6840	COSM6947606,	lung	carcinoma	p.I204F	Substitution - Missense	15:66481796-66481796,	PATHOGENIC	0.98916	28481359
MAP2K1	6840	COSM1167912,	skin	malignant_melanoma	p.P124Q	Substitution - Missense	15:66436825-66436825,	PATHOGENIC	0.98911	25452114
MAP2K1	6840	COSM1167912,	skin	malignant_melanoma	p.P124Q	Substitution - Missense	15:66436825-66436825,	PATHOGENIC	0.98911	25452114
MAP2K1	6840	COSM1167912,	skin	malignant_melanoma	p.P124Q	Substitution - Missense	15:66436825-66436825,	PATHOGENIC	0.98911	25452114
MAP2K1	6840	COSM6969753,	NS	carcinoma	p.E44K	Substitution - Missense	15:66435076-66435076,	PATHOGENIC	0.98899	28481359
MAP2K1	6840	COSM5609277,	skin	malignant_melanoma	p.P293S	Substitution - Missense	15:66485173-66485173,	PATHOGENIC	0.98828	26343386
MAP2K1	6840	COSM1235481,	lung	carcinoma	p.Q56P	Substitution - Missense	15:66435113-66435113,	PATHOGENIC	0.98738	28481359
MAP2K1	6840	COSM1235481,	stomach	carcinoma	p.Q56P	Substitution - Missense	15:66435113-66435113,	PATHOGENIC	0.98738	25253779
MAP2K1	6840	COSM4756761,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K57T	Substitution - Missense	15:66435116-66435116,	PATHOGENIC	0.98738	28481359
MAP2K1	6840	COSM4756761,	salivary_gland	carcinoma	p.K57T	Substitution - Missense	15:66435116-66435116,	PATHOGENIC	0.98738	27334835
MAP2K1	6840	COSM1235481,	stomach	carcinoma	p.Q56P	Substitution - Missense	15:66435113-66435113,	PATHOGENIC	0.98738	25253779
MAP2K1	6840	COSM1235481,	large_intestine	carcinoma	p.Q56P	Substitution - Missense	15:66435113-66435113,	PATHOGENIC	0.98738	28481359
MAP2K1	6840	COSM1235481,	lung	carcinoma	p.Q56P	Substitution - Missense	15:66435113-66435113,	PATHOGENIC	0.98738	23371856
MAP2K1	6840	COSM1235481,	stomach	carcinoma	p.Q56P	Substitution - Missense	15:66435113-66435113,	PATHOGENIC	0.98738	22327936
MAP2K1	6840	COSM4756761,	large_intestine	carcinoma	p.K57T	Substitution - Missense	15:66435116-66435116,	PATHOGENIC	0.98738	28481359
MAP2K1	6840	COSM1235481,	endometrium	carcinoma	p.Q56P	Substitution - Missense	15:66435113-66435113,	PATHOGENIC	0.98738	28481359
MAP2K1	6840	COSM4756761,	small_intestine	carcinoma	p.K57T	Substitution - Missense	15:66435116-66435116,	PATHOGENIC	0.98738	28481359
MAP2K1	6840	COSM1235481,	large_intestine	carcinoma	p.Q56P	Substitution - Missense	15:66435113-66435113,	PATHOGENIC	0.98738	28481359
MAP2K1	6840	COSM6958663,	kidney	carcinoma	p.N78S	Substitution - Missense	15:66435179-66435179,	PATHOGENIC	0.98703	28481359
MAP2K1	6840	COSM555601,	salivary_gland	carcinoma	p.C121S	Substitution - Missense	15:66436815-66436815,	PATHOGENIC	0.9868	27334835
MAP2K1	6840	COSM555601,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C121S	Substitution - Missense	15:66436815-66436815,	PATHOGENIC	0.9868	25899310
MAP2K1	6840	COSM555601,	urinary_tract	carcinoma	p.C121S	Substitution - Missense	15:66436815-66436815,	PATHOGENIC	0.9868	28481359
MAP2K1	6840	COSM6987199,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y130N	Substitution - Missense	15:66436842-66436842,	PATHOGENIC	0.9868	28481359
MAP2K1	6840	COSM555601,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C121S	Substitution - Missense	15:66436815-66436815,	PATHOGENIC	0.9868	24982505
MAP2K1	6840	COSM555601,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C121S	Substitution - Missense	15:66436815-66436815,	PATHOGENIC	0.9868	27241017
MAP2K1	6840	COSM4700232,	large_intestine	carcinoma	p.N345T	Substitution - Missense	15:66489729-66489729,	PATHOGENIC	0.98666	28481359
