Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
NFKBIA	7797	COSM6978520,	lung	carcinoma	p.I94T	Substitution - Missense	14:35403745-35403745,	PATHOGENIC	0.99522	28481359
NFKBIA	7797	COSM6986761,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q112*	Substitution - Nonsense	14:35403692-35403692,	PATHOGENIC	0.9932	28481359
NFKBIA	7797	COSM6961050,	skin	malignant_melanoma	p.S36P	Substitution - Missense	14:35404539-35404539,	PATHOGENIC	0.98964	28481359
NFKBIA	7797	COSM6961260,	upper_aerodigestive_tract	carcinoma	p.S32N	Substitution - Missense	14:35404550-35404550,	PATHOGENIC	0.98891	28481359
NFKBIA	7797	COSM6954148,	large_intestine	carcinoma	p.S191F	Substitution - Missense	14:35402835-35402835,	PATHOGENIC	0.98651	28481359
NFKBIA	7797	COSM6929032,	central_nervous_system	glioma	p.G74R	Substitution - Missense	14:35404425-35404425,	PATHOGENIC	0.98422	28481359
NFKBIA	7797	COSM6966271,	lung	carcinoma	p.W66C	Substitution - Missense	14:35404447-35404447,	PATHOGENIC	0.984	28481359
NFKBIA	7797	COSM6980731,	large_intestine	carcinoma	p.Y42C	Substitution - Missense	14:35404520-35404520,	PATHOGENIC	0.98376	28481359
NFKBIA	7797	COSM6936749,	large_intestine	carcinoma	p.A190T	Substitution - Missense	14:35402839-35402839,	PATHOGENIC	0.98115	28481359
NFKBIA	7797	COSM6056953,	large_intestine	carcinoma	p.A151S	Substitution - Missense	14:35403246-35403246,	PATHOGENIC	0.97462	27023146
NFKBIA	7797	COSM6983722,	endometrium	carcinoma	p.T146I	Substitution - Missense	14:35403260-35403260,	PATHOGENIC	0.9735	28481359
NFKBIA	7797	COSM4990678,	skin	carcinoma	p.I94I	Substitution - coding silent	14:35403744-35403744,	PATHOGENIC	0.96936	25589618
NFKBIA	7797	COSM5705689,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.?	Unknown	14:35403361-35403361,	PATHOGENIC	0.96581	26437031
NFKBIA	7797	COSM6212447,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.?	Unknown	14:35403361-35403361,	PATHOGENIC	0.96083	28481359
NFKBIA	7797	COSM6977883,	breast	carcinoma	p.E14Q	Substitution - Missense	14:35404605-35404605,	PATHOGENIC	0.95945	28481359
NFKBIA	7797	COSM6986634,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.P65S	Substitution - Missense	14:35404452-35404452,	PATHOGENIC	0.9549	28481359
NFKBIA	7797	COSM6947328,	soft_tissue	gastrointestinal_stromal_tumour	p.H116R	Substitution - Missense	14:35403350-35403350,	PATHOGENIC	0.94815	28481359
NFKBIA	7797	COSM4609909,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q44*	Substitution - Nonsense	14:35404515-35404515,	PATHOGENIC	0.92058	28481359
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM3753951,	soft_tissue	haemangioblastoma	p.D27D	Substitution - coding silent	14:35404564-35404564,	PATHOGENIC	0.91971	25589003
NFKBIA	7797	COSM4441978,	central_nervous_system	glioma	p.V199M	Substitution - Missense	14:35402812-35402812,	PATHOGENIC	0.91911	28481359
NFKBIA	7797	COSM4441978,	large_intestine	carcinoma	p.V199M	Substitution - Missense	14:35402812-35402812,	PATHOGENIC	0.91911	28481359
NFKBIA	7797	COSM6928099,	oesophagus	carcinoma	p.E58Q	Substitution - Missense	14:35404473-35404473,	PATHOGENIC	0.91511	28481359
NFKBIA	7797	COSM6975264,	breast	carcinoma	p.E302K	Substitution - Missense	14:35402396-35402396,	PATHOGENIC	0.9108	28481359
