Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
AKT3	393	COSM6984313,	endometrium	carcinoma	p.?	Unknown	1:243545508-243545508,	PATHOGENIC	0.99753	28481359
AKT3	393	COSM6911334,	skin	carcinoma	p.?	Unknown	1:243664884-243664884,	PATHOGENIC	0.99586	28481359
AKT3	393	COSM6934910,	skin	malignant_melanoma	p.S472F	Substitution - Missense	1:243505274-243505274,	PATHOGENIC	0.99574	28481359
AKT3	393	COSM6914235,	skin	carcinoma	p.G230V	Substitution - Missense	1:243613678-243613678,	PATHOGENIC	0.99468	28481359
AKT3	393	COSM5020693,	soft_tissue	haemangioblastoma	p.?	Unknown	1:243613670-243613670,	PATHOGENIC	0.99458	25589003
AKT3	393	COSM6923916,	central_nervous_system	glioma	p.P469L	Substitution - Missense	1:243505283-243505283,	PATHOGENIC	0.9941	28481359
AKT3	393	COSM6935170,	endometrium	carcinoma	p.T81I	Substitution - Missense	1:243664814-243664814,	PATHOGENIC	0.99409	28481359
AKT3	393	COSM6944884,	skin	carcinoma	p.D384N	Substitution - Missense	1:243552742-243552742,	PATHOGENIC	0.99403	28481359
AKT3	393	COSM6915262,	biliary_tract	carcinoma	p.R388H	Substitution - Missense	1:243552729-243552729,	PATHOGENIC	0.99403	28481359
AKT3	393	COSM6968756,	NS	malignant_melanoma	p.S428F	Substitution - Missense	1:243512395-243512395,	PATHOGENIC	0.99395	28481359
AKT3	393	COSM6939214,	large_intestine	carcinoma	p.D384G	Substitution - Missense	1:243552741-243552741,	PATHOGENIC	0.99388	28481359
AKT3	393	COSM6982203,	lung	carcinoma	p.P50L	Substitution - Missense	1:243695614-243695614,	PATHOGENIC	0.99387	28481359
AKT3	393	COSM6926170,	lung	carcinoma	p.D126V	Substitution - Missense	1:243645945-243645945,	PATHOGENIC	0.99328	28481359
AKT3	393	COSM4606125,	upper_aerodigestive_tract	carcinoma	p.P310R	Substitution - Missense	1:243563739-243563739,	PATHOGENIC	0.99306	25056374
AKT3	393	COSM6984802,	large_intestine	carcinoma	p.K143N	Substitution - Missense	1:243645893-243645893,	PATHOGENIC	0.9927	28481359
AKT3	393	COSM6956029,	pancreas	carcinoma	p.R66P	Substitution - Missense	1:243664859-243664859,	PATHOGENIC	0.99121	28481359
AKT3	393	COSM6981895,	endometrium	carcinoma	p.L77I	Substitution - Missense	1:243664827-243664827,	PATHOGENIC	0.9912	28481359
AKT3	393	COSM6983187,	upper_aerodigestive_tract	carcinoma	p.S34L	Substitution - Missense	1:243695662-243695662,	PATHOGENIC	0.99101	28481359
AKT3	393	COSM6911247,	large_intestine	carcinoma	p.T86S	Substitution - Missense	1:243664800-243664800,	PATHOGENIC	0.99077	28481359
AKT3	393	COSM324691,	skin	malignant_melanoma	p.R66L	Substitution - Missense	1:243664859-243664859,	PATHOGENIC	0.99073	26343386
AKT3	393	COSM2050914,	breast	carcinoma	p.S474F	Substitution - Missense	1:243505268-243505268,	PATHOGENIC	0.98981	28481359
AKT3	393	COSM6984316,	endometrium	carcinoma	p.F159V	Substitution - Missense	1:243637697-243637697,	PATHOGENIC	0.9895	28481359
AKT3	393	COSM6967976,	breast	carcinoma	p.?	Unknown	1:243512427-243512427,	PATHOGENIC	0.98949	28481359
AKT3	393	COSM6967976,	breast	carcinoma	p.?	Unknown	1:243512427-243512427,	PATHOGENIC	0.98949	28481359
AKT3	393	COSM6975757,	skin	carcinoma	p.S214P	Substitution - Missense	1:243613727-243613727,	PATHOGENIC	0.98946	28481359