MAP2K1	6840	COSM6934425,	urinary_tract	carcinoma	p.A257V	Substitution - Missense	15:66485066-66485066,	PATHOGENIC	0.98664	28481359
MAP2K1	6840	COSM1644233,	urinary_tract	carcinoma	p.D336H	Substitution - Missense	15:66489260-66489260,	PATHOGENIC	0.98584	28481359
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	24463458
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	22588879
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	22197931
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	22588879
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	22197931
MAP2K1	6840	COSM1315861,	skin	malignant_melanoma	p.P124L	Substitution - Missense	15:66436825-66436825,	PATHOGENIC	0.98583	28356599
MAP2K1	6840	COSM1315861,	NS	malignant_melanoma	p.P124L	Substitution - Missense	15:66436825-66436825,	PATHOGENIC	0.98583	28481359
MAP2K1	6840	COSM2257212,	large_intestine	carcinoma	p.H119Y	Substitution - Missense	15:66436809-66436809,	PATHOGENIC	0.98583	28481359
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	22197931
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	22588879
MAP2K1	6840	COSM1315861,	skin	malignant_melanoma	p.P124L	Substitution - Missense	15:66436825-66436825,	PATHOGENIC	0.98583	28481359
MAP2K1	6840	COSM235614,	NS	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	24336498
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	25515853
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	22197931
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	25515853
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	26343386
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	22588879
MAP2K1	6840	COSM235614,	NS	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	24336498
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	22588879
MAP2K1	6840	COSM1315861,	skin	malignant_melanoma	p.P124L	Substitution - Missense	15:66436825-66436825,	PATHOGENIC	0.98583	26744134
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	28481359
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	22588879
MAP2K1	6840	COSM235614,	skin	malignant_melanoma	p.P124S	Substitution - Missense	15:66436824-66436824,	PATHOGENIC	0.98583	24463458
MAP2K1	6840	COSM1315861,	skin	malignant_melanoma	p.P124L	Substitution - Missense	15:66436825-66436825,	PATHOGENIC	0.98583	26343386
MAP2K1	6840	COSM1315861,	skin	malignant_melanoma	p.P124L	Substitution - Missense	15:66436825-66436825,	PATHOGENIC	0.98583	19915144
MAP2K1	6840	COSM5369532,	biliary_tract	carcinoma	p.K57E	Substitution - Missense	15:66435115-66435115,	PATHOGENIC	0.98578	28481359
MAP2K1	6840	COSM5369532,	large_intestine	carcinoma	p.K57E	Substitution - Missense	15:66435115-66435115,	PATHOGENIC	0.98578	28481359
MAP2K1	6840	COSM5369532,	central_nervous_system	glioma	p.K57E	Substitution - Missense	15:66435115-66435115,	PATHOGENIC	0.98578	28481359
MAP2K1	6840	COSM5369532,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K57E	Substitution - Missense	15:66435115-66435115,	PATHOGENIC	0.98578	28481359
MAP2K1	6840	COSM5369532,	breast	carcinoma	p.K57E	Substitution - Missense	15:66435115-66435115,	PATHOGENIC	0.98578	28481359
MAP2K1	6840	COSM5369532,	skin	malignant_melanoma	p.K57E	Substitution - Missense	15:66435115-66435115,	PATHOGENIC	0.98578	24463458
MAP2K1	6840	COSM5369532,	large_intestine	carcinoma	p.K57E	Substitution - Missense	15:66435115-66435115,	PATHOGENIC	0.98578	28481359
MAP2K1	6840	COSM6920098,	lung	carcinoma	p.Y130H	Substitution - Missense	15:66436842-66436842,	PATHOGENIC	0.98501	28481359
