Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
STAT5B	11367	COSM6941748,	large_intestine	carcinoma	p.T344I	Substitution - Missense	17:42218289-42218289,	PATHOGENIC	0.99796	28481359
STAT5B	11367	COSM6967611,	pancreas	carcinoma	p.?	Unknown	17:42217375-42217375,	PATHOGENIC	0.99779	28481359
STAT5B	11367	COSM6948418,	lung	carcinoma	p.E771*	Substitution - Nonsense	17:42201791-42201791,	PATHOGENIC	0.99769	28481359
STAT5B	11367	COSM285417,	penis	carcinoma	p.R638I	Substitution - Missense	17:42207722-42207722,	PATHOGENIC	0.99737	28481359
STAT5B	11367	COSM6955694,	breast	carcinoma	p.S138P	Substitution - Missense	17:42223520-42223520,	PATHOGENIC	0.99722	28481359
STAT5B	11367	COSM1716592,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y665F	Substitution - Missense	17:42207641-42207641,	PATHOGENIC	0.99721	23596048
STAT5B	11367	COSM1716592,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y665F	Substitution - Missense	17:42207641-42207641,	PATHOGENIC	0.99721	27697773
STAT5B	11367	COSM1716592,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y665F	Substitution - Missense	17:42207641-42207641,	PATHOGENIC	0.99721	23596048
STAT5B	11367	COSM6962803,	central_nervous_system	glioma	p.T346I	Substitution - Missense	17:42218283-42218283,	PATHOGENIC	0.99719	28481359
STAT5B	11367	COSM6973869,	large_intestine	carcinoma	p.D754N	Substitution - Missense	17:42201842-42201842,	PATHOGENIC	0.99705	28481359
STAT5B	11367	COSM6906905,	salivary_gland	carcinoma	p.G661E	Substitution - Missense	17:42207653-42207653,	PATHOGENIC	0.99694	28481359
STAT5B	11367	COSM6906905,	salivary_gland	carcinoma	p.G661E	Substitution - Missense	17:42207653-42207653,	PATHOGENIC	0.99694	29420467
STAT5B	11367	COSM6959084,	urinary_tract	carcinoma	p.D391N	Substitution - Missense	17:42217463-42217463,	PATHOGENIC	0.99693	28481359
STAT5B	11367	COSM1716817,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.G596V	Substitution - Missense	17:42210290-42210290,	PATHOGENIC	0.99691	19624718
STAT5B	11367	COSM1716817,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.G596V	Substitution - Missense	17:42210290-42210290,	PATHOGENIC	0.99691	19624718
STAT5B	11367	COSM6955605,	central_nervous_system	glioma	p.H111Y	Substitution - Missense	17:42224823-42224823,	PATHOGENIC	0.99686	28481359
STAT5B	11367	COSM6977133,	large_intestine	carcinoma	p.S787P	Substitution - Missense	17:42201743-42201743,	PATHOGENIC	0.99678	28481359
STAT5B	11367	COSM6022929,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.T628S	Substitution - Missense	17:42210194-42210194,	PATHOGENIC	0.99626	26917488
STAT5B	11367	COSM6930393,	lung	carcinoma	p.E201*	Substitution - Nonsense	17:42219792-42219792,	PATHOGENIC	0.99603	28481359
STAT5B	11367	COSM6964323,	lung	carcinoma	p.Q340E	Substitution - Missense	17:42218302-42218302,	PATHOGENIC	0.99528	28481359
STAT5B	11367	COSM6971060,	large_intestine	carcinoma	p.F711V	Substitution - Missense	17:42202446-42202446,	PATHOGENIC	0.99448	28481359
STAT5B	11367	COSM6933742,	lung	carcinoma	p.D727Y	Substitution - Missense	17:42202398-42202398,	PATHOGENIC	0.99428	28481359
STAT5B	11367	COSM6931191,	NS	carcinoma	p.L153R	Substitution - Missense	17:42223474-42223474,	PATHOGENIC	0.99377	28481359
STAT5B	11367	COSM5386387,	skin	carcinoma	p.P709S	Substitution - Missense	17:42202761-42202761,	PATHOGENIC	0.99351	28481359
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	24947020
