Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
ESR1	3467	COSM6984732,	lung	carcinoma	p.D374Y	Substitution - Missense	6:152011679-152011679,	PATHOGENIC	0.99995	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	24398047
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	29420467
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	26563128
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	24055055
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	24185512
ESR1	3467	COSM6656369,	central_nervous_system	glioma	p.R394H	Substitution - Missense	6:152011740-152011740,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM3829320,	breast	carcinoma	p.E380Q	Substitution - Missense	6:152011697-152011697,	PATHOGENIC	0.99994	28481359
ESR1	3467	COSM6952570,	pancreas	carcinoma	p.K401*	Substitution - Nonsense	6:152011760-152011760,	PATHOGENIC	0.99993	28481359
ESR1	3467	COSM6918284,	large_intestine	carcinoma	p.L410S	Substitution - Missense	6:152011788-152011788,	PATHOGENIC	0.99992	28481359
ESR1	3467	COSM6922376,	central_nervous_system	malignant_melanoma	p.L403R	Substitution - Missense	6:152011767-152011767,	PATHOGENIC	0.99988	28481359
ESR1	3467	COSM6940362,	urinary_tract	carcinoma	p.E385D	Substitution - Missense	6:152011714-152011714,	PATHOGENIC	0.99986	28481359
ESR1	3467	COSM6956615,	large_intestine	carcinoma	p.D369Y	Substitution - Missense	6:152011664-152011664,	PATHOGENIC	0.99985	28481359
ESR1	3467	COSM6941088,	breast	carcinoma	p.L466Q	Substitution - Missense	6:152094412-152094412,	PATHOGENIC	0.99984	28481359
ESR1	3467	COSM6934684,	breast	carcinoma	p.F461V	Substitution - Missense	6:152094396-152094396,	PATHOGENIC	0.99982	28481359
ESR1	3467	COSM6925367,	NS	carcinoma	p.H398P	Substitution - Missense	6:152011752-152011752,	PATHOGENIC	0.99974	28481359
ESR1	3467	COSM6922301,	lung	carcinoma	p.L370F	Substitution - Missense	6:152011669-152011669,	PATHOGENIC	0.9997	28481359
ESR1	3467	COSM4745842,	breast	carcinoma	p.R503W	Substitution - Missense	6:152094522-152094522,	PATHOGENIC	0.99959	24398047
ESR1	3467	COSM4745939,	breast	carcinoma	p.M396V	Substitution - Missense	6:152011745-152011745,	PATHOGENIC	0.99954	7861463
ESR1	3467	COSM1441227,	skin	malignant_melanoma	p.R259Q	Substitution - Missense	6:151944188-151944188,	PATHOGENIC	0.99938	28481359
ESR1	3467	COSM6970478,	skin	malignant_melanoma	p.E470K	Substitution - Missense	6:152094423-152094423,	PATHOGENIC	0.99931	28481359
ESR1	3467	COSM6957690,	breast	carcinoma	p.V478L	Substitution - Missense	6:152094447-152094447,	PATHOGENIC	0.99925	28481359
ESR1	3467	COSM1545070,	central_nervous_system	glioma	p.V392I	Substitution - Missense	6:152011733-152011733,	PATHOGENIC	0.99917	28481359
ESR1	3467	COSM1545070,	breast	carcinoma	p.V392I	Substitution - Missense	6:152011733-152011733,	PATHOGENIC	0.99917	24185512
ESR1	3467	COSM6934332,	prostate	carcinoma	p.Q506H	Substitution - Missense	6:152094533-152094533,	PATHOGENIC	0.99915	28481359
ESR1	3467	COSM94249,	lung	carcinoma	p.M490I	Substitution - Missense	6:152094485-152094485,	PATHOGENIC	0.99911	20668451
ESR1	3467	COSM740571,	lung	carcinoma	p.H488Y	Substitution - Missense	6:152094477-152094477,	PATHOGENIC	0.99907	28481359
ESR1	3467	COSM6922218,	lung	carcinoma	p.A361T	Substitution - Missense	6:151944493-151944493,	PATHOGENIC	0.999	28481359
ESR1	3467	COSM6939264,	large_intestine	carcinoma	p.D258Y	Substitution - Missense	6:151944184-151944184,	PATHOGENIC	0.99899	28481359
ESR1	3467	COSM5404575,	large_intestine	carcinoma	p.R477Q	Substitution - Missense	6:152094445-152094445,	PATHOGENIC	0.99897	28481359
ESR1	3467	COSM5404575,	stomach	carcinoma	p.R477Q	Substitution - Missense	6:152094445-152094445,	PATHOGENIC	0.99897	29420467
ESR1	3467	COSM6974982,	large_intestine	carcinoma	p.A361E	Substitution - Missense	6:151944494-151944494,	PATHOGENIC	0.99868	28481359
