* We recommend a score >= 0.08 for meaningful Gene-Disease associations

GeneID	Gene_Symbol	DisGeNet_diseaseID	Disease_name	DisGeNet score	DisGeNet_sourceDB
238	ALK	C0027819	Neuroblastoma	0.443283897861771	BEFREE;CTD_human;GAD;LHGDN;ORPHANET
238	ALK	C0206180	Ki-1+ Anaplastic Large Cell Lymphoma	0.304596212183324	BEFREE;CTD_human;LHGDN
238	ALK	C0007131	Non-Small Cell Lung Carcinoma	0.28	BEFREE;CTD_human
238	ALK	C0152013	Adenocarcinoma of lung (disorder)	0.226648498068671	BEFREE;CTD_human
238	ALK	C0334121	Inflammatory Myofibroblastic Tumor	0.218406694542278	BEFREE;ORPHANET
238	ALK	C0079744	Diffuse Large B-Cell Lymphoma	0.209586726692824	BEFREE;CTD_human;LHGDN
238	ALK	C0027627	Neoplasm Metastasis	0.20796707674218	BEFREE;CTD_human
238	ALK	C1332079	Anaplastic Large Cell Lymphoma, ALK-Positive	0.207417623173754	BEFREE;ORPHANET
238	ALK	C0036341	Schizophrenia	0.202681755307501	BEFREE;GAD;PSYGENET
238	ALK	C0007621	Neoplastic Cell Transformation	0.202407028523288	CTD_human;GAD
238	ALK	C0007134	Renal Cell Carcinoma	0.201923087489492	BEFREE;CTD_human
238	ALK	C1333294	ALK positive large B-cell lymphoma	0.201098907136852	BEFREE;ORPHANET
238	ALK	C0238463	Papillary thyroid carcinoma	0.200549453568426	BEFREE;ORPHANET
238	ALK	C0278601	Inflammatory Breast Carcinoma	0.200549453568426	BEFREE;CTD_human
238	ALK	C0006118	Brain Neoplasms	0.200274726784213	BEFREE;CTD_human
238	ALK	C0085269	Plasma Cell Granuloma, Pulmonary	0.200274726784213	BEFREE;CTD_human
238	ALK	C2931189	Neural crest tumor	0.200274726784213	BEFREE;ORPHANET
238	ALK	C2751681	NEUROBLASTOMA, SUSCEPTIBILITY TO, 3	0.2	UNIPROT
238	ALK	C0001973	Alcoholic Intoxication, Chronic	0.2	PSYGENET
238	ALK	C0011570	Mental Depression	0.2	PSYGENET
238	ALK	C0011581	Depressive disorder	0.2	PSYGENET
238	ALK	C0018199	Granuloma, Plasma Cell	0.2	CTD_human
238	ALK	C0027643	Neoplasm Recurrence, Local	0.2	CTD_human
238	ALK	C0027766	Nervous System Neoplasms	0.2	HPO
238	ALK	C0241577	Catecholamines urine increased	0.2	HPO
238	ALK	C0242379	Malignant neoplasm of lung	0.0441654997236792	BEFREE;GAD
238	ALK	C0024299	Lymphoma	0.0419183549660663	BEFREE;LHGDN
238	ALK	C0001418	Adenocarcinoma	0.0383818818778869	BEFREE;GAD;LHGDN
238	ALK	C0684249	Carcinoma of lung	0.0304946730476541	BEFREE
238	ALK	C1306460	Primary malignant neoplasm of lung	0.0304946730476541	BEFREE
238	ALK	C0700095	Central neuroblastoma	0.024725410579179	BEFREE
238	ALK	C0024121	Lung Neoplasms	0.0199177658263402	BEFREE;GAD;LHGDN
238	ALK	C0596263	Carcinogenesis	0.013736339210655	BEFREE
238	ALK	C0079731	B-Cell Lymphomas	0.00986145347703711	BEFREE;LHGDN
238	ALK	C0079772	T-Cell Lymphoma	0.00850217493328885	BEFREE;LHGDN
238	ALK	C0019829	Hodgkin Disease	0.00795272136486265	BEFREE;LHGDN
238	ALK	C0017636	Glioblastoma	0.0076636392033323	BEFREE;LHGDN
238	ALK	C0024305	Lymphoma, Non-Hodgkin	0.00657908744379715	BEFREE;LHGDN
238	ALK	C1321546	Anaplastic large B-cell lymphoma	0.005494535684262	BEFREE