MAP2K1	6840	COSM1374189,	large_intestine	carcinoma	p.S231L	Substitution - Missense	15:66481878-66481878,	PATHOGENIC	0.98366	28481359
MAP2K1	6840	COSM6853712,	haematopoietic_and_lymphoid_tissue	other	p.L115V	Substitution - Missense	15:66436797-66436797,	PATHOGENIC	0.98287	28597077
MAP2K1	6840	COSM1235483,	stomach	carcinoma	p.I204T	Substitution - Missense	15:66481797-66481797,	PATHOGENIC	0.98286	22327936
MAP2K1	6840	COSM6906560,	urinary_tract	carcinoma	p.R160T	Substitution - Missense	15:66443320-66443320,	PATHOGENIC	0.98214	29420467
MAP2K1	6840	COSM1562837,	lung	carcinoma	p.F53C	Substitution - Missense	15:66435104-66435104,	PATHOGENIC	0.98164	28481359
MAP2K1	6840	COSM5077832,	kidney	carcinoma	p.F53V	Substitution - Missense	15:66435103-66435103,	PATHOGENIC	0.98164	28481359
MAP2K1	6840	COSM6019388,	pancreas	carcinoma	p.L42H	Substitution - Missense	15:66435071-66435071,	PATHOGENIC	0.98054	28054945
MAP2K1	6840	COSM5702508,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.A76V	Substitution - Missense	15:66435173-66435173,	PATHOGENIC	0.98049	26980021
MAP2K1	6840	COSM6914093,	pleura	mesothelioma	p.P321H	Substitution - Missense	15:66489216-66489216,	PATHOGENIC	0.97955	28481359
MAP2K1	6840	COSM555604,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.F53L	Substitution - Missense	15:66435103-66435103,	PATHOGENIC	0.97795	28481359
MAP2K1	6840	COSM6937927,	urinary_tract	carcinoma	p.M256L	Substitution - Missense	15:66485062-66485062,	PATHOGENIC	0.97527	28481359
MAP2K1	6840	COSM6005671,	prostate	carcinoma	p.D303N	Substitution - Missense	15:66487239-66487239,	PATHOGENIC	0.97474	20579941
MAP2K1	6840	COSM6965919,	lung	carcinoma	p.I103M	Substitution - Missense	15:66436763-66436763,	PATHOGENIC	0.97318	28481359
MAP2K1	6840	COSM6854664,	large_intestine	other	p.L375P	Substitution - Missense	15:66490557-66490557,	PATHOGENIC	0.97125	28524162
MAP2K1	6840	COSM4990763,	skin	carcinoma	p.E102E	Substitution - coding silent	15:66436760-66436760,	PATHOGENIC	0.96973	25589618
MAP2K1	6840	COSM2257207,	penis	carcinoma	p.R49C	Substitution - Missense	15:66435091-66435091,	PATHOGENIC	0.96922	28481359
MAP2K1	6840	COSM2257207,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R49C	Substitution - Missense	15:66435091-66435091,	PATHOGENIC	0.96922	24982505
MAP2K1	6840	COSM6968497,	central_nervous_system	glioma	p.G301E	Substitution - Missense	15:66487234-66487234,	PATHOGENIC	0.96542	28481359
MAP2K1	6840	COSM1235484,	large_intestine	carcinoma	p.P306H	Substitution - Missense	15:66487249-66487249,	PATHOGENIC	0.96182	22327936
MAP2K1	6840	COSM5702507,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q58*	Substitution - Nonsense	15:66435118-66435118,	PATHOGENIC	0.96158	26980021
MAP2K1	6840	COSM6923985,	central_nervous_system	glioma	p.L206F	Substitution - Missense	15:66481802-66481802,	PATHOGENIC	0.95691	28481359
MAP2K1	6840	COSM1235485,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R47Q	Substitution - Missense	15:66435086-66435086,	PATHOGENIC	0.94777	24982505
MAP2K1	6840	COSM1235485,	breast	carcinoma	p.R47Q	Substitution - Missense	15:66435086-66435086,	PATHOGENIC	0.94777	22327936
MAP2K1	6840	COSM6934020,	lung	carcinoma	p.L177V	Substitution - Missense	15:66444668-66444668,	PATHOGENIC	0.94269	28481359
MAP2K1	6840	COSM6983081,	breast	carcinoma	p.L352F	Substitution - Missense	15:66489751-66489751,	PATHOGENIC	0.94152	28481359