ESR1	3467	COSM6964085,	large_intestine	carcinoma	p.A350E	Substitution - Missense	6:151944461-151944461,	PATHOGENIC	0.99868	28481359
ESR1	3467	COSM6925825,	lung	carcinoma	p.Q314K	Substitution - Missense	6:151944352-151944352,	PATHOGENIC	0.99867	28481359
ESR1	3467	COSM4771561,	breast	carcinoma	p.S463P	Substitution - Missense	6:152094402-152094402,	PATHOGENIC	0.99865	28481359
ESR1	3467	COSM4771561,	endometrium	carcinoma	p.S463P	Substitution - Missense	6:152094402-152094402,	PATHOGENIC	0.99865	28481359
ESR1	3467	COSM4771561,	breast	carcinoma	p.S463P	Substitution - Missense	6:152094402-152094402,	PATHOGENIC	0.99865	28481359
ESR1	3467	COSM4771561,	breast	carcinoma	p.S463P	Substitution - Missense	6:152094402-152094402,	PATHOGENIC	0.99865	24185512
ESR1	3467	COSM4771561,	breast	carcinoma	p.S463P	Substitution - Missense	6:152094402-152094402,	PATHOGENIC	0.99865	28283903
ESR1	3467	COSM4771561,	breast	carcinoma	p.S463P	Substitution - Missense	6:152094402-152094402,	PATHOGENIC	0.99865	24185512
ESR1	3467	COSM94248,	ovary	other	p.L489V	Substitution - Missense	6:152094480-152094480,	PATHOGENIC	0.99848	20668451
ESR1	3467	COSM6933531,	lung	carcinoma	p.P324S	Substitution - Missense	6:151944382-151944382,	PATHOGENIC	0.9984	28481359
ESR1	3467	COSM6915590,	prostate	carcinoma	p.A361V	Substitution - Missense	6:151944494-151944494,	PATHOGENIC	0.9984	28481359
ESR1	3467	COSM6915590,	large_intestine	carcinoma	p.A361V	Substitution - Missense	6:151944494-151944494,	PATHOGENIC	0.9984	28481359
ESR1	3467	COSM6967832,	skin	carcinoma	p.P325S	Substitution - Missense	6:151944385-151944385,	PATHOGENIC	0.9984	28481359
ESR1	3467	COSM6977544,	lung	carcinoma	p.V478I	Substitution - Missense	6:152094447-152094447,	PATHOGENIC	0.99833	28481359
ESR1	3467	COSM6926145,	oesophagus	carcinoma	p.S294R	Substitution - Missense	6:151944292-151944292,	PATHOGENIC	0.99825	28481359
ESR1	3467	COSM6948657,	breast	carcinoma	p.S329Y	Substitution - Missense	6:151944398-151944398,	PATHOGENIC	0.99821	28481359
ESR1	3467	COSM6944767,	central_nervous_system	glioma	p.R260K	Substitution - Missense	6:151944191-151944191,	PATHOGENIC	0.99777	28481359
ESR1	3467	COSM40959,	central_nervous_system	glioma	p.S341L	Substitution - Missense	6:151944434-151944434,	PATHOGENIC	0.99777	18772396
ESR1	3467	COSM40959,	large_intestine	carcinoma	p.S341L	Substitution - Missense	6:151944434-151944434,	PATHOGENIC	0.99777	28481359
ESR1	3467	COSM4877756,	large_intestine	carcinoma	p.R256*	Substitution - Nonsense	6:151944178-151944178,	PATHOGENIC	0.99765	28481359
ESR1	3467	COSM6955042,	large_intestine	carcinoma	p.R269H	Substitution - Missense	6:151944218-151944218,	PATHOGENIC	0.99659	28481359
ESR1	3467	COSM4969495,	lung	carcinoma	p.R269C	Substitution - Missense	6:151944217-151944217,	PATHOGENIC	0.99594	28481359
ESR1	3467	COSM4969495,	pancreas	carcinoma	p.R269C	Substitution - Missense	6:151944217-151944217,	PATHOGENIC	0.99594	28481359
ESR1	3467	COSM6970476,	skin	malignant_melanoma	p.R363K	Substitution - Missense	6:151944500-151944500,	PATHOGENIC	0.99562	28481359
ESR1	3467	COSM6940360,	urinary_tract	carcinoma	p.E330K	Substitution - Missense	6:151944400-151944400,	PATHOGENIC	0.99532	28481359
ESR1	3467	COSM6942514,	NS	carcinoma	p.R277S	Substitution - Missense	6:151944243-151944243,	PATHOGENIC	0.99429	28481359
ESR1	3467	COSM5895812,	ovary	carcinoma	p.G284E	Substitution - Missense	6:151944263-151944263,	PATHOGENIC	0.99423	28481359
ESR1	3467	COSM6921388,	breast	carcinoma	p.G344D	Substitution - Missense	6:151944443-151944443,	PATHOGENIC	0.99364	28481359
ESR1	3467	COSM6924887,	lung	carcinoma	p.N304H	Substitution - Missense	6:151944322-151944322,	PATHOGENIC	0.99346	28481359
ESR1	3467	COSM1074619,	endometrium	carcinoma	p.D218N	Substitution - Missense	6:151880663-151880663,	PATHOGENIC	0.9909	28481359
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	23236557
