Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
CDK4	1773	COSM6959333,	large_intestine	carcinoma	p.A79V	Substitution - Missense	12:57751325-57751325,	PATHOGENIC	0.98969	28481359
CDK4	1773	COSM6915152,	lung	carcinoma	p.R210P	Substitution - Missense	12:57750659-57750659,	PATHOGENIC	0.98917	28481359
CDK4	1773	COSM3463915,	skin	malignant_melanoma	p.K22M	Substitution - Missense	12:57751653-57751653,	PATHOGENIC	0.98736	28481359
CDK4	1773	COSM1677139,	skin	malignant_melanoma	p.R24C	Substitution - Missense	12:57751648-57751648,	PATHOGENIC	0.98231	28481359
CDK4	1773	COSM1677139,	skin	malignant_melanoma	p.R24C	Substitution - Missense	12:57751648-57751648,	PATHOGENIC	0.98231	28481359
CDK4	1773	COSM3463914,	skin	malignant_melanoma	p.R24S	Substitution - Missense	12:57751648-57751648,	PATHOGENIC	0.98131	28481359
CDK4	1773	COSM6943737,	large_intestine	carcinoma	p.?	Unknown	12:57749453-57749453,	PATHOGENIC	0.98039	28481359
CDK4	1773	COSM1989836,	lung	carcinoma	p.R24H	Substitution - Missense	12:57751647-57751647,	PATHOGENIC	0.97752	28481359
CDK4	1773	COSM1989836,	skin	malignant_melanoma	p.R24H	Substitution - Missense	12:57751647-57751647,	PATHOGENIC	0.97752	28481359
CDK4	1773	COSM1989836,	lung	carcinoma	p.R24H	Substitution - Missense	12:57751647-57751647,	PATHOGENIC	0.97752	28481359
CDK4	1773	COSM1989836,	urinary_tract	carcinoma	p.R24H	Substitution - Missense	12:57751647-57751647,	PATHOGENIC	0.97752	28481359
CDK4	1773	COSM6980178,	large_intestine	carcinoma	p.T172R	Substitution - Missense	12:57750930-57750930,	PATHOGENIC	0.97677	28481359
CDK4	1773	COSM3359874,	bone	osteosarcoma	p.Q168E	Substitution - Missense	12:57750943-57750943,	PATHOGENIC	0.97649	28481359
CDK4	1773	COSM6934699,	lung	carcinoma	p.S285P	Substitution - Missense	12:57748584-57748584,	PATHOGENIC	0.97225	28481359
CDK4	1773	COSM1578941,	breast	carcinoma	p.G201R	Substitution - Missense	12:57750687-57750687,	PATHOGENIC	0.97208	18186519
CDK4	1773	COSM6908630,	breast	carcinoma	p.D196H	Substitution - Missense	12:57750702-57750702,	PATHOGENIC	0.97183	28481359
CDK4	1773	COSM1579050,	skin	carcinoma	p.?	Unknown	12:57749506-57749506,	PATHOGENIC	0.97082	18186519
CDK4	1773	COSM5635851,	NS	carcinoma	p.T102K	Substitution - Missense	12:57751256-57751256,	PATHOGENIC	0.96694	28481359
CDK4	1773	COSM6934235,	skin	carcinoma	p.L34F	Substitution - Missense	12:57751618-57751618,	PATHOGENIC	0.95672	28481359
CDK4	1773	COSM6975029,	adrenal_gland	adrenal_cortical_carcinoma	p.R139Q	Substitution - Missense	12:57751029-57751029,	PATHOGENIC	0.95662	28481359
CDK4	1773	COSM327249,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L74L	Substitution - coding silent	12:57751341-57751341,	PATHOGENIC	0.95574	22675565
CDK4	1773	COSM363684,	lung	carcinoma	p.R24L	Substitution - Missense	12:57751647-57751647,	PATHOGENIC	0.95518	28481359
CDK4	1773	COSM363684,	lung	carcinoma	p.R24L	Substitution - Missense	12:57751647-57751647,	PATHOGENIC	0.95518	28481359
CDK4	1773	COSM363684,	lung	carcinoma	p.R24L	Substitution - Missense	12:57751647-57751647,	PATHOGENIC	0.95518	28481359
CDK4	1773	COSM363684,	lung	carcinoma	p.R24L	Substitution - Missense	12:57751647-57751647,	PATHOGENIC	0.95518	28481359
CDK4	1773	COSM363684,	lung	carcinoma	p.R24L	Substitution - Missense	12:57751647-57751647,	PATHOGENIC	0.95518	28481359
CDK4	1773	COSM363684,	lung	carcinoma	p.R24L	Substitution - Missense	12:57751647-57751647,	PATHOGENIC	0.95518	28481359
CDK4	1773	COSM6934066,	large_intestine	carcinoma	p.R209C	Substitution - Missense	12:57750663-57750663,	PATHOGENIC	0.95505	28481359