AKT3	393	COSM6598026,	large_intestine	carcinoma	p.E438*	Substitution - Nonsense	1:243512366-243512366,	PATHOGENIC	0.98911	28481359
AKT3	393	COSM4856466,	skin	carcinoma	p.S210F	Substitution - Missense	1:243613738-243613738,	PATHOGENIC	0.98857	28481359
AKT3	393	COSM4990553,	skin	carcinoma	p.R66Q	Substitution - Missense	1:243664859-243664859,	PATHOGENIC	0.98848	25589618
AKT3	393	COSM4458723,	small_intestine	carcinoma	p.P366S	Substitution - Missense	1:243552796-243552796,	PATHOGENIC	0.98835	28481359
AKT3	393	COSM6986510,	kidney	carcinoma	p.Y452C	Substitution - Missense	1:243505334-243505334,	PATHOGENIC	0.98829	28481359
AKT3	393	COSM6939220,	large_intestine	carcinoma	p.L200*	Substitution - Nonsense	1:243615124-243615124,	PATHOGENIC	0.98808	28481359
AKT3	393	COSM6911827,	lung	carcinoma	p.G129*	Substitution - Nonsense	1:243645937-243645937,	PATHOGENIC	0.98803	28481359
AKT3	393	COSM6963439,	skin	carcinoma	p.G391E	Substitution - Missense	1:243545589-243545589,	PATHOGENIC	0.98801	28481359
AKT3	393	COSM5575814,	stomach	carcinoma	p.G37A	Substitution - Missense	1:243695653-243695653,	PATHOGENIC	0.98784	26489445
AKT3	393	COSM6984710,	soft_tissue	leiomyosarcoma	p.S136F	Substitution - Missense	1:243645915-243645915,	PATHOGENIC	0.98732	28481359
AKT3	393	COSM6929446,	lung	carcinoma	p.E316*	Substitution - Nonsense	1:243563722-243563722,	PATHOGENIC	0.98732	28481359
AKT3	393	COSM6985065,	endometrium	carcinoma	p.M339I	Substitution - Missense	1:243552875-243552875,	PATHOGENIC	0.98677	28481359
AKT3	393	COSM6913233,	lung	carcinoma	p.G342W	Substitution - Missense	1:243552868-243552868,	PATHOGENIC	0.98677	28481359
AKT3	393	COSM6982620,	endometrium	carcinoma	p.H402Y	Substitution - Missense	1:243545557-243545557,	PATHOGENIC	0.98615	28481359
AKT3	393	COSM6941230,	soft_tissue	rhabdomyosarcoma	p.P206H	Substitution - Missense	1:243615106-243615106,	PATHOGENIC	0.98567	28481359
AKT3	393	COSM6937602,	urinary_tract	carcinoma	p.E17*	Substitution - Nonsense	1:243695714-243695714,	PATHOGENIC	0.9835	28481359
AKT3	393	COSM6958251,	lung	carcinoma	p.G171*	Substitution - Nonsense	1:243637661-243637661,	PATHOGENIC	0.98347	28481359
AKT3	393	COSM6931614,	central_nervous_system	glioma	p.G37E	Substitution - Missense	1:243695653-243695653,	PATHOGENIC	0.98331	28481359
AKT3	393	COSM48227,	lung	carcinoma	p.Q124L	Substitution - Missense	1:243645951-243645951,	PATHOGENIC	0.98328	18948947
AKT3	393	COSM6951246,	skin	carcinoma	p.P206L	Substitution - Missense	1:243615106-243615106,	PATHOGENIC	0.98315	28481359
AKT3	393	COSM4990550,	skin	carcinoma	p.P206S	Substitution - Missense	1:243615107-243615107,	PATHOGENIC	0.98315	25589618
AKT3	393	COSM6975917,	pancreas	carcinoma	p.M117L	Substitution - Missense	1:243645973-243645973,	PATHOGENIC	0.98244	28481359
AKT3	393	COSM6933040,	urinary_tract	carcinoma	p.M176I	Substitution - Missense	1:243637644-243637644,	PATHOGENIC	0.98243	28481359
AKT3	393	COSM6956931,	skin	carcinoma	p.?	Unknown	1:243637610-243637610,	PATHOGENIC	0.98243	28481359
AKT3	393	COSM6933040,	salivary_gland	carcinoma	p.M176I	Substitution - Missense	1:243637644-243637644,	PATHOGENIC	0.98243	28481359
AKT3	393	COSM2050921,	NS	carcinoma	p.Y347C	Substitution - Missense	1:243552852-243552852,	PATHOGENIC	0.98218	28481359
