Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
PTPRK	9674	COSM25715,	kidney	carcinoma	p.T1185A	Substitution - Missense	6:127981274-127981274,	PATHOGENIC	0.99681	20054297
PTPRK	9674	COSM3172214,	oesophagus	carcinoma	p.G1381S	Substitution - Missense	6:127973150-127973150,	PATHOGENIC	0.99559	24686850
PTPRK	9674	COSM5610340,	skin	malignant_melanoma	p.S533L	Substitution - Missense	6:128082616-128082616,	PATHOGENIC	0.99472	26343386
PTPRK	9674	COSM1697925,	skin	malignant_melanoma	p.P536S	Substitution - Missense	6:128082608-128082608,	PATHOGENIC	0.99472	26343386
PTPRK	9674	COSM5047807,	oesophagus	carcinoma	p.R1105T	Substitution - Missense	6:127983315-127983315,	PATHOGENIC	0.99387	24686850
PTPRK	9674	COSM5610434,	skin	malignant_melanoma	p.D1110N	Substitution - Missense	6:127983301-127983301,	PATHOGENIC	0.99224	26343386
PTPRK	9674	COSM5610349,	skin	malignant_melanoma	p.F888L	Substitution - Missense	6:127998737-127998737,	PATHOGENIC	0.9912	26343386
PTPRK	9674	COSM3172283,	skin	malignant_melanoma	p.S1063F	Substitution - Missense	6:127985784-127985784,	PATHOGENIC	0.99102	26343386
PTPRK	9674	COSM5610422,	skin	malignant_melanoma	p.H835Y	Substitution - Missense	6:127998896-127998896,	PATHOGENIC	0.99063	26343386
PTPRK	9674	COSM5610395,	skin	malignant_melanoma	p.E487K	Substitution - Missense	6:128089696-128089696,	PATHOGENIC	0.98957	26343386
PTPRK	9674	COSM5610358,	skin	malignant_melanoma	p.R916Q	Substitution - Missense	6:127996921-127996921,	PATHOGENIC	0.98904	26343386
PTPRK	9674	COSM5610410,	skin	malignant_melanoma	p.?	Unknown	6:127985719-127985719,	PATHOGENIC	0.98878	26343386
PTPRK	9674	COSM5610331,	skin	malignant_melanoma	p.D1278Y	Substitution - Missense	6:127976934-127976934,	PATHOGENIC	0.98773	26343386
PTPRK	9674	COSM5610352,	skin	malignant_melanoma	p.G1048S	Substitution - Missense	6:127985830-127985830,	PATHOGENIC	0.98668	26343386
PTPRK	9674	COSM3172222,	skin	malignant_melanoma	p.R1314Q	Substitution - Missense	6:127976685-127976685,	PATHOGENIC	0.98605	26343386
PTPRK	9674	COSM22163,	skin	malignant_melanoma	p.R1294Q	Substitution - Missense	6:127976745-127976745,	PATHOGENIC	0.98588	26343386
PTPRK	9674	COSM5610398,	skin	malignant_melanoma	p.G1338E	Substitution - Missense	6:127973784-127973784,	PATHOGENIC	0.98462	26343386
PTPRK	9674	COSM5610428,	skin	malignant_melanoma	p.?	Unknown	6:127973828-127973828,	PATHOGENIC	0.98462	26343386
PTPRK	9674	COSM5610389,	skin	malignant_melanoma	p.G854E	Substitution - Missense	6:127998838-127998838,	PATHOGENIC	0.98265	26343386
PTPRK	9674	COSM5610355,	skin	malignant_melanoma	p.D266N	Substitution - Missense	6:128218994-128218994,	PATHOGENIC	0.98219	26343386
PTPRK	9674	COSM5610334,	skin	malignant_melanoma	p.F1406F	Substitution - coding silent	6:127973073-127973073,	PATHOGENIC	0.97811	26343386
PTPRK	9674	COSM5586352,	skin	malignant_melanoma	p.S254F	Substitution - Missense	6:128219029-128219029,	PATHOGENIC	0.97674	26343386
PTPRK	9674	COSM249399,	kidney	carcinoma	p.Y1230*	Substitution - Nonsense	6:127981137-127981137,	PATHOGENIC	0.97594	22138691
PTPRK	9674	COSM5610380,	skin	malignant_melanoma	p.Q809*	Substitution - Nonsense	6:128005153-128005153,	PATHOGENIC	0.97406	26343386
PTPRK	9674	COSM3620426,	skin	malignant_melanoma	p.R233Q	Substitution - Missense	6:128219092-128219092,	PATHOGENIC	0.97142	26343386
PTPRK	9674	COSM5602161,	skin	malignant_melanoma	p.E635K	Substitution - Missense	6:128067773-128067773,	PATHOGENIC	0.96937	26343386
PTPRK	9674	COSM5610404,	skin	malignant_melanoma	p.S497F	Substitution - Missense	6:128083800-128083800,	PATHOGENIC	0.96872	26343386
PTPRK	9674	COSM5610416,	skin	malignant_melanoma	p.S82F	Substitution - Missense	6:128322289-128322289,	PATHOGENIC	0.96655	26343386
PTPRK	9674	COSM5610407,	skin	malignant_melanoma	p.G1282D	Substitution - Missense	6:127976781-127976781,	PATHOGENIC	0.96502	26343386
PTPRK	9674	COSM5610419,	skin	malignant_melanoma	p.P297L	Substitution - Missense	6:128184704-128184704,	PATHOGENIC	0.96372	26343386
