Interacting Partner Detection_method PPI_type Lit_support PPI_score Source_databases ADA Negative Genetic, Synthetic Lethality genetic 27453043, 28319113 NA BioGRID AKT1 Negative Genetic genetic 28319113 NA BioGRID APP Reconstituted Complex physical 21832049 NA BioGRID ARID1A Negative Genetic genetic 28319113 NA BioGRID ATAD5 Synthetic Lethality genetic 27453043 NA BioGRID ATM Biochemical Activity, Negative Genetic, Protein-peptide genetic, physical 10608806, 12676583, 28319113 NA BioGRID ATR Affinity Capture-Western, Biochemical Activity, Protein-peptide, Synthetic Lethality, protein kinase assay direct interaction, genetic, physical 10608806, 11390642, 15775976, 17686975, 19330022, 21566061, 27453043 0.44 BioGRID, IntAct ATRIP fluorescence microscopy colocalization 20639859 0.27 IntAct, MINT ATXN3 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 28180282 NA BioGRID BCL2L1 Biochemical Activity physical 22617334 NA BioGRID BCL2L14 Affinity Capture-MS physical 26186194, 28514442 NA BioGRID BLM Affinity Capture-Western, Co-localization, Synthetic Lethality genetic, physical 15364958, 27453043 NA BioGRID BRCA1 Affinity Capture-Western, Biochemical Activity, Negative Genetic, anti bait coimmunoprecipitation, confocal microscopy colocalization, genetic, physical, physical association 11836499, 17380128, 28319113 0.46 BioGRID, IntAct BRD4 Synthetic Lethality genetic 27453043 NA BioGRID BTG3 Affinity Capture-Western physical 23533280 NA BioGRID CASP8 Negative Genetic genetic 28319113 NA BioGRID CBY1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435, 0.27 BioGRID, IntAct CDC14A Synthetic Lethality genetic 27453043 NA BioGRID CDC25A Affinity Capture-MS, Biochemical Activity, Reconstituted Complex, protein kinase assay phosphorylation reaction, physical 12399544, 12676583, 12759351, 12963847, 17292828, 18480045, 27432908, 9278511 0.44 BioGRID, IntAct CDC25B Biochemical Activity, Reconstituted Complex physical 9278511 NA BioGRID CDC25C Biochemical Activity, Reconstituted Complex, protein kinase assay phosphorylation reaction, physical 10681541, 11016625, 11390642, 11836499, 12660173, 15705874, 16330544, 16705183, 17035231, 19330022, 9278511 0.62 BioGRID, IntAct CDC5L Affinity Capture-MS, anti bait coimmunoprecipitation association, physical 20467437 0.35 BioGRID, IntAct, MINT CDC6 Synthetic Lethality genetic 27453043 NA BioGRID CDC73 Synthetic Lethality genetic 27453043 NA BioGRID CDK1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 0.35 BioGRID, IntAct CDK9 Negative Genetic genetic 28319113 NA BioGRID CDKN1A Affinity Capture-Western physical 11896572 NA BioGRID CEP164 confocal microscopy colocalization 22863007 0.27 IntAct CHEK2 Synthetic Lethality genetic 27453043 NA BioGRID CHRNA9 Affinity Capture-MS physical 26186194, 28514442 NA BioGRID CLSPN Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti tag coimmunoprecipitation, protein kinase assay, pull down phosphorylation reaction, physical, physical association 12766152, 16123041, 16963448, 23109433 0.60 BioGRID, IntAct COPS5 Affinity Capture-MS physical 21145461 NA BioGRID CSNK2A1 Affinity Capture-Western, Reconstituted Complex physical 12902976, 15225637 NA BioGRID CSNK2B experimental interaction detection phosphorylation reaction 15225637 0.31 IntAct, MINT CTSE Affinity Capture-MS physical 28514442 NA BioGRID CUL1 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16137618, 17290223, 19808933, 23109433 0.40 BioGRID, IntAct, MINT CUL4A Affinity Capture-Western physical 16137618, 19276361, 19808933, 23109433 NA BioGRID DAAM1 Synthetic Lethality genetic 27453043 NA BioGRID DDB1 Affinity Capture-MS, Affinity Capture-Western physical 19276361, 23109433, 25024738 NA BioGRID DENND1A Affinity Capture-MS physical 27173435 NA BioGRID DHFR Synthetic Lethality genetic 27453043 NA BioGRID DNMT1 Affinity Capture-Western physical 17991895, 20940144 NA BioGRID DTL Affinity Capture-Western, Biochemical Activity physical 23109433, 23533280 NA BioGRID EIF4E2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435, 0.27 BioGRID, IntAct ERCC6L Affinity Capture-MS physical 28514442 NA BioGRID ERRFI1 enzymatic study phosphorylation reaction 22505024 0.44 