| Gene Name | HGNC ID | COSMIC_MutID | Primary site | Primary histology | AA-Mutation | Mutation Type | Genomic Position | FATHMM prediction | FATHMM score | Literature evidence |
| RYR1 | 10483 | COSM4077755, | large_intestine | carcinoma | p.R492H | Substitution - Missense | 19:38455269-38455269, | PATHOGENIC | 0.99974 | 24951259 |
| RYR1 | 10483 | COSM6492127, | lung | carcinoma | p.D1828N | Substitution - Missense | 19:38486137-38486137, | PATHOGENIC | 0.99608 | 26503331 |
| RYR1 | 10483 | COSM5009318, | large_intestine | carcinoma | p.G224* | Substitution - Nonsense | 19:38446510-38446510, | PATHOGENIC | 0.99142 | 24951259 |
| RYR1 | 10483 | COSM6492838, | lung | carcinoma | p.E342K | Substitution - Missense | 19:38448715-38448715, | PATHOGENIC | 0.9898 | 26503331 |
| RYR1 | 10483 | COSM5009431, | large_intestine | carcinoma | p.R3337Q | Substitution - Missense | 19:38517683-38517683, | PATHOGENIC | 0.98953 | 24951259 |
| RYR1 | 10483 | COSM1645295, | large_intestine | carcinoma | p.P1773S | Substitution - Missense | 19:38485972-38485972, | PATHOGENIC | 0.98868 | 23700467 |
| RYR1 | 10483 | COSM5010142, | large_intestine | carcinoma | p.E2545K | Substitution - Missense | 19:38502525-38502525, | PATHOGENIC | 0.98513 | 24951259 |
| RYR1 | 10483 | COSM6492146, | lung | carcinoma | p.E3375* | Substitution - Nonsense | 19:38519318-38519318, | PATHOGENIC | 0.98453 | 26503331 |
| RYR1 | 10483 | COSM1224460, | salivary_gland | carcinoma | p.A1962V | Substitution - Missense | 19:38490146-38490146, | PATHOGENIC | 0.98209 | 23778141 |
| RYR1 | 10483 | COSM6492810, | lung | carcinoma | p.R1140L | Substitution - Missense | 19:38469003-38469003, | PATHOGENIC | 0.97734 | 26503331 |
| RYR1 | 10483 | COSM5009757, | large_intestine | carcinoma | p.D1821N | Substitution - Missense | 19:38486116-38486116, | PATHOGENIC | 0.97573 | 24951259 |
| RYR1 | 10483 | COSM5009323, | large_intestine | carcinoma | p.A3774V | Substitution - Missense | 19:38534781-38534781, | PATHOGENIC | 0.97439 | 24951259 |
| RYR1 | 10483 | COSM5010143, | large_intestine | carcinoma | p.F2955L | Substitution - Missense | 19:38507758-38507758, | PATHOGENIC | 0.96632 | 24951259 |
| RYR1 | 10483 | COSM5008398, | large_intestine | carcinoma | p.R4179H | Substitution - Missense | 19:38561366-38561366, | PATHOGENIC | 0.95929 | 24951259 |
| RYR1 | 10483 | COSM5008398, | large_intestine | carcinoma | p.R4179H | Substitution - Missense | 19:38561366-38561366, | PATHOGENIC | 0.95929 | 24951259 |
| RYR1 | 10483 | COSM5008640, | large_intestine | carcinoma | p.P4154L | Substitution - Missense | 19:38561291-38561291, | PATHOGENIC | 0.95206 | 24951259 |
| RYR1 | 10483 | COSM3692719, | large_intestine | carcinoma | p.R391H | Substitution - Missense | 19:38451813-38451813, | PATHOGENIC | 0.95108 | 24951259 |
| RYR1 | 10483 | COSM5009321, | large_intestine | carcinoma | p.R3395W | Substitution - Missense | 19:38519378-38519378, | PATHOGENIC | 0.94502 | 24951259 |
| RYR1 | 10483 | COSM1645269, | large_intestine | carcinoma | p.E1919K | Substitution - Missense | 19:38489384-38489384, | PATHOGENIC | 0.94188 | 23700467 |
