Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
FYN	4037	COSM6938170,	lung	carcinoma	p.G83V	Substitution - Missense	6:111714443-111714443,	PATHOGENIC	0.99768	28481359
FYN	4037	COSM6976799,	central_nervous_system	glioma	p.G83E	Substitution - Missense	6:111714443-111714443,	PATHOGENIC	0.99747	28481359
FYN	4037	COSM6935315,	endometrium	carcinoma	p.?	Unknown	6:111696275-111696275,	PATHOGENIC	0.99741	28481359
FYN	4037	COSM4992392,	skin	carcinoma	p.G152E	Substitution - Missense	6:111704091-111704091,	PATHOGENIC	0.99739	25589618
FYN	4037	COSM48987,	lung	carcinoma	p.?	Unknown	6:111696276-111696276,	PATHOGENIC	0.99636	18948947
FYN	4037	COSM48987,	lung	carcinoma	p.?	Unknown	6:111696276-111696276,	PATHOGENIC	0.99636	20668451
FYN	4037	COSM6963832,	breast	carcinoma	p.A526V	Substitution - Missense	6:111661776-111661776,	PATHOGENIC	0.99502	28481359
FYN	4037	COSM6963832,	breast	carcinoma	p.A526V	Substitution - Missense	6:111661776-111661776,	PATHOGENIC	0.99502	28481359
FYN	4037	COSM6983754,	bone	osteosarcoma	p.E509K	Substitution - Missense	6:111661828-111661828,	PATHOGENIC	0.99498	28481359
FYN	4037	COSM5709803,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y531D	Substitution - Missense	6:111661762-111661762,	PATHOGENIC	0.99465	26437031
FYN	4037	COSM5709801,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q532*	Substitution - Nonsense	6:111661759-111661759,	PATHOGENIC	0.99434	26437031
FYN	4037	COSM6976976,	lung	carcinoma	p.E528Q	Substitution - Missense	6:111661771-111661771,	PATHOGENIC	0.99376	28481359
FYN	4037	COSM6983609,	kidney	carcinoma	p.R190S	Substitution - Missense	6:111703014-111703014,	PATHOGENIC	0.99371	28481359
FYN	4037	COSM6933333,	breast	carcinoma	p.D158H	Substitution - Missense	6:111704074-111704074,	PATHOGENIC	0.99353	28481359
FYN	4037	COSM6982474,	lung	carcinoma	p.E107Q	Substitution - Missense	6:111714372-111714372,	PATHOGENIC	0.99349	28481359
FYN	4037	COSM6960526,	large_intestine	carcinoma	p.Q5*	Substitution - Nonsense	6:111720039-111720039,	PATHOGENIC	0.99293	28481359
FYN	4037	COSM6934917,	skin	malignant_melanoma	p.P488L	Substitution - Missense	6:111661890-111661890,	PATHOGENIC	0.99255	28481359
FYN	4037	COSM6969725,	NS	carcinoma	p.P468Q	Substitution - Missense	6:111674501-111674501,	PATHOGENIC	0.99244	28481359
FYN	4037	COSM4172396,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R176C	Substitution - Missense	6:111704020-111704020,	PATHOGENIC	0.99188	26437031
FYN	4037	COSM1544672,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R96Q	Substitution - Missense	6:111714404-111714404,	PATHOGENIC	0.99142	26437031
FYN	4037	COSM1544672,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R96Q	Substitution - Missense	6:111714404-111714404,	PATHOGENIC	0.99142	26437031
FYN	4037	COSM6984878,	large_intestine	carcinoma	p.R389I	Substitution - Missense	6:111694482-111694482,	PATHOGENIC	0.99073	28481359
FYN	4037	COSM6928942,	central_nervous_system	glioma	p.S307F	Substitution - Missense	6:111696399-111696399,	PATHOGENIC	0.9903	28481359
FYN	4037	COSM1072255,	breast	carcinoma	p.A315V	Substitution - Missense	6:111696375-111696375,	PATHOGENIC	0.9903	28481359