MAP2K1	6840	COSM6909133,	breast	carcinoma	p.Q164E	Substitution - Missense	15:66443331-66443331,	PATHOGENIC	0.93815	28481359
MAP2K1	6840	COSM1235480,	large_intestine	carcinoma	p.F129L	Substitution - Missense	15:66436841-66436841,	PATHOGENIC	0.93601	21705440
MAP2K1	6840	COSM235617,	skin	malignant_melanoma	p.N382H	Substitution - Missense	15:66490577-66490577,	PATHOGENIC	0.93362	22197931
MAP2K1	6840	COSM6929035,	central_nervous_system	glioma	p.G328E	Substitution - Missense	15:66489237-66489237,	PATHOGENIC	0.92831	28481359
MAP2K1	6840	COSM6920937,	ovary	carcinoma	p.Q58H	Substitution - Missense	15:66435120-66435120,	PATHOGENIC	0.92789	28481359
MAP2K1	6840	COSM6946331,	large_intestine	carcinoma	p.R363I	Substitution - Missense	15:66490521-66490521,	PATHOGENIC	0.92089	28481359
MAP2K1	6840	COSM5520914,	lung	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.91955	28481359
MAP2K1	6840	COSM5520914,	biliary_tract	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.91955	28481359
MAP2K1	6840	COSM1235478,	lung	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	18632602
MAP2K1	6840	COSM1235478,	skin	malignant_melanoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	19411838
MAP2K1	6840	COSM1235478,	lung	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	23371856
MAP2K1	6840	COSM1235478,	prostate	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	28481359
MAP2K1	6840	COSM1235478,	lung	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	18632602
MAP2K1	6840	COSM1235478,	lung	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	23371856
MAP2K1	6840	COSM1235478,	lung	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	28481359
MAP2K1	6840	COSM1235478,	NS	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	28481359
MAP2K1	6840	COSM1235478,	lung	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	23371856
MAP2K1	6840	COSM1235478,	autonomic_ganglia	neuroblastoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	22142829
MAP2K1	6840	COSM1235478,	large_intestine	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	28481359
MAP2K1	6840	COSM1235478,	lung	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	28481359
MAP2K1	6840	COSM1235478,	lung	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	28481359
MAP2K1	6840	COSM1235478,	large_intestine	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	28481359
MAP2K1	6840	COSM1235478,	lung	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	20354455
MAP2K1	6840	COSM1235478,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	27241017
MAP2K1	6840	COSM1235478,	stomach	carcinoma	p.K57N	Substitution - Missense	15:66435117-66435117,	PATHOGENIC	0.90521	28481359
MAP2K1	6840	COSM5413591,	stomach	carcinoma	p.S72G	Substitution - Missense	15:66435160-66435160,	PATHOGENIC	0.90383	25253779
MAP2K1	6840	COSM6970068,	breast	carcinoma	p.S377F	Substitution - Missense	15:66490563-66490563,	PATHOGENIC	0.88712	28481359
MAP2K1	6840	COSM6957553,	large_intestine	carcinoma	p.R47*	Substitution - Nonsense	15:66435085-66435085,	PATHOGENIC	0.87871	28481359
MAP2K1	6840	COSM6957553,	penis	carcinoma	p.R47*	Substitution - Nonsense	15:66435085-66435085,	PATHOGENIC	0.87871	28481359
MAP2K1	6840	COSM6931156,	lung	carcinoma	p.G22V	Substitution - Missense	15:66387412-66387412,	PATHOGENIC	0.85775	28481359
MAP2K1	6840	COSM6931156,	lung	carcinoma	p.G22V	Substitution - Missense	15:66387412-66387412,	PATHOGENIC	0.85775	28481359
MAP2K1	6840	COSM1725008,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.F53L	Substitution - Missense	15:66435105-66435105,	PATHOGENIC	0.7852	28481359
