Interacting Partner Detection_method PPI_type Lit_support PPI_score Source_databases ABL1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, peptide array physical, physical association 16135792, 16219545, 17474147, 19380743, 8294442 0.40 BioGRID, IntAct ACTA1 Affinity Capture-Western physical 23353701 NA BioGRID ADAM12 Affinity Capture-Western, Reconstituted Complex physical 11313349 NA BioGRID ADAMTS2 Two-hybrid physical 18624398 NA BioGRID AGAP2 Affinity Capture-Western, Reconstituted Complex physical 11136977 NA BioGRID AKT1 Affinity Capture-Western physical 19117013 NA BioGRID ALK Reconstituted Complex physical 16135792 NA BioGRID ALOX5 Affinity Capture-Western physical 21200133 NA BioGRID APPL1 Affinity Capture-Western, Two-hybrid, two hybrid array, validated two hybrid physical, physical association 12621049, 25814554 0.49 BioGRID, IntAct ARAF Reconstituted Complex, coimmunoprecipitation, phage display, pull down direct interaction, physical, physical association 10967104, 11812000 0.61 BioGRID, IntAct, MINT ARHGAP1 Reconstituted Complex physical 8253717 NA BioGRID ARHGAP17 Reconstituted Complex physical 11431473 NA BioGRID ARHGAP32 Affinity Capture-Western physical 12454018 NA BioGRID AXL Affinity Capture-Western, Biochemical Activity, coimmunoprecipitation, far western blotting association, physical 18346204, 9178760 0.46 BioGRID, IntAct, MINT BCAR1 Affinity Capture-Western, Reconstituted Complex physical 10799562 NA BioGRID BCR Far Western physical 18346204 NA BioGRID BRCA1 Reconstituted Complex, peptide array physical, physical association 16135792, 17474147 0.40 BioGRID, IntAct CBL Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Far Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, coimmunoprecipitation, experimental interaction detection, far western blotting, pull down, tandem affinity purification, two hybrid, two hybrid array, validated two hybrid association, physical, physical association 10025673, 10358153, 10620516, 10918571, 11030146, 11042121, 11087752, 11157475, 11418612, 11944898, 11994282, 14530346, 15107835, 15556646, 15581361, 16135792, 16219545, 16289966, 16982329, 17237826, 18374639, 19190244, 19380743, 19861161, 21203488, 24113870, 25814554, 7642581, 7791764, 8612729, 8621719, 8662998, 8695807, 8702998, 8896416, 8941725, 8995243, 9092538, 9160881, 9174058, 9259313, 9414268, 9461587, 9541596, 9890943, 9890970, 9918857, 9988765 0.49, 0.94 BioGRID, IntAct, MINT CBLB Affinity Capture-Western physical 10022120, 11526404, 19190244, 9614102 NA BioGRID CCL14 Two-hybrid, two hybrid array physical, physical association 21988832 0.37 BioGRID, IntAct CD244 Affinity Capture-MS physical 26186194 NA BioGRID CD247 Affinity Capture-Western physical 11526404 NA BioGRID CD28 Affinity Capture-Western, Protein-peptide, coimmunoprecipitation, competition binding, pull down association, physical 10820259, 11526404, 19190244, 7568038, 7584133, 7807015, 8146197, 8183372, 8621607, 9417079 0.89 BioGRID, IntAct, MINT CD3E Affinity Capture-Western physical 19190244, 9312149 NA BioGRID CD40 Affinity Capture-Western physical 21200133 NA BioGRID CD7 Affinity Capture-Western, Reconstituted Complex, competition binding association, physical 12594831, 8918688 0.35 BioGRID, IntAct, MINT CHAF1A Affinity Capture-MS, anti tag coimmunoprecipitation, peptide array association, physical, physical association 17474147, 26496610 0.56 BioGRID, IntAct CLNK Two-hybrid, two hybrid array, validated two hybrid physical, physical association 25814554 0.49 BioGRID, IntAct CMIP Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 20018188 0.52 BioGRID, IntAct, MINT CRK Affinity Capture-MS, Affinity Capture-Western, Co-localization, Two-hybrid, proximity ligation assay, tandem affinity purification, two hybrid array, validated two hybrid association, physical, physical association 10962563, 11418612, 19380743, 25241761, 25814554 0.49, 0.56 BioGRID, IntAct CRKL Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay physical, physical association 11418612, 16135792, 16982329, 23397142, 9461587 0.59 BioGRID, IntAct, MINT CSF1R Affinity Capture-Western, Co-localization, proximity ligation assay physical, physical