CDK4	1773	COSM6968938,	small_intestine	carcinoma	p.R181Q	Substitution - Missense	12:57750746-57750746,	PATHOGENIC	0.95501	28481359
CDK4	1773	COSM6965677,	lung	carcinoma	p.I51T	Substitution - Missense	12:57751566-57751566,	PATHOGENIC	0.95419	28481359
CDK4	1773	COSM1989825,	large_intestine	carcinoma	p.R283Q	Substitution - Missense	12:57748589-57748589,	PATHOGENIC	0.95232	28481359
CDK4	1773	COSM1989825,	endometrium	carcinoma	p.R283Q	Substitution - Missense	12:57748589-57748589,	PATHOGENIC	0.95232	28481359
CDK4	1773	COSM94059,	lung	carcinoma	p.D221N	Substitution - Missense	12:57749476-57749476,	PATHOGENIC	0.95117	20668451
CDK4	1773	COSM6956519,	breast	carcinoma	p.L186V	Substitution - Missense	12:57750732-57750732,	PATHOGENIC	0.95068	28481359
CDK4	1773	COSM6969138,	lung	carcinoma	p.L147V	Substitution - Missense	12:57751006-57751006,	PATHOGENIC	0.94884	28481359
CDK4	1773	COSM6914569,	prostate	carcinoma	p.E184K	Substitution - Missense	12:57750738-57750738,	PATHOGENIC	0.94856	28481359
CDK4	1773	COSM6929825,	skin	malignant_melanoma	p.R55C	Substitution - Missense	12:57751555-57751555,	PATHOGENIC	0.94798	28481359
CDK4	1773	COSM6929825,	skin	malignant_melanoma	p.R55C	Substitution - Missense	12:57751555-57751555,	PATHOGENIC	0.94798	28481359
CDK4	1773	COSM6937557,	urinary_tract	carcinoma	p.P262S	Substitution - Missense	12:57749217-57749217,	PATHOGENIC	0.94362	28481359
CDK4	1773	COSM6950764,	skin	malignant_melanoma	p.P26S	Substitution - Missense	12:57751642-57751642,	PATHOGENIC	0.92834	28481359
CDK4	1773	COSM6929125,	urinary_tract	carcinoma	p.D241N	Substitution - Missense	12:57749280-57749280,	PATHOGENIC	0.91397	28481359
CDK4	1773	COSM327248,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L161L	Substitution - coding silent	12:57750964-57750964,	PATHOGENIC	0.90677	22675565
CDK4	1773	COSM327248,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L161L	Substitution - coding silent	12:57750964-57750964,	PATHOGENIC	0.90677	22675565
CDK4	1773	COSM5980330,	bone	chondrosarcoma	p.V174M	Substitution - Missense	12:57750925-57750925,	PATHOGENIC	0.8325	28481359
CDK4	1773	COSM6922383,	skin	malignant_melanoma	p.I230L	Substitution - Missense	12:57749313-57749313,	PATHOGENIC	0.80957	28481359
CDK4	1773	COSM4671149,	skin	carcinoma	p.R255H	Substitution - Missense	12:57749237-57749237,	PATHOGENIC	0.77587	28481359
CDK4	1773	COSM13311,	central_nervous_system	glioma	p.S243S	Substitution - coding silent	12:57749272-57749272,	NEUTRAL	0.41202	16618716
CDK4	1773	COSM13311,	central_nervous_system	glioma	p.S243S	Substitution - coding silent	12:57749272-57749272,	NEUTRAL	0.41202	16618716
CDK4	1773	COSM6917940,	adrenal_gland	adrenal_cortical_carcinoma	p.R288Q	Substitution - Missense	12:57748574-57748574,	NEUTRAL	0.21385	28481359
CDK4	1773	COSM4990293,	skin	carcinoma	p.A114V	Substitution - Missense	12:57751220-57751220,	NEUTRAL	0.07585	25589618
CDK4	1773	COSM1578969,	large_intestine	carcinoma	p.A2A	Substitution - coding silent	12:57751712-57751712,	Info_not_available	0.6821	18186519
CDK4	1773	COSM94060,	breast	carcinoma	p.G43E	Substitution - Missense	12:57751590-57751590,	Info_not_available	0.6038	20668451
CDK4	1773	COSM4990294,	skin	carcinoma	p.P26P	Substitution - coding silent	12:57751640-57751640,	Info_not_available	0.56336	25589618
CDK4	1773	COSM6977564,	kidney, large_intestine, lung, small_intestine	carcinoma	p.G48delG, p.S4P, p.T190A, p.Y103*	Deletion - In frame, Substitution - Missense, Substitution - Nonsense	12:57751708-57751708,	Info_not_available	0.54705, .61764, .6922, Info_not_available	28481359