MAP2K1	6840	COSM1725008,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.F53L	Substitution - Missense	15:66435105-66435105,	PATHOGENIC	0.7852	29768143
MAP2K1	6840	COSM6965265,	stomach	carcinoma	p.L332V	Substitution - Missense	15:66489248-66489248,	PATHOGENIC	0.76311	28481359
MAP2K1	6840	COSM3711844,	skin	malignant_melanoma	p.F223F	Substitution - coding silent	15:66481855-66481855,	PATHOGENIC	0.74137	26343386
MAP2K1	6840	COSM6995450,	ovary	germ_cell_tumour	p.?	Unknown	15:66485194-66485194,	PATHOGENIC	0.74027	28954785
MAP2K1	6840	COSM6953658,	large_intestine	carcinoma	p.P6T	Substitution - Missense	15:66387363-66387363,	PATHOGENIC	0.73015	28481359
MAP2K1	6840	COSM6494374,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A309A	Substitution - coding silent	15:66487259-66487259,	NEUTRAL	0.22187	27534895
MAP2K1	6840	COSM6494374,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.A309A	Substitution - coding silent	15:66487259-66487259,	NEUTRAL	0.22187	27534895
MAP2K1	6840	COSM5020742,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.G237G	Substitution - coding silent	15:66485007-66485007,	NEUTRAL	0.18288	27534895
MAP2K1	6840	COSM5020742,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.G237G	Substitution - coding silent	15:66485007-66485007,	NEUTRAL	0.18288	27534895
MAP2K1	6840	COSM5020742,	soft_tissue	haemangioblastoma	p.G237G	Substitution - coding silent	15:66485007-66485007,	NEUTRAL	0.18288	25589003
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	soft_tissue	haemangioblastoma	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	25589003
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	soft_tissue	haemangioblastoma	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	25589003
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	soft_tissue	haemangioblastoma	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	25589003
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM3999588,	soft_tissue	haemangioblastoma	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	25589003
MAP2K1	6840	COSM3999588,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489710-66489710,	NEUTRAL	0.18038	27534895
MAP2K1	6840	COSM1236223,	lung	carcinoma	p.Q56P	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	18632602
MAP2K1	6840	COSM1237324,	skin	malignant_melanoma	p.K59del, p.P387S	Deletion - In frame, Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	22389471
MAP2K1	6840	COSM1570285,	breast, large_intestine	carcinoma	p.F129L, p.L115P	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	22402123
MAP2K1	6840	COSM1236672,	lung	carcinoma	p.K57N	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	23196793
MAP2K1	6840	COSM1236673,	lung	carcinoma	p.D67N, p.K57N	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	23277484
MAP2K1	6840	COSM1238038,	skin	malignant_melanoma	p.K57N, p.P124S	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	23444215
MAP2K1	6840	COSM1315807,	skin	malignant_melanoma	p.E203K, p.K57E, p.P124L, p.P124S, p.Q56P	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	23569304
MAP2K1	6840	COSM1315805,	NS	malignant_melanoma	p.P124L	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	23890154
MAP2K1	6840	COSM1717460,	lung	carcinoma	p.Y130C	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24236184
