Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
PPM1D	9277	COSM6972552,	prostate	carcinoma	p.C329F	Substitution - Missense	17:60648051-60648051,	PATHOGENIC	0.99776	28481359
PPM1D	9277	COSM6753654,	endometrium	carcinoma	p.R181Q	Substitution - Missense	17:60623590-60623590,	PATHOGENIC	0.99503	28481359
PPM1D	9277	COSM6941610,	skin	malignant_melanoma	p.G166S	Substitution - Missense	17:60623544-60623544,	PATHOGENIC	0.99321	28481359
PPM1D	9277	COSM6906533,	large_intestine	carcinoma	p.E220Q	Substitution - Missense	17:60623706-60623706,	PATHOGENIC	0.99296	28481359
PPM1D	9277	COSM6906533,	large_intestine	carcinoma	p.E220Q	Substitution - Missense	17:60623706-60623706,	PATHOGENIC	0.99296	29420467
PPM1D	9277	COSM6975019,	central_nervous_system	glioma	p.G276D	Substitution - Missense	17:60647892-60647892,	PATHOGENIC	0.9881	28481359
PPM1D	9277	COSM6972954,	skin	carcinoma	p.P267L	Substitution - Missense	17:60633951-60633951,	PATHOGENIC	0.98595	28481359
PPM1D	9277	COSM4969938,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.W427*	Substitution - Nonsense	17:60663015-60663015,	PATHOGENIC	0.98367	29386642
PPM1D	9277	COSM6955238,	large_intestine	carcinoma	p.S239Y	Substitution - Missense	17:60633867-60633867,	PATHOGENIC	0.98309	28481359
PPM1D	9277	COSM982224,	endometrium	carcinoma	p.E525*	Substitution - Nonsense	17:60663307-60663307,	PATHOGENIC	0.98223	28481359
PPM1D	9277	COSM4423082,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E540*	Substitution - Nonsense	17:60663352-60663352,	PATHOGENIC	0.98223	29386642
PPM1D	9277	COSM4423082,	central_nervous_system	glioma	p.E540*	Substitution - Nonsense	17:60663352-60663352,	PATHOGENIC	0.98223	28481359
PPM1D	9277	COSM982224,	endometrium	carcinoma	p.E525*	Substitution - Nonsense	17:60663307-60663307,	PATHOGENIC	0.98223	28481359
PPM1D	9277	COSM6937263,	lung	carcinoma	p.E475*	Substitution - Nonsense	17:60663157-60663157,	PATHOGENIC	0.97908	28481359
PPM1D	9277	COSM6966002,	genital_tract	germ_cell_tumour	p.K511*	Substitution - Nonsense	17:60663265-60663265,	PATHOGENIC	0.97884	28481359
PPM1D	9277	COSM6908449,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.K535*	Substitution - Nonsense	17:60663337-60663337,	PATHOGENIC	0.97884	29386642
PPM1D	9277	COSM6941046,	oesophagus	carcinoma	p.D366N	Substitution - Missense	17:60656677-60656677,	PATHOGENIC	0.97874	28481359
PPM1D	9277	COSM6907701,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K514*	Substitution - Nonsense	17:60663274-60663274,	PATHOGENIC	0.97868	29386642
PPM1D	9277	COSM6984618,	endometrium	carcinoma	p.T537A	Substitution - Missense	17:60663343-60663343,	PATHOGENIC	0.97867	28481359
PPM1D	9277	COSM6943233,	skin	malignant_melanoma	p.P222L	Substitution - Missense	17:60623713-60623713,	PATHOGENIC	0.97818	28481359
PPM1D	9277	COSM6953471,	large_intestine	carcinoma	p.R582H	Substitution - Missense	17:60663479-60663479,	PATHOGENIC	0.97808	28481359
PPM1D	9277	COSM5025107,	breast	carcinoma	p.V298A	Substitution - Missense	17:60647958-60647958,	PATHOGENIC	0.97689	25850943
PPM1D	9277	COSM6964238,	prostate	carcinoma	p.P500H	Substitution - Missense	17:60663233-60663233,	PATHOGENIC	0.97353	28481359
PPM1D	9277	COSM6951347,	lung	carcinoma	p.S327*	Substitution - Nonsense	17:60648045-60648045,	PATHOGENIC	0.97245	28481359
PPM1D	9277	COSM6907715,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K480*	Substitution - Nonsense	17:60663172-60663172,	PATHOGENIC	0.97163	29386642