238	ALK	C0026769	Multiple Sclerosis	0.004814057046576	GAD
238	ALK	C0220650	Metastatic malignant neoplasm to brain	0.0046703553316227	BEFREE
238	ALK	C0079774	Peripheral T-Cell Lymphoma	0.0038461749789834	BEFREE
238	ALK	C0598766	Leukemogenesis	0.0035714481947703	BEFREE
238	ALK	C1336548	Systemic Anaplastic Large Cell Lymphoma	0.0035714481947703	BEFREE
238	ALK	C0007137	Squamous cell carcinoma	0.0032967214105572	BEFREE
238	ALK	C1301362	Lymphoma, Primary Cutaneous Anaplastic Large Cell	0.0030219946263441	BEFREE
238	ALK	C0242596	Neoplasm, Residual	0.00300763924902685	BEFREE;LHGDN
238	ALK	C0009402	Colorectal Carcinoma	0.002747267842131	BEFREE
238	ALK	C0008626	Congenital chromosomal disease	0.0024725410579179	BEFREE
238	ALK	C1527249	Colorectal Cancer	0.0024725410579179	BEFREE
238	ALK	C0023434	Chronic Lymphocytic Leukemia	0.002407028523288	GAD
238	ALK	C0040336	Tobacco Use Disorder	0.002407028523288	GAD
238	ALK	C0280100	solid tumor	0.0021978142737048	BEFREE
238	ALK	C1261473	Sarcoma	0.0021978142737048	BEFREE
238	ALK	C1332078	Anaplastic large cell lymphoma, ALK negative	0.0021978142737048	BEFREE
238	ALK	C3899155	Familial Neuroblastoma	0.0019230874894917	BEFREE
238	ALK	C0035412	Rhabdomyosarcoma	0.0016483607052786	BEFREE
238	ALK	C0206182	Lymphomatoid Papulosis	0.0016483607052786	BEFREE
238	ALK	C0149782	Squamous cell carcinoma of lung	0.0013736339210655	BEFREE
238	ALK	C0678222	Breast Carcinoma	0.0013736339210655	BEFREE
238	ALK	C0006142	Malignant neoplasm of breast	0.0010989071368524	BEFREE
238	ALK	C0023418	leukemia	0.0010989071368524	BEFREE
238	ALK	C0024314	Lymphoproliferative Disorders	0.0010989071368524	BEFREE
238	ALK	C0494165	Secondary malignant neoplasm of liver	0.0010989071368524	BEFREE
238	ALK	C0549473	Thyroid carcinoma	0.0010989071368524	BEFREE
238	ALK	C1333064	Classical Hodgkin's Lymphoma	0.0010989071368524	BEFREE
238	ALK	C2239176	Liver carcinoma	0.0010989071368524	BEFREE
238	ALK	C0024302	Reticulosarcoma	0.0008241803526393	BEFREE
238	ALK	C0025202	melanoma	0.0008241803526393	BEFREE
238	ALK	C0037054	Sickle Cell Trait	0.0008241803526393	BEFREE
238	ALK	C0153676	Secondary malignant neoplasm of lung	0.0008241803526393	BEFREE
238	ALK	C0206623	Adenosquamous carcinoma	0.0008241803526393	BEFREE
238	ALK	C0278704	Malignant Childhood Neoplasm	0.0008241803526393	BEFREE
238	ALK	C0686619	Secondary malignant neoplasm of lymph node	0.0008241803526393	BEFREE
238	ALK	C0729233	Dissecting aneurysm of the thoracic aorta	0.0008241803526393	BEFREE
238	ALK	C0854988	Adenocarcinoma of lung, stage IV	0.0008241803526393	BEFREE
238	ALK	C0007115	Malignant neoplasm of thyroid	0.0005494535684262	BEFREE
238	ALK	C0007130	Mucinous Adenocarcinoma	0.0005494535684262	BEFREE
238	ALK	C0007140	Carcinosarcoma	0.0005494535684262	BEFREE
238	ALK	C0015230	Exanthema	0.0005494535684262	BEFREE
238	ALK	C0024301	Lymphoma, Follicular	0.0005494535684262	BEFREE
238	ALK	C0027831	Neurofibromatosis 1	0.0005494535684262	BEFREE