FYN	4037	COSM6950221,	central_nervous_system	glioma	p.?	Unknown	6:111694374-111694374,	PATHOGENIC	0.99021	28481359
FYN	4037	COSM3156598,	penis	carcinoma	p.S70L	Substitution - Missense	6:111719843-111719843,	PATHOGENIC	0.9891	28481359
FYN	4037	COSM6937739,	urinary_tract	carcinoma	p.W450R	Substitution - Missense	6:111674556-111674556,	PATHOGENIC	0.98899	28481359
FYN	4037	COSM6949655,	endometrium	carcinoma	p.K505M	Substitution - Missense	6:111661839-111661839,	PATHOGENIC	0.98893	28481359
FYN	4037	COSM6926329,	central_nervous_system	glioma	p.P34L	Substitution - Missense	6:111719951-111719951,	PATHOGENIC	0.98856	28481359
FYN	4037	COSM4776928,	breast	carcinoma	p.R481Q	Substitution - Missense	6:111661911-111661911,	PATHOGENIC	0.98841	28481359
FYN	4037	COSM5997073,	large_intestine	carcinoma	p.E382K	Substitution - Missense	6:111694504-111694504,	PATHOGENIC	0.9879	28481359
FYN	4037	COSM6974691,	large_intestine	carcinoma	p.I298T	Substitution - Missense	6:111696426-111696426,	PATHOGENIC	0.98736	28481359
FYN	4037	COSM6974123,	lung	carcinoma	p.K405R	Substitution - Missense	6:111694434-111694434,	PATHOGENIC	0.98712	28481359
FYN	4037	COSM6953771,	lung	carcinoma	p.D324H	Substitution - Missense	6:111696349-111696349,	PATHOGENIC	0.9865	28481359
FYN	4037	COSM6938751,	biliary_tract	carcinoma	p.V200I	Substitution - Missense	6:111702984-111702984,	PATHOGENIC	0.98625	28481359
FYN	4037	COSM6940349,	urinary_tract	carcinoma	p.E222K	Substitution - Missense	6:111702918-111702918,	PATHOGENIC	0.98625	28481359
FYN	4037	COSM6983262,	large_intestine	carcinoma	p.K7T	Substitution - Missense	6:111720032-111720032,	PATHOGENIC	0.98572	28481359
FYN	4037	COSM6958209,	large_intestine	carcinoma	p.F64I	Substitution - Missense	6:111719862-111719862,	PATHOGENIC	0.98531	28481359
FYN	4037	COSM5709805,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q530*	Substitution - Nonsense	6:111661765-111661765,	PATHOGENIC	0.98503	26437031
FYN	4037	COSM5709805,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q530*	Substitution - Nonsense	6:111661765-111661765,	PATHOGENIC	0.98503	26437031
FYN	4037	COSM5709805,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q530*	Substitution - Nonsense	6:111661765-111661765,	PATHOGENIC	0.98503	27369867
FYN	4037	COSM5709805,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q530*	Substitution - Nonsense	6:111661765-111661765,	PATHOGENIC	0.98503	27369867
FYN	4037	COSM6957394,	penis	carcinoma	p.R481*	Substitution - Nonsense	6:111661912-111661912,	PATHOGENIC	0.98483	28481359
FYN	4037	COSM6926541,	lung	carcinoid-endocrine_tumour	p.T62S	Substitution - Missense	6:111719867-111719867,	PATHOGENIC	0.98395	28481359
FYN	4037	COSM6906799,	breast	carcinoma	p.V44M	Substitution - Missense	6:111719922-111719922,	PATHOGENIC	0.98369	28481359
FYN	4037	COSM6979421,	NS	carcinoma	p.G453E	Substitution - Missense	6:111674546-111674546,	PATHOGENIC	0.98361	28481359
FYN	4037	COSM281268,	endometrium	carcinoma	p.R206C	Substitution - Missense	6:111702966-111702966,	PATHOGENIC	0.98282	28481359