PPM1D	9277	COSM6907715,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K480*	Substitution - Nonsense	17:60663172-60663172,	PATHOGENIC	0.97163	29386642
PPM1D	9277	COSM6984617,	endometrium	carcinoma	p.R361C	Substitution - Missense	17:60656662-60656662,	PATHOGENIC	0.97116	28481359
PPM1D	9277	COSM3989203,	endometrium	carcinoma	p.R581Q	Substitution - Missense	17:60663476-60663476,	PATHOGENIC	0.97011	28481359
PPM1D	9277	COSM6945548,	lung	carcinoma	p.E424*	Substitution - Nonsense	17:60663004-60663004,	PATHOGENIC	0.96718	28481359
PPM1D	9277	COSM6753653,	breast	carcinoma	p.F283L	Substitution - Missense	17:60647914-60647914,	PATHOGENIC	0.96577	28481359
PPM1D	9277	COSM6933875,	lung	carcinoma	p.G108D	Substitution - Missense	17:60600737-60600737,	PATHOGENIC	0.95808	28481359
PPM1D	9277	COSM6963417,	lung	carcinoma	p.K420*	Substitution - Nonsense	17:60656839-60656839,	PATHOGENIC	0.95791	28481359
PPM1D	9277	COSM982228,	stomach	carcinoma	p.R572Q	Substitution - Missense	17:60663449-60663449,	PATHOGENIC	0.95309	28481359
PPM1D	9277	COSM6973863,	endometrium	carcinoma	p.G108S	Substitution - Missense	17:60600736-60600736,	PATHOGENIC	0.94391	28481359
PPM1D	9277	COSM6969139,	lung	carcinoma	p.Q404E	Substitution - Missense	17:60656791-60656791,	PATHOGENIC	0.94018	28481359
PPM1D	9277	COSM6946378,	large_intestine	carcinoma	p.F284S	Substitution - Missense	17:60647916-60647916,	PATHOGENIC	0.9346	28481359
PPM1D	9277	COSM4852412,	soft_tissue	sarcoma	p.S446*	Substitution - Nonsense	17:60663071-60663071,	PATHOGENIC	0.93376	28481359
PPM1D	9277	COSM4852412,	breast	carcinoma	p.S446*	Substitution - Nonsense	17:60663071-60663071,	PATHOGENIC	0.93376	28481359
PPM1D	9277	COSM4969798,	upper_aerodigestive_tract	carcinoma	p.Q404*	Substitution - Nonsense	17:60656791-60656791,	PATHOGENIC	0.93297	28481359
PPM1D	9277	COSM1679984,	liver	carcinoma	p.R441C	Substitution - Missense	17:60663055-60663055,	PATHOGENIC	0.92778	28481359
PPM1D	9277	COSM1679984,	skin	malignant_melanoma	p.R441C	Substitution - Missense	17:60663055-60663055,	PATHOGENIC	0.92778	28481359
PPM1D	9277	COSM6951271,	skin	carcinoma	p.R225K	Substitution - Missense	17:60623722-60623722,	PATHOGENIC	0.92458	28481359
PPM1D	9277	COSM2793552,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R572*	Substitution - Nonsense	17:60663448-60663448,	PATHOGENIC	0.91652	29386642
PPM1D	9277	COSM2793552,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R572*	Substitution - Nonsense	17:60663448-60663448,	PATHOGENIC	0.91652	29386642
PPM1D	9277	COSM2793552,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R572*	Substitution - Nonsense	17:60663448-60663448,	PATHOGENIC	0.91652	29386642
PPM1D	9277	COSM2793552,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R572*	Substitution - Nonsense	17:60663448-60663448,	PATHOGENIC	0.91652	29386642
PPM1D	9277	COSM2793552,	large_intestine	carcinoma	p.R572*	Substitution - Nonsense	17:60663448-60663448,	PATHOGENIC	0.91652	28481359
PPM1D	9277	COSM2793552,	endometrium	carcinoma	p.R572*	Substitution - Nonsense	17:60663448-60663448,	PATHOGENIC	0.91652	29420467
PPM1D	9277	COSM2793552,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R572*	Substitution - Nonsense	17:60663448-60663448,	PATHOGENIC	0.91652	29386642
PPM1D	9277	COSM6931284,	lung	carcinoma	p.E36*	Substitution - Nonsense	17:60600520-60600520,	PATHOGENIC	0.90894	28481359
PPM1D	9277	COSM6932851,	skin	carcinoma	p.Q524*	Substitution - Nonsense	17:60663304-60663304,	PATHOGENIC	0.90239	28481359