MAP2K1	6840	COSM1725011,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C121S, p.F53L, p.K57E, p.K57N, p.K57T, p.Q56P	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24241536
MAP2K1	6840	COSM1238038,	skin	malignant_melanoma	p.P124S	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24628946
MAP2K1	6840	COSM1236223,	lung	carcinoma	p.Q56P	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24700479
MAP2K1	6840	COSM4166154,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E102_I103del, p.F53_Q58>L, p.H100_I103>PL, p.I99_K104del, p.K57_G61del	Complex - deletion inframe, Deletion - In frame	15:66436758-66436763,	Info_not_available	Info_not_available	24982505
MAP2K1	6840	COSM1315805,	skin	malignant_melanoma	p.P124L, p.Q56P	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25070294
MAP2K1	6840	COSM1236672,	lung	carcinoma	p.K57N	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25376516
MAP2K1	6840	COSM5232995,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q56_G61>R	Complex - deletion inframe	15:66435113-66435127,	Info_not_available	Info_not_available	25899310
MAP2K1	6840	COSM1236672,	NS	carcinoma	p.K57N	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	26182302
MAP2K1	6840	COSM1236223,	lung	carcinoma	p.Q56P	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	26860843
MAP2K1	6840	COSM5702512,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.G61_D65del, p.I103_K104del, p.L63_D67del	Deletion - In frame	15:66436761-66436766,	Info_not_available	Info_not_available	26980021
MAP2K1	6840	COSM6506639,	large_intestine	carcinoma	p.E69G, p.K64*	Substitution - Missense, Substitution - Nonsense	Info_not_available	Info_not_available	Info_not_available	27155048
MAP2K1	6840	COSM1315806,	pleura	mesothelioma	p.E203K	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	27507853
MAP2K1	6840	COSM1315806,	lung	carcinoma	p.E203K	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	27528220
MAP2K1	6840	COSM6494375,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.?	Unknown	15:66489771-66489772,	Info_not_available	Info_not_available	27534895
MAP2K1	6840	COSM5946089,	ovary	carcinoma	p.P105_A106del	Deletion - In frame	15:66436767-66436772,	Info_not_available	Info_not_available	27575406
MAP2K1	6840	COSM5730253,	skin	malignant_melanoma	p.I103_K104delIK	Deletion - In frame	15:66436759-66436764,	Info_not_available	Info_not_available	28356599
MAP2K1	6840	COSM6972727,	NS, biliary_tract, breast, haematopoietic_and_lymphoid_tissue, large_intestine, lung, prostate, skin	carcinoma, lymphoid_neoplasm, malignant_melanoma	p.?, p.A347fs*19, p.E102_I103delEI, p.E51_Q58delEAFLTQKQ, p.H100fs*10, p.I103_K104del, p.I99_K104delIHLEIK, p.M219fs*67, p.N109_R113delNQIIR, p.P105_A106delPA, p.P105_I107>L, p.P124M	Complex - deletion inframe, Complex - frameshift, Deletion - In frame, Insertion - Frameshift, Substitution - Missense, Unknown	15:66489729-66489730,	Info_not_available	Info_not_available	28481359
MAP2K1	6840	COSM6907381,	skin	benign_melanocytic_nevus	p.?del	Deletion - In frame	Info_not_available	Info_not_available	Info_not_available	28796000
MAP2K1	6840	COSM6904621,	breast	carcinoma	p.I379I	Substitution - coding silent	Info_not_available	Info_not_available	Info_not_available	28921573
MAP2K1	6840	COSM6997554,	liver	carcinoma	p.V60M	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	29487225
MAP2K1	6840	COSM7002403,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L98_K104>Q	Complex - deletion inframe	15:66436747-66436764,	Info_not_available	Info_not_available	29768711