| Gene Name | HGNC ID | COSMIC_MutID | Primary site | Primary histology | AA-Mutation | Mutation Type | Genomic Position | FATHMM prediction | FATHMM score | Literature evidence |
| HIST1H1C | 4716 | COSM6941135, | NS | carcinoma | p.G56E | Substitution - Missense | 6:26056262-26056262, | PATHOGENIC | 0.7061 | 28481359 |
| HIST1H1C | 4716 | COSM6941135, | NS | carcinoma | p.G56E | Substitution - Missense | 6:26056262-26056262, | PATHOGENIC | 0.7061 | 28481359 |
| HIST1H1C | 4716 | COSM6209319, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.A101T | Substitution - Missense | 6:26056128-26056128, | NEUTRAL | 0.48703 | 28481359 |
| HIST1H1C | 4716 | COSM1581000, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.G98D | Substitution - Missense | 6:26056136-26056136, | NEUTRAL | 0.48374 | 23292937 |
| HIST1H1C | 4716 | COSM6923164, | lung | carcinoma | p.K212M | Substitution - Missense | 6:26055794-26055794, | NEUTRAL | 0.45025 | 28481359 |
| HIST1H1C | 4716 | COSM6982153, | NS | carcinoma | p.P9L | Substitution - Missense | 6:26056403-26056403, | NEUTRAL | 0.43976 | 28481359 |
| HIST1H1C | 4716 | COSM6928933, | central_nervous_system | glioma | p.P128L | Substitution - Missense | 6:26056046-26056046, | NEUTRAL | 0.43286 | 28481359 |
| HIST1H1C | 4716 | COSM6918923, | prostate | carcinoma | p.N77S | Substitution - Missense | 6:26056199-26056199, | NEUTRAL | 0.41352 | 28481359 |
| HIST1H1C | 4716 | COSM6918923, | breast | carcinoma | p.N77S | Substitution - Missense | 6:26056199-26056199, | NEUTRAL | 0.41352 | 28481359 |
| HIST1H1C | 4716 | COSM3829819, | pancreas | carcinoma | p.K168N | Substitution - Missense | 6:26055925-26055925, | NEUTRAL | 0.40306 | 28481359 |
| HIST1H1C | 4716 | COSM77846, | upper_aerodigestive_tract | carcinoma | p.A61V | Substitution - Missense | 6:26056247-26056247, | NEUTRAL | 0.39744 | 28481359 |
| HIST1H1C | 4716 | COSM6487184, | prostate | carcinoma | p.E42Q | Substitution - Missense | 6:26056305-26056305, | NEUTRAL | 0.38398 | 28481359 |
| HIST1H1C | 4716 | COSM6986983, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.A47S | Substitution - Missense | 6:26056290-26056290, | NEUTRAL | 0.37716 | 28481359 |
| HIST1H1C | 4716 | COSM220713, | large_intestine | carcinoma | p.V132L | Substitution - Missense | 6:26056035-26056035, | NEUTRAL | 0.37627 | 28481359 |
| HIST1H1C | 4716 | COSM5520874, | NS | malignant_melanoma | p.E42K | Substitution - Missense | 6:26056305-26056305, | NEUTRAL | 0.37415 | 28481359 |
| HIST1H1C | 4716 | COSM6987183, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.K157T | Substitution - Missense | 6:26055959-26055959, | NEUTRAL | 0.36488 | 28481359 |
| HIST1H1C | 4716 | COSM6963841, | breast | carcinoma | p.K211Q | Substitution - Missense | 6:26055798-26055798, | NEUTRAL | 0.35995 | 28481359 |
| HIST1H1C | 4716 | COSM4845097, | lung | carcinoma | p.K129N | Substitution - Missense | 6:26056042-26056042, | NEUTRAL | 0.35641 | 28481359 |
| HIST1H1C | 4716 | COSM220715, | lung | carcinoma | p.E74K | Substitution - Missense | 6:26056209-26056209, | NEUTRAL | 0.34974 | 28481359 |
| HIST1H1C | 4716 | COSM6986752, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.A65P | Substitution - Missense | 6:26056236-26056236, | NEUTRAL | 0.34806 | 28481359 |
| HIST1H1C | 4716 | COSM1580998, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.A171V | Substitution - Missense | 6:26055917-26055917, | NEUTRAL | 0.34066 | 23292937 |
