Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
AURKA	11393	COSM6972534,	breast	carcinoma	p.?	Unknown	20:56382984-56382984,	PATHOGENIC	0.99764	28481359
AURKA	11393	COSM6913738,	central_nervous_system	glioma	p.Q223*	Substitution - Nonsense	20:56381471-56381471,	PATHOGENIC	0.99724	28481359
AURKA	11393	COSM6962112,	skin	malignant_melanoma	p.P106L	Substitution - Missense	20:56386259-56386259,	PATHOGENIC	0.99501	28481359
AURKA	11393	COSM6925954,	breast	carcinoma	p.Q177*	Substitution - Nonsense	20:56383022-56383022,	PATHOGENIC	0.99444	28481359
AURKA	11393	COSM6910569,	breast	carcinoma	p.H254Y	Substitution - Missense	20:56373502-56373502,	PATHOGENIC	0.99405	28481359
AURKA	11393	COSM6910494,	endometrium	carcinoma	p.V279L	Substitution - Missense	20:56373427-56373427,	PATHOGENIC	0.99262	28481359
AURKA	11393	COSM6942139,	skin	malignant_melanoma	p.E134K	Substitution - Missense	20:56383151-56383151,	PATHOGENIC	0.99246	28481359
AURKA	11393	COSM6955317,	large_intestine	carcinoma	p.E239*	Substitution - Nonsense	20:56373547-56373547,	PATHOGENIC	0.99229	28481359
AURKA	11393	COSM6954896,	pancreas	carcinoma	p.R285M	Substitution - Missense	20:56373408-56373408,	PATHOGENIC	0.99214	28481359
AURKA	11393	COSM6955318,	large_intestine	carcinoma	p.E175K	Substitution - Missense	20:56383028-56383028,	PATHOGENIC	0.99033	28481359
AURKA	11393	COSM6942279,	pancreas	carcinoma	p.W277*	Substitution - Nonsense	20:56373432-56373432,	PATHOGENIC	0.99003	28481359
AURKA	11393	COSM6962316,	lung	carcinoma	p.G355R	Substitution - Missense	20:56370307-56370307,	PATHOGENIC	0.98872	28481359
AURKA	11393	COSM4991385,	skin	carcinoma	p.L240F	Substitution - Missense	20:56373542-56373542,	PATHOGENIC	0.98096	25589618
AURKA	11393	COSM6965176,	breast	carcinoma	p.G173E	Substitution - Missense	20:56383033-56383033,	PATHOGENIC	0.98054	28481359
AURKA	11393	COSM93921,	ovary	other	p.L318V	Substitution - Missense	20:56370562-56370562,	PATHOGENIC	0.97919	20668451
AURKA	11393	COSM6958988,	prostate	carcinoma	p.S388*	Substitution - Nonsense	20:56370207-56370207,	PATHOGENIC	0.97842	28481359
AURKA	11393	COSM6960782,	large_intestine	carcinoma	p.S388L	Substitution - Missense	20:56370207-56370207,	PATHOGENIC	0.9766	28481359
AURKA	11393	COSM5554787,	oesophagus	carcinoma	p.G173R	Substitution - Missense	20:56383034-56383034,	PATHOGENIC	0.97593	28481359
AURKA	11393	COSM20447,	large_intestine	carcinoma	p.S155R	Substitution - Missense	20:56383088-56383088,	PATHOGENIC	0.97481	Info_not_available
AURKA	11393	COSM20447,	large_intestine	carcinoma	p.S155R	Substitution - Missense	20:56383088-56383088,	PATHOGENIC	0.97481	Info_not_available
AURKA	11393	COSM6978056,	skin	malignant_melanoma	p.D358N	Substitution - Missense	20:56370298-56370298,	PATHOGENIC	0.96971	28481359
AURKA	11393	COSM6956624,	large_intestine	carcinoma	p.L378R	Substitution - Missense	20:56370237-56370237,	PATHOGENIC	0.96828	28481359
AURKA	11393	COSM21244,	lung	carcinoma	p.S361*	Substitution - Nonsense	20:56370288-56370288,	PATHOGENIC	0.96261	Info_not_available
AURKA	11393	COSM21244,	lung	carcinoma	p.S361*	Substitution - Nonsense	20:56370288-56370288,	PATHOGENIC	0.96261	16140923
AURKA	11393	COSM21244,	lung	carcinoma	p.S361*	Substitution - Nonsense	20:56370288-56370288,	PATHOGENIC	0.96261	16140923
AURKA	11393	COSM21244,	lung	carcinoma	p.S361*	Substitution - Nonsense	20:56370288-56370288,	PATHOGENIC	0.96261	Info_not_available
AURKA	11393	COSM6938063,	urinary_tract	carcinoma	p.G316E	Substitution - Missense	20:56370567-56370567,	PATHOGENIC	0.96167	28481359