AKT3	393	COSM6926144,	oesophagus	carcinoma	p.E196A	Substitution - Missense	1:243615136-243615136,	PATHOGENIC	0.98195	28481359
AKT3	393	COSM6979085,	lung	carcinoid-endocrine_tumour	p.S371*	Substitution - Nonsense	1:243552780-243552780,	PATHOGENIC	0.98133	28481359
AKT3	393	COSM6945303,	lung	carcinoma	p.T288R	Substitution - Missense	1:243563805-243563805,	PATHOGENIC	0.98113	28481359
AKT3	393	COSM6965183,	urinary_tract	carcinoma	p.F346L	Substitution - Missense	1:243552854-243552854,	PATHOGENIC	0.98068	28481359
AKT3	393	COSM4990547,	skin	carcinoma	p.S214F	Substitution - Missense	1:243613726-243613726,	PATHOGENIC	0.97878	25589618
AKT3	393	COSM13303,	central_nervous_system	glioma	p.G171R	Substitution - Missense	1:243637661-243637661,	PATHOGENIC	0.97795	16618716
AKT3	393	COSM13303,	central_nervous_system	glioma	p.G171R	Substitution - Missense	1:243637661-243637661,	PATHOGENIC	0.97795	16618716
AKT3	393	COSM6960375,	pancreas	carcinoma	p.R478*	Substitution - Nonsense	1:243505257-243505257,	PATHOGENIC	0.97792	28481359
AKT3	393	COSM1718009,	skin	carcinoma	p.M360I	Substitution - Missense	1:243552812-243552812,	PATHOGENIC	0.97788	25589618
AKT3	393	COSM224779,	penis	carcinoma	p.E17K	Substitution - Missense	1:243695714-243695714,	PATHOGENIC	0.97752	28481359
AKT3	393	COSM224779,	skin	malignant_melanoma	p.E17K	Substitution - Missense	1:243695714-243695714,	PATHOGENIC	0.97752	28481359
AKT3	393	COSM224779,	prostate	carcinoma	p.E17K	Substitution - Missense	1:243695714-243695714,	PATHOGENIC	0.97752	28481359
AKT3	393	COSM224779,	soft_tissue	leiomyosarcoma	p.E17K	Substitution - Missense	1:243695714-243695714,	PATHOGENIC	0.97752	28481359
AKT3	393	COSM3418989,	biliary_tract	carcinoma	p.R478Q	Substitution - Missense	1:243505256-243505256,	PATHOGENIC	0.97686	28481359
AKT3	393	COSM3418989,	large_intestine	carcinoma	p.R478Q	Substitution - Missense	1:243505256-243505256,	PATHOGENIC	0.97686	28481359
AKT3	393	COSM6941874,	large_intestine	carcinoma	p.K180M	Substitution - Missense	1:243637633-243637633,	PATHOGENIC	0.97619	28481359
AKT3	393	COSM6970050,	lung	carcinoma	p.Q43*	Substitution - Nonsense	1:243695636-243695636,	PATHOGENIC	0.9757	28481359
AKT3	393	COSM5633254,	biliary_tract	carcinoma	p.T195S	Substitution - Missense	1:243615139-243615139,	PATHOGENIC	0.97272	28481359
AKT3	393	COSM6508942,	lung	carcinoma	p.L211F	Substitution - Missense	1:243613734-243613734,	PATHOGENIC	0.97178	28481359
AKT3	393	COSM6939217,	large_intestine	carcinoma	p.F290V	Substitution - Missense	1:243563800-243563800,	PATHOGENIC	0.97079	28481359
AKT3	393	COSM6355932,	large_intestine	carcinoma	p.R388C	Substitution - Missense	1:243552730-243552730,	PATHOGENIC	0.96921	28481359
AKT3	393	COSM6355932,	lung	carcinoma	p.R388C	Substitution - Missense	1:243552730-243552730,	PATHOGENIC	0.96921	28481359
AKT3	393	COSM906618,	prostate	carcinoma	p.R367Q	Substitution - Missense	1:243552792-243552792,	PATHOGENIC	0.96831	28481359
AKT3	393	COSM6932727,	stomach	carcinoma	p.E275V	Substitution - Missense	1:243563844-243563844,	PATHOGENIC	0.96816	28481359
AKT3	393	COSM6986111,	breast	carcinoma	p.S257C	Substitution - Missense	1:243572975-243572975,	PATHOGENIC	0.96751	28481359
