Cancer-causing mutations

Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
PLCG1	9065	COSM3734686,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S520F	Substitution - Missense	20:41165499-41165499,	PATHOGENIC	0.99789	24497536
PLCG1	9065	COSM3734686,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S520F	Substitution - Missense	20:41165499-41165499,	PATHOGENIC	0.99789	27369867
PLCG1	9065	COSM3734686,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S520F	Substitution - Missense	20:41165499-41165499,	PATHOGENIC	0.99789	26415585
PLCG1	9065	COSM3734686,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S520F	Substitution - Missense	20:41165499-41165499,	PATHOGENIC	0.99789	27369867
PLCG1	9065	COSM3734686,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S520F	Substitution - Missense	20:41165499-41165499,	PATHOGENIC	0.99789	26437031
PLCG1	9065	COSM3734686,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S520F	Substitution - Missense	20:41165499-41165499,	PATHOGENIC	0.99789	26437031
PLCG1	9065	COSM3734686,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S520F	Substitution - Missense	20:41165499-41165499,	PATHOGENIC	0.99789	26437031
PLCG1	9065	COSM5707410,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.H508R	Substitution - Missense	20:41165463-41165463,	PATHOGENIC	0.99788	26437031
PLCG1	9065	COSM1220947,	biliary_tract	carcinoma	p.V585M	Substitution - Missense	20:41165780-41165780,	PATHOGENIC	0.99517	29360550
PLCG1	9065	COSM3769785,	soft_tissue	angiosarcoma	p.R707Q	Substitution - Missense	20:41166595-41166595,	PATHOGENIC	0.99236	25252913
PLCG1	9065	COSM3769785,	soft_tissue	angiosarcoma	p.R707Q	Substitution - Missense	20:41166595-41166595,	PATHOGENIC	0.99236	25252913
PLCG1	9065	COSM3769785,	soft_tissue	angiosarcoma	p.R707Q	Substitution - Missense	20:41166595-41166595,	PATHOGENIC	0.99236	25252913
PLCG1	9065	COSM5707426,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.G940R	Substitution - Missense	20:41172202-41172202,	PATHOGENIC	0.99175	26437031
PLCG1	9065	COSM1411792,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S489P	Substitution - Missense	20:41165323-41165323,	PATHOGENIC	0.9906	26437031
PLCG1	9065	COSM5049788,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D342N	Substitution - Missense	20:41163934-41163934,	PATHOGENIC	0.98625	25910029
PLCG1	9065	COSM6023748,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.G869E	Substitution - Missense	20:41169482-41169482,	PATHOGENIC	0.98519	28148900
PLCG1	9065	COSM5049787,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D342G	Substitution - Missense	20:41163935-41163935,	PATHOGENIC	0.9849	25910029
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707423,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.P867R	Substitution - Missense	20:41169476-41169476,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707423,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.P867R	Substitution - Missense	20:41169476-41169476,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707423,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.P867R	Substitution - Missense	20:41169476-41169476,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707431,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165H	Substitution - Missense	20:41173750-41173750,	PATHOGENIC	0.98425	26437031
PLCG1	9065	COSM5707435,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1169H	Substitution - Missense	20:41173762-41173762,	PATHOGENIC	0.98366	26437031
PLCG1	9065	COSM5707419,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.M750V	Substitution - Missense	20:41166806-41166806,	PATHOGENIC	0.98134	26437031
PLCG1	9065	COSM5574251,	large_intestine	other	p.R1158H	Substitution - Missense	20:41173730-41173730,	PATHOGENIC	0.98103	28524162
PLCG1	9065	COSM5574251,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R1158H	Substitution - Missense	20:41173730-41173730,	PATHOGENIC	0.98103	26415585
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	24497536
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	27369867
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	24497536
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	24497536
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26415585
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	27369867
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	24497536
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	24497536
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	27369867
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	24497536
