Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
GRM3	4595	COSM5609044,	skin	malignant_melanoma	p.G587D	Substitution - Missense	7:86839274-86839274,	PATHOGENIC	0.99819	26343386
GRM3	4595	COSM5609062,	skin	malignant_melanoma	p.P443L	Substitution - Missense	7:86838842-86838842,	PATHOGENIC	0.99801	26343386
GRM3	4595	COSM5609036,	skin	malignant_melanoma	p.D25N	Substitution - Missense	7:86765218-86765218,	PATHOGENIC	0.99469	26343386
GRM3	4595	COSM141843,	skin	malignant_melanoma	p.D511N	Substitution - Missense	7:86839045-86839045,	PATHOGENIC	0.9944	26343386
GRM3	4595	COSM141843,	skin	malignant_melanoma	p.D511N	Substitution - Missense	7:86839045-86839045,	PATHOGENIC	0.9944	21946352
GRM3	4595	COSM141844,	skin	malignant_melanoma	p.E517K	Substitution - Missense	7:86839063-86839063,	PATHOGENIC	0.9944	21946352
GRM3	4595	COSM5609038,	skin	malignant_melanoma	p.V622I	Substitution - Missense	7:86839378-86839378,	PATHOGENIC	0.99282	26343386
GRM3	4595	COSM94404,	prostate	carcinoma	p.G58R	Substitution - Missense	7:86765317-86765317,	PATHOGENIC	0.99185	20668451
GRM3	4595	COSM3721989,	upper_aerodigestive_tract	carcinoma	p.R679K	Substitution - Missense	7:86839550-86839550,	PATHOGENIC	0.99132	23619168
GRM3	4595	COSM3641788,	skin	malignant_melanoma	p.G312S	Substitution - Missense	7:86786726-86786726,	PATHOGENIC	0.99111	26343386
GRM3	4595	COSM94405,	lung	carcinoma	p.D77Y	Substitution - Missense	7:86765374-86765374,	PATHOGENIC	0.99106	20668451
GRM3	4595	COSM5048985,	oesophagus	carcinoma	p.M521I	Substitution - Missense	7:86839077-86839077,	PATHOGENIC	0.99078	24686850
GRM3	4595	COSM5609013,	skin	malignant_melanoma	p.D353N	Substitution - Missense	7:86786849-86786849,	PATHOGENIC	0.99068	26343386
GRM3	4595	COSM141840,	skin	malignant_melanoma	p.D280N	Substitution - Missense	7:86786630-86786630,	PATHOGENIC	0.99034	21946352
GRM3	4595	COSM221733,	skin	malignant_melanoma	p.M518I	Substitution - Missense	7:86839068-86839068,	PATHOGENIC	0.99024	26343386
GRM3	4595	COSM5609053,	skin	malignant_melanoma	p.A577V	Substitution - Missense	7:86839244-86839244,	PATHOGENIC	0.99019	26343386
GRM3	4595	COSM5609059,	skin	malignant_melanoma	p.E224K	Substitution - Missense	7:86786462-86786462,	PATHOGENIC	0.9898	26343386
GRM3	4595	COSM5609028,	skin	malignant_melanoma	p.D77N	Substitution - Missense	7:86765374-86765374,	PATHOGENIC	0.98976	26343386
GRM3	4595	COSM141838,	skin	malignant_melanoma	p.S154F	Substitution - Missense	7:86765606-86765606,	PATHOGENIC	0.98919	26343386
GRM3	4595	COSM141838,	skin	malignant_melanoma	p.S154F	Substitution - Missense	7:86765606-86765606,	PATHOGENIC	0.98919	21946352
GRM3	4595	COSM5609055,	skin	malignant_melanoma	p.E203K	Substitution - Missense	7:86786399-86786399,	PATHOGENIC	0.98896	26343386
GRM3	4595	COSM1698828,	skin	malignant_melanoma	p.E283K	Substitution - Missense	7:86786639-86786639,	PATHOGENIC	0.98669	26343386
GRM3	4595	COSM3412421,	skin	malignant_melanoma	p.D257N	Substitution - Missense	7:86786561-86786561,	PATHOGENIC	0.98669	26343386
GRM3	4595	COSM39724,	central_nervous_system	glioma	p.V271I	Substitution - Missense	7:86786603-86786603,	PATHOGENIC	0.98607	18772396