238	ALK	C0029925	Ovarian Carcinoma	0.0005494535684262	BEFREE
238	ALK	C0032227	Pleural effusion disorder	0.0005494535684262	BEFREE
238	ALK	C0037579	Soft Tissue Neoplasms	0.0005494535684262	BEFREE
238	ALK	C0085281	Addictive Behavior	0.0005494535684262	BEFREE
238	ALK	C0149925	Small cell carcinoma of lung	0.0005494535684262	BEFREE
238	ALK	C0178874	Tumor Progression	0.0005494535684262	BEFREE
238	ALK	C0205697	Carcinoma, Spindle-Cell	0.0005494535684262	BEFREE
238	ALK	C0206644	Histiocytoma, Benign Fibrous	0.0005494535684262	BEFREE
238	ALK	C0206718	Ganglioneuroblastoma	0.0005494535684262	BEFREE
238	ALK	C0220612	childhood non-Hodgkin's lymphoma	0.0005494535684262	BEFREE
238	ALK	C0220654	Meningeal Carcinomatosis	0.0005494535684262	BEFREE
238	ALK	C0235598	HODGKIN'S-LIKE	0.0005494535684262	BEFREE
238	ALK	C0238461	Anaplastic thyroid carcinoma	0.0005494535684262	BEFREE
238	ALK	C0268621	Hepatic methionine adenosyltransferase deficiency	0.0005494535684262	BEFREE
238	ALK	C0332996	Persistent embryonic structure	0.0005494535684262	BEFREE
238	ALK	C0376545	Hematologic Neoplasms	0.0005494535684262	BEFREE
238	ALK	C0546837	Malignant neoplasm of esophagus	0.0005494535684262	BEFREE
238	ALK	C0677932	Progressive Neoplastic Disease	0.0005494535684262	BEFREE
238	ALK	C0677936	Refractory cancer	0.0005494535684262	BEFREE
238	ALK	C0686377	CNS metastases	0.0005494535684262	BEFREE
238	ALK	C0751691	Perineurioma	0.0005494535684262	BEFREE
238	ALK	C0848332	Spots on skin	0.0005494535684262	BEFREE
238	ALK	C1266002	Non-small cell carcinoma	0.0005494535684262	BEFREE
238	ALK	C1335302	Pancreatic Ductal Adenocarcinoma	0.0005494535684262	BEFREE
238	ALK	C4049328	Kidney Medullary Carcinoma	0.0005494535684262	BEFREE
238	ALK	C3539781	Progressive cGVHD	0.0005494535684262	BEFREE
238	ALK	C3281200	LEUKOENCEPHALOPATHY, BRAIN CALCIFICATIONS, AND CYSTS	0.0002747267842131	BEFREE
238	ALK	C4086165	Childhood Neuroblastoma	0.0002747267842131	BEFREE
238	ALK	C4049711	Lepidic Predominant Adenocarcinoma	0.0002747267842131	BEFREE
238	ALK	C4024986	Congenital neuroblastoma	0.0002747267842131	BEFREE
238	ALK	C3811653	Experimental Organism Basal Cell Carcinoma	0.0002747267842131	BEFREE
238	ALK	C3536893	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	0.0002747267842131	BEFREE
238	ALK	C3472614	Plasmablastic lymphoma	0.0002747267842131	BEFREE
238	ALK	C1835009	MESOMELIC DYSPLASIA, KANTAPUTRA TYPE	0.0002747267842131	BEFREE
238	ALK	C2939461	Myeloid neoplasm	0.0002747267842131	BEFREE
238	ALK	C2363142	T-Cell Prolymphocytic Leukemia	0.0002747267842131	BEFREE
238	ALK	C2145472	Urothelial Carcinoma	0.0002747267842131	BEFREE
238	ALK	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	0.0002747267842131	BEFREE
238	ALK	C1850900	Familial primary gastric lymphoma	0.0002747267842131	BEFREE
238	ALK	C1845055	ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED	0.0002747267842131	BEFREE
238	ALK	C0000744	Abetalipoproteinemia	0.0002747267842131	BEFREE