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	24497536
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	24497536
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25910029
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	27369867
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26415585
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	28148900
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	26437031
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	25304611
PLCG1	9065	COSM3734685,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S345F	Substitution - Missense	20:41163944-41163944,	PATHOGENIC	0.98075	24497536
PLCG1	9065	COSM5707414,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D625Y	Substitution - Missense	20:41166267-41166267,	PATHOGENIC	0.97988	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26415585
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM3405078,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E1163K	Substitution - Missense	20:41173744-41173744,	PATHOGENIC	0.97959	26437031
PLCG1	9065	COSM5707413,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q606R	Substitution - Missense	20:41166211-41166211,	PATHOGENIC	0.97949	26437031
PLCG1	9065	COSM5707413,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q606R	Substitution - Missense	20:41166211-41166211,	PATHOGENIC	0.97949	26437031
PLCG1	9065	COSM5707413,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q606R	Substitution - Missense	20:41166211-41166211,	PATHOGENIC	0.97949	26437031
PLCG1	9065	COSM5707436,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1169G	Substitution - Missense	20:41173763-41173763,	PATHOGENIC	0.97799	26437031
PLCG1	9065	COSM5707436,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1169G	Substitution - Missense	20:41173763-41173763,	PATHOGENIC	0.97799	26437031
PLCG1	9065	COSM5857868,	biliary_tract	carcinoma	p.V846M	Substitution - Missense	20:41169131-41169131,	PATHOGENIC	0.97771	29360550
PLCG1	9065	COSM5707433,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165V	Substitution - Missense	20:41173751-41173751,	PATHOGENIC	0.97748	26437031
PLCG1	9065	COSM5707432,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165G	Substitution - Missense	20:41173751-41173751,	PATHOGENIC	0.97743	26437031
PLCG1	9065	COSM5707432,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1165G	Substitution - Missense	20:41173751-41173751,	PATHOGENIC	0.97743	26437031
PLCG1	9065	COSM5707428,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q1016L	Substitution - Missense	20:41172562-41172562,	PATHOGENIC	0.9751	26437031
PLCG1	9065	COSM5707428,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q1016L	Substitution - Missense	20:41172562-41172562,	PATHOGENIC	0.9751	26437031
PLCG1	9065	COSM5707428,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q1016L	Substitution - Missense	20:41172562-41172562,	PATHOGENIC	0.9751	26437031
PLCG1	9065	COSM5707427,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q1016R	Substitution - Missense	20:41172562-41172562,	PATHOGENIC	0.97503	26437031
PLCG1	9065	COSM5707417,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R748G	Substitution - Missense	20:41166800-41166800,	PATHOGENIC	0.97447	26437031
PLCG1	9065	COSM362125,	pleura	mesothelioma	p.V896I	Substitution - Missense	20:41170147-41170147,	PATHOGENIC	0.97418	26928227
PLCG1	9065	COSM5707434,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.F1167I	Substitution - Missense	20:41173756-41173756,	PATHOGENIC	0.97138	26437031
PLCG1	9065	COSM5707416,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L734R	Substitution - Missense	20:41166759-41166759,	PATHOGENIC	0.97121	26437031
PLCG1	9065	COSM5707418,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R748C	Substitution - Missense	20:41166800-41166800,	PATHOGENIC	0.96863	26437031
PLCG1	9065	COSM5707418,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R748C	Substitution - Missense	20:41166800-41166800,	PATHOGENIC	0.96863	26437031
PLCG1	9065	COSM5707418,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R748C	Substitution - Missense	20:41166800-41166800,	PATHOGENIC	0.96863	26437031
PLCG1	9065	COSM7325443,	biliary_tract	carcinoma	p.R978Q	Substitution - Missense	20:41172448-41172448,	PATHOGENIC	0.96675	29360550
PLCG1	9065	COSM5707425,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.L872R	Substitution - Missense	20:41169491-41169491,	PATHOGENIC	0.96601	26437031
PLCG1	9065	COSM5025037,	breast	carcinoma	p.T576A	Substitution - Missense	20:41165753-41165753,	PATHOGENIC	0.96569	25850943