GRM3	4595	COSM141849,	skin	malignant_melanoma	p.E870K	Substitution - Missense	7:86864323-86864323,	PATHOGENIC	0.98607	21946352
GRM3	4595	COSM141849,	skin	malignant_melanoma	p.E870K	Substitution - Missense	7:86864323-86864323,	PATHOGENIC	0.98607	26343386
GRM3	4595	COSM94406,	lung	carcinoma	p.Y336H	Substitution - Missense	7:86786798-86786798,	PATHOGENIC	0.98161	20668451
GRM3	4595	COSM141837,	skin	malignant_melanoma	p.G88E	Substitution - Missense	7:86765408-86765408,	PATHOGENIC	0.98148	21946352
GRM3	4595	COSM94407,	skin	malignant_melanoma	p.S610L	Substitution - Missense	7:86839343-86839343,	PATHOGENIC	0.981	21946352
GRM3	4595	COSM94407,	lung	carcinoma	p.S610L	Substitution - Missense	7:86839343-86839343,	PATHOGENIC	0.981	20668451
GRM3	4595	COSM141839,	skin	malignant_melanoma	p.P192L	Substitution - Missense	7:86786367-86786367,	PATHOGENIC	0.9797	21946352
GRM3	4595	COSM141835,	skin	malignant_melanoma	p.G18E	Substitution - Missense	7:86765198-86765198,	PATHOGENIC	0.9787	21946352
GRM3	4595	COSM141847,	skin	malignant_melanoma	p.E573K	Substitution - Missense	7:86839231-86839231,	PATHOGENIC	0.97506	21946352
GRM3	4595	COSM1623230,	liver	carcinoma	p.M775I	Substitution - Missense	7:86839839-86839839,	PATHOGENIC	0.96966	Info_not_available
GRM3	4595	COSM39425,	central_nervous_system	glioma	p.T758M	Substitution - Missense	7:86839787-86839787,	PATHOGENIC	0.96757	18772396
GRM3	4595	COSM5609033,	skin	malignant_melanoma	p.G772S	Substitution - Missense	7:86839828-86839828,	PATHOGENIC	0.96638	26343386
GRM3	4595	COSM141845,	skin	malignant_melanoma	p.D548N	Substitution - Missense	7:86839156-86839156,	PATHOGENIC	0.96559	21946352
GRM3	4595	COSM141842,	skin	malignant_melanoma	p.V468L	Substitution - Missense	7:86838916-86838916,	PATHOGENIC	0.9619	21946352
GRM3	4595	COSM5609017,	skin	malignant_melanoma	p.R189K	Substitution - Missense	7:86786358-86786358,	PATHOGENIC	0.96143	26343386
GRM3	4595	COSM5048538,	oesophagus	carcinoma	p.L648M	Substitution - Missense	7:86839456-86839456,	PATHOGENIC	0.95729	24686850
GRM3	4595	COSM141836,	skin	malignant_melanoma	p.R59Q	Substitution - Missense	7:86765321-86765321,	PATHOGENIC	0.95703	21946352
GRM3	4595	COSM110558,	skin	malignant_melanoma	p.G848E	Substitution - Missense	7:86850521-86850521,	PATHOGENIC	0.9504	21946352
GRM3	4595	COSM5609068,	skin	malignant_melanoma	p.P712L	Substitution - Missense	7:86839649-86839649,	PATHOGENIC	0.94967	26343386
GRM3	4595	COSM5047602,	oesophagus	carcinoma	p.G811V	Substitution - Missense	7:86850410-86850410,	PATHOGENIC	0.94853	24686850
GRM3	4595	COSM94408,	lung	carcinoma	p.I696T	Substitution - Missense	7:86839601-86839601,	PATHOGENIC	0.94665	20668451
GRM3	4595	COSM141846,	skin	malignant_melanoma	p.G561E	Substitution - Missense	7:86839196-86839196,	PATHOGENIC	0.93752	21946352
GRM3	4595	COSM1698831,	skin	malignant_melanoma	p.D744N	Substitution - Missense	7:86839744-86839744,	PATHOGENIC	0.93677	26343386
GRM3	4595	COSM141848,	skin	malignant_melanoma	p.E767K	Substitution - Missense	7:86839813-86839813,	PATHOGENIC	0.93389	21946352
GRM3	4595	COSM141848,	skin	malignant_melanoma	p.E767K	Substitution - Missense	7:86839813-86839813,	PATHOGENIC	0.93389	26343386