238	ALK	C0001546	Adjustment Disorders	0.0002747267842131	BEFREE
238	ALK	C0001956	alcohol use disorder	0.0002747267842131	BEFREE
238	ALK	C0002690	Amputation Stumps	0.0002747267842131	BEFREE
238	ALK	C0004114	Astrocytoma	0.0002747267842131	BEFREE
238	ALK	C0004134	Ataxia	0.0002747267842131	BEFREE
238	ALK	C0004135	Ataxia Telangiectasia	0.0002747267842131	BEFREE
238	ALK	C0006111	Brain Diseases	0.0002747267842131	BEFREE
238	ALK	C0007102	Malignant tumor of colon	0.0002747267842131	BEFREE
238	ALK	C0007120	Bronchioloalveolar Adenocarcinoma	0.0002747267842131	BEFREE
238	ALK	C0007129	Merkel cell carcinoma	0.0002747267842131	BEFREE
238	ALK	C0007133	Carcinoma, Papillary	0.0002747267842131	BEFREE
238	ALK	C0007138	Carcinoma, Transitional Cell	0.0002747267842131	BEFREE
238	ALK	C0007682	CNS disorder	0.0002747267842131	BEFREE
238	ALK	C0007758	Cerebellar Ataxia	0.0002747267842131	BEFREE
238	ALK	C0011265	Presenile dementia	0.0002747267842131	BEFREE
238	ALK	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	0.0002747267842131	BEFREE
238	ALK	C0017075	Ganglioneuroma	0.0002747267842131	BEFREE
238	ALK	C0017638	Glioma	0.0002747267842131	BEFREE
238	ALK	C0018790	Cardiac Arrest	0.0002747267842131	BEFREE
238	ALK	C0019163	Hepatitis B	0.0002747267842131	BEFREE
238	ALK	C0019569	Hirschsprung Disease	0.0002747267842131	BEFREE
238	ALK	C0019623	Malignant histiocytosis	0.0002747267842131	BEFREE
238	ALK	C0019693	HIV Infections	0.0002747267842131	BEFREE
238	ALK	C0020532	Hypersplenism	0.0002747267842131	BEFREE
238	ALK	C0020981	Angioimmunoblastic Lymphadenopathy	0.0002747267842131	BEFREE
238	ALK	C0021051	Immunologic Deficiency Syndromes	0.0002747267842131	BEFREE
238	ALK	C0021294	Infant, Premature	0.0002747267842131	BEFREE
238	ALK	C0021831	Intestinal Diseases	0.0002747267842131	BEFREE
238	ALK	C0023440	Acute Erythroblastic Leukemia	0.0002747267842131	BEFREE
238	ALK	C0023448	Lymphoid leukemia	0.0002747267842131	BEFREE
238	ALK	C0023449	Acute lymphocytic leukemia	0.0002747267842131	BEFREE
238	ALK	C0023493	Adult T-Cell Lymphoma/Leukemia	0.0002747267842131	BEFREE
238	ALK	C0023903	Liver neoplasms	0.0002747267842131	BEFREE
238	ALK	C0024117	Chronic Obstructive Airway Disease	0.0002747267842131	BEFREE
238	ALK	C0024899	Mastocytosis	0.0002747267842131	BEFREE
238	ALK	C0026948	Mycosis Fungoides	0.0002747267842131	BEFREE
238	ALK	C0027654	Embryonal Neoplasm	0.0002747267842131	BEFREE
238	ALK	C0027960	Nevus	0.0002747267842131	BEFREE
238	ALK	C0030297	Pancreatic Neoplasm	0.0002747267842131	BEFREE
238	ALK	C0032226	Pleural Diseases	0.0002747267842131	BEFREE
238	ALK	C0032326	Pneumothorax	0.0002747267842131	BEFREE
238	ALK	C0035078	Kidney Failure	0.0002747267842131	BEFREE
238	ALK	C0035335	Retinoblastoma	0.0002747267842131	BEFREE
238	ALK	C0035369	Retroviridae Infections	0.0002747267842131	BEFREE
238	ALK	C0037274	Dermatologic disorders	0.0002747267842131	BEFREE
238	ALK	C0085584	Encephalopathies	0.0002747267842131	BEFREE