PPM1D	9277	COSM6956984,	skin	carcinoma	p.S453*	Substitution - Nonsense	17:60663092-60663092,	PATHOGENIC	0.89655	28481359
PPM1D	9277	COSM98068,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C478*	Substitution - Nonsense	17:60663168-60663168,	PATHOGENIC	0.88366	29386642
PPM1D	9277	COSM98068,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C478*	Substitution - Nonsense	17:60663168-60663168,	PATHOGENIC	0.88366	29386642
PPM1D	9277	COSM98068,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C478*	Substitution - Nonsense	17:60663168-60663168,	PATHOGENIC	0.88366	29386642
PPM1D	9277	COSM98068,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C478*	Substitution - Nonsense	17:60663168-60663168,	PATHOGENIC	0.88366	29386642
PPM1D	9277	COSM98068,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C478*	Substitution - Nonsense	17:60663168-60663168,	PATHOGENIC	0.88366	29386642
PPM1D	9277	COSM98068,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C478*	Substitution - Nonsense	17:60663168-60663168,	PATHOGENIC	0.88366	29386642
PPM1D	9277	COSM98068,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C478*	Substitution - Nonsense	17:60663168-60663168,	PATHOGENIC	0.88366	29386642
PPM1D	9277	COSM98068,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.C478*	Substitution - Nonsense	17:60663168-60663168,	PATHOGENIC	0.88366	29386642
PPM1D	9277	COSM6934373,	lung	carcinoma	p.R528*	Substitution - Nonsense	17:60663316-60663316,	PATHOGENIC	0.87602	28481359
PPM1D	9277	COSM5035438,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.S453*	Substitution - Nonsense	17:60663092-60663092,	PATHOGENIC	0.87075	29386642
PPM1D	9277	COSM6973146,	central_nervous_system	glioma	p.P471L	Substitution - Missense	17:60663146-60663146,	PATHOGENIC	0.84373	28481359
PPM1D	9277	COSM4427415,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R581*	Substitution - Nonsense	17:60663475-60663475,	PATHOGENIC	0.8422	29386642
PPM1D	9277	COSM4792721,	urinary_tract	carcinoma	p.D397N	Substitution - Missense	17:60656770-60656770,	PATHOGENIC	0.84033	28481359
PPM1D	9277	COSM6907736,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L484*	Substitution - Nonsense	17:60663185-60663185,	PATHOGENIC	0.83999	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM982226,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R552*	Substitution - Nonsense	17:60663388-60663388,	PATHOGENIC	0.82352	29386642
PPM1D	9277	COSM2793544,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R458*	Substitution - Nonsense	17:60663106-60663106,	PATHOGENIC	0.81981	28481359
PPM1D	9277	COSM2793544,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R458*	Substitution - Nonsense	17:60663106-60663106,	PATHOGENIC	0.81981	29386642
PPM1D	9277	COSM2793544,	skin	malignant_melanoma	p.R458*	Substitution - Nonsense	17:60663106-60663106,	PATHOGENIC	0.81981	28481359
PPM1D	9277	COSM2793544,	central_nervous_system	glioma	p.R458*	Substitution - Nonsense	17:60663106-60663106,	PATHOGENIC	0.81981	28481359
PPM1D	9277	COSM6927650,	central_nervous_system	glioma	p.M508I	Substitution - Missense	17:60663258-60663258,	PATHOGENIC	0.81595	28481359
PPM1D	9277	COSM6970906,	lung	carcinoma	p.E378Q	Substitution - Missense	17:60656713-60656713,	PATHOGENIC	0.81272	28481359
PPM1D	9277	COSM6927199,	lung	carcinoma	p.P426T	Substitution - Missense	17:60663010-60663010,	PATHOGENIC	0.76667	28481359