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	hyperplasia	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	10945602
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	16280033
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM4745827,	breast	carcinoma	p.K303R	Substitution - Missense	6:151944320-151944320,	PATHOGENIC	0.99072	17545528
ESR1	3467	COSM6942930,	lung	carcinoma	p.E247*	Substitution - Nonsense	6:151880750-151880750,	PATHOGENIC	0.98993	28481359
ESR1	3467	COSM6929567,	lung	carcinoma	p.C237Y	Substitution - Missense	6:151880721-151880721,	PATHOGENIC	0.98849	28481359
ESR1	3467	COSM6656383,	large_intestine	carcinoma	p.R243H	Substitution - Missense	6:151880739-151880739,	PATHOGENIC	0.98845	28481359
ESR1	3467	COSM6656383,	large_intestine	carcinoma	p.R243H	Substitution - Missense	6:151880739-151880739,	PATHOGENIC	0.98845	28481359
ESR1	3467	COSM206426,	large_intestine	carcinoma	p.T311M	Substitution - Missense	6:151944344-151944344,	PATHOGENIC	0.98795	28481359
ESR1	3467	COSM206426,	lung	carcinoma	p.T311M	Substitution - Missense	6:151944344-151944344,	PATHOGENIC	0.98795	28481359
ESR1	3467	COSM6918924,	prostate	carcinoma	p.T228A	Substitution - Missense	6:151880693-151880693,	PATHOGENIC	0.98578	28481359
ESR1	3467	COSM6854583,	large_intestine	other	p.T224S	Substitution - Missense	6:151880682-151880682,	PATHOGENIC	0.98449	28524162
ESR1	3467	COSM6854583,	large_intestine	other	p.T224S	Substitution - Missense	6:151880682-151880682,	PATHOGENIC	0.98449	28524162
ESR1	3467	COSM6854583,	large_intestine	other	p.T224S	Substitution - Missense	6:151880682-151880682,	PATHOGENIC	0.98449	28524162
ESR1	3467	COSM6854583,	large_intestine	other	p.T224S	Substitution - Missense	6:151880682-151880682,	PATHOGENIC	0.98449	28524162
ESR1	3467	COSM6854583,	large_intestine	other	p.T224S	Substitution - Missense	6:151880682-151880682,	PATHOGENIC	0.98449	28524162
ESR1	3467	COSM6909339,	skin	carcinoma	p.Q159L	Substitution - Missense	6:151842620-151842620,	PATHOGENIC	0.97663	28481359
ESR1	3467	COSM6919266,	large_intestine	carcinoma	p.R157Q	Substitution - Missense	6:151842614-151842614,	PATHOGENIC	0.97554	28481359
ESR1	3467	COSM6936639,	stomach	carcinoma	p.A307P	Substitution - Missense	6:151944331-151944331,	PATHOGENIC	0.97452	28481359
ESR1	3467	COSM4681733,	breast	carcinoma	p.A546T	Substitution - Missense	6:152098814-152098814,	PATHOGENIC	0.97376	28905136
ESR1	3467	COSM6995431,	ovary	germ_cell_tumour	p.D190H	Substitution - Missense	6:151842712-151842712,	PATHOGENIC	0.97082	28954785
ESR1	3467	COSM6918537,	breast	carcinoma	p.E542G	Substitution - Missense	6:152098803-152098803,	PATHOGENIC	0.97081	28481359
ESR1	3467	COSM1205680,	large_intestine	carcinoma	p.R211I	Substitution - Missense	6:151842776-151842776,	PATHOGENIC	0.96826	28481359
ESR1	3467	COSM1441237,	kidney	carcinoma	p.R548H	Substitution - Missense	6:152098821-152098821,	PATHOGENIC	0.96753	29420467
ESR1	3467	COSM1441237,	NS	carcinoma	p.R548H	Substitution - Missense	6:152098821-152098821,	PATHOGENIC	0.96753	28481359
ESR1	3467	COSM1441237,	stomach	carcinoma	p.R548H	Substitution - Missense	6:152098821-152098821,	PATHOGENIC	0.96753	26489445
ESR1	3467	COSM6957742,	large_intestine	carcinoma	p.E444*	Substitution - Nonsense	6:152061085-152061085,	PATHOGENIC	0.96723	28481359
ESR1	3467	COSM6913283,	breast	carcinoma	p.A546D	Substitution - Missense	6:152098815-152098815,	PATHOGENIC	0.96618	28481359
ESR1	3467	COSM6913283,	breast	carcinoma	p.A546D	Substitution - Missense	6:152098815-152098815,	PATHOGENIC	0.96618	28481359
ESR1	3467	COSM6957990,	endometrium	carcinoma	p.A207T	Substitution - Missense	6:151842763-151842763,	PATHOGENIC	0.96556	28481359
ESR1	3467	COSM6957990,	endometrium	carcinoma	p.A207T	Substitution - Missense	6:151842763-151842763,	PATHOGENIC	0.96556	28481359
ESR1	3467	COSM6916263,	large_intestine	carcinoma	p.K206T	Substitution - Missense	6:151842761-151842761,	PATHOGENIC	0.96232	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	24185512