AKT3	393	COSM6937099,	breast	carcinoma	p.E295Q	Substitution - Missense	1:243563785-243563785,	PATHOGENIC	0.96717	28481359
AKT3	393	COSM6920945,	breast	carcinoma	p.D282N	Substitution - Missense	1:243563824-243563824,	PATHOGENIC	0.96636	28481359
AKT3	393	COSM1340758,	large_intestine	carcinoma	p.E352D	Substitution - Missense	1:243552836-243552836,	PATHOGENIC	0.96635	28481359
AKT3	393	COSM1340758,	endometrium	carcinoma	p.E352D	Substitution - Missense	1:243552836-243552836,	PATHOGENIC	0.96635	28481359
AKT3	393	COSM6980610,	large_intestine	carcinoma	p.K416T	Substitution - Missense	1:243545514-243545514,	PATHOGENIC	0.96616	28481359
AKT3	393	COSM6929127,	lung	carcinoma	p.R465W	Substitution - Missense	1:243505296-243505296,	PATHOGENIC	0.96599	28481359
AKT3	393	COSM6962953,	skin	carcinoma	p.?	Unknown	1:243545598-243545598,	PATHOGENIC	0.96571	28481359
AKT3	393	COSM6910646,	lung	carcinoma	p.R249S	Substitution - Missense	1:243573000-243573000,	PATHOGENIC	0.96511	28481359
AKT3	393	COSM6910646,	lung	carcinoma	p.R249S	Substitution - Missense	1:243573000-243573000,	PATHOGENIC	0.96511	28481359
AKT3	393	COSM6951333,	lung	carcinoma	p.H236N	Substitution - Missense	1:243573039-243573039,	PATHOGENIC	0.96414	28481359
AKT3	393	COSM1177537,	lung	carcinoma	p.S264F	Substitution - Missense	1:243572954-243572954,	PATHOGENIC	0.96188	28481359
AKT3	393	COSM6927316,	endometrium	carcinoma	p.S244F	Substitution - Missense	1:243573014-243573014,	PATHOGENIC	0.96188	28481359
AKT3	393	COSM6940606,	pancreas	carcinoma	p.S238L	Substitution - Missense	1:243573032-243573032,	PATHOGENIC	0.96188	28481359
AKT3	393	COSM6917936,	adrenal_gland	adrenal_cortical_carcinoma	p.R220H	Substitution - Missense	1:243613708-243613708,	PATHOGENIC	0.96126	28481359
AKT3	393	COSM6945353,	skin	carcinoma	p.F404L	Substitution - Missense	1:243545549-243545549,	PATHOGENIC	0.96107	28481359
AKT3	393	COSM5576014,	stomach	carcinoma	p.L272R	Substitution - Missense	1:243572930-243572930,	PATHOGENIC	0.95867	26489445
AKT3	393	COSM425791,	large_intestine	carcinoma	p.R66*	Substitution - Nonsense	1:243664860-243664860,	PATHOGENIC	0.95845	28481359
AKT3	393	COSM99009,	stomach	carcinoma	p.T298A	Substitution - Missense	1:243563776-243563776,	PATHOGENIC	0.95651	21097718
AKT3	393	COSM6974201,	prostate	carcinoma	p.Y269H	Substitution - Missense	1:243572940-243572940,	PATHOGENIC	0.95514	28481359
AKT3	393	COSM6929832,	skin	malignant_melanoma	p.V45G	Substitution - Missense	1:243695629-243695629,	PATHOGENIC	0.95509	28481359
AKT3	393	COSM6953016,	lung	carcinoma	p.Y251N	Substitution - Missense	1:243572994-243572994,	PATHOGENIC	0.95449	28481359
AKT3	393	COSM6935167,	endometrium	carcinoma	p.E254*	Substitution - Nonsense	1:243572985-243572985,	PATHOGENIC	0.94959	28481359
AKT3	393	COSM6982626,	endometrium	carcinoma	p.E240*	Substitution - Nonsense	1:243573027-243573027,	PATHOGENIC	0.94959	28481359
AKT3	393	COSM6949635,	endometrium	carcinoma	p.L151V	Substitution - Missense	1:243637721-243637721,	PATHOGENIC	0.94168	28481359
AKT3	393	COSM6914004,	large_intestine	carcinoma	p.R270H	Substitution - Missense	1:243572936-243572936,	PATHOGENIC	0.94009	28481359