association 10025673, 25241761 0.40 BioGRID, IntAct CSF2RA Affinity Capture-Western, peptide array physical, physical association 12538575, 17474147 0.40 BioGRID, IntAct CTNNB1 Co-localization, Reconstituted Complex, proximity ligation assay physical, physical association 10477752, 25241761 0.40 BioGRID, IntAct CUL3 Affinity Capture-MS, Affinity Capture-Western physical 21145461, 27708159 NA BioGRID CXCL2 Two-hybrid physical 18624398 NA BioGRID CYP4A11 Two-hybrid physical 18624398 NA BioGRID DAB2IP Affinity Capture-Western, Reconstituted Complex physical 19903888 NA BioGRID DEFA5 Affinity Capture-MS physical 28514442 NA BioGRID DLX2 Two-hybrid, two hybrid array physical, physical association 21988832 0.37 BioGRID, IntAct DNM2 Affinity Capture-Western physical 21996738 NA BioGRID DOK1 Protein-peptide, Reconstituted Complex physical 11071635, 22974441 NA BioGRID EFNB2 Affinity Capture-MS physical 26186194 NA BioGRID EGFR Affinity Capture-MS, Affinity Capture-Western, Co-localization, Protein-peptide, coimmunoprecipitation, competition binding, protein array, proximity ligation assay association, direct interaction, physical, physical association 16273093, 19531499, 21701776, 25241761, 7797556, 8662998 0.78 BioGRID, IntAct, MINT EP300 Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 21057544 0.40 BioGRID, IntAct EPHA2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 7982920 NA BioGRID EPN1 Affinity Capture-Western physical 24113870 NA BioGRID EPOR Affinity Capture-Western, PCA, Reconstituted Complex physical 15644415, 24113870, 7559499, 9162069 NA BioGRID ERBB2 Affinity Capture-Western, Protein-peptide, anti bait coimmunoprecipitation, protein array, pull down association, direct interaction, physical 16273093, 16843263, 21075308, 9756944 0.69 BioGRID, IntAct, MINT ERBB3 Affinity Capture-MS, Affinity Capture-Western, Protein-peptide, anti bait coimmunoprecipitation, protein array, tandem affinity purification association, direct interaction, physical, physical association 10383151, 10572067, 11546794, 11694521, 15812817, 16273093, 18803287, 20007781, 20227043, 21075308, 21278786, 22439932, 24189400, 9130710, 9756944 0.92 BioGRID, IntAct, MINT ESR1 Affinity Capture-Western, anti bait coimmunoprecipitation, proximity ligation assay association, physical, physical association 11029009, 11689445, 17043237, 23065768 0.56 BioGRID, IntAct EZR Affinity Capture-Western, Reconstituted Complex, pull down association, physical 10377409 0.35 BioGRID, IntAct, MINT FAS Affinity Capture-Western physical 18328427 NA BioGRID FASLG Co-localization, phage display, proximity ligation assay direct interaction, physical, physical association 19807924, 25241761 0.61 BioGRID, IntAct FBXL2 Affinity Capture-Western physical 23604317 NA BioGRID FCGR2A Affinity Capture-Western, Reconstituted Complex physical 8631888, 9268059 NA BioGRID FER Two-hybrid, two hybrid array physical, physical association 25814554 0.37 BioGRID, IntAct FES Affinity Capture-Western physical 8916957 NA BioGRID FGFR1 Co-localization, Reconstituted Complex, Two-hybrid, coimmunoprecipitation, proximity ligation assay, pull down association, physical, physical association 15117958, 18412956, 25241761, 8321198 0.62 BioGRID, IntAct, MINT FGFR2 Affinity Capture-Western physical 18374639 NA BioGRID FLRT1 Affinity Capture-MS physical 28514442 NA BioGRID FLT1 Affinity Capture-Western, coimmunoprecipitation, proximity ligation assay association, physical, physical association 20805333, 23397142, 7657594 0.56 BioGRID, IntAct, MINT FLT3 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16982329 0.40 BioGRID, IntAct, MINT FYN Reconstituted Complex, mammalian protein protein interaction trap physical, physical association 25416956, 8294442 0.37 BioGRID, IntAct GAB1 Affinity Capture-Western, Far Western, Reconstituted Complex, Two-hybrid, coimmunoprecipitation, fluorescence polarization spectroscopy, pull down, two hybrid association, direct interaction, physical, physical association 10978177, 16638574, 23612964, 24728074, 8596638, 9658397, 9804835, 9891995 0.80 BioGRID, IntAct, MINT GAB2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down