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	endometrium	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28283903
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	24185512
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	24055055
ESR1	3467	COSM1074639,	endometrium	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	endometrium	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	24185512
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	24055055
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	24398047
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28283903
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	24185512
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	24398047
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	24185512
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	24055055
ESR1	3467	COSM1074639,	breast	carcinoma	p.Y537S	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.96146	28481359
ESR1	3467	COSM6954697,	stomach	carcinoma	p.E203V	Substitution - Missense	6:151842752-151842752,	PATHOGENIC	0.95934	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24185512
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24217577
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	endometrium	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24185512
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28283903
ESR1	3467	COSM6444650,	endometrium	carcinoma	p.N519S	Substitution - Missense	6:152098734-152098734,	PATHOGENIC	0.95919	27159395
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24398047
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24185512
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24217577
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24217577
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	ovary	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24185512
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24217577
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24398047
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	25746663
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24185512
ESR1	3467	COSM6444650,	large_intestine	carcinoma	p.N519S	Substitution - Missense	6:152098734-152098734,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24398047
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28283903
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24185512
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28283903
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	24217577
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	27284958
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28283903
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	25746663
ESR1	3467	COSM4766057,	breast	carcinoma	p.K531E	Substitution - Missense	6:152098769-152098769,	PATHOGENIC	0.95919	9102207
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	20668451
ESR1	3467	COSM94250,	breast	carcinoma	p.D538G	Substitution - Missense	6:152098791-152098791,	PATHOGENIC	0.95919	28481359
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28283903
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	24185512
ESR1	3467	COSM1074637,	skin	adnexal_tumour	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28481359
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28481359
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	25746663
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28481359
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	24398047
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28481359
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28481359
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28481359