NFKBIA	7797	COSM5418942,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q68*	Substitution - Nonsense	14:35404443-35404443,	PATHOGENIC	0.90226	28481359
NFKBIA	7797	COSM6975989,	pleura	mesothelioma	p.R17G	Substitution - Missense	14:35404596-35404596,	PATHOGENIC	0.89964	28481359
NFKBIA	7797	COSM6949670,	endometrium	carcinoma	p.M13V	Substitution - Missense	14:35404608-35404608,	PATHOGENIC	0.89819	28481359
NFKBIA	7797	COSM6947762,	soft_tissue	angiosarcoma	p.C308S	Substitution - Missense	14:35402044-35402044,	PATHOGENIC	0.86547	28481359
NFKBIA	7797	COSM6947762,	meninges	meningioma	p.C308S	Substitution - Missense	14:35402044-35402044,	PATHOGENIC	0.86547	28481359
NFKBIA	7797	COSM6937915,	urinary_tract	carcinoma	p.A127T	Substitution - Missense	14:35403318-35403318,	PATHOGENIC	0.83353	28481359
NFKBIA	7797	COSM6930822,	testis	germ_cell_tumour	p.D307E	Substitution - Missense	14:35402046-35402046,	PATHOGENIC	0.83016	28481359
NFKBIA	7797	COSM6948160,	urinary_tract	carcinoma	p.E153K	Substitution - Missense	14:35403240-35403240,	PATHOGENIC	0.82432	28481359
NFKBIA	7797	COSM1607646,	urinary_tract	carcinoma	p.R143Q	Substitution - Missense	14:35403269-35403269,	PATHOGENIC	0.79911	28481359
NFKBIA	7797	COSM6448770,	vagina	carcinoma	p.E43Q	Substitution - Missense	14:35404518-35404518,	PATHOGENIC	0.77369	28481359
NFKBIA	7797	COSM6961258,	upper_aerodigestive_tract	carcinoma	p.E51D	Substitution - Missense	14:35404492-35404492,	PATHOGENIC	0.76852	28481359
NFKBIA	7797	COSM4169986,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N276K	Substitution - Missense	14:35402472-35402472,	PATHOGENIC	0.7006	24345752
NFKBIA	7797	COSM6976856,	central_nervous_system	glioma	p.G270S	Substitution - Missense	14:35402492-35402492,	NEUTRAL	0.49161	28481359
NFKBIA	7797	COSM5705685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q249R	Substitution - Missense	14:35402554-35402554,	NEUTRAL	0.4865	26437031
NFKBIA	7797	COSM6974581,	breast	carcinoma	p.Q268K	Substitution - Missense	14:35402498-35402498,	NEUTRAL	0.38271	28481359
NFKBIA	7797	COSM5021016,	soft_tissue	haemangioblastoma	p.?	Unknown	14:35402862-35402862,	NEUTRAL	0.33622	25589003
NFKBIA	7797	COSM23078,	breast	carcinoma	p.R143fs*11	Insertion - Frameshift	14:35403269-35403270,	Info_not_available	Info_not_available	16959974
NFKBIA	7797	COSM5705687,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L157fs*52	Insertion - Frameshift	14:35403229-35403230,	Info_not_available	Info_not_available	26437031
NFKBIA	7797	COSM6987036,	NS, breast, central_nervous_system, haematopoietic_and_lymphoid_tissue, large_intestine, lung, prostate, skin, soft_tissue, upper_aerodigestive_tract	carcinoma, glioma, liposarcoma, lymphoid_neoplasm, rhabdomyosarcoma	p.?, p.A127fs*2, p.C152fs*12, p.D208_V209insD, p.E6K, p.F310fs*>8, p.G270R, p.I120fs*9, p.I198_V199>M, p.I94fs*29, p.L148fs*16, p.P214F, p.Q44fs*43, p.Q69_E72delQLTE, p.R143fs*21, p.R260C, p.R61_P65delRGSEP, p.R7_E14delRPQEWAME, p.S204_G206delSLG, p.T121fs*43, p.W258_T291del34	Complex - deletion inframe, Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Insertion - In frame, Substitution - Missense, Unknown	14:35404629-35404629,	Info_not_available	0.59394, .60261, .66235, Info_not_available	28481359