PPM1D	9277	COSM6928600,	stomach	carcinoma	p.V9A	Substitution - Missense	17:60600440-60600440,	PATHOGENIC	0.75708	28481359
PPM1D	9277	COSM6976506,	large_intestine	carcinoma	p.P68T	Substitution - Missense	17:60600616-60600616,	PATHOGENIC	0.71509	28481359
PPM1D	9277	COSM6986458,	ovary	carcinoma	p.S44W	Substitution - Missense	17:60600545-60600545,	NEUTRAL	0.49509	28481359
PPM1D	9277	COSM6987235,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L555S	Substitution - Missense	17:60663398-60663398,	NEUTRAL	0.42859	28481359
PPM1D	9277	COSM6958449,	skin	malignant_melanoma	p.A82V	Substitution - Missense	17:60600659-60600659,	NEUTRAL	0.35329	28481359
PPM1D	9277	COSM6907702,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S421*	Substitution - Nonsense	17:60662996-60662996,	NEUTRAL	0.22178	29386642
PPM1D	9277	COSM6907771,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.T504A	Substitution - Missense	17:60663244-60663244,	NEUTRAL	0.15217	29386642
PPM1D	9277	COSM6931386,	skin	malignant_melanoma	p.P51S	Substitution - Missense	17:60600565-60600565,	NEUTRAL	0.12325	28481359
PPM1D	9277	COSM6907151,	urinary_tract	carcinoma	p.S54*	Substitution - Nonsense	17:60600575-60600575,	NEUTRAL	0.10806	29420467
PPM1D	9277	COSM6934528,	breast	carcinoma	p.S54L	Substitution - Missense	17:60600575-60600575,	NEUTRAL	0.08895	28481359
PPM1D	9277	COSM6941609,	skin	malignant_melanoma	p.A57V	Substitution - Missense	17:60600584-60600584,	NEUTRAL	0.06455	28481359
PPM1D	9277	COSM6941609,	large_intestine	carcinoma	p.A57V	Substitution - Missense	17:60600584-60600584,	NEUTRAL	0.06455	28481359
PPM1D	9277	COSM6953384,	lung	carcinoma	p.P59S	Substitution - Missense	17:60600589-60600589,	NEUTRAL	0.05738	28481359
PPM1D	9277	COSM6973775,	adrenal_gland	adrenal_cortical_carcinoma	p.P53Q	Substitution - Missense	17:60600572-60600572,	NEUTRAL	0.04887	28481359
PPM1D	9277	COSM6940461,	urinary_tract	carcinoma	p.A57T	Substitution - Missense	17:60600583-60600583,	NEUTRAL	0.04065	28481359
PPM1D	9277	COSM6984616,	endometrium	carcinoma	p.S46P	Substitution - Missense	17:60600550-60600550,	NEUTRAL	0.03116	28481359
PPM1D	9277	COSM6945246,	urinary_tract	carcinoma	p.L79V	Substitution - Missense	17:60600649-60600649,	NEUTRAL	0.01512	28481359
PPM1D	9277	COSM6019394,	central_nervous_system	glioma	p.E472*, p.E525*, p.L484*	Substitution - Nonsense	Info_not_available	Info_not_available	Info_not_available	24880341
PPM1D	9277	COSM6904495,	upper_aerodigestive_tract	carcinoma	p.S468fs*?	Frameshift	Info_not_available	Info_not_available	Info_not_available	28493366
PPM1D	9277	COSM6908442,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm, lymphoid_neoplasm	p.A454fs*2, p.A481fs*2, p.C478fs*5, p.E540fs*1, p.F534fs*5, p.G519fs*3, p.L450fs*1, p.P426fs*7, p.S468*, p.S468fs*15, p.S489fs*2, p.V430fs*1, p.V464fs*19, p.W427fs*7	Deletion - Frameshift, Insertion - Frameshift, Substitution - Nonsense	17:60663350-60663351,	Info_not_available	0.52255, Info_not_available	29386642
PPM1D	9277	COSM6979319,	biliary_tract, bone, breast, endometrium, large_intestine, lung, salivary_gland, small_intestine, stomach, upper_aerodigestive_tract	carcinoma, osteosarcoma	p.A481fs*2, p.C414fs*20, p.E540fs*10, p.L450fs*1, p.L484fs*1, p.L494F, p.L546fs*1, p.N491fs*3, p.N512fs*16, p.N512fs*2, p.R52_P59delRPSPAALP, p.R73Q, p.R93H, p.T406fs*3	Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Substitution - Missense, Unknown	17:60663366-60663366,	Info_not_available	0.51117, .5689, .62769, Info_not_available	28481359