PLCG1	9065	COSM5707408,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E47K	Substitution - Missense	20:41137780-41137780,	PATHOGENIC	0.96486	26437031
PLCG1	9065	COSM7325446,	biliary_tract	carcinoma	p.Q677K	Substitution - Missense	20:41166504-41166504,	PATHOGENIC	0.96071	29360550
PLCG1	9065	COSM7325522,	biliary_tract	carcinoma	p.I490M	Substitution - Missense	20:41165328-41165328,	PATHOGENIC	0.95665	29360550
PLCG1	9065	COSM5609953,	skin	malignant_melanoma	p.Q215*	Substitution - Nonsense	20:41162687-41162687,	PATHOGENIC	0.94898	26343386
PLCG1	9065	COSM5707411,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.H508Q	Substitution - Missense	20:41165464-41165464,	PATHOGENIC	0.94038	26437031
PLCG1	9065	COSM5609950,	skin	malignant_melanoma	p.P1257Q	Substitution - Missense	20:41174248-41174248,	PATHOGENIC	0.93109	26343386
PLCG1	9065	COSM48681,	lung	carcinoma	p.V108I	Substitution - Missense	20:41159710-41159710,	PATHOGENIC	0.92524	18948947
PLCG1	9065	COSM5609952,	skin	malignant_melanoma	p.P507S	Substitution - Missense	20:41165459-41165459,	PATHOGENIC	0.92363	26343386
PLCG1	9065	COSM5707438,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q1170R	Substitution - Missense	20:41173766-41173766,	PATHOGENIC	0.90757	26437031
PLCG1	9065	COSM21858,	breast	carcinoma	p.A995P	Substitution - Missense	20:41172498-41172498,	PATHOGENIC	0.89343	16959974
PLCG1	9065	COSM5609954,	skin	malignant_melanoma	p.S279S	Substitution - coding silent	20:41163425-41163425,	PATHOGENIC	0.88786	26343386
PLCG1	9065	COSM5609955,	skin	malignant_melanoma	p.K387K	Substitution - coding silent	20:41164145-41164145,	PATHOGENIC	0.87712	26343386
PLCG1	9065	COSM4134539,	soft_tissue	haemangioblastoma	p.S279G	Substitution - Missense	20:41163423-41163423,	PATHOGENIC	0.85751	25589003
PLCG1	9065	COSM4134539,	soft_tissue	haemangioblastoma	p.S279G	Substitution - Missense	20:41163423-41163423,	PATHOGENIC	0.85751	25589003
PLCG1	9065	COSM4134539,	soft_tissue	haemangioblastoma	p.S279G	Substitution - Missense	20:41163423-41163423,	PATHOGENIC	0.85751	25589003
PLCG1	9065	COSM4134539,	soft_tissue	haemangioblastoma	p.S279G	Substitution - Missense	20:41163423-41163423,	PATHOGENIC	0.85751	25589003
PLCG1	9065	COSM4134539,	soft_tissue	haemangioblastoma	p.S279G	Substitution - Missense	20:41163423-41163423,	PATHOGENIC	0.85751	25589003
PLCG1	9065	COSM5609956,	skin	malignant_melanoma	p.P686L	Substitution - Missense	20:41166532-41166532,	PATHOGENIC	0.85444	26343386
PLCG1	9065	COSM96136,	lung	carcinoma	p.D1122D	Substitution - coding silent	20:41173506-41173506,	PATHOGENIC	0.80299	20668451
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM5707409,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R48W	Substitution - Missense	20:41137783-41137783,	PATHOGENIC	0.79124	26437031
PLCG1	9065	COSM3291378,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R778C	Substitution - Missense	20:41167882-41167882,	PATHOGENIC	0.77179	26437031
PLCG1	9065	COSM5609951,	skin	malignant_melanoma	p.Y379Y	Substitution - coding silent	20:41164121-41164121,	PATHOGENIC	0.73589	26343386
PLCG1	9065	COSM6006334,	skin	adnexal_tumour	p.S1234*	Substitution - Nonsense	20:41174179-41174179,	NEUTRAL	0.27687	27287813
PLCG1	9065	COSM6748243,	biliary_tract	carcinoma	p.R270H	Substitution - Missense	20:41163397-41163397,	NEUTRAL	0.20784	29360550
PLCG1	9065	COSM5020502,	soft_tissue	haemangioblastoma	p.Y991Y	Substitution - coding silent	20:41172488-41172488,	NEUTRAL	0.12921	25589003
PLCG1	9065	COSM5020502,	soft_tissue	haemangioblastoma	p.Y991Y	Substitution - coding silent	20:41172488-41172488,	NEUTRAL	0.12921	25589003
PLCG1	9065	COSM5574252,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y1162_M1166delYEEDM	Deletion - In frame	20:41173739-41173753,	Info_not_available	Info_not_available	26415585
PLCG1	9065	COSM5707443,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.D1169_Q1170>E, p.D732delD, p.E1164delE, p.E522delE, p.F1172delF, p.N1171_F1172>I, p.N1171delN, p.Q1170_N1171>H	Complex - deletion inframe, Deletion - In frame	20:41173772-41173774,	Info_not_available	Info_not_available	26437031
PLCG1	9065	COSM6995404,	soft_tissue	angiosarcoma	p.R707L, p.R707Q, p.S345F	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	26735859
PLCG1	9065	COSM7325517,	biliary_tract	carcinoma	p.P319L	Substitution - Missense	20:41163779-41163779,	Info_not_available	0.6148	29360550
PLCG1	9065	COSM5020784,	soft_tissue	haemangioblastoma	p.N851N, p.R1232R	Substitution - coding silent	20:41174174-41174174,	Info_not_available	0.50912, .53842	25589003