IntAct, MINT FANCD2 Biochemical Activity, Phenotypic Enhancement genetic, physical 14988723, 19861535 NA BioGRID FANCE Biochemical Activity physical 17296736 NA BioGRID FBXO6 Affinity Capture-Western physical 28180282 NA BioGRID FEM1B Affinity Capture-Western physical 19330022 NA BioGRID FHIT Synthetic Lethality genetic 27453043 NA BioGRID FUS Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 25852190 0.40 BioGRID, IntAct FZR1 Synthetic Lethality genetic 27453043 NA BioGRID GIGYF1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435, 0.27 BioGRID, IntAct HECW2 Affinity Capture-MS physical 24163370 NA BioGRID HLA-DRB5 Affinity Capture-MS physical 26186194, 28514442 NA BioGRID HNRNPD Co-fractionation physical 26344197 NA BioGRID HSP90AA1 Affinity Capture-Luminescence, Affinity Capture-Western, Reconstituted Complex physical 16330544, 21566061, 22939624 NA BioGRID HSP90AB1 anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping, pull down physical association 16330544, 22939624 0.66 IntAct IGF1R Negative Genetic genetic 28319113 NA BioGRID IL13RA2 Affinity Capture-MS physical 28514442 NA BioGRID ILKAP Biochemical Activity physical 29371914 NA BioGRID IMPDH1 Synthetic Lethality genetic 27453043 NA BioGRID JUN anti bait coimmunoprecipitation association 25609649 0.35 IntAct, MINT KAT5 confocal microscopy colocalization 22863007 0.27 IntAct KCTD3 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435, 0.27 BioGRID, IntAct KIF13B Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435, 0.27 BioGRID, IntAct KSR1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435, 0.27 BioGRID, IntAct L3HYPDH Affinity Capture-MS physical 26186194 NA BioGRID LATS2 Biochemical Activity physical 21118956, 23886938 NA BioGRID LDLRAP1 Affinity Capture-MS physical 26186194, 28514442 NA BioGRID LLGL1 Synthetic Lethality genetic 27453043 NA BioGRID LRFN1 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435, 0.27 BioGRID, IntAct LRRC6 Affinity Capture-MS physical 28514442 NA BioGRID MAP2K1 Negative Genetic genetic 28319113 NA BioGRID MAPK1 Co-fractionation physical 26344197 NA BioGRID MAPKAPK2 Phenotypic Suppression genetic 20932473 NA BioGRID MCPH1 Reconstituted Complex physical 16783362 NA BioGRID MDM4 Biochemical Activity, protein kinase assay phosphorylation reaction, physical 16163388, 16511572 0.44 BioGRID, IntAct, MINT MED15 Co-fractionation physical 22939629 NA BioGRID MEN1 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 20969866 0.40 BioGRID, IntAct, MINT MEPE Affinity Capture-Western, Co-localization, Two-hybrid physical 19808933 NA BioGRID MET Negative Genetic genetic 28319113 NA BioGRID MSH2 Affinity Capture-Western physical 15647386 NA BioGRID MSH6 Affinity Capture-Western physical 20029092 NA BioGRID MTOR Negative Genetic, Synthetic Lethality genetic 27453043, 28319113 NA BioGRID NAT9 Affinity Capture-MS physical 28514442 NA BioGRID NBN Phenotypic Enhancement genetic 14988723 NA BioGRID NEK2 Co-fractionation physical 15311285 NA BioGRID NEK9 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 20562859 0.40 BioGRID, IntAct NELL1 Affinity Capture-MS physical 28514442 NA BioGRID NFATC1 Affinity Capture-MS, Affinity Capture-Western physical 27637333 NA BioGRID NFATC2 Affinity Capture-MS, Affinity Capture-Western physical 27637333 NA BioGRID PARP1 Negative Genetic genetic 28319113 NA BioGRID PCNA Affinity Capture-Western physical 18448427 NA BioGRID PIGM Two-hybrid, two hybrid array physical, physical association 21988832 0.37 BioGRID, IntAct PIK3CA Negative Genetic genetic 28319113 NA BioGRID PKM protein kinase assay phosphorylation reaction 24606918 0.44 IntAct PLA2G10 Affinity Capture-MS physical 28514442 NA BioGRID POLA1 Affinity Capture-Western physical 19177015 NA BioGRID PPM1A Co-fractionation physical 26344197 NA BioGRID PPP1R15A anti tag coimmunoprecipitation association 29109149 0.35 IntAct PRKDC Negative Genetic, Protein-peptide, Reconstituted Complex genetic, physical 10608806, 12756247, 28319113 NA BioGRID PTBP1 Co-fractionation physical 26344197 NA BioGRID PTBP3 Co-fractionation physical 26344197 NA BioGRID PTEN Negative Genetic genetic 28319113 NA BioGRID RACGAP1 Affinity