| HIST1H1C | 4716 | COSM1580998, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.A171V | Substitution - Missense | 6:26055917-26055917, | NEUTRAL | 0.34066 | 23292937 |
| HIST1H1C | 4716 | COSM6976535, | lung | carcinoma | p.P38L | Substitution - Missense | 6:26056316-26056316, | NEUTRAL | 0.32892 | 28481359 |
| HIST1H1C | 4716 | COSM6943751, | urinary_tract | carcinoma | p.K152N | Substitution - Missense | 6:26055973-26055973, | NEUTRAL | 0.29468 | 28481359 |
| HIST1H1C | 4716 | COSM6943751, | NS | carcinoma | p.K152N | Substitution - Missense | 6:26055973-26055973, | NEUTRAL | 0.29468 | 28481359 |
| HIST1H1C | 4716 | COSM6948051, | lung | carcinoma | p.K183R | Substitution - Missense | 6:26055881-26055881, | NEUTRAL | 0.27894 | 28481359 |
| HIST1H1C | 4716 | COSM1209702, | breast | carcinoma | p.K212N | Substitution - Missense | 6:26055793-26055793, | NEUTRAL | 0.27466 | 28481359 |
| HIST1H1C | 4716 | COSM1209702, | central_nervous_system | glioma | p.K212N | Substitution - Missense | 6:26055793-26055793, | NEUTRAL | 0.27466 | 28481359 |
| HIST1H1C | 4716 | COSM390278, | breast | carcinoma | p.D72N | Substitution - Missense | 6:26056215-26056215, | NEUTRAL | 0.27435 | 28481359 |
| HIST1H1C | 4716 | COSM390278, | urinary_tract | carcinoma | p.D72N | Substitution - Missense | 6:26056215-26056215, | NEUTRAL | 0.27435 | 28481359 |
| HIST1H1C | 4716 | COSM390278, | breast | carcinoma | p.D72N | Substitution - Missense | 6:26056215-26056215, | NEUTRAL | 0.27435 | 28481359 |
| HIST1H1C | 4716 | COSM6939705, | kidney | carcinoma | p.K110E | Substitution - Missense | 6:26056101-26056101, | NEUTRAL | 0.26352 | 28481359 |
| HIST1H1C | 4716 | COSM6946187, | large_intestine | carcinoma | p.K156N | Substitution - Missense | 6:26055961-26055961, | NEUTRAL | 0.25248 | 28481359 |
| HIST1H1C | 4716 | COSM6915337, | skin | carcinoma | p.K26I | Substitution - Missense | 6:26056352-26056352, | NEUTRAL | 0.24556 | 28481359 |
| HIST1H1C | 4716 | COSM1581002, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.V40L | Substitution - Missense | 6:26056311-26056311, | NEUTRAL | 0.24011 | 23292937 |
| HIST1H1C | 4716 | COSM4909975, | lung | carcinoma | p.K85N | Substitution - Missense | 6:26056174-26056174, | NEUTRAL | 0.22895 | 28481359 |
| HIST1H1C | 4716 | COSM4909975, | lung | carcinoma | p.K85N | Substitution - Missense | 6:26056174-26056174, | NEUTRAL | 0.22895 | 28481359 |
| HIST1H1C | 4716 | COSM6980031, | lung | carcinoma | p.K46N | Substitution - Missense | 6:26056291-26056291, | NEUTRAL | 0.22435 | 28481359 |
| HIST1H1C | 4716 | COSM6944325, | large_intestine | carcinoma | p.P9A | Substitution - Missense | 6:26056404-26056404, | NEUTRAL | 0.20249 | 28481359 |
| HIST1H1C | 4716 | COSM220712, | endometrium | carcinoma | p.P118S | Substitution - Missense | 6:26056077-26056077, | NEUTRAL | 0.18488 | 28481359 |
| HIST1H1C | 4716 | COSM6934719, | prostate | carcinoma | p.A158V | Substitution - Missense | 6:26055956-26055956, | NEUTRAL | 0.16339 | 28481359 |
| HIST1H1C | 4716 | COSM6986882, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.E42D | Substitution - Missense | 6:26056303-26056303, | NEUTRAL | 0.15879 | 28481359 |
| HIST1H1C | 4716 | COSM161529, | breast | carcinoma | p.E115K | Substitution - Missense | 6:26056086-26056086, | NEUTRAL | 0.15489 | 28481359 |
| HIST1H1C | 4716 | COSM161529, | breast | carcinoma | p.E115K | Substitution - Missense | 6:26056086-26056086, | NEUTRAL | 0.15489 | 28481359 |