FYN	4037	COSM6955359,	lung	carcinoma	p.K505R	Substitution - Missense	6:111661839-111661839,	PATHOGENIC	0.98199	28481359
FYN	4037	COSM6961876,	pancreas	carcinoid-endocrine_tumour	p.V327I	Substitution - Missense	6:111696340-111696340,	PATHOGENIC	0.9812	28481359
FYN	4037	COSM6935317,	endometrium	carcinoma	p.?	Unknown	6:111696457-111696457,	PATHOGENIC	0.9812	28481359
FYN	4037	COSM13325,	central_nervous_system	glioma	p.W290*	Substitution - Nonsense	6:111696449-111696449,	PATHOGENIC	0.9812	16618716
FYN	4037	COSM5009992,	large_intestine	carcinoma	p.E309K	Substitution - Missense	6:111696394-111696394,	PATHOGENIC	0.9812	24951259
FYN	4037	COSM5009992,	skin	malignant_melanoma	p.E309K	Substitution - Missense	6:111696394-111696394,	PATHOGENIC	0.9812	28481359
FYN	4037	COSM6965186,	urinary_tract	carcinoma	p.D324N	Substitution - Missense	6:111696349-111696349,	PATHOGENIC	0.9812	28481359
FYN	4037	COSM13325,	central_nervous_system	glioma	p.W290*	Substitution - Nonsense	6:111696449-111696449,	PATHOGENIC	0.9812	16618716
FYN	4037	COSM6933660,	breast	carcinoma	p.E335K	Substitution - Missense	6:111696316-111696316,	PATHOGENIC	0.9812	28481359
FYN	4037	COSM6928429,	urinary_tract	carcinoma	p.G357R	Substitution - Missense	6:111694678-111694678,	PATHOGENIC	0.98078	28481359
FYN	4037	COSM6950223,	central_nervous_system	glioma	p.S124F	Substitution - Missense	6:111707994-111707994,	PATHOGENIC	0.97767	28481359
FYN	4037	COSM5019630,	soft_tissue	haemangioblastoma	p.D506E	Substitution - Missense	6:111661835-111661835,	PATHOGENIC	0.97722	25589003
FYN	4037	COSM3156600,	lung	carcinoma	p.V63I	Substitution - Missense	6:111719865-111719865,	PATHOGENIC	0.97716	28481359
FYN	4037	COSM4625651,	pancreas	carcinoma	p.R77H	Substitution - Missense	6:111719822-111719822,	PATHOGENIC	0.97673	28481359
FYN	4037	COSM4625651,	prostate	carcinoma	p.R77H	Substitution - Missense	6:111719822-111719822,	PATHOGENIC	0.97673	28481359
FYN	4037	COSM6963473,	skin	carcinoma	p.W120R	Substitution - Missense	6:111708007-111708007,	PATHOGENIC	0.97558	28481359
FYN	4037	COSM5977688,	central_nervous_system	glioma	p.V138L	Substitution - Missense	6:111707953-111707953,	PATHOGENIC	0.97464	26487540
FYN	4037	COSM5008899,	large_intestine	carcinoma	p.T82A	Substitution - Missense	6:111719808-111719808,	PATHOGENIC	0.97236	24951259
FYN	4037	COSM6955032,	large_intestine	carcinoma	p.V138M	Substitution - Missense	6:111707953-111707953,	PATHOGENIC	0.96953	28481359
FYN	4037	COSM6940764,	large_intestine	carcinoma	p.G131S	Substitution - Missense	6:111707974-111707974,	PATHOGENIC	0.96938	28481359
FYN	4037	COSM21242,	lung	carcinoma	p.V243L	Substitution - Missense	6:111700239-111700239,	PATHOGENIC	0.96867	16140923
FYN	4037	COSM21242,	lung	carcinoma	p.V243L	Substitution - Missense	6:111700239-111700239,	PATHOGENIC	0.96867	Info_not_available
FYN	4037	COSM21242,	lung	carcinoma	p.V243L	Substitution - Missense	6:111700239-111700239,	PATHOGENIC	0.96867	Info_not_available
FYN	4037	COSM21242,	lung	carcinoma	p.V243L	Substitution - Missense	6:111700239-111700239,	PATHOGENIC	0.96867	16140923
FYN	4037	COSM6979177,	prostate	carcinoma	p.V141I	Substitution - Missense	6:111707944-111707944,	PATHOGENIC	0.96655	28481359