238	ALK	C0085648	Synovial Cyst	0.0002747267842131	BEFREE
238	ALK	C0149678	Epstein-Barr Virus Infections	0.0002747267842131	BEFREE
238	ALK	C0152268	Hodgkin's disease, nodular sclerosis (clinical)	0.0002747267842131	BEFREE
238	ALK	C0154038	Benign neoplasm of thyroid gland	0.0002747267842131	BEFREE
238	ALK	C0205696	Anaplastic carcinoma	0.0002747267842131	BEFREE
238	ALK	C0206062	Lung Diseases, Interstitial	0.0002747267842131	BEFREE
238	ALK	C0206629	Pulmonary Blastoma	0.0002747267842131	BEFREE
238	ALK	C0206630	Endometrial Stromal Sarcoma	0.0002747267842131	BEFREE
238	ALK	C0206654	Leiomyomatosis	0.0002747267842131	BEFREE
238	ALK	C0206655	Alveolar rhabdomyosarcoma	0.0002747267842131	BEFREE
238	ALK	C0206656	Rhabdomyosarcoma, Embryonal	0.0002747267842131	BEFREE
238	ALK	C0206701	Cystadenocarcinoma, Serous	0.0002747267842131	BEFREE
238	ALK	C0206703	Carcinoma, Giant Cell	0.0002747267842131	BEFREE
238	ALK	C0206704	Carcinoma, Large Cell	0.0002747267842131	BEFREE
238	ALK	C0206708	Cervical Intraepithelial Neoplasia	0.0002747267842131	BEFREE
238	ALK	C0206754	Neuroendocrine Tumors	0.0002747267842131	BEFREE
238	ALK	C0233629	Thinking and speaking disturbances	0.0002747267842131	BEFREE
238	ALK	C0235593	Thoracic lymphadenopathy	0.0002747267842131	BEFREE
238	ALK	C0235974	Pancreatic carcinoma	0.0002747267842131	BEFREE
238	ALK	C0238305	Sickle cell nephropathy	0.0002747267842131	BEFREE
238	ALK	C0238462	Medullary carcinoma of thyroid	0.0002747267842131	BEFREE
238	ALK	C0242647	Mucosa-Associated Lymphoid Tissue Lymphoma	0.0002747267842131	BEFREE
238	ALK	C0262584	Carcinoma, Small Cell	0.0002747267842131	BEFREE
238	ALK	C0265122	Disorder of pericardium	0.0002747267842131	BEFREE
238	ALK	C0265783	Congenital hypoplasia of lung	0.0002747267842131	BEFREE
238	ALK	C0275524	Coinfection	0.0002747267842131	BEFREE
238	ALK	C0278987	Non-small cell lung cancer metastatic	0.0002747267842131	BEFREE
238	ALK	C0279557	Adenosquamous cell lung cancer	0.0002747267842131	BEFREE
238	ALK	C0279682	Bladder Adenocarcinoma	0.0002747267842131	BEFREE
238	ALK	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	0.0002747267842131	BEFREE
238	ALK	C0280217	stage, non-small cell lung cancer	0.0002747267842131	BEFREE
238	ALK	C0334054	cystic disease	0.0002747267842131	BEFREE
238	ALK	C0334233	Pleomorphic carcinoma	0.0002747267842131	BEFREE
238	ALK	C0334254	Lymphoepithelial carcinoma	0.0002747267842131	BEFREE
238	ALK	C0334607	Psammomatous Meningioma	0.0002747267842131	BEFREE
238	ALK	C0334660	Angioendotheliomatosis	0.0002747267842131	BEFREE
238	ALK	C0345967	Malignant mesothelioma	0.0002747267842131	BEFREE
238	ALK	C0346053	Atypical fibroxanthoma of skin	0.0002747267842131	BEFREE
238	ALK	C0346109	Malignant Mesothelioma of Peritoneum	0.0002747267842131	BEFREE
238	ALK	C0346647	Malignant neoplasm of pancreas	0.0002747267842131	BEFREE
238	ALK	C0347016	Secondary malignant neoplasm of spinal cord	0.0002747267842131	BEFREE
238	ALK	C0349532	Gastric lymphoma	0.0002747267842131	BEFREE