| HIST1H1C | 4716 | COSM161529, | breast | carcinoma | p.E115K | Substitution - Missense | 6:26056086-26056086, | NEUTRAL | 0.15489 | 28481359 |
| HIST1H1C | 4716 | COSM6916482, | lung | carcinoma | p.P39L | Substitution - Missense | 6:26056313-26056313, | NEUTRAL | 0.15044 | 28481359 |
| HIST1H1C | 4716 | COSM1672274, | urinary_tract | carcinoma | p.I80M | Substitution - Missense | 6:26056189-26056189, | NEUTRAL | 0.1472 | 28481359 |
| HIST1H1C | 4716 | COSM6946458, | large_intestine | carcinoma | p.G125* | Substitution - Nonsense | 6:26056056-26056056, | NEUTRAL | 0.12914 | 28481359 |
| HIST1H1C | 4716 | COSM6915775, | stomach | carcinoma | p.K213* | Substitution - Nonsense | 6:26055792-26055792, | NEUTRAL | 0.12844 | 28481359 |
| HIST1H1C | 4716 | COSM1316557, | lung | carcinoma | p.P182A | Substitution - Missense | 6:26055885-26055885, | NEUTRAL | 0.12261 | 28481359 |
| HIST1H1C | 4716 | COSM6942690, | prostate | carcinoma | p.L82F | Substitution - Missense | 6:26056185-26056185, | NEUTRAL | 0.11828 | 28481359 |
| HIST1H1C | 4716 | COSM6942690, | skin | carcinoma | p.L82F | Substitution - Missense | 6:26056185-26056185, | NEUTRAL | 0.11828 | 28481359 |
| HIST1H1C | 4716 | COSM6934838, | lung | carcinoma | p.K97N | Substitution - Missense | 6:26056138-26056138, | NEUTRAL | 0.11188 | 28481359 |
| HIST1H1C | 4716 | COSM5605767, | central_nervous_system | glioma | p.K175N | Substitution - Missense | 6:26055904-26055904, | NEUTRAL | 0.10788 | 28481359 |
| HIST1H1C | 4716 | COSM5605767, | breast | carcinoma | p.K175N | Substitution - Missense | 6:26055904-26055904, | NEUTRAL | 0.10788 | 28481359 |
| HIST1H1C | 4716 | COSM6943612, | testis | germ_cell_tumour | p.P39T | Substitution - Missense | 6:26056314-26056314, | NEUTRAL | 0.09673 | 28481359 |
| HIST1H1C | 4716 | COSM6925159, | urinary_tract | carcinoma | p.G125E | Substitution - Missense | 6:26056055-26056055, | NEUTRAL | 0.07924 | 28481359 |
| HIST1H1C | 4716 | COSM6920630, | lung | carcinoma | p.E3D | Substitution - Missense | 6:26056420-26056420, | NEUTRAL | 0.07762 | 28481359 |
| HIST1H1C | 4716 | COSM6920630, | lung | carcinoma | p.E3D | Substitution - Missense | 6:26056420-26056420, | NEUTRAL | 0.07762 | 28481359 |
| HIST1H1C | 4716 | COSM6927862, | skin | carcinoma | p.A111T | Substitution - Missense | 6:26056098-26056098, | NEUTRAL | 0.06766 | 28481359 |
| HIST1H1C | 4716 | COSM6927862, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.A111T | Substitution - Missense | 6:26056098-26056098, | NEUTRAL | 0.06766 | 28481359 |
| HIST1H1C | 4716 | COSM1580999, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.A151G | Substitution - Missense | 6:26055977-26055977, | NEUTRAL | 0.06681 | 23292937 |
| HIST1H1C | 4716 | COSM6979418, | NS | carcinoma | p.R33C | Substitution - Missense | 6:26056332-26056332, | NEUTRAL | 0.05182 | 28481359 |
| HIST1H1C | 4716 | COSM6918282, | large_intestine | carcinoma | p.A142V | Substitution - Missense | 6:26056004-26056004, | NEUTRAL | 0.05092 | 28481359 |
| HIST1H1C | 4716 | COSM6960304, | upper_aerodigestive_tract | carcinoma | p.G30A | Substitution - Missense | 6:26056340-26056340, | NEUTRAL | 0.05084 | 28481359 |
| HIST1H1C | 4716 | COSM6909765, | breast | carcinoma | p.K149N | Substitution - Missense | 6:26055982-26055982, | NEUTRAL | 0.04918 | 28481359 |
