* We recommend a score >= 0.08 for meaningful Gene-Disease associations

GeneID	Gene_Symbol	DisGeNet_diseaseID	Disease_name	DisGeNet score	DisGeNet_sourceDB
249	ALPL	C0268412	Infantile hypophosphatasia	0.685978476718058	BEFREE;CTD_human;GAD;HPO;MGD;ORPHANET;UNIPROT
249	ALPL	C0268413	Adult hypophosphatasia (disorder)	0.681098907136852	BEFREE;CTD_human;MGD;ORPHANET;UNIPROT
249	ALPL	C0220743	Childhood hypophosphatasia (disorder)	0.680549453568426	BEFREE;CTD_human;MGD;ORPHANET;UNIPROT
249	ALPL	C0036572	Seizures	0.400274726784213	BEFREE;CTD_human;HPO
249	ALPL	C0016663	Pathological fracture	0.202732912464814	HPO;LHGDN
249	ALPL	C0023895	Liver diseases	0.202732912464814	CTD_human;LHGDN
249	ALPL	C0014544	Epilepsy	0.200274726784213	BEFREE;HPO
249	ALPL	C0020437	Hypercalcemia	0.200274726784213	BEFREE;HPO
249	ALPL	C1840322	ODONTOHYPOPHOSPHATASIA (disorder)	0.200274726784213	BEFREE;ORPHANET
249	ALPL	C0002382	Alveolar Bone Loss	0.2	CTD_human
249	ALPL	C0002871	Anemia	0.2	HPO
249	ALPL	C0003123	Anorexia	0.2	HPO
249	ALPL	C0003578	Apnea	0.2	HPO
249	ALPL	C0006663	Calcinosis	0.2	CTD_human
249	ALPL	C0009806	Constipation	0.2	HPO
249	ALPL	C0010278	Craniosynostosis	0.2	HPO
249	ALPL	C0011334	Dental caries	0.2	HPO
249	ALPL	C0015300	Exophthalmos	0.2	HPO
249	ALPL	C0015967	Fever	0.2	HPO
249	ALPL	C0016506	Foot Deformities	0.2	HPO
249	ALPL	C0018843	Heat Stroke	0.2	CTD_human
249	ALPL	C0020224	Polyhydramnios	0.2	HPO
249	ALPL	C0020438	Hypercalciuria	0.2	HPO
249	ALPL	C0020503	Hyperparathyroidism, Secondary	0.2	CTD_human
249	ALPL	C0025995	Micromelia	0.2	HPO
249	ALPL	C0026827	Muscle hypotonia	0.2	HPO
249	ALPL	C0026848	Myopathy	0.2	HPO
249	ALPL	C0027709	Nephrocalcinosis	0.2	HPO
249	ALPL	C0029442	Osteomalacia	0.2	HPO
249	ALPL	C0035579	Rickets	0.2	HPO
249	ALPL	C0040427	Tooth Abnormalities	0.2	HPO
249	ALPL	C0042963	Vomiting	0.2	HPO
249	ALPL	C0151699	Intracranial Hemorrhages	0.2	HPO
249	ALPL	C0162119	Hemoglobin low	0.2	HPO
249	ALPL	C0221354	Frontal bossing	0.2	HPO
249	ALPL	C0221358	Long narrow head	0.2	HPO
249	ALPL	C0231246	Failure to gain weight	0.2	HPO
249	ALPL	C0231712	Waddling gait	0.2	HPO
249	ALPL	C0235942	Skull malformation	0.2	HPO
249	ALPL	C0237326	Dyschezia	0.2	HPO
249	ALPL	C0262444	Dental abnormalities	0.2	HPO
249	ALPL	C0266052	Precocious exfoliation of primary tooth	0.2	HPO
249	ALPL	C0349588	Short stature	0.2	HPO
249	ALPL	C0426817	Short ribs	0.2	HPO
249	ALPL	C0426824	Beading of ribs	0.2	HPO
249	ALPL	C0426901	Short leg	0.2	HPO
249	ALPL	C0542514	Blue sclera	0.2	HPO
249	ALPL	C0544755	Genu varum	0.2	HPO
249	ALPL	C0553730	Calcium pyrophosphate deposition disease	0.2	HPO
249	ALPL	C0595939	Stillbirth	0.2	HPO
249	ALPL	C1390474	Increased susceptibility to fractures	0.2	HPO
249	ALPL	C1833752	Varying degree of multiple fractures	0.2	HPO
249	ALPL	C1833762	Soft calvaria	0.2	HPO
249	ALPL	C1837082	Metaphyseal cupping	0.2	HPO
249	ALPL	C1837760	Prominent eyes	0.2	HPO
249	ALPL	C1844704	Platyspondyly	0.2	HPO
249	ALPL	C1844947	Death in early childhood	0.2	HPO
249	ALPL	C1848490	Protruding eyes	0.2	HPO
249	ALPL	C1849300	Widely patent fontanels and sutures	0.2	HPO
249	ALPL	C1849937	Short limb dwarfism, disproportionate	0.2	HPO
249	ALPL	C1855815	Skin dimple over apex of long bone angulation	0.2	HPO
249	ALPL	C1855828	Vertebral clefts	0.2	HPO
249	ALPL	C1858430	Death in infancy	0.2	HPO
249	ALPL	C1860130	Low alkaline phosphatase	0.2	HPO
249	ALPL	C1860202	Unossified vertebral bodies	0.2	HPO
249	ALPL	C1862425	Prominent globes	0.2	HPO