GRM3	4595	COSM5585368,	skin	malignant_melanoma	p.G561R	Substitution - Missense	7:86839195-86839195,	PATHOGENIC	0.91528	26343386
GRM3	4595	COSM141841,	skin	malignant_melanoma	p.R352W	Substitution - Missense	7:86786846-86786846,	PATHOGENIC	0.91183	21946352
GRM3	4595	COSM5609051,	skin	malignant_melanoma	p.K722T	Substitution - Missense	7:86839679-86839679,	PATHOGENIC	0.89219	26343386
GRM3	4595	COSM1488732,	skin	malignant_melanoma	p.V259V	Substitution - coding silent	7:86786569-86786569,	PATHOGENIC	0.8904	26343386
GRM3	4595	COSM5609022,	skin	malignant_melanoma	p.R759R	Substitution - coding silent	7:86839791-86839791,	PATHOGENIC	0.87745	26343386
GRM3	4595	COSM5609064,	skin	malignant_melanoma	p.D25D	Substitution - coding silent	7:86765220-86765220,	PATHOGENIC	0.85542	26343386
GRM3	4595	COSM1658902,	salivary_gland	carcinoma	p.D25E	Substitution - Missense	7:86765220-86765220,	PATHOGENIC	0.85098	23778141
GRM3	4595	COSM3032180,	skin	malignant_melanoma	p.I390I	Substitution - coding silent	7:86786962-86786962,	PATHOGENIC	0.84095	26343386
GRM3	4595	COSM3032180,	skin	malignant_melanoma	p.I390I	Substitution - coding silent	7:86786962-86786962,	PATHOGENIC	0.84095	26343386
GRM3	4595	COSM5609031,	skin	malignant_melanoma	p.V89V	Substitution - coding silent	7:86765412-86765412,	PATHOGENIC	0.79939	26343386
GRM3	4595	COSM5609066,	skin	malignant_melanoma	p.R101R	Substitution - coding silent	7:86765448-86765448,	PATHOGENIC	0.78438	26343386
GRM3	4595	COSM747777,	skin	malignant_melanoma	p.I826I	Substitution - coding silent	7:86850456-86850456,	PATHOGENIC	0.73669	26343386
GRM3	4595	COSM3641795,	skin	malignant_melanoma	p.I379I	Substitution - coding silent	7:86786929-86786929,	NEUTRAL	0.3645	26343386
GRM3	4595	COSM5609048,	skin	malignant_melanoma	p.R249R	Substitution - coding silent	7:86786539-86786539,	NEUTRAL	0.28805	26343386
GRM3	4595	COSM3032153,	skin	malignant_melanoma	p.F230F	Substitution - coding silent	7:86786482-86786482,	NEUTRAL	0.16731	26343386
GRM3	4595	COSM1452512,	skin	malignant_melanoma	p.S496F	Substitution - Missense	7:86839001-86839001,	NEUTRAL	0.16504	26343386
GRM3	4595	COSM1550472,	skin	malignant_melanoma	p.I138I	Substitution - coding silent	7:86765559-86765559,	NEUTRAL	0.13791	26343386
GRM3	4595	COSM3641784,	skin	malignant_melanoma	p.V271V	Substitution - coding silent	7:86786605-86786605,	NEUTRAL	0.13497	26343386
GRM3	4595	COSM3032219,	skin	malignant_melanoma	p.T864T	Substitution - coding silent	7:86864307-86864307,	NEUTRAL	0.10335	26343386
GRM3	4595	COSM3641812,	skin	malignant_melanoma	p.F652F	Substitution - coding silent	7:86839470-86839470,	NEUTRAL	0.04028	26343386
GRM3	4595	COSM3641812,	skin	malignant_melanoma	p.F652F	Substitution - coding silent	7:86839470-86839470,	NEUTRAL	0.04028	26343386
GRM3	4595	COSM5049315,	oesophagus	carcinoma	p.Y790fs*6	Insertion - Frameshift	7:86839881-86839882,	Info_not_available	Info_not_available	24686850
GRM3	4595	COSM5611303,	skin	malignant_melanoma	p.F770F, p.F785F, p.G647K	Substitution - Missense, Substitution - coding silent	7:86839869-86839869,	Info_not_available	0.54518, .61665, Info_not_available	26343386