FYN	4037	COSM6975012,	endometrium	carcinoma	p.L367F	Substitution - Missense	6:111694648-111694648,	PATHOGENIC	0.96387	28481359
FYN	4037	COSM6975012,	central_nervous_system	glioma	p.L367F	Substitution - Missense	6:111694648-111694648,	PATHOGENIC	0.96387	28481359
FYN	4037	COSM5709809,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D522E	Substitution - Missense	6:111661787-111661787,	PATHOGENIC	0.96192	26437031
FYN	4037	COSM5009581,	large_intestine	carcinoma	p.N471T	Substitution - Missense	6:111661941-111661941,	PATHOGENIC	0.96127	24951259
FYN	4037	COSM6942607,	oesophagus	carcinoma	p.T62A	Substitution - Missense	6:111719868-111719868,	PATHOGENIC	0.95681	28481359
FYN	4037	COSM6971893,	endometrium	carcinoma	p.H230Q	Substitution - Missense	6:111702892-111702892,	PATHOGENIC	0.9545	28481359
FYN	4037	COSM1439851,	soft_tissue	haemangioblastoma	p.R190H	Substitution - Missense	6:111703013-111703013,	PATHOGENIC	0.94808	25589003
FYN	4037	COSM5709811,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R96G	Substitution - Missense	6:111714405-111714405,	PATHOGENIC	0.91623	26437031
FYN	4037	COSM5709811,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R96G	Substitution - Missense	6:111714405-111714405,	PATHOGENIC	0.91623	26437031
FYN	4037	COSM5709811,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R96G	Substitution - Missense	6:111714405-111714405,	PATHOGENIC	0.91623	26437031
FYN	4037	COSM5008894,	large_intestine	carcinoma	p.R484R	Substitution - coding silent	6:111661901-111661901,	PATHOGENIC	0.90635	24951259
FYN	4037	COSM6971074,	breast	carcinoma	p.M195I	Substitution - Missense	6:111702997-111702997,	PATHOGENIC	0.88985	28481359
FYN	4037	COSM4992391,	skin	carcinoma	p.L277L	Substitution - coding silent	6:111700135-111700135,	PATHOGENIC	0.88931	25589618
FYN	4037	COSM5008896,	large_intestine	carcinoma	p.R276R	Substitution - coding silent	6:111700138-111700138,	PATHOGENIC	0.87688	24951259
FYN	4037	COSM5008897,	large_intestine	carcinoma	p.N136K	Substitution - Missense	6:111707957-111707957,	PATHOGENIC	0.87141	28481359
FYN	4037	COSM5008897,	large_intestine	carcinoma	p.N136K	Substitution - Missense	6:111707957-111707957,	PATHOGENIC	0.87141	24951259
FYN	4037	COSM6948134,	urinary_tract	carcinoma	p.L112F	Substitution - Missense	6:111714355-111714355,	PATHOGENIC	0.80714	28481359
FYN	4037	COSM48929,	lung	carcinoma	p.W119fs*1	Insertion - Frameshift	6:111708009-111708010,	Info_not_available	Info_not_available	18948947
FYN	4037	COSM5709807,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.F524fs*10	Deletion - Frameshift	6:111661779-111661783,	Info_not_available	Info_not_available	26437031
FYN	4037	COSM6498639,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.0	Whole gene deletion	Info_not_available	Info_not_available	Info_not_available	27369867
FYN	4037	COSM6982061,	lung, skin, thyroid, urinary_tract	adenoma-nodule-goitre, carcinoma	p.E474fs*26, p.K505fs*>33, p.T35I, p.T461_V465delTKGRV	Deletion - Frameshift, Deletion - In frame, Substitution - Missense	6:111719947-111719948,	Info_not_available	Info_not_available	28481359