| RYR1 | 10483 | COSM5028562, | breast | carcinoma | p.R1067H | Substitution - Missense | 19:38467631-38467631, | PATHOGENIC | 0.93856 | 22722193 |
| RYR1 | 10483 | COSM1645331, | large_intestine | carcinoma | p.G2899S | Substitution - Missense | 19:38506831-38506831, | PATHOGENIC | 0.9156 | 23700467 |
| RYR1 | 10483 | COSM148613, | lung | carcinoma | p.E2779E | Substitution - coding silent | 19:38505335-38505335, | PATHOGENIC | 0.91273 | 26503331 |
| RYR1 | 10483 | COSM249413, | kidney | carcinoma | p.S2122N | Substitution - Missense | 19:38494442-38494442, | PATHOGENIC | 0.9052 | 22138691 |
| RYR1 | 10483 | COSM314959, | lung | carcinoma | p.H2100Y | Substitution - Missense | 19:38494375-38494375, | PATHOGENIC | 0.88488 | 22941188 |
| RYR1 | 10483 | COSM5009320, | large_intestine | carcinoma | p.D1460G | Substitution - Missense | 19:38477795-38477795, | PATHOGENIC | 0.8808 | 24951259 |
| RYR1 | 10483 | COSM995995, | large_intestine | carcinoma | p.R1015C | Substitution - Missense | 19:38466263-38466263, | PATHOGENIC | 0.87642 | 24951259 |
| RYR1 | 10483 | COSM314960, | lung | carcinoma | p.L2506L | Substitution - coding silent | 19:38500894-38500894, | PATHOGENIC | 0.87399 | 22941188 |
| RYR1 | 10483 | COSM4077778, | haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm | p.R1996H | Substitution - Missense | 19:38490248-38490248, | PATHOGENIC | 0.86501 | 29386642 |
| RYR1 | 10483 | COSM4077778, | large_intestine | carcinoma | p.R1996H | Substitution - Missense | 19:38490248-38490248, | PATHOGENIC | 0.86501 | 24951259 |
| RYR1 | 10483 | COSM50981, | breast | carcinoma | p.R1469R | Substitution - coding silent | 19:38477823-38477823, | PATHOGENIC | 0.81711 | 17932254 |
| RYR1 | 10483 | COSM5009322, | large_intestine | carcinoma | p.I3728I | Substitution - coding silent | 19:38532532-38532532, | PATHOGENIC | 0.80136 | 24951259 |
| RYR1 | 10483 | COSM6492110, | lung | carcinoma | p.S712S | Substitution - coding silent | 19:38458261-38458261, | PATHOGENIC | 0.74936 | 26503331 |
| RYR1 | 10483 | COSM5008125, | large_intestine | carcinoma | p.Q3813R | Substitution - Missense | 19:38535219-38535219, | PATHOGENIC | 0.73993 | 24951259 |
| RYR1 | 10483 | COSM5009873, | large_intestine | carcinoma | p.V2509V | Substitution - coding silent | 19:38500903-38500903, | PATHOGENIC | 0.71687 | 24951259 |
| RYR1 | 10483 | COSM1645559, | large_intestine | carcinoma | p.F3995L | Substitution - Missense | 19:38543848-38543848, | NEUTRAL | 0.48847 | 23700467 |
| RYR1 | 10483 | COSM5009503, | large_intestine | carcinoma | p.V2627V | Substitution - coding silent | 19:38502925-38502925, | NEUTRAL | 0.48821 | 24951259 |
| RYR1 | 10483 | COSM4973098, | haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm | p.A882V | Substitution - Missense | 19:38463490-38463490, | NEUTRAL | 0.34328 | 29386642 |
| RYR1 | 10483 | COSM1612191, | liver | carcinoma | p.R3903W | Substitution - Missense | 19:38543364-38543364, | NEUTRAL | 0.33322 | Info_not_available |
| RYR1 | 10483 | COSM4772208, | large_intestine | carcinoma | p.S1770S | Substitution - coding silent | 19:38485965-38485965, | NEUTRAL | 0.31338 | 24951259 |