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	23596048
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	26917488
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	23596048
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	24947020
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	27697773
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	24947020
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	24573384
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	24573384
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	26917488
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	26415585
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	24947020
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	26917488
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	24947020
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	26379152
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	26917488
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	26917488
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	24573384
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	27697773
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	27697773
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	24947020
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	24947020
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	23596048
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	26415585
STAT5B	11367	COSM1716590,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	17:42207711-42207711,	PATHOGENIC	0.99288	24573384
STAT5B	11367	COSM48779,	lung	carcinoma	p.G592V	Substitution - Missense	17:42210403-42210403,	PATHOGENIC	0.99227	18948947
STAT5B	11367	COSM6984610,	endometrium	carcinoma	p.P687S	Substitution - Missense	17:42207576-42207576,	PATHOGENIC	0.99196	28481359
STAT5B	11367	COSM6005724,	prostate	carcinoma	p.L342P	Substitution - Missense	17:42218295-42218295,	PATHOGENIC	0.9918	20579941
STAT5B	11367	COSM6967094,	urinary_tract	carcinoma	p.N539D	Substitution - Missense	17:42212049-42212049,	PATHOGENIC	0.99136	28481359
STAT5B	11367	COSM6950771,	skin	malignant_melanoma	p.S420F	Substitution - Missense	17:42217281-42217281,	PATHOGENIC	0.99131	28481359
STAT5B	11367	COSM6937977,	urinary_tract	carcinoma	p.V598I	Substitution - Missense	17:42210285-42210285,	PATHOGENIC	0.99106	28481359
STAT5B	11367	COSM6906825,	breast	carcinoma	p.D79H	Substitution - Missense	17:42227579-42227579,	PATHOGENIC	0.9907	28481359
STAT5B	11367	COSM6906825,	breast	carcinoma	p.D79H	Substitution - Missense	17:42227579-42227579,	PATHOGENIC	0.9907	29420467
STAT5B	11367	COSM6009008,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q706L	Substitution - Missense	17:42202769-42202769,	PATHOGENIC	0.99047	27697773
STAT5B	11367	COSM6009008,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q706L	Substitution - Missense	17:42202769-42202769,	PATHOGENIC	0.99047	26917488
STAT5B	11367	COSM6009008,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Q706L	Substitution - Missense	17:42202769-42202769,	PATHOGENIC	0.99047	26917488
STAT5B	11367	COSM6979440,	NS	carcinoma	p.R775W	Substitution - Missense	17:42201779-42201779,	PATHOGENIC	0.99041	28481359
STAT5B	11367	COSM6959116,	urinary_tract	carcinoma	p.N398K	Substitution - Missense	17:42217440-42217440,	PATHOGENIC	0.99039	28481359
