Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
SRC	11283	COSM6945715,	ovary	carcinoma	p.D368N	Substitution - Missense	20:37401664-37401664,	PATHOGENIC	0.99145	28481359
SRC	11283	COSM49003,	lung	carcinoma	p.?	Unknown	20:37402881-37402881,	PATHOGENIC	0.99127	18948947
SRC	11283	COSM6953075,	lung	carcinoma	p.R463L	Substitution - Missense	20:37402866-37402866,	PATHOGENIC	0.99127	28481359
SRC	11283	COSM6940752,	lung	carcinoma	p.R463Q	Substitution - Missense	20:37402866-37402866,	PATHOGENIC	0.99043	28481359
SRC	11283	COSM6970693,	upper_aerodigestive_tract	carcinoma	p.Q372E	Substitution - Missense	20:37401676-37401676,	PATHOGENIC	0.98793	28481359
SRC	11283	COSM6941267,	large_intestine	carcinoma	p.G2D	Substitution - Missense	20:37384158-37384158,	PATHOGENIC	0.97648	28481359
SRC	11283	COSM6450791,	biliary_tract	carcinoma	p.R163Q	Substitution - Missense	20:37394212-37394212,	PATHOGENIC	0.97331	28481359
SRC	11283	COSM6931487,	urinary_tract	carcinoma	p.S75F	Substitution - Missense	20:37384377-37384377,	PATHOGENIC	0.97275	28481359
SRC	11283	COSM6932103,	central_nervous_system	glioma	p.V397M	Substitution - Missense	20:37402507-37402507,	PATHOGENIC	0.97009	28481359
SRC	11283	COSM6967930,	pancreas	carcinoma	p.Q256E	Substitution - Missense	20:37397761-37397761,	PATHOGENIC	0.96802	28481359
SRC	11283	COSM6964603,	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	p.L353V	Substitution - Missense	20:37401619-37401619,	PATHOGENIC	0.96757	28481359
SRC	11283	COSM6191356,	skin	carcinoma	p.E508K	Substitution - Missense	20:37403290-37403290,	PATHOGENIC	0.96236	28481359
SRC	11283	COSM3389722,	ovary	carcinoma	p.E527K	Substitution - Missense	20:37403347-37403347,	PATHOGENIC	0.96236	25986173
SRC	11283	COSM6191356,	lung	carcinoma	p.E508K	Substitution - Missense	20:37403290-37403290,	PATHOGENIC	0.96236	27056568
SRC	11283	COSM6949788,	large_intestine	carcinoma	p.R509Q	Substitution - Missense	20:37403294-37403294,	PATHOGENIC	0.96236	28481359
SRC	11283	COSM3389722,	lung	carcinoma	p.E527K	Substitution - Missense	20:37403347-37403347,	PATHOGENIC	0.96236	28481359
SRC	11283	COSM6910493,	endometrium	carcinoma	p.D476N	Substitution - Missense	20:37403194-37403194,	PATHOGENIC	0.95479	28481359
SRC	11283	COSM6913737,	central_nervous_system	glioma	p.G303D	Substitution - Missense	20:37400163-37400163,	PATHOGENIC	0.95424	28481359
SRC	11283	COSM4430704,	urinary_tract	carcinoma	p.A421V	Substitution - Missense	20:37402580-37402580,	PATHOGENIC	0.95249	28481359
SRC	11283	COSM6973499,	upper_aerodigestive_tract	carcinoma	p.V177M	Substitution - Missense	20:37394253-37394253,	PATHOGENIC	0.95041	28481359
SRC	11283	COSM6944149,	urinary_tract	carcinoma	p.Q531K	Substitution - Missense	20:37403359-37403359,	PATHOGENIC	0.95024	28481359
SRC	11283	COSM6944149,	urinary_tract	carcinoma	p.Q531K	Substitution - Missense	20:37403359-37403359,	PATHOGENIC	0.95024	28481359
SRC	11283	COSM6443889,	central_nervous_system	glioma	p.P491L	Substitution - Missense	20:37403240-37403240,	PATHOGENIC	0.94734	28481359
SRC	11283	COSM1227526,	small_intestine	carcinoma	p.P487L	Substitution - Missense	20:37403228-37403228,	PATHOGENIC	0.94734	28481359
SRC	11283	COSM3396381,	urinary_tract	carcinoma	p.S70L	Substitution - Missense	20:37384362-37384362,	PATHOGENIC	0.94704	28481359
SRC	11283	COSM6909672,	thyroid	carcinoma	p.T293A	Substitution - Missense	20:37400132-37400132,	PATHOGENIC	0.94546	28481359
SRC	11283	COSM6973721,	large_intestine	carcinoma	p.A186T	Substitution - Missense	20:37396164-37396164,	PATHOGENIC	0.94315	28481359
SRC	11283	COSM1369,	large_intestine	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	9988270