association, physical, physical association 10871282, 11334882, 11782427, 14530346, 16135792, 16219545, 16253990 0.56 BioGRID, IntAct, MINT GNAQ Affinity Capture-Western physical 12704201 NA BioGRID GNB1 Affinity Capture-Western physical 19117013 NA BioGRID GRB10 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 12783867, 23246379 0.40 BioGRID, IntAct, MINT GRB2 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, mammalian protein protein interaction trap, pull down, tandem affinity purification, two hybrid pooling approach association, physical, physical association 11418612, 16219545, 18346204, 19380743, 20936779, 21706016, 25416956, 7642581, 7737969, 7759531, 9174058, 9541596, 9886492 0.86 BioGRID, IntAct, MINT GSPT1 Two-hybrid, two hybrid array physical, physical association 21988832 0.37 BioGRID, IntAct HAVCR2 Affinity Capture-MS, anti bait coimmunoprecipitation, pull down association, physical 26492563, 28514442 0.46 BioGRID, IntAct HCST Protein-peptide physical 10426994 NA BioGRID HDAC3 Affinity Capture-Western physical 22027828 NA BioGRID HOXA1 Two-hybrid, two hybrid array physical, physical association 21988832 0.37 BioGRID, IntAct HRAS Affinity Capture-Western, Co-localization, Reconstituted Complex, proximity ligation assay physical, physical association 10212255, 25241761, 9150145 0.40 BioGRID, IntAct HTT Two-hybrid, two hybrid, two hybrid prey pooling approach physical, physical association 17500595, 23275563 0.55 BioGRID, IntAct IFNAR1 Affinity Capture-Western physical 10542297 NA BioGRID IGF1R Co-localization, coimmunoprecipitation, proximity ligation assay, pull down, two hybrid association, physical, physical association 25241761, 7589433, 7642582, 8603569 0.75 BioGRID, IntAct, MINT IL1R1 Affinity Capture-Western physical 9360994 NA BioGRID IL20RA Affinity Capture-MS physical 28514442 NA BioGRID IL6ST Affinity Capture-Western physical 10579793 NA BioGRID INPP5D Affinity Capture-Western physical 9918857 NA BioGRID INPPL1 Affinity Capture-MS, tandem affinity purification association, physical 19380743 0.35 BioGRID, IntAct IRS1 Affinity Capture-Luminescence, Affinity Capture-Western, Far Western, Protein-peptide, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, cross-linking study, enzymatic study, luminescence based mammalian interactome mapping, nuclear magnetic resonance, pull down, surface plasmon resonance, two hybrid, two hybrid array, validated two hybrid association, physical, physical association 11403293, 11416002, 12107746, 12173038, 12730242, 1381348, 14511371, 14632132, 15514089, 16150444, 16230374, 16354680, 17640984, 19561084, 22974441, 23439647, 23643389, 25814554, 7680095, 7680644, 8175658, 8382612, 8628286, 9564850 0.57, 0.92 BioGRID, IntAct, MINT IRS2 Affinity Capture-MS, Affinity Capture-Western, Far Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 12107746, 15514089, 19561084, 21241768, 23439647, 23617393, 26496610, 8910607, 9334184, 9852124 0.69 BioGRID, IntAct, MINT IRS4 Affinity Capture-Luminescence, Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25036637 0.35 BioGRID, IntAct ITSN1 Two-hybrid physical 22558309 NA BioGRID JAK2 Negative Genetic, Reconstituted Complex, peptide array genetic, physical, physical association 16135792, 17474147, 28319113 0.40 BioGRID, IntAct KBTBD2 Affinity Capture-Western, Reconstituted Complex physical 27708159 NA BioGRID KHDRBS1 Affinity Capture-Western, FRET, Protein-peptide, Reconstituted Complex physical 10467411, 11604231, 22745667, 8175658 NA BioGRID KIT Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid, coimmunoprecipitation, fluorescence polarization spectroscopy, proximity ligation assay association, direct interaction, physical, physical association 10022833, 11071635, 1382595, 17452978, 24728074, 25241761, 7509796, 7537096, 9233773 0.77 BioGRID, IntAct, MINT LAT Affinity Capture-Western, Reconstituted Complex, coimmunoprecipitation, pull down association, physical 10811803, 11368773 0.46 BioGRID, IntAct, MINT LCK Reconstituted Complex, pull down physical, physical association 8246987, 8294442 0.40 BioGRID, IntAct, MINT LCP2 Affinity Capture-Western, Two-hybrid, pull down physical, physical