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28481359
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28481359
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28481359
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	24185512
ESR1	3467	COSM1074637,	endometrium	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28103826
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28481359
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	24398047
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28283903
ESR1	3467	COSM1074637,	breast	carcinoma	p.Y537C	Substitution - Missense	6:152098788-152098788,	PATHOGENIC	0.95916	28481359
ESR1	3467	COSM6957408,	penis	carcinoma	p.K449R	Substitution - Missense	6:152061101-152061101,	PATHOGENIC	0.95793	28481359
ESR1	3467	COSM6930803,	lung	carcinoma	p.R183G	Substitution - Missense	6:151842691-151842691,	PATHOGENIC	0.95673	28481359
ESR1	3467	COSM6906869,	urinary_tract	carcinoma	p.Q214E	Substitution - Missense	6:151842784-151842784,	PATHOGENIC	0.95609	29420467
ESR1	3467	COSM6921911,	lung	carcinoma	p.P333T	Substitution - Missense	6:151944409-151944409,	PATHOGENIC	0.95295	28481359
ESR1	3467	COSM6918757,	breast	carcinoma	p.Y537D	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94804	28481359
ESR1	3467	COSM4774826,	breast	carcinoma	p.L536R	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94792	24185512
ESR1	3467	COSM4774826,	breast	carcinoma	p.L536R	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94792	28481359
ESR1	3467	COSM4774826,	breast	carcinoma	p.L536R	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94792	24185512
ESR1	3467	COSM4774826,	breast	carcinoma	p.L536R	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94792	28481359
ESR1	3467	COSM4774827,	breast	carcinoma	p.V534E	Substitution - Missense	6:152098779-152098779,	PATHOGENIC	0.94596	28481359
ESR1	3467	COSM4774827,	breast	carcinoma	p.V534E	Substitution - Missense	6:152098779-152098779,	PATHOGENIC	0.94596	24185512
ESR1	3467	COSM6981619,	breast	carcinoma	p.L540Q	Substitution - Missense	6:152098797-152098797,	PATHOGENIC	0.94594	28481359
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	9102207
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	28481359
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	24398047
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	28481359
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	28481359
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	24185512
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	24185512
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	28481359
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	28481359
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	28481359
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	28481359
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	28481359
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	28283903
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	28481359
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	27551012
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	24398047
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	24185512
ESR1	3467	COSM1074635,	breast	carcinoma	p.Y537N	Substitution - Missense	6:152098787-152098787,	PATHOGENIC	0.94588	27551012
ESR1	3467	COSM6843697,	breast	carcinoma	p.L536H	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94575	28481359
ESR1	3467	COSM6843697,	breast	carcinoma	p.L536H	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94575	28481359
ESR1	3467	COSM6843697,	breast	carcinoma	p.L536H	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94575	28283903
ESR1	3467	COSM6843697,	breast	carcinoma	p.L536H	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94575	28481359
ESR1	3467	COSM6843697,	breast	carcinoma	p.L536H	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94575	28481359