| HIST1H1C | 4716 | COSM3829820, | lung | carcinoma | p.K149N | Substitution - Missense | 6:26055982-26055982, | NEUTRAL | 0.04547 | 28481359 |
| HIST1H1C | 4716 | COSM3829820, | NS | carcinoma | p.K149N | Substitution - Missense | 6:26055982-26055982, | NEUTRAL | 0.04547 | 28481359 |
| HIST1H1C | 4716 | COSM6980318, | kidney | carcinoma | p.A177T | Substitution - Missense | 6:26055900-26055900, | NEUTRAL | 0.04039 | 28481359 |
| HIST1H1C | 4716 | COSM6952940, | lung | carcinoma | p.K211N | Substitution - Missense | 6:26055796-26055796, | NEUTRAL | 0.03498 | 28481359 |
| HIST1H1C | 4716 | COSM6987717, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.A69G | Substitution - Missense | 6:26056223-26056223, | NEUTRAL | 0.0318 | 28481359 |
| HIST1H1C | 4716 | COSM6680194, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.A134T | Substitution - Missense | 6:26056029-26056029, | NEUTRAL | 0.03118 | 28481359 |
| HIST1H1C | 4716 | COSM6986751, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.V120I | Substitution - Missense | 6:26056071-26056071, | NEUTRAL | 0.0306 | 28481359 |
| HIST1H1C | 4716 | COSM6986751, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.V120I | Substitution - Missense | 6:26056071-26056071, | NEUTRAL | 0.0306 | 28481359 |
| HIST1H1C | 4716 | COSM6945486, | NS | malignant_melanoma | p.K17E | Substitution - Missense | 6:26056380-26056380, | NEUTRAL | 0.02772 | 28481359 |
| HIST1H1C | 4716 | COSM6986749, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.A151T | Substitution - Missense | 6:26055978-26055978, | NEUTRAL | 0.02223 | 28481359 |
| HIST1H1C | 4716 | COSM6986750, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.G133A | Substitution - Missense | 6:26056031-26056031, | NEUTRAL | 0.01987 | 28481359 |
| HIST1H1C | 4716 | COSM4592385, | large_intestine | carcinoma | p.A116G | Substitution - Missense | 6:26056082-26056082, | NEUTRAL | 0.01841 | 28481359 |
| HIST1H1C | 4716 | COSM1580997, | breast | carcinoma | p.A186V | Substitution - Missense | 6:26055872-26055872, | NEUTRAL | 0.01696 | 28481359 |
| HIST1H1C | 4716 | COSM6987561, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.S150C | Substitution - Missense | 6:26055981-26055981, | NEUTRAL | 0.0134 | 28481359 |
| HIST1H1C | 4716 | COSM6210079, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.S89N | Substitution - Missense | 6:26056163-26056163, | NEUTRAL | 0.01163 | 28481359 |
| HIST1H1C | 4716 | COSM6976990, | breast | carcinoma | p.A25T | Substitution - Missense | 6:26056356-26056356, | NEUTRAL | 0.00885 | 28481359 |
| HIST1H1C | 4716 | COSM5047848, | oesophagus | carcinoma | p.G30fs*33 | Deletion - Frameshift | 6:26056340-26056340, | Info_not_available | Info_not_available | 24686850 |
| HIST1H1C | 4716 | COSM6987560, | NS, biliary_tract, breast, haematopoietic_and_lymphoid_tissue, large_intestine, lung, prostate, skin, stomach, thyroid, upper_aerodigestive_tract, urinary_tract | carcinoma, lymphoid_neoplasm, malignant_melanoma | p.A101V, p.A164T, p.A171G, p.A197_K201delAAKPK, p.A8_A15delAPAAAPPA, p.E74Q, p.G29fs*6, p.G98A, p.K149delK, p.K152*, p.K156R, p.K194fs*>20, p.K23delK, p.K64fs*8, p.L43V, p.N77delN, p.P131L, p.P138_K140delPKK, p.P6S, p.Q95* | Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Substitution - Missense, Substitution - Nonsense | 6:26056413-26056413, | Info_not_available | 0.50096, .50164, .5263, .53034, .53259, .54047, .56846, .56926, .57336, .62881, Info_not_available | 28481359 |