PTPRK	9674	COSM5610343,	skin	malignant_melanoma	p.S1348S	Substitution - coding silent	6:127973753-127973753,	PATHOGENIC	0.95997	26343386
PTPRK	9674	COSM5610383,	skin	malignant_melanoma	p.E327K	Substitution - Missense	6:128184615-128184615,	PATHOGENIC	0.95609	26343386
PTPRK	9674	COSM5610386,	skin	malignant_melanoma	p.G321S	Substitution - Missense	6:128184633-128184633,	PATHOGENIC	0.95609	26343386
PTPRK	9674	COSM1754476,	skin	malignant_melanoma	p.E370K	Substitution - Missense	6:128184486-128184486,	PATHOGENIC	0.94433	26343386
PTPRK	9674	COSM5610364,	skin	malignant_melanoma	p.S316L	Substitution - Missense	6:128184647-128184647,	PATHOGENIC	0.94398	26343386
PTPRK	9674	COSM5610431,	skin	malignant_melanoma	p.P447P	Substitution - coding silent	6:128089814-128089814,	PATHOGENIC	0.94317	26343386
PTPRK	9674	COSM1440361,	skin	malignant_melanoma	p.E437K	Substitution - Missense	6:128089846-128089846,	PATHOGENIC	0.93863	26343386
PTPRK	9674	COSM5610337,	skin	malignant_melanoma	p.D824N	Substitution - Missense	6:128005108-128005108,	PATHOGENIC	0.93545	26343386
PTPRK	9674	COSM5610346,	skin	malignant_melanoma	p.S841S	Substitution - coding silent	6:127998876-127998876,	PATHOGENIC	0.93436	26343386
PTPRK	9674	COSM5610361,	skin	malignant_melanoma	p.D743N	Substitution - Missense	6:128009236-128009236,	PATHOGENIC	0.92283	26343386
PTPRK	9674	COSM5610437,	skin	malignant_melanoma	p.P830S	Substitution - Missense	6:128005090-128005090,	PATHOGENIC	0.90952	26343386
PTPRK	9674	COSM1672746,	skin	malignant_melanoma	p.E358K	Substitution - Missense	6:128184522-128184522,	PATHOGENIC	0.904	26343386
PTPRK	9674	COSM3172250,	oesophagus	carcinoma	p.R1187Q	Substitution - Missense	6:127981267-127981267,	PATHOGENIC	0.90196	24686850
PTPRK	9674	COSM3928072,	skin	malignant_melanoma	p.R1372W	Substitution - Missense	6:127973683-127973683,	PATHOGENIC	0.89846	26343386
PTPRK	9674	COSM5610373,	skin	malignant_melanoma	p.L1274V	Substitution - Missense	6:127976946-127976946,	PATHOGENIC	0.8974	26343386
PTPRK	9674	COSM40518,	central_nervous_system	glioma	p.A787V	Substitution - Missense	6:128005218-128005218,	PATHOGENIC	0.88027	18772396
PTPRK	9674	COSM5610367,	skin	malignant_melanoma	p.L1353L	Substitution - coding silent	6:127973738-127973738,	PATHOGENIC	0.87934	26343386
PTPRK	9674	COSM5047228,	oesophagus	carcinoma	p.A745T	Substitution - Missense	6:128009230-128009230,	PATHOGENIC	0.86927	24686850
PTPRK	9674	COSM5610377,	skin	malignant_melanoma	p.V634V	Substitution - coding silent	6:128067774-128067774,	PATHOGENIC	0.85431	26343386
PTPRK	9674	COSM5610392,	skin	malignant_melanoma	p.D749N	Substitution - Missense	6:128009218-128009218,	PATHOGENIC	0.84234	26343386
PTPRK	9674	COSM5610413,	skin	malignant_melanoma	p.I1298I	Substitution - coding silent	6:127976732-127976732,	PATHOGENIC	0.8385	26343386
PTPRK	9674	COSM5610401,	skin	malignant_melanoma	p.L879L	Substitution - coding silent	6:127998762-127998762,	PATHOGENIC	0.82298	26343386
PTPRK	9674	COSM4900093,	skin	malignant_melanoma	p.R147K	Substitution - Missense	6:128322094-128322094,	PATHOGENIC	0.79504	26343386
PTPRK	9674	COSM5610370,	skin	malignant_melanoma	p.S502S	Substitution - coding silent	6:128083784-128083784,	PATHOGENIC	0.77365	26343386
PTPRK	9674	COSM5610425,	skin	malignant_melanoma	p.A913T	Substitution - Missense	6:127996931-127996931,	PATHOGENIC	0.76613	26343386
PTPRK	9674	COSM4493322,	skin	malignant_melanoma	p.G1371G	Substitution - coding silent	6:127973684-127973684,	NEUTRAL	0.4385	26343386
PTPRK	9674	COSM314594,	lung	carcinoma	p.T1013T	Substitution - coding silent	6:127990826-127990826,	NEUTRAL	0.02399	22941188
PTPRK	9674	COSM314595,	lung	carcinoma	p.R869>?	Complex	6:127998792-127998793,	Info_not_available	Info_not_available	22941188
PTPRK	9674	COSM5611382,	skin	malignant_melanoma	p.G677E, p.P858S	Substitution - Missense	6:128067646-128067646,	Info_not_available	0.53003, Info_not_available	26343386