ESR1	3467	COSM6843697,	endometrium	carcinoma	p.L536H	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94575	28481359
ESR1	3467	COSM6926544,	breast	carcinoma	p.V418E	Substitution - Missense	6:152061008-152061008,	PATHOGENIC	0.94533	28481359
ESR1	3467	COSM6981202,	skin	malignant_melanoma	p.R183C	Substitution - Missense	6:151842691-151842691,	PATHOGENIC	0.94522	28481359
ESR1	3467	COSM6948873,	large_intestine	carcinoma	p.S338R	Substitution - Missense	6:151944426-151944426,	PATHOGENIC	0.94485	28481359
ESR1	3467	COSM1599950,	large_intestine	carcinoma	p.R158C	Substitution - Missense	6:151842616-151842616,	PATHOGENIC	0.94311	28481359
ESR1	3467	COSM6906109,	breast	carcinoma	p.L536P	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94043	28481359
ESR1	3467	COSM6906109,	breast	carcinoma	p.L536P	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94043	28481359
ESR1	3467	COSM6906109,	endometrium	carcinoma	p.L536P	Substitution - Missense	6:152098785-152098785,	PATHOGENIC	0.94043	28481359
ESR1	3467	COSM6506424,	breast	carcinoma	p.M437I	Substitution - Missense	6:152061066-152061066,	PATHOGENIC	0.93112	26011570
ESR1	3467	COSM6981341,	breast	carcinoma	p.K252N	Substitution - Missense	6:151880767-151880767,	PATHOGENIC	0.9277	28481359
ESR1	3467	COSM6910059,	skin	carcinoma	p.M437I	Substitution - Missense	6:152061066-152061066,	PATHOGENIC	0.92676	28481359
ESR1	3467	COSM6959903,	large_intestine	carcinoma	p.K32Q	Substitution - Missense	6:151808006-151808006,	PATHOGENIC	0.91755	28481359
ESR1	3467	COSM6920433,	large_intestine	carcinoma	p.R548C	Substitution - Missense	6:152098820-152098820,	PATHOGENIC	0.91639	28481359
ESR1	3467	COSM6950123,	skin	malignant_melanoma	p.R151K	Substitution - Missense	6:151808364-151808364,	PATHOGENIC	0.91267	28481359
ESR1	3467	COSM6972087,	lung	carcinoma	p.C245*	Substitution - Nonsense	6:151880746-151880746,	PATHOGENIC	0.91134	28481359
ESR1	3467	COSM6944804,	urinary_tract	carcinoma	p.E56K	Substitution - Missense	6:151808078-151808078,	PATHOGENIC	0.89692	28481359
ESR1	3467	COSM6908826,	lung	carcinoma	p.L117Q	Substitution - Missense	6:151808262-151808262,	PATHOGENIC	0.86903	28481359
ESR1	3467	COSM6937289,	NS	malignant_melanoma	p.A288T	Substitution - Missense	6:151944274-151944274,	PATHOGENIC	0.86738	28481359
ESR1	3467	COSM6980964,	breast	carcinoma	p.M421V	Substitution - Missense	6:152061016-152061016,	PATHOGENIC	0.86274	28481359
ESR1	3467	COSM6937508,	lung	carcinoma	p.Y54C	Substitution - Missense	6:151808073-151808073,	PATHOGENIC	0.86188	28481359
ESR1	3467	COSM6911498,	lung	carcinoma	p.G57C	Substitution - Missense	6:151808081-151808081,	PATHOGENIC	0.85834	28481359
ESR1	3467	COSM6949657,	endometrium	carcinoma	p.Y80H	Substitution - Missense	6:151808150-151808150,	PATHOGENIC	0.83472	28481359
ESR1	3467	COSM1559733,	soft_tissue	haemangioblastoma	p.H6Y	Substitution - Missense	6:151807928-151807928,	PATHOGENIC	0.82961	25589003
ESR1	3467	COSM239746,	lung	carcinoma	p.V533M	Substitution - Missense	6:152098775-152098775,	PATHOGENIC	0.82502	28481359
ESR1	3467	COSM6939368,	lung	carcinoma	p.T4A	Substitution - Missense	6:151807922-151807922,	PATHOGENIC	0.81815	28481359
ESR1	3467	COSM6910794,	central_nervous_system	glioma	p.G57S	Substitution - Missense	6:151808081-151808081,	PATHOGENIC	0.81414	28481359
ESR1	3467	COSM6925644,	endometrium	carcinoma	p.G442R	Substitution - Missense	6:152061079-152061079,	PATHOGENIC	0.81072	28481359
ESR1	3467	COSM6910289,	breast	carcinoma	p.S432L	Substitution - Missense	6:152061050-152061050,	PATHOGENIC	0.80448	28481359
ESR1	3467	COSM6910289,	breast	carcinoma	p.S432L	Substitution - Missense	6:152061050-152061050,	PATHOGENIC	0.80448	28481359
ESR1	3467	COSM6910289,	lung	carcinoma	p.S432L	Substitution - Missense	6:152061050-152061050,	PATHOGENIC	0.80448	28481359