association 15388330, 15929943 0.40 BioGRID, IntAct, MINT LTK Affinity Capture-Western, coimmunoprecipitation association, physical 8084603, 9223670 0.35 BioGRID, IntAct, MINT MAP3K5 Affinity Capture-Western physical 19903888 NA BioGRID MAPT Affinity Capture-Western, Reconstituted Complex physical 19681044 NA BioGRID MED28 Affinity Capture-Western, peptide array physical, physical association 16964398 0.40 BioGRID, IntAct, MINT MYO16 Reconstituted Complex physical 21946561 NA BioGRID NCK1 Affinity Capture-Western physical 11418612 NA BioGRID NCL Affinity Capture-Western physical 16571724 NA BioGRID NFKBIA Reconstituted Complex, coimmunoprecipitation, competition binding association, physical 9892650 0.46 BioGRID, IntAct, MINT NISCH Affinity Capture-MS, inference by socio-affinity scoring physical, physical association 27173435, 0.27 BioGRID, IntAct NLGN3 Affinity Capture-MS physical 28514442 NA BioGRID NPM1 Affinity Capture-MS physical 14968112 NA BioGRID NTRK1 Affinity Capture-MS, coimmunoprecipitation, competition binding association, physical 25921289, 8226808 0.46 BioGRID, IntAct, MINT NTRK2 Two-hybrid physical 12074588 NA BioGRID NYAP1 Reconstituted Complex physical 21946561 NA BioGRID NYAP2 Affinity Capture-MS, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 21946561, 26496610 0.35 BioGRID, IntAct PCBP1 Affinity Capture-MS physical 26186194, 28514442 NA BioGRID PDE4D Far Western physical 10571082 NA BioGRID PDGFRA Affinity Capture-Western, Co-localization, proximity ligation assay physical, physical association 17452978, 25241761 0.40 BioGRID, IntAct PDGFRB Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, biophysical, circular dichroism, classical fluorescence spectroscopy, coimmunoprecipitation, cross-linking study, isothermal titration calorimetry, nuclear magnetic resonance, proximity ligation assay, pull down, surface plasmon resonance, two hybrid association, physical, physical association 10697503, 10752619, 11710529, 11896612, 1314164, 1330535, 15377662, 16135792, 19864249, 28514442, 7536927, 7680644, 7692233, 8382612, 8564419, 8670861, 9153411 0.95 BioGRID, IntAct, MINT PECAM1 Affinity Capture-Western physical 9774384 NA BioGRID PIK3CA Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, phosphotransferase assay, pull down, x-ray crystallography association, direct interaction, phosphorylation reaction, physical, physical association 11526404, 15377662, 16043515, 16135792, 19117013, 19574958, 19805105, 20018188, 20713702, 22402981, 23643389, 25253337, 26496610, 7929193 0.96 BioGRID, IntAct, MINT PIK3CB Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Co-localization, anti tag coimmunoprecipitation, barcode fusion genetics two hybrid, proximity ligation assay, two hybrid, validated two hybrid association, physical, physical association 20713702, 22939629, 25241761, 26344197, 26496610, 27107012, 8139559 0.56, 0.69 BioGRID, IntAct PIK3CD Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, mass spectrometry study of hydrogen/deuterium exchange, molecular sieving, protein kinase assay, pull down, two hybrid array, two hybrid prey pooling approach colocalization, direct interaction, physical, physical association 21827948, 22020336, 26496610, 9113989, 0.46, 0.49, 0.74 BioGRID, IntAct PIK3R1 Reconstituted Complex, coimmunoprecipitation association, physical 11337495, 8294442 0.35 BioGRID, IntAct, MINT PIK3R2 Affinity Capture-MS physical 19380743, 26186194, 28514442 NA BioGRID PIK3R3 Affinity Capture-MS physical 28514442 NA BioGRID PLCG2 Co-localization, peptide array, proximity ligation assay physical, physical association 17474147, 25241761 0.59 BioGRID, IntAct PRMT2 Affinity Capture-MS physical 26186194 NA BioGRID PROM1 Affinity Capture-Western, Reconstituted Complex physical 23569237 NA BioGRID PTGER3 Affinity Capture-MS physical 26186194 NA BioGRID PTK2 Affinity Capture-Western, Far Western physical 10973983, 11119718, 19889638, 7537275 NA BioGRID PTPN11 Affinity Capture-Western physical 10962556, 11593409, 16371368, 9361008, 9886492, 9918857 NA BioGRID PTPN6 Two-hybrid, coimmunoprecipitation, pull down association, physical 10488096, 11160222 0.46 