AURKA	11393	COSM6956225,	large_intestine	carcinoma	p.G291D	Substitution - Missense	20:56370642-56370642,	PATHOGENIC	0.96167	28481359
AURKA	11393	COSM6957640,	penis	carcinoma	p.E376*	Substitution - Nonsense	20:56370244-56370244,	PATHOGENIC	0.95454	28481359
AURKA	11393	COSM5024915,	breast	carcinoma	p.S155R	Substitution - Missense	20:56383086-56383086,	PATHOGENIC	0.95035	25850943
AURKA	11393	COSM6913385,	endometrium	carcinoma	p.V218F	Substitution - Missense	20:56381486-56381486,	PATHOGENIC	0.95005	28481359
AURKA	11393	COSM6929919,	salivary_gland	carcinoma	p.S51L	Substitution - Missense	20:56386424-56386424,	PATHOGENIC	0.94024	28481359
AURKA	11393	COSM6919557,	genital_tract	germ_cell_tumour	p.R24H	Substitution - Missense	20:56386505-56386505,	PATHOGENIC	0.93742	28481359
AURKA	11393	COSM6985252,	endometrium	carcinoma	p.R343W	Substitution - Missense	20:56370487-56370487,	PATHOGENIC	0.93175	28481359
AURKA	11393	COSM6954237,	breast	carcinoma	p.K396E	Substitution - Missense	20:56370184-56370184,	PATHOGENIC	0.91062	28481359
AURKA	11393	COSM5607923,	skin	malignant_melanoma	p.T287A	Substitution - Missense	20:56370655-56370655,	PATHOGENIC	0.90384	26343386
AURKA	11393	COSM6946648,	lung	carcinoma	p.?	Unknown	20:56386535-56386535,	PATHOGENIC	0.88793	28481359
AURKA	11393	COSM6968884,	vagina	carcinoma	p.Q43*	Substitution - Nonsense	20:56386449-56386449,	PATHOGENIC	0.88545	28481359
AURKA	11393	COSM5019517,	soft_tissue	haemangioblastoma	p.M373V	Substitution - Missense	20:56370253-56370253,	PATHOGENIC	0.86615	25589003
AURKA	11393	COSM5019517,	soft_tissue	haemangioblastoma	p.M373V	Substitution - Missense	20:56370253-56370253,	PATHOGENIC	0.86615	25589003
AURKA	11393	COSM6946489,	large_intestine	carcinoma	p.R357S	Substitution - Missense	20:56370299-56370299,	PATHOGENIC	0.86401	28481359
AURKA	11393	COSM6980581,	breast	carcinoma	p.S54F	Substitution - Missense	20:56386415-56386415,	PATHOGENIC	0.86394	28481359
AURKA	11393	COSM6954175,	large_intestine	carcinoma	p.A44S	Substitution - Missense	20:56386446-56386446,	PATHOGENIC	0.85847	28481359
AURKA	11393	COSM6944123,	lung	carcinoma	p.Q55L	Substitution - Missense	20:56386412-56386412,	PATHOGENIC	0.84156	28481359
AURKA	11393	COSM4099638,	endometrium	carcinoma	p.R56C	Substitution - Missense	20:56386410-56386410,	PATHOGENIC	0.82965	28481359
AURKA	11393	COSM6961790,	upper_aerodigestive_tract	carcinoma	p.A385P	Substitution - Missense	20:56370217-56370217,	PATHOGENIC	0.82133	28481359
AURKA	11393	COSM6927879,	skin	carcinoma	p.K63N	Substitution - Missense	20:56386387-56386387,	PATHOGENIC	0.81645	28481359
AURKA	11393	COSM5631904,	skin	malignant_melanoma	p.P58S	Substitution - Missense	20:56386404-56386404,	PATHOGENIC	0.81326	28481359
AURKA	11393	COSM6984650,	endometrium	carcinoma	p.R251K	Substitution - Missense	20:56373510-56373510,	PATHOGENIC	0.77572	28481359
AURKA	11393	COSM6950662,	lung	carcinoma	p.E113K	Substitution - Missense	20:56384307-56384307,	PATHOGENIC	0.76781	28481359
AURKA	11393	COSM6926878,	skin	carcinoma	p.P87L	Substitution - Missense	20:56386316-56386316,	PATHOGENIC	0.74424	28481359
AURKA	11393	COSM6929917,	salivary_gland	carcinoma	p.H68D	Substitution - Missense	20:56386374-56386374,	PATHOGENIC	0.72873	28481359
AURKA	11393	COSM6985253,	endometrium	carcinoma	p.S245P	Substitution - Missense	20:56373529-56373529,	NEUTRAL	0.4958	28481359
AURKA	11393	COSM6929916,	salivary_gland	carcinoma	p.P91Q	Substitution - Missense	20:56386304-56386304,	NEUTRAL	0.49158	28481359
AURKA	11393	COSM3548024,	skin	malignant_melanoma	p.P32S	Substitution - Missense	20:56386482-56386482,	NEUTRAL	0.42586	28481359