249	ALPL	C1969738	Premature loss of secondary teeth	0.2	HPO
249	ALPL	C2315100	Pediatric failure to thrive	0.2	HPO
249	ALPL	C2700617	Irritation - emotion	0.2	HPO
249	ALPL	C3805574	Increased fracture rate	0.2	HPO
249	ALPL	C3806283	Frequent fractures	0.2	HPO
249	ALPL	C3806482	Recurrent respiratory infections	0.2	HPO
249	ALPL	C4020899	Autosomal recessive predisposition	0.2	HPO
249	ALPL	C4021776	Abnormality of the voice	0.2	HPO
249	ALPL	C4023157	Elevated plasma pyrophosphate	0.2	HPO
249	ALPL	C4025607	Elevated urine pyrophosphate	0.2	HPO
249	ALPL	C4280623	Rotting teeth	0.2	HPO
249	ALPL	C4280653	Turridolichocephaly	0.2	HPO
249	ALPL	C4280654	Narrow skull shape	0.2	HPO
249	ALPL	C4280655	Narrow head shape	0.2	HPO
249	ALPL	C4280656	Narrow cranium shape	0.2	HPO
249	ALPL	C4280679	Increased calcium level in kidney	0.2	HPO
249	ALPL	C0020630	Hypophosphatasia	0.0338346085319439	BEFREE;GAD;LHGDN
249	ALPL	C0520739	Hereditary pyropoikilocytosis	0.0038461749789834	BEFREE
249	ALPL	C0025286	Meningioma	0.00300763924902685	BEFREE;LHGDN
249	ALPL	C0029422	Osteochondrodysplasias	0.00300763924902685	BEFREE;LHGDN
249	ALPL	C0020492	Hyperostosis	0.00273291246481375	LHGDN
249	ALPL	C0021368	Inflammation	0.00273291246481375	LHGDN
249	ALPL	C0022658	Kidney Diseases	0.00273291246481375	LHGDN
249	ALPL	C0029464	Osteosclerosis	0.00273291246481375	LHGDN
249	ALPL	C0031090	Periodontal Diseases	0.00273291246481375	LHGDN
249	ALPL	C0033578	Prostatic Neoplasms	0.00273291246481375	LHGDN
249	ALPL	C0002395	Alzheimer's Disease	0.002407028523288	GAD
249	ALPL	C0020538	Hypertensive disease	0.002407028523288	GAD
249	ALPL	C0028754	Obesity	0.002407028523288	GAD
249	ALPL	C0029458	Osteoporosis, Postmenopausal	0.002407028523288	GAD
249	ALPL	C0038013	Ankylosing spondylitis	0.002407028523288	GAD
249	ALPL	C0040336	Tobacco Use Disorder	0.002407028523288	GAD
249	ALPL	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	0.002407028523288	GAD
249	ALPL	C0025521	Inborn Errors of Metabolism	0.0008241803526393	BEFREE
249	ALPL	C0005940	Bone Diseases	0.0005494535684262	BEFREE
249	ALPL	C0001787	Osteoporosis, Age-Related	0.0002747267842131	BEFREE
249	ALPL	C0003467	Anxiety	0.0002747267842131	BEFREE
249	ALPL	C0003469	Anxiety Disorders	0.0002747267842131	BEFREE
249	ALPL	C0004096	Asthma	0.0002747267842131	BEFREE
249	ALPL	C0005944	Metabolic Bone Disorder	0.0002747267842131	BEFREE
249	ALPL	C0006111	Brain Diseases	0.0002747267842131	BEFREE
249	ALPL	C0011570	Mental Depression	0.0002747267842131	BEFREE
249	ALPL	C0011581	Depressive disorder	0.0002747267842131	BEFREE
249	ALPL	C0022650	Kidney Calculi	0.0002747267842131	BEFREE
249	ALPL	C0025517	Metabolic Diseases	0.0002747267842131	BEFREE
249	ALPL	C0029408	Degenerative polyarthritis	0.0002747267842131	BEFREE
249	ALPL	C0029434	Osteogenesis Imperfecta	0.0002747267842131	BEFREE
249	ALPL	C0029456	Osteoporosis	0.0002747267842131	BEFREE
249	ALPL	C0029463	Osteosarcoma	0.0002747267842131	BEFREE
249	ALPL	C0034068	Pulmonary Eosinophilia	0.0002747267842131	BEFREE
249	ALPL	C0085584	Encephalopathies	0.0002747267842131	BEFREE
249	ALPL	C0392525	Nephrolithiasis	0.0002747267842131	BEFREE
249	ALPL	C0410528	Skeletal dysplasia	0.0002747267842131	BEFREE
249	ALPL	C0410719	Deformity of bone	0.0002747267842131	BEFREE
249	ALPL	C0585442	Osteosarcoma of bone	0.0002747267842131	BEFREE
249	ALPL	C0795796	Chromosome 1, monosomy 1p	0.0002747267842131	BEFREE
249	ALPL	C0936215	Vitamin B 6 Deficiency	0.0002747267842131	BEFREE
249	ALPL	C1861922	CAMPOMELIC DYSPLASIA	0.0002747267842131	BEFREE