| RYR1 | 10483 | COSM5009324, | large_intestine | carcinoma | p.L4801F | Substitution - Missense | 19:38580018-38580018, | NEUTRAL | 0.29327 | 24951259 |
| RYR1 | 10483 | COSM249508, | kidney | carcinoma | p.V1112E | Substitution - Missense | 19:38467766-38467766, | NEUTRAL | 0.27101 | 22138691 |
| RYR1 | 10483 | COSM249391, | kidney | carcinoma | p.P1787S | Substitution - Missense | 19:38486014-38486014, | NEUTRAL | 0.24706 | 22138691 |
| RYR1 | 10483 | COSM6492884, | lung | carcinoma | p.Y892* | Substitution - Nonsense | 19:38463521-38463521, | NEUTRAL | 0.18292 | 26503331 |
| RYR1 | 10483 | COSM4965632, | large_intestine | carcinoma | p.A1826T | Substitution - Missense | 19:38486131-38486131, | NEUTRAL | 0.17392 | 24951259 |
| RYR1 | 10483 | COSM5008639, | large_intestine | carcinoma | p.R1667H | Substitution - Missense | 19:38485655-38485655, | NEUTRAL | 0.15047 | 24951259 |
| RYR1 | 10483 | COSM5818436, | lung | carcinoma | p.A4185A | Substitution - coding silent | 19:38561385-38561385, | NEUTRAL | 0.11428 | 26503331 |
| RYR1 | 10483 | COSM1581623, | haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | p.P1774L | Substitution - Missense | 19:38485976-38485976, | NEUTRAL | 0.11373 | 23292937 |
| RYR1 | 10483 | COSM88159, | central_nervous_system | primitive_neuroectodermal_tumour-medulloblastoma | p.P1408P | Substitution - coding silent | 19:38475381-38475381, | NEUTRAL | 0.10291 | 21163964 |
| RYR1 | 10483 | COSM314961, | lung | carcinoma | p.I4009I | Substitution - coding silent | 19:38546459-38546459, | NEUTRAL | 0.09401 | 22941188 |
| RYR1 | 10483 | COSM5009700, | large_intestine | carcinoma | p.L198L | Substitution - coding silent | 19:38444640-38444640, | NEUTRAL | 0.09022 | 24951259 |
| RYR1 | 10483 | COSM5028563, | breast | carcinoma | p.A3342A | Substitution - coding silent | 19:38519221-38519221, | NEUTRAL | 0.08637 | 22722193 |
| RYR1 | 10483 | COSM314958, | lung | carcinoma | p.T2585T | Substitution - coding silent | 19:38502647-38502647, | NEUTRAL | 0.07323 | 22941188 |
| RYR1 | 10483 | COSM5009875, | large_intestine | carcinoma | p.Y3406Y | Substitution - coding silent | 19:38519413-38519413, | NEUTRAL | 0.06749 | 24951259 |
| RYR1 | 10483 | COSM5009875, | large_intestine | carcinoma | p.Y3406Y | Substitution - coding silent | 19:38519413-38519413, | NEUTRAL | 0.06749 | 24951259 |
| RYR1 | 10483 | COSM148605, | large_intestine | carcinoma | p.I1152I | Substitution - coding silent | 19:38469040-38469040, | NEUTRAL | 0.05611 | 24951259 |
| RYR1 | 10483 | COSM4000709, | large_intestine | carcinoma | p.D668D | Substitution - coding silent | 19:38458129-38458129, | NEUTRAL | 0.05302 | 24951259 |
| RYR1 | 10483 | COSM4000709, | large_intestine | carcinoma | p.D668D | Substitution - coding silent | 19:38458129-38458129, | NEUTRAL | 0.05302 | 24951259 |
| RYR1 | 10483 | COSM1612186, | liver | carcinoma | p.P1591P | Substitution - coding silent | 19:38483355-38483355, | NEUTRAL | 0.04689 | Info_not_available |
| RYR1 | 10483 | COSM6908338, | haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm | p.H2520H | Substitution - coding silent | 19:38500936-38500936, | NEUTRAL | 0.0369 | 29386642 |