BioGRID, IntAct, MINT PTPRK Proximity Label-MS physical 27880917 NA BioGRID PTTG1 Affinity Capture-Western physical 15845362 NA BioGRID PXK Affinity Capture-Western physical 20086096 NA BioGRID PXN Co-localization, proximity ligation assay physical, physical association 23397142, 25241761 0.59 BioGRID, IntAct RAB5A Affinity Capture-Western physical 15377662 NA BioGRID RASD2 Affinity Capture-Western, Reconstituted Complex physical 22683505 NA BioGRID RET Reconstituted Complex physical 10995764 NA BioGRID RNF19B Affinity Capture-MS physical 28514442 NA BioGRID RRAS2 Affinity Capture-Western physical 11850823 NA BioGRID RXRA Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy colocalization, physical, physical association 20541701 0.56 BioGRID, IntAct SELPLG Affinity Capture-Western physical 17632516 NA BioGRID SH2D2A Affinity Capture-Luminescence, Two-hybrid, luminescence based mammalian interactome mapping, two hybrid array, validated two hybrid physical, physical association 25814554 0.57 BioGRID, IntAct SH3KBP1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, peptide array physical, physical association 10921882, 15476827, 17474147, 20457601 0.40 BioGRID, IntAct SHB Affinity Capture-Western, Reconstituted Complex physical 7537362 NA BioGRID SHC1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, coimmunoprecipitation, proximity ligation assay, pull down, tandem affinity purification association, physical, physical association 16135792, 16219545, 19380743, 19889638, 23397142, 7537361, 8621719, 8662998, 9541596 0.83 BioGRID, IntAct, MINT SIRT1 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 21241768 0.40 BioGRID, IntAct SNX32 Affinity Capture-MS physical 28514442 NA BioGRID SOCS1 Two-hybrid, two hybrid array, validated two hybrid physical, physical association 25814554 0.49 BioGRID, IntAct SOCS6 Affinity Capture-MS physical 12052866 NA BioGRID SOS1 Co-localization, peptide array, proximity ligation assay physical, physical association 17474147, 25241761 0.59 BioGRID, IntAct SQSTM1 Affinity Capture-Western, Far Western physical 9564850 NA BioGRID SRC Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation, proximity ligation assay association, physical, physical association 10487518, 19861161, 19903481, 23065768, 23397142, 24498420, 25241761 0.82 BioGRID, IntAct, MINT STAT3 Two-hybrid physical 25814554 NA BioGRID SYK Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, pull down, two hybrid physical, physical association 15536084, 16921024 0.58 BioGRID, IntAct, MINT SYN1 Affinity Capture-Western physical 10899172 NA BioGRID SYNM Affinity Capture-Western physical 17437541 NA BioGRID TGFBR1 Affinity Capture-Western physical 9435577 NA BioGRID TGFBR2 Affinity Capture-MS, Affinity Capture-Western physical 26186194, 28514442, 9435577 NA BioGRID TLR3 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 15502848, 16858407 0.52 BioGRID, IntAct, MINT TMEM17 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 0.35 BioGRID, IntAct TNFRSF1A Affinity Capture-Western physical 18606683 NA BioGRID TNIP1 Affinity Capture-Western physical 17632516 NA BioGRID TNS4 Two-hybrid, two hybrid array, validated two hybrid physical, physical association 25814554 0.49 BioGRID, IntAct TTR Two-hybrid physical 18624398 NA BioGRID TUBA1B Affinity Capture-Western, Reconstituted Complex physical 7592789 NA BioGRID TYRO3 Affinity Capture-Western, Two-hybrid physical 10627473 NA BioGRID VAV1 Affinity Capture-Western, Reconstituted Complex, pull down association, physical 17050525, 9162069, 9891995 0.35 BioGRID, IntAct, MINT VHL Negative Genetic genetic 28319113 NA BioGRID VSIG4 Affinity Capture-MS physical 26186194, 28514442 NA BioGRID WAS Affinity Capture-Western, Reconstituted Complex physical 8805332 NA BioGRID WDR26 Affinity Capture-Western physical 26895380 NA BioGRID WEE1 Negative Genetic genetic 28319113 NA BioGRID YWHAG Affinity Capture-MS, anti bait coimmunoprecipitation, coimmunoprecipitation physical, physical association 15324660, 17353931 0.59 BioGRID, IntAct, MINT ZAP70 Affinity Capture-Western physical 15536084 NA BioGRID ZDHHC17 Affinity Capture-Western, Two-hybrid physical 24705354 NA BioGRID