ESR1	3467	COSM6942951,	breast	carcinoma	p.G442R	Substitution - Missense	6:152061079-152061079,	PATHOGENIC	0.80098	28481359
ESR1	3467	COSM4992439,	skin	carcinoma	p.K210K	Substitution - coding silent	6:151842774-151842774,	PATHOGENIC	0.79943	25589618
ESR1	3467	COSM6944548,	pancreas	carcinoma	p.R211S	Substitution - Missense	6:151842777-151842777,	PATHOGENIC	0.78725	28481359
ESR1	3467	COSM6020450,	large_intestine	carcinoma	p.A65V	Substitution - Missense	6:151808106-151808106,	PATHOGENIC	0.75832	28481359
ESR1	3467	COSM6656374,	oesophagus	carcinoma	p.R28H	Substitution - Missense	6:151807995-151807995,	PATHOGENIC	0.75203	28481359
ESR1	3467	COSM6980799,	breast	carcinoma	p.G160D	Substitution - Missense	6:151842623-151842623,	PATHOGENIC	0.74777	28481359
ESR1	3467	COSM4992437,	skin	carcinoma	p.F208F	Substitution - coding silent	6:151842768-151842768,	PATHOGENIC	0.73976	25589618
ESR1	3467	COSM6987501,	large_intestine	carcinoma	p.A87T	Substitution - Missense	6:151808171-151808171,	PATHOGENIC	0.73379	28481359
ESR1	3467	COSM6952587,	lung	carcinoma	p.L15V	Substitution - Missense	6:151807955-151807955,	PATHOGENIC	0.73162	28481359
ESR1	3467	COSM6916343,	lung	carcinoma	p.L26M	Substitution - Missense	6:151807988-151807988,	PATHOGENIC	0.73021	28481359
ESR1	3467	COSM6933530,	lung	carcinoma	p.K48N	Substitution - Missense	6:151808056-151808056,	PATHOGENIC	0.72609	28481359
ESR1	3467	COSM6922147,	lung	carcinoma	p.P113L	Substitution - Missense	6:151808250-151808250,	PATHOGENIC	0.72038	28481359
ESR1	3467	COSM6922147,	large_intestine	carcinoma	p.P113L	Substitution - Missense	6:151808250-151808250,	PATHOGENIC	0.72038	28481359
ESR1	3467	COSM3621508,	skin	malignant_melanoma	p.R243C	Substitution - Missense	6:151880738-151880738,	PATHOGENIC	0.71503	28481359
ESR1	3467	COSM6910996,	upper_aerodigestive_tract	carcinoma	p.R37L	Substitution - Missense	6:151808022-151808022,	PATHOGENIC	0.70487	28481359
ESR1	3467	COSM4766056,	breast	carcinoma	p.S47T	Substitution - Missense	6:151808052-151808052,	NEUTRAL	0.44628	9102207
ESR1	3467	COSM6975196,	lung	carcinoma	p.P25T	Substitution - Missense	6:151807985-151807985,	NEUTRAL	0.42707	28481359
ESR1	3467	COSM6976469,	breast	carcinoma	p.P147Q	Substitution - Missense	6:151808352-151808352,	NEUTRAL	0.23113	28481359
ESR1	3467	COSM6976469,	breast	carcinoma	p.P147Q	Substitution - Missense	6:151808352-151808352,	NEUTRAL	0.23113	28481359
ESR1	3467	COSM6978568,	large_intestine	carcinoma	p.T585M	Substitution - Missense	6:152098932-152098932,	NEUTRAL	0.20275	28481359
ESR1	3467	COSM4745938,	breast	carcinoma	p.N69K	Substitution - Missense	6:151808119-151808119,	NEUTRAL	0.15334	7861463
ESR1	3467	COSM6913235,	lung	carcinoma	p.D564Y	Substitution - Missense	6:152098868-152098868,	NEUTRAL	0.12016	28481359
ESR1	3467	COSM6934797,	urinary_tract	carcinoma	p.A593V	Substitution - Missense	6:152098956-152098956,	NEUTRAL	0.11436	28481359
ESR1	3467	COSM1074642,	breast	carcinoma	p.R555H	Substitution - Missense	6:152098842-152098842,	NEUTRAL	0.08887	28905136
ESR1	3467	COSM6973584,	skin	malignant_melanoma	p.G590S	Substitution - Missense	6:152098946-152098946,	NEUTRAL	0.02132	28481359
ESR1	3467	COSM6920293,	soft_tissue	angiosarcoma	p.D564N	Substitution - Missense	6:152098868-152098868,	NEUTRAL	0.0087	28481359
ESR1	3467	COSM3761556,	soft_tissue	haemangioblastoma	p.T594T	Substitution - coding silent	6:152098960-152098960,	NEUTRAL	0.00739	25589003
ESR1	3467	COSM3761556,	soft_tissue	haemangioblastoma	p.T594T	Substitution - coding silent	6:152098960-152098960,	NEUTRAL	0.00739	25589003
ESR1	3467	COSM3761556,	breast	carcinoma	p.T594T	Substitution - coding silent	6:152098960-152098960,	NEUTRAL	0.00739	28270497
ESR1	3467	COSM3761556,	soft_tissue	haemangioblastoma	p.T594T	Substitution - coding silent	6:152098960-152098960,	NEUTRAL	0.00739	25589003
ESR1	3467	COSM3761556,	soft_tissue	haemangioblastoma	p.T594T	Substitution - coding silent	6:152098960-152098960,	NEUTRAL	0.00739	25589003