STAT5B	11367	COSM6964009,	endometrium	carcinoma	p.?	Unknown	17:42212192-42212192,	PATHOGENIC	0.99027	28481359
STAT5B	11367	COSM6964498,	skin	malignant_melanoma	p.E579K	Substitution - Missense	17:42210443-42210443,	PATHOGENIC	0.9902	28481359
STAT5B	11367	COSM6986870,	lung	carcinoma	p.G77V	Substitution - Missense	17:42227584-42227584,	PATHOGENIC	0.9902	28481359
STAT5B	11367	COSM6926355,	central_nervous_system	glioma	p.G698E	Substitution - Missense	17:42202793-42202793,	PATHOGENIC	0.99009	28481359
STAT5B	11367	COSM6927648,	central_nervous_system	glioma	p.R659C	Substitution - Missense	17:42207660-42207660,	PATHOGENIC	0.9895	28481359
STAT5B	11367	COSM48780,	lung	carcinoma	p.L412F	Substitution - Missense	17:42217400-42217400,	PATHOGENIC	0.98899	18948947
STAT5B	11367	COSM6960595,	lung	carcinoma	p.D547Y	Substitution - Missense	17:42212025-42212025,	PATHOGENIC	0.98864	28481359
STAT5B	11367	COSM1383348,	oesophagus	carcinoma	p.T147M	Substitution - Missense	17:42223492-42223492,	PATHOGENIC	0.98819	28481359
STAT5B	11367	COSM6939754,	prostate	carcinoma	p.R31W	Substitution - Missense	17:42232037-42232037,	PATHOGENIC	0.98787	28481359
STAT5B	11367	COSM6981964,	endometrium	carcinoma	p.A480V	Substitution - Missense	17:42216048-42216048,	PATHOGENIC	0.98771	28481359
STAT5B	11367	COSM6927765,	lung	carcinoma	p.G431V	Substitution - Missense	17:42217248-42217248,	PATHOGENIC	0.98751	28481359
STAT5B	11367	COSM6005723,	prostate	carcinoma	p.A510V	Substitution - Missense	17:42212135-42212135,	PATHOGENIC	0.98709	20579941
STAT5B	11367	COSM6935535,	endometrium	carcinoma	p.R353H	Substitution - Missense	17:42218262-42218262,	PATHOGENIC	0.98708	28481359
STAT5B	11367	COSM6907160,	urinary_tract	carcinoma	p.P129A	Substitution - Missense	17:42223547-42223547,	PATHOGENIC	0.98595	29420467
STAT5B	11367	COSM6980516,	lung	carcinoid-endocrine_tumour	p.E438V	Substitution - Missense	17:42217227-42217227,	PATHOGENIC	0.98486	28481359
STAT5B	11367	COSM6960990,	NS	malignant_melanoma	p.V466M	Substitution - Missense	17:42216091-42216091,	PATHOGENIC	0.98413	28481359
STAT5B	11367	COSM6979223,	lung	carcinoma	p.D475N	Substitution - Missense	17:42216064-42216064,	PATHOGENIC	0.98384	28481359
STAT5B	11367	COSM6929784,	prostate	carcinoma	p.R107C	Substitution - Missense	17:42224835-42224835,	PATHOGENIC	0.98148	28481359
STAT5B	11367	COSM6926864,	skin	carcinoma	p.P783S	Substitution - Missense	17:42201755-42201755,	PATHOGENIC	0.98038	28481359
STAT5B	11367	COSM3188594,	skin	malignant_melanoma	p.R121*	Substitution - Nonsense	17:42224793-42224793,	PATHOGENIC	0.98001	28481359
STAT5B	11367	COSM1716826,	skin	carcinoma	p.R566Q	Substitution - Missense	17:42210481-42210481,	PATHOGENIC	0.97926	23774526
STAT5B	11367	COSM6984206,	prostate	carcinoma	p.N390K	Substitution - Missense	17:42217464-42217464,	PATHOGENIC	0.97871	28481359
STAT5B	11367	COSM6952375,	large_intestine	carcinoma	p.F619L	Substitution - Missense	17:42210220-42210220,	PATHOGENIC	0.97829	28481359
STAT5B	11367	COSM6953063,	lung	carcinoma	p.H89L	Substitution - Missense	17:42227548-42227548,	PATHOGENIC	0.97435	28481359
STAT5B	11367	COSM6948546,	lung	carcinoma	p.I667V	Substitution - Missense	17:42207636-42207636,	PATHOGENIC	0.97309	28481359
STAT5B	11367	COSM6009009,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.S715F	Substitution - Missense	17:42202433-42202433,	PATHOGENIC	0.96289	27697773
STAT5B	11367	COSM1227818,	stomach	carcinoma	p.R423Q	Substitution - Missense	17:42217272-42217272,	PATHOGENIC	0.95873	28481359