SRC	11283	COSM1369,	large_intestine	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	27756406
SRC	11283	COSM1369,	large_intestine	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	15818752
SRC	11283	COSM1369,	large_intestine	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	9988270
SRC	11283	COSM1369,	large_intestine	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	9988270
SRC	11283	COSM1369,	large_intestine	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	9988270
SRC	11283	COSM1369,	large_intestine	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	9988270
SRC	11283	COSM1369,	large_intestine	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	9988270
SRC	11283	COSM1369,	large_intestine	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	9988270
SRC	11283	COSM1369,	large_intestine	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	9988270
SRC	11283	COSM1369,	large_intestine	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	9988270
SRC	11283	COSM1369,	endometrium	carcinoma	p.Q531*	Substitution - Nonsense	20:37403359-37403359,	PATHOGENIC	0.93959	10804287
SRC	11283	COSM6005721,	prostate	carcinoma	p.?	Unknown	20:37401682-37401682,	PATHOGENIC	0.93694	20579941
SRC	11283	COSM6914441,	skin	carcinoma	p.R16H	Substitution - Missense	20:37384200-37384200,	PATHOGENIC	0.9367	28481359
SRC	11283	COSM6973157,	central_nervous_system	glioma	p.P142L	Substitution - Missense	20:37393969-37393969,	PATHOGENIC	0.93634	28481359
SRC	11283	COSM6927041,	large_intestine	carcinoma	p.R220H	Substitution - Missense	20:37396267-37396267,	PATHOGENIC	0.93415	28481359
SRC	11283	COSM5576141,	stomach	carcinoma	p.M317K	Substitution - Missense	20:37400205-37400205,	PATHOGENIC	0.93185	26489445
SRC	11283	COSM6918006,	breast	carcinoma	p.S3C	Substitution - Missense	20:37384160-37384160,	PATHOGENIC	0.93089	28481359
SRC	11283	COSM6444834,	endometrium	carcinoma	p.E534D	Substitution - Missense	20:37403370-37403370,	PATHOGENIC	0.92936	27159395
SRC	11283	COSM6944357,	large_intestine	carcinoma	p.L320P	Substitution - Missense	20:37400214-37400214,	PATHOGENIC	0.9256	28481359
SRC	11283	COSM6928639,	lung	carcinoma	p.R14W	Substitution - Missense	20:37384193-37384193,	PATHOGENIC	0.92337	28481359
SRC	11283	COSM6962009,	pancreas	carcinoid-endocrine_tumour	p.R362W	Substitution - Missense	20:37401646-37401646,	PATHOGENIC	0.92034	28481359
SRC	11283	COSM6929489,	lung	carcinoma	p.V247L	Substitution - Missense	20:37397734-37397734,	PATHOGENIC	0.91574	28481359
SRC	11283	COSM6956824,	lung	carcinoma	p.Q312H	Substitution - Missense	20:37400191-37400191,	PATHOGENIC	0.91433	28481359
SRC	11283	COSM6943245,	skin	malignant_melanoma	p.P307S	Substitution - Missense	20:37400174-37400174,	PATHOGENIC	0.90994	28481359
SRC	11283	COSM6914442,	skin	carcinoma	p.R110Q	Substitution - Missense	20:37386153-37386153,	PATHOGENIC	0.90876	28481359
SRC	11283	COSM6931486,	urinary_tract	carcinoma	p.S35L	Substitution - Missense	20:37384257-37384257,	PATHOGENIC	0.9078	28481359
SRC	11283	COSM6956766,	large_intestine	carcinoma	p.P506S	Substitution - Missense	20:37403284-37403284,	PATHOGENIC	0.90665	28481359
SRC	11283	COSM6913794,	skin	carcinoma	p.E100Q	Substitution - Missense	20:37386122-37386122,	PATHOGENIC	0.90212	28481359
SRC	11283	COSM6967761,	lung	carcinoma	p.K62M	Substitution - Missense	20:37384338-37384338,	PATHOGENIC	0.89356	28481359
SRC	11283	COSM6973944,	NS	malignant_melanoma	p.R472C	Substitution - Missense	20:37403182-37403182,	PATHOGENIC	0.89166	28481359
SRC	11283	COSM6931035,	kidney	carcinoma	p.R503Q	Substitution - Missense	20:37403276-37403276,	PATHOGENIC	0.88812	28481359