Capture-MS physical 28514442 NA BioGRID RAD17 Synthetic Lethality genetic 27453043 NA BioGRID RAD23A Affinity Capture-Western, Reconstituted Complex physical 26296656 NA BioGRID RAD51 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 15665856 0.52 BioGRID, IntAct RB1 Biochemical Activity, Reconstituted Complex, protein kinase assay, pull down direct interaction, phosphorylation reaction, physical 17380128 0.56 BioGRID, IntAct, MINT RELA Biochemical Activity physical 15775976 NA BioGRID RFC1 Synthetic Lethality genetic 27453043 NA BioGRID RPA2 fluorescence microscopy colocalization 20639859 0.27 IntAct, MINT RPS10 Synthetic Lethality genetic 27453043 NA BioGRID SETMAR Affinity Capture-Western physical 25024738 NA BioGRID SFN Affinity Capture-Western physical 11896572 NA BioGRID SH3PXD2A Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435, 0.27 BioGRID, IntAct SLX4 anti tag coimmunoprecipitation association 19596235 0.35 IntAct SMARCA4 Negative Genetic genetic 28319113 NA BioGRID SMARCC1 Synthetic Lethality genetic 27453043 NA BioGRID SMO Negative Genetic genetic 28319113 NA BioGRID SMURF1 anti tag coimmunoprecipitation, protein kinase assay, pull down direct interaction, phosphorylation reaction, physical association 25249323 0.40, 0.61 IntAct SNW1 Affinity Capture-MS, anti bait coimmunoprecipitation association, physical 20467437 0.35 BioGRID, IntAct, MINT SNX11 Affinity Capture-MS physical 26186194, 28514442 NA BioGRID SQSTM1 anti tag coimmunoprecipitation physical association 20562859 0.40 IntAct SRC Negative Genetic genetic 28319113 NA BioGRID SRGAP2 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435, 0.27 BioGRID, IntAct SRSF2 confocal microscopy colocalization 22863007 0.27 IntAct TARS Co-fractionation physical 26344197 NA BioGRID TCEA1 Synthetic Lethality genetic 27453043 NA BioGRID TCEAL1 Affinity Capture-MS physical 26186194, 28514442 NA BioGRID TIMELESS Affinity Capture-Western physical 15798197 NA BioGRID TIMELESS anti tag coimmunoprecipitation physical association 15798197 0.40 IntAct TLK1 Biochemical Activity physical 12955071 NA BioGRID TNRC6B Affinity Capture-MS physical 24778252 NA BioGRID TOP1 Synthetic Lethality genetic 27453043 NA BioGRID TOP2A Synthetic Lethality genetic 27453043 NA BioGRID TOP3A Synthetic Lethality genetic 27453043 NA BioGRID TOPBP1 Biochemical Activity physical 17686975 NA BioGRID TP53 Affinity Capture-Western, Biochemical Activity, Co-localization, protein kinase assay phosphorylation reaction, physical 10673501, 11896572, 12756247, 15364958, 16511572 0.44 BioGRID, IntAct, MINT TP53BP1 Co-localization physical 15364958 NA BioGRID TTN Synthetic Lethality genetic 27453043 NA BioGRID TUBA1A Synthetic Lethality genetic 27453043 NA BioGRID TUSC3 Synthetic Lethality genetic 27453043 NA BioGRID TYMS Negative Genetic genetic 28319113 NA BioGRID UBA1 Reconstituted Complex physical 26296656 NA BioGRID UBA2 Reconstituted Complex physical 26296656 NA BioGRID UBE2T Biochemical Activity physical 28162934 NA BioGRID UNC5CL Affinity Capture-MS physical 28514442 NA BioGRID USP11 Synthetic Lethality genetic 27453043 NA BioGRID USP7 Affinity Capture-Western, Biochemical Activity physical 21845734, 25086746, 25483066, 26296656 NA BioGRID VAV1 Affinity Capture-MS physical 28514442 NA BioGRID VCP Affinity Capture-MS physical 23383273 NA BioGRID VEGFA Negative Genetic genetic 28319113 NA BioGRID VHL Negative Genetic genetic 28319113 NA BioGRID WEE1 Synthetic Lethality genetic 27453043 NA BioGRID WRN Synthetic Lethality genetic 27453043 NA BioGRID XIAP Affinity Capture-Western, Reconstituted Complex physical 14759516 NA BioGRID XPO1 Reconstituted Complex physical 12676962 NA BioGRID XRCC5 Affinity Capture-Western physical 12756247 NA BioGRID XRCC6 Affinity Capture-Western physical 12756247 NA BioGRID YWHAB pull down physical association 20639859 0.40 IntAct, MINT YWHAG coimmunoprecipitation, pull down direct interaction, physical association 20639859 0.60 IntAct, MINT YWHAZ pull down physical association 20639859 0.40 IntAct, MINT ZBTB21 Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435, 0.27 BioGRID, IntAct ZEB1 Affinity Capture-Western physical 25086746 NA BioGRID