STAT5B	11367	COSM6937978,	urinary_tract	carcinoma	p.A136V	Substitution - Missense	17:42223525-42223525,	PATHOGENIC	0.95504	28481359
STAT5B	11367	COSM6932259,	skin	carcinoma	p.L133F	Substitution - Missense	17:42223535-42223535,	PATHOGENIC	0.95198	28481359
STAT5B	11367	COSM5954625,	large_intestine	carcinoma	p.R767W	Substitution - Missense	17:42201803-42201803,	PATHOGENIC	0.95078	28481359
STAT5B	11367	COSM6943232,	skin	malignant_melanoma	p.R429C	Substitution - Missense	17:42217255-42217255,	PATHOGENIC	0.94938	28481359
STAT5B	11367	COSM6949888,	lung	carcinoma	p.K705N	Substitution - Missense	17:42202771-42202771,	PATHOGENIC	0.94616	28481359
STAT5B	11367	COSM1266910,	skin	malignant_melanoma	p.R110C	Substitution - Missense	17:42224826-42224826,	PATHOGENIC	0.9402	28481359
STAT5B	11367	COSM1716827,	skin	carcinoma	p.P736L	Substitution - Missense	17:42202370-42202370,	PATHOGENIC	0.9175	23774526
STAT5B	11367	COSM1716827,	skin	carcinoma	p.P736L	Substitution - Missense	17:42202370-42202370,	PATHOGENIC	0.9175	28481359
STAT5B	11367	COSM1716827,	skin	carcinoma	p.P736L	Substitution - Missense	17:42202370-42202370,	PATHOGENIC	0.9175	23774526
STAT5B	11367	COSM6929068,	central_nervous_system	glioma	p.P730S	Substitution - Missense	17:42202389-42202389,	PATHOGENIC	0.91499	28481359
STAT5B	11367	COSM6941395,	large_intestine	carcinoma	p.M103V	Substitution - Missense	17:42224847-42224847,	PATHOGENIC	0.91396	28481359
STAT5B	11367	COSM1610266,	liver	carcinoma	p.S556S	Substitution - coding silent	17:42211996-42211996,	PATHOGENIC	0.8764	Info_not_available
STAT5B	11367	COSM6936752,	large_intestine	carcinoma	p.R110H	Substitution - Missense	17:42224825-42224825,	PATHOGENIC	0.84776	28481359
STAT5B	11367	COSM6961990,	pancreas	carcinoid-endocrine_tumour	p.S722N	Substitution - Missense	17:42202412-42202412,	NEUTRAL	0.07249	28481359
STAT5B	11367	COSM6791710,	large_intestine	carcinoma	p.A723T	Substitution - Missense	17:42202410-42202410,	NEUTRAL	0.06968	28481359
STAT5B	11367	COSM6791710,	large_intestine	carcinoma	p.A723T	Substitution - Missense	17:42202410-42202410,	NEUTRAL	0.06968	28481359
STAT5B	11367	COSM1716828,	skin	carcinoma	p.P736F	Substitution - Missense	17:42202370-42202371,	Info_not_available	Info_not_available	23774526
STAT5B	11367	COSM4169185,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.Y665F	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24573384
STAT5B	11367	COSM4765000,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	24972766
STAT5B	11367	COSM5033524,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E579K, p.I704L, p.N642H, p.Y665F	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25586472
STAT5B	11367	COSM4765000,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642H	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25749351
STAT5B	11367	COSM5751395,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.N642fs*31	Complex - frameshift	17:42207711-42207711,	Info_not_available	Info_not_available	26206799
STAT5B	11367	COSM6970960,	biliary_tract, endometrium, large_intestine, prostate, skin, small_intestine, urinary_tract	carcinoma	p.A190V, p.K164fs*17, p.K583fs*16, p.L189fs*30, p.L595fs*4, p.M103fs*14, p.Q368fs*2, p.Q368fs*9	Deletion - Frameshift, Insertion - Frameshift, Substitution - Missense	17:42224847-42224848,	Info_not_available	Info_not_available	28481359