AURKA	11393	COSM93922,	breast	carcinoma	p.H86Y	Substitution - Missense	20:56386320-56386320,	NEUTRAL	0.3919	20668451
AURKA	11393	COSM6984992,	large_intestine	carcinoma	p.K117T	Substitution - Missense	20:56384294-56384294,	NEUTRAL	0.37905	28481359
AURKA	11393	COSM6959251,	large_intestine	carcinoma	p.R3*	Substitution - Nonsense	20:56388191-56388191,	NEUTRAL	0.37435	28481359
AURKA	11393	COSM6950986,	stomach	carcinoma	p.T384R	Substitution - Missense	20:56370219-56370219,	NEUTRAL	0.3617	28481359
AURKA	11393	COSM6933617,	urinary_tract	carcinoma	p.S10L	Substitution - Missense	20:56388169-56388169,	NEUTRAL	0.26715	28481359
AURKA	11393	COSM6933617,	urinary_tract	carcinoma	p.S10L	Substitution - Missense	20:56388169-56388169,	NEUTRAL	0.26715	28481359
AURKA	11393	COSM6915198,	lung	carcinoma	p.R90M	Substitution - Missense	20:56386307-56386307,	NEUTRAL	0.25256	28481359
AURKA	11393	COSM5576093,	stomach	carcinoma	p.V27M	Substitution - Missense	20:56386497-56386497,	NEUTRAL	0.213	26489445
AURKA	11393	COSM5576093,	breast	carcinoma	p.V27M	Substitution - Missense	20:56386497-56386497,	NEUTRAL	0.213	28481359
AURKA	11393	COSM48249,	lung	carcinoma	p.S398L	Substitution - Missense	20:56370177-56370177,	NEUTRAL	0.18076	18948947
AURKA	11393	COSM6944520,	endometrium	carcinoma	p.S398A	Substitution - Missense	20:56370178-56370178,	NEUTRAL	0.15	28481359
AURKA	11393	COSM6917678,	endometrium	carcinoma	p.S98R	Substitution - Missense	20:56386282-56386282,	NEUTRAL	0.10942	28481359
AURKA	11393	COSM6941636,	skin	malignant_melanoma	p.L37F	Substitution - Missense	20:56386465-56386465,	NEUTRAL	0.08823	28481359
AURKA	11393	COSM6935590,	endometrium	carcinoma	p.R3Q	Substitution - Missense	20:56388190-56388190,	NEUTRAL	0.08586	28481359
AURKA	11393	COSM6965399,	large_intestine	carcinoma	p.L37I	Substitution - Missense	20:56386467-56386467,	NEUTRAL	0.06992	28481359
AURKA	11393	COSM3736282,	soft_tissue	haemangioblastoma	p.F31I	Substitution - Missense	20:56386485-56386485,	NEUTRAL	0.06665	25589003
AURKA	11393	COSM3736282,	soft_tissue	haemangioblastoma	p.F31I	Substitution - Missense	20:56386485-56386485,	NEUTRAL	0.06665	25589003
AURKA	11393	COSM3736282,	soft_tissue	haemangioblastoma	p.F31I	Substitution - Missense	20:56386485-56386485,	NEUTRAL	0.06665	25589003
AURKA	11393	COSM3736282,	soft_tissue	haemangioblastoma	p.F31I	Substitution - Missense	20:56386485-56386485,	NEUTRAL	0.06665	25589003
AURKA	11393	COSM3736282,	soft_tissue	haemangioblastoma	p.F31I	Substitution - Missense	20:56386485-56386485,	NEUTRAL	0.06665	25589003
AURKA	11393	COSM3736282,	soft_tissue	haemangioblastoma	p.F31I	Substitution - Missense	20:56386485-56386485,	NEUTRAL	0.06665	25589003
AURKA	11393	COSM3736282,	soft_tissue	haemangioblastoma	p.F31I	Substitution - Missense	20:56386485-56386485,	NEUTRAL	0.06665	25589003
AURKA	11393	COSM3736282,	soft_tissue	haemangioblastoma	p.F31I	Substitution - Missense	20:56386485-56386485,	NEUTRAL	0.06665	25589003
AURKA	11393	COSM5977603,	central_nervous_system	glioma	p.Q154fs*8	Deletion - Frameshift	20:56383090-56383091,	Info_not_available	Info_not_available	26487540
AURKA	11393	COSM6983010,	breast, endometrium, lung, pancreas, salivary_gland, skin, thyroid	carcinoma, malignant_melanoma	p.?, p.L161fs*6, p.P18_V19delPV, p.P91fs*4, p.R304Q, p.R304W, p.S53F, p.W128fs*7	Complex - frameshift, Deletion - In frame, Insertion - Frameshift, Substitution - Missense, Unknown	20:56386519-56386524,	Info_not_available	0.54564, .63269, .64067, Info_not_available	28481359