| RYR1 | 10483 | COSM5009319, | large_intestine | carcinoma | p.I586I | Substitution - coding silent | 19:38455718-38455718, | NEUTRAL | 0.03397 | 24951259 |
| RYR1 | 10483 | COSM3756756, | lung | carcinoma | p.P3062P | Substitution - coding silent | 19:38512085-38512085, | NEUTRAL | 0.03384 | 26503331 |
| RYR1 | 10483 | COSM148612, | lung | carcinoma | p.D2730D | Substitution - coding silent | 19:38504870-38504870, | NEUTRAL | 0.03299 | 26503331 |
| RYR1 | 10483 | COSM3756752, | lung | carcinoma | p.T981T | Substitution - coding silent | 19:38466163-38466163, | NEUTRAL | 0.0196 | 26503331 |
| RYR1 | 10483 | COSM5009872, | large_intestine | carcinoma | p.A2500A | Substitution - coding silent | 19:38500876-38500876, | NEUTRAL | 0.01321 | 24951259 |
| RYR1 | 10483 | COSM5009874, | large_intestine | carcinoma | p.P2528P | Substitution - coding silent | 19:38500960-38500960, | NEUTRAL | 0.01198 | 24951259 |
| RYR1 | 10483 | COSM5009874, | large_intestine | carcinoma | p.P2528P | Substitution - coding silent | 19:38500960-38500960, | NEUTRAL | 0.01198 | 24951259 |
| RYR1 | 10483 | COSM148614, | lung | carcinoma | p.S2863S | Substitution - coding silent | 19:38506350-38506350, | NEUTRAL | 0.0111 | 26503331 |
| RYR1 | 10483 | COSM148610, | lung | carcinoma | p.T2659T | Substitution - coding silent | 19:38504270-38504270, | NEUTRAL | 0.01048 | 26503331 |
| RYR1 | 10483 | COSM4131782, | lung | carcinoma | p.P762P | Substitution - coding silent | 19:38459264-38459264, | NEUTRAL | 0.01035 | 26503331 |
| RYR1 | 10483 | COSM4131782, | lung | carcinoma | p.P762P | Substitution - coding silent | 19:38459264-38459264, | NEUTRAL | 0.01035 | 26503331 |
| RYR1 | 10483 | COSM5009871, | large_intestine | carcinoma | p.A2427A | Substitution - coding silent | 19:38499974-38499974, | NEUTRAL | 0.00767 | 24951259 |
| RYR1 | 10483 | COSM5009871, | large_intestine | carcinoma | p.A2427A | Substitution - coding silent | 19:38499974-38499974, | NEUTRAL | 0.00767 | 24951259 |
| RYR1 | 10483 | COSM3771045, | large_intestine | carcinoma | p.R2403R | Substitution - coding silent | 19:38499816-38499816, | NEUTRAL | 0.00448 | 24951259 |
| RYR1 | 10483 | COSM3771045, | large_intestine | carcinoma | p.R2403R | Substitution - coding silent | 19:38499816-38499816, | NEUTRAL | 0.00448 | 24951259 |
| RYR1 | 10483 | COSM6490873, | lung | carcinoma | p.S556S | Substitution - coding silent | 19:38455542-38455542, | NEUTRAL | 0.0006 | 26503331 |
| RYR1 | 10483 | COSM6490873, | lung | carcinoma | p.S556S | Substitution - coding silent | 19:38455542-38455542, | NEUTRAL | 0.0006 | 26503331 |
| RYR1 | 10483 | COSM1612189, | liver | carcinoma | p.D3242fs*79 | Deletion - Frameshift | 19:38517394-38517394, | Info_not_available | Info_not_available | Info_not_available |
| RYR1 | 10483 | COSM996048, | large_intestine | carcinoma | p.D2014Y, p.K3497delK, p.V3163V | Deletion - In frame, Substitution - Missense, Substitution - coding silent | 19:38525359-38525361, | Info_not_available | 0.53717, .55172, Info_not_available | 24951259 |
| RYR1 | 10483 | COSM249532, | kidney | carcinoma | p.R1964P | Substitution - Missense | 19:38490152-38490152, | Info_not_available | 0.52433 | 22138691 |