AKT3	393	COSM6914004,	large_intestine	carcinoma	p.R270H	Substitution - Missense	1:243572936-243572936,	PATHOGENIC	0.94009	28481359
AKT3	393	COSM6055017,	skin	carcinoma	p.R247H	Substitution - Missense	1:243573005-243573005,	PATHOGENIC	0.93908	28481359
AKT3	393	COSM6926534,	stomach	carcinoma	p.E240K	Substitution - Missense	1:243573027-243573027,	PATHOGENIC	0.93908	28481359
AKT3	393	COSM6055017,	central_nervous_system	glioma	p.R247H	Substitution - Missense	1:243573005-243573005,	PATHOGENIC	0.93908	28481359
AKT3	393	COSM6055017,	large_intestine	carcinoma	p.R247H	Substitution - Missense	1:243573005-243573005,	PATHOGENIC	0.93908	28481359
AKT3	393	COSM6914747,	large_intestine	carcinoma	p.R249H	Substitution - Missense	1:243572999-243572999,	PATHOGENIC	0.93573	28481359
AKT3	393	COSM6910034,	lung	carcinoma	p.R247C	Substitution - Missense	1:243573006-243573006,	PATHOGENIC	0.92999	28481359
AKT3	393	COSM6929955,	stomach	carcinoma	p.R166Q	Substitution - Missense	1:243637675-243637675,	PATHOGENIC	0.92367	28481359
AKT3	393	COSM6929955,	pancreas	carcinoma	p.R166Q	Substitution - Missense	1:243637675-243637675,	PATHOGENIC	0.92367	28481359
AKT3	393	COSM906623,	large_intestine	carcinoma	p.R166*	Substitution - Nonsense	1:243637676-243637676,	PATHOGENIC	0.92254	28481359
AKT3	393	COSM906623,	large_intestine	carcinoma	p.R166*	Substitution - Nonsense	1:243637676-243637676,	PATHOGENIC	0.92254	28481359
AKT3	393	COSM906623,	lung	carcinoma	p.R166*	Substitution - Nonsense	1:243637676-243637676,	PATHOGENIC	0.92254	28481359
AKT3	393	COSM6957269,	penis	carcinoma	p.E167D	Substitution - Missense	1:243637671-243637671,	PATHOGENIC	0.91901	28481359
AKT3	393	COSM6952110,	large_intestine	carcinoma	p.E40D	Substitution - Missense	1:243695643-243695643,	PATHOGENIC	0.90481	28481359
AKT3	393	COSM6949417,	stomach	carcinoma	p.R25G	Substitution - Missense	1:243695690-243695690,	PATHOGENIC	0.89858	28481359
AKT3	393	COSM6982623,	endometrium	carcinoma	p.S371P	Substitution - Missense	1:243552781-243552781,	PATHOGENIC	0.87875	28481359
AKT3	393	COSM1602015,	liver	carcinoma	p.H140H	Substitution - coding silent	1:243645902-243645902,	PATHOGENIC	0.87452	Info_not_available
AKT3	393	COSM6924257,	urinary_tract	carcinoma	p.E295D	Substitution - Missense	1:243563783-243563783,	PATHOGENIC	0.86846	28481359
AKT3	393	COSM95755,	breast	carcinoma	p.S378S	Substitution - coding silent	1:243552758-243552758,	PATHOGENIC	0.86829	20668451
AKT3	393	COSM6981041,	NS	carcinoma	p.R15K	Substitution - Missense	1:243843127-243843127,	PATHOGENIC	0.8443	28481359
AKT3	393	COSM6941726,	large_intestine	carcinoma	p.E93D	Substitution - Missense	1:243664777-243664777,	PATHOGENIC	0.83209	28481359
AKT3	393	COSM6964023,	lung	carcinoma	p.I128M	Substitution - Missense	1:243645938-243645938,	PATHOGENIC	0.80631	28481359
AKT3	393	COSM1182444,	large_intestine	carcinoma	p.F207L	Substitution - Missense	1:243615102-243615102,	PATHOGENIC	0.76221	28481359
AKT3	393	COSM6978543,	kidney, lung, stomach	carcinoma	p.D372fs*10, p.E196fs*9, p.G33I, p.W98fs*22	Deletion - Frameshift, Insertion - Frameshift, Substitution - Missense	1:243695665-243695666,	Info_not_available	Info_not_available	28481359