SRC	11283	COSM6949805,	NS	carcinoma	p.R388G	Substitution - Missense	20:37402480-37402480,	PATHOGENIC	0.87972	28481359
SRC	11283	COSM3738173,	upper_aerodigestive_tract	carcinoma	p.K260N	Substitution - Missense	20:37397775-37397775,	PATHOGENIC	0.86265	28481359
SRC	11283	COSM6912684,	large_intestine	carcinoma	p.R463W	Substitution - Missense	20:37402865-37402865,	PATHOGENIC	0.85792	28481359
SRC	11283	COSM6960711,	lung	carcinoma	p.F215L	Substitution - Missense	20:37396253-37396253,	PATHOGENIC	0.85283	28481359
SRC	11283	COSM6955310,	large_intestine	carcinoma	p.R362Q	Substitution - Missense	20:37401647-37401647,	PATHOGENIC	0.85115	28481359
SRC	11283	COSM2760683,	skin	carcinoma	p.R163W	Substitution - Missense	20:37394211-37394211,	PATHOGENIC	0.84516	28481359
SRC	11283	COSM5610701,	skin	malignant_melanoma	p.T182T	Substitution - coding silent	20:37394270-37394270,	PATHOGENIC	0.84151	26343386
SRC	11283	COSM5610699,	skin	malignant_melanoma	p.I429I	Substitution - coding silent	20:37402765-37402765,	PATHOGENIC	0.84125	26343386
SRC	11283	COSM6979022,	soft_tissue	sarcoma	p.S69A	Substitution - Missense	20:37384358-37384358,	PATHOGENIC	0.82209	28481359
SRC	11283	COSM6946401,	large_intestine	carcinoma	p.E323D	Substitution - Missense	20:37400224-37400224,	PATHOGENIC	0.80141	28481359
SRC	11283	COSM6951599,	pancreas	carcinoma	p.S345C	Substitution - Missense	20:37400288-37400288,	PATHOGENIC	0.78857	28481359
SRC	11283	COSM2760688,	large_intestine	carcinoma	p.T250M	Substitution - Missense	20:37397744-37397744,	PATHOGENIC	0.78551	28481359
SRC	11283	COSM6938320,	lung	carcinoma	p.K198N	Substitution - Missense	20:37396202-37396202,	PATHOGENIC	0.77253	28481359
SRC	11283	COSM6932617,	large_intestine	carcinoma	p.R509W	Substitution - Missense	20:37403293-37403293,	PATHOGENIC	0.75772	28481359
SRC	11283	COSM4991378,	skin	carcinoma	p.A44V	Substitution - Missense	20:37384284-37384284,	PATHOGENIC	0.7471	25589618
SRC	11283	COSM6941404,	large_intestine	carcinoma	p.V73I	Substitution - Missense	20:37384370-37384370,	PATHOGENIC	0.72585	28481359
SRC	11283	COSM5610700,	skin	malignant_melanoma	p.S525S	Substitution - coding silent	20:37403343-37403343,	PATHOGENIC	0.71069	26343386
SRC	11283	COSM4991380,	skin	carcinoma	p.A517A	Substitution - coding silent	20:37403319-37403319,	PATHOGENIC	0.70621	25589618
SRC	11283	COSM6958813,	large_intestine	carcinoma	p.G46S	Substitution - Missense	20:37384289-37384289,	NEUTRAL	0.34295	28481359
SRC	11283	COSM6953408,	large_intestine	carcinoma	p.A57V	Substitution - Missense	20:37384323-37384323,	NEUTRAL	0.21925	28481359
SRC	11283	COSM5020526,	soft_tissue	haemangioblastoma	p.?	Unknown	20:37394002-37394002,	NEUTRAL	0.10102	25589003
SRC	11283	COSM5020149,	soft_tissue	haemangioblastoma	p.T526T	Substitution - coding silent	20:37403346-37403346,	NEUTRAL	0.07211	25589003
SRC	11283	COSM6954647,	large_intestine	carcinoma	p.A34T	Substitution - Missense	20:37384253-37384253,	NEUTRAL	0.07185	28481359
SRC	11283	COSM6960679,	stomach	carcinoma	p.A21T	Substitution - Missense	20:37384214-37384214,	NEUTRAL	0.0623	28481359
SRC	11283	COSM4991379,	skin	carcinoma	p.A44A	Substitution - coding silent	20:37384285-37384285,	NEUTRAL	0.05576	25589618
SRC	11283	COSM6506611,	breast	carcinoma	p.E527D	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	27034166
SRC	11283	COSM6980951,	NS, biliary_tract, breast, kidney, lung, skin	carcinoma, malignant_melanoma	p.A433T, p.A53_A59delAFAPAAA, p.C403fs*4, p.F512L, p.G28_G29>RW, p.P20S, p.V284fs*17	Complex - compound substitution, Complex - frameshift, Deletion - Frameshift, Deletion - In frame, Substitution - Missense	20:37403304-37403304,	Info_not_available	0.57449, .65461, Info_not_available	28481359