238	ALK	C0376358	Malignant neoplasm of prostate	0.0002747267842131	BEFREE
238	ALK	C0424295	Hyperactive behavior	0.0002747267842131	BEFREE
238	ALK	C0497327	Dementia	0.0002747267842131	BEFREE
238	ALK	C0553580	Ewings sarcoma	0.0002747267842131	BEFREE
238	ALK	C0598935	Tumor Initiation	0.0002747267842131	BEFREE
238	ALK	C0600139	Prostate carcinoma	0.0002747267842131	BEFREE
238	ALK	C0677886	Epithelial ovarian cancer	0.0002747267842131	BEFREE
238	ALK	C0699791	Stomach Carcinoma	0.0002747267842131	BEFREE
238	ALK	C0751688	Malignant Squamous Cell Neoplasm	0.0002747267842131	BEFREE
238	ALK	C0795801	trisomy 2	0.0002747267842131	BEFREE
238	ALK	C0836924	Thrombocytosis	0.0002747267842131	BEFREE
238	ALK	C0854821	Anaplastic large cell lymphoma T- and null-cell types refractory	0.0002747267842131	BEFREE
238	ALK	C0919267	ovarian neoplasm	0.0002747267842131	BEFREE
238	ALK	C1140680	Malignant neoplasm of ovary	0.0002747267842131	BEFREE
238	ALK	C1145670	Respiratory Failure	0.0002747267842131	BEFREE
238	ALK	C1258666	Myxoid cyst	0.0002747267842131	BEFREE
238	ALK	C1266034	Bronchiolo-alveolar carcinoma, non-mucinous	0.0002747267842131	BEFREE
238	ALK	C1279296	Chronic leukemia (category)	0.0002747267842131	BEFREE
238	ALK	C1290375	Mesothelioma (malignant, clinical disorder) (disorder)	0.0002747267842131	BEFREE
238	ALK	C1292769	Precursor B-cell lymphoblastic leukemia	0.0002747267842131	BEFREE
238	ALK	C1301363	Blastic plasmacytoid dendritic cell neoplasm	0.0002747267842131	BEFREE
238	ALK	C1302772	Primary cutaneous lymphoma	0.0002747267842131	BEFREE
238	ALK	C1319315	Adenocarcinoma of large intestine	0.0002747267842131	BEFREE
238	ALK	C1332942	Childhood Anaplastic Large Cell Lymphoma	0.0002747267842131	BEFREE
238	ALK	C1333967	Inflammatory pseudotumor of liver	0.0002747267842131	BEFREE
238	ALK	C1334699	Mesenchymal Cell Neoplasm	0.0002747267842131	BEFREE
238	ALK	C1334953	Neuroblastic Tumor	0.0002747267842131	BEFREE
238	ALK	C1335433	Pleural Carcinomatosis	0.0002747267842131	BEFREE
238	ALK	C1336052	Spindle Cell Neoplasm	0.0002747267842131	BEFREE
238	ALK	C1336891	Urinary Bladder Inflammatory Myofibroblastic Tumor	0.0002747267842131	BEFREE
238	ALK	C1337013	Differentiated Thyroid Gland Carcinoma	0.0002747267842131	BEFREE
238	ALK	C1368683	Epithelioma	0.0002747267842131	BEFREE
238	ALK	C1370723	Stromal sarcoma	0.0002747267842131	BEFREE
238	ALK	C1402294	Primary Lesion	0.0002747267842131	BEFREE
238	ALK	C1514517	Prostate Stromal Proliferation of Uncertain Malignant Potential	0.0002747267842131	BEFREE
238	ALK	C1519670	Tumor Angiogenesis	0.0002747267842131	BEFREE
238	ALK	C1527390	Neoplasms, Intracranial	0.0002747267842131	BEFREE
238	ALK	C1565489	Renal Insufficiency	0.0002747267842131	BEFREE
238	ALK	C1708751	Low grade myofibroblastic sarcoma	0.0002747267842131	BEFREE
238	ALK	C1708781	Lung Sarcomatoid Carcinoma	0.0002747267842131	BEFREE
238	ALK	C1709246	Non-Neoplastic Disorder	0.0002747267842131	BEFREE