ESR1	3467	COSM3761556,	soft_tissue	haemangioblastoma	p.T594T	Substitution - coding silent	6:152098960-152098960,	NEUTRAL	0.00739	25589003
ESR1	3467	COSM3761556,	soft_tissue	haemangioblastoma	p.T594T	Substitution - coding silent	6:152098960-152098960,	NEUTRAL	0.00739	25589003
ESR1	3467	COSM3761556,	soft_tissue	haemangioblastoma	p.T594T	Substitution - coding silent	6:152098960-152098960,	NEUTRAL	0.00739	25589003
ESR1	3467	COSM3761556,	soft_tissue	haemangioblastoma	p.T594T	Substitution - coding silent	6:152098960-152098960,	NEUTRAL	0.00739	25589003
ESR1	3467	COSM3761556,	soft_tissue	haemangioblastoma	p.T594T	Substitution - coding silent	6:152098960-152098960,	NEUTRAL	0.00739	25589003
ESR1	3467	COSM3761556,	soft_tissue	haemangioblastoma	p.T594T	Substitution - coding silent	6:152098960-152098960,	NEUTRAL	0.00739	25589003
ESR1	3467	COSM7002165,	liver	carcinoma	p.P592R	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	29487225
ESR1	3467	COSM5574254,	breast	carcinoma	p.E380Q	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	29166868
ESR1	3467	COSM6904331,	endometrium	carcinoma	p.Y52_A59del	Deletion - In frame	6:151808066-151808089,	Info_not_available	Info_not_available	28984674
ESR1	3467	COSM6904687,	breast	carcinoma	p.A50A, p.D538G, p.E380Q, p.F209del	Deletion - In frame, Substitution - Missense, Substitution - coding silent	Info_not_available	Info_not_available	Info_not_available	28921573
ESR1	3467	COSM6201639,	breast	carcinoma	p.D538G, p.E380Q, p.L536H, p.Y537C, p.Y537N, p.Y537S	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	28799536
ESR1	3467	COSM6904475,	upper_aerodigestive_tract	carcinoma	p.K449Q	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	28493366
ESR1	3467	COSM6201638,	breast	carcinoma	p.E279V, p.G557R	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	28283903
ESR1	3467	COSM5413589,	ovary	carcinoma	p.Y537S	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	27575406
ESR1	3467	COSM5415895,	breast	carcinoma	p.D538G, p.L536_D538>P, p.V533M, p.Y537C, p.Y537N, p.Y537S	Complex - deletion inframe, Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	26648736
ESR1	3467	COSM5413590,	breast	carcinoma	p.D538G, p.Y537C, p.Y537S	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	26500237
ESR1	3467	COSM5415894,	breast	carcinoma	p.D538G, p.Y537C, p.Y537N, p.Y537S	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	26434753
ESR1	3467	COSM6024066,	NS	carcinoma	p.R256Q, p.Y537S	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	26182302
ESR1	3467	COSM5574254,	breast	carcinoma	p.D538G, p.E380Q, p.Y537S	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25979954
ESR1	3467	COSM4745843,	breast	carcinoma	p.G344_L345insC	Insertion - In frame	6:151944445-151944446,	Info_not_available	Info_not_available	24398047
ESR1	3467	COSM4944018,	breast	carcinoma	p.P535H	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24185512
ESR1	3467	COSM4745828,	breast	carcinoma	p.K302fs*9	Deletion - Frameshift	6:151944317-151944317,	Info_not_available	Info_not_available	16280033
ESR1	3467	COSM6979734,	breast, large_intestine, lung, skin, urinary_tract	carcinoma, malignant_melanoma	p.?, p.D538_L539insHD, p.E275fs*5, p.G521fs*18, p.G96fs*13, p.I326fs*17, p.L100fs*57, p.L536H, p.L536Q, p.M109T, p.N532K, p.P99fs*10, p.Q500_H501insQ, p.S576L, p.T224I, p.V422delV, p.Y328_S329delYS, p.Y537S	Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Insertion - In frame, Substitution - Missense, Unknown	6:152098905-152098905,	Info_not_available	0.63495, .64632, .68086, Info_not_available	28481359
ESR1	3467	COSM6024072,	breast	carcinoma	p.S576L	Substitution - Missense	6:152098905-152098905,	Info_not_available	0.63495	26563128
ESR1	3467	COSM5575622,	stomach	carcinoma	p.A64T	Substitution - Missense	6:151808102-151808102,	Info_not_available	0.6332	26489445