Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
PPP6C	9323	COSM1686099,	skin	carcinoma	p.L305F	Substitution - Missense	9:125149678-125149678,	PATHOGENIC	0.99496	28481359
PPP6C	9323	COSM1686099,	skin	malignant_melanoma	p.L305F	Substitution - Missense	9:125149678-125149678,	PATHOGENIC	0.99496	26343386
PPP6C	9323	COSM1167883,	NS	carcinoma	p.P186S	Substitution - Missense	9:125153646-125153646,	PATHOGENIC	0.99029	28481359
PPP6C	9323	COSM6967994,	skin	malignant_melanoma	p.P199S	Substitution - Missense	9:125153607-125153607,	PATHOGENIC	0.99029	28481359
PPP6C	9323	COSM6969063,	central_nervous_system	glioma	p.S197L	Substitution - Missense	9:125153612-125153612,	PATHOGENIC	0.99029	28481359
PPP6C	9323	COSM6937816,	urinary_tract	carcinoma	p.R293H	Substitution - Missense	9:125149713-125149713,	PATHOGENIC	0.98901	28481359
PPP6C	9323	COSM6936606,	skin	malignant_melanoma	p.G124R	Substitution - Missense	9:125158250-125158250,	PATHOGENIC	0.9878	28481359
PPP6C	9323	COSM6973241,	small_intestine	carcinoma	p.F93S	Substitution - Missense	9:125158342-125158342,	PATHOGENIC	0.98738	28481359
PPP6C	9323	COSM6975017,	central_nervous_system	glioma	p.T221I	Substitution - Missense	9:125153540-125153540,	PATHOGENIC	0.98635	28481359
PPP6C	9323	COSM3432859,	eye	malignant_melanoma	p.R177*	Substitution - Nonsense	9:125153673-125153673,	PATHOGENIC	0.98621	28481359
PPP6C	9323	COSM6972228,	NS	carcinoma	p.G213C	Substitution - Missense	9:125153565-125153565,	PATHOGENIC	0.98582	28481359
PPP6C	9323	COSM6906810,	breast	carcinoma	p.S45*	Substitution - Nonsense	9:125171122-125171122,	PATHOGENIC	0.98549	28481359
PPP6C	9323	COSM6906810,	breast	carcinoma	p.S45*	Substitution - Nonsense	9:125171122-125171122,	PATHOGENIC	0.98549	29420467
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28481359
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28356599
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28356599
PPP6C	9323	COSM221754,	skin	carcinoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28481359
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	26343386
PPP6C	9323	COSM221754,	NS	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28481359
PPP6C	9323	COSM221754,	NS	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	24336958
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28356599
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28481359
PPP6C	9323	COSM221754,	skin	malignant_melanoma	p.R264C	Substitution - Missense	9:125149801-125149801,	PATHOGENIC	0.98509	28481359
PPP6C	9323	COSM6952255,	large_intestine	carcinoma	p.E281*	Substitution - Nonsense	9:125149750-125149750,	PATHOGENIC	0.98407	28481359
PPP6C	9323	COSM6958337,	soft_tissue	desmoplastic_small_round_cell_tumour	p.W256*	Substitution - Nonsense	9:125149823-125149823,	PATHOGENIC	0.98351	28481359
PPP6C	9323	COSM228125,	skin	malignant_melanoma	p.S270L	Substitution - Missense	9:125149782-125149782,	PATHOGENIC	0.98267	28481359
PPP6C	9323	COSM228125,	salivary_gland	carcinoma	p.S270L	Substitution - Missense	9:125149782-125149782,	PATHOGENIC	0.98267	28481359
PPP6C	9323	COSM1105142,	skin	malignant_melanoma	p.D53N	Substitution - Missense	9:125171099-125171099,	PATHOGENIC	0.98258	28481359
PPP6C	9323	COSM177866,	endometrium	carcinoma	p.E180K	Substitution - Missense	9:125153664-125153664,	PATHOGENIC	0.98154	25233892
PPP6C	9323	COSM6965507,	urinary_tract	carcinoma	p.D203N	Substitution - Missense	9:125153595-125153595,	PATHOGENIC	0.98154	28481359
PPP6C	9323	COSM5609973,	skin	malignant_melanoma	p.G211E	Substitution - Missense	9:125153570-125153570,	PATHOGENIC	0.98154	26343386
PPP6C	9323	COSM177866,	endometrium	carcinoma	p.E180K	Substitution - Missense	9:125153664-125153664,	PATHOGENIC	0.98154	28481359
PPP6C	9323	COSM6961909,	pancreas	carcinoid-endocrine_tumour	p.G211R	Substitution - Missense	9:125153571-125153571,	PATHOGENIC	0.98154	28481359
PPP6C	9323	COSM6928662,	cervix	carcinoma	p.D174N	Substitution - Missense	9:125153682-125153682,	PATHOGENIC	0.98154	28481359
PPP6C	9323	COSM6503474,	skin	malignant_melanoma	p.D193Y	Substitution - Missense	9:125153625-125153625,	PATHOGENIC	0.98028	28356599
PPP6C	9323	COSM6956644,	breast	carcinoma	p.D105H	Substitution - Missense	9:125158307-125158307,	PATHOGENIC	0.9765	28481359
PPP6C	9323	COSM6948846,	urinary_tract	carcinoma	p.E200K	Substitution - Missense	9:125153604-125153604,	PATHOGENIC	0.97559	28481359
PPP6C	9323	COSM5413506,	NS	malignant_melanoma	p.R181Q	Substitution - Missense	9:125153660-125153660,	PATHOGENIC	0.97559	28481359
PPP6C	9323	COSM5413506,	NS	malignant_melanoma	p.R181Q	Substitution - Missense	9:125153660-125153660,	PATHOGENIC	0.97559	28481359
PPP6C	9323	COSM5415295,	endometrium	carcinoma	p.G86C	Substitution - Missense	9:125158364-125158364,	PATHOGENIC	0.97479	25233892
PPP6C	9323	COSM5731126,	breast	other	p.R264L	Substitution - Missense	9:125149800-125149800,	PATHOGENIC	0.97046	26832993
PPP6C	9323	COSM6957468,	penis	carcinoma	p.V122A	Substitution - Missense	9:125158255-125158255,	PATHOGENIC	0.97023	28481359
PPP6C	9323	COSM6983905,	large_intestine	carcinoma	p.?	Unknown	9:125171182-125171182,	PATHOGENIC	0.96793	28481359
PPP6C	9323	COSM3654316,	skin	malignant_melanoma	p.F304F	Substitution - coding silent	9:125149679-125149679,	PATHOGENIC	0.96474	26343386
PPP6C	9323	COSM3654316,	skin	malignant_melanoma	p.F304F	Substitution - coding silent	9:125149679-125149679,	PATHOGENIC	0.96474	26343386
PPP6C	9323	COSM6942564,	urinary_tract	carcinoma	p.M79V	Substitution - Missense	9:125160843-125160843,	PATHOGENIC	0.94256	28481359
PPP6C	9323	COSM6754539,	NS	carcinoma	p.R286W	Substitution - Missense	9:125149735-125149735,	PATHOGENIC	0.94247	28481359
PPP6C	9323	COSM6943627,	NS	carcinoma	p.Y141*	Substitution - Nonsense	9:125153942-125153942,	PATHOGENIC	0.93453	28481359
PPP6C	9323	COSM6955464,	prostate	carcinoma	p.R111G	Substitution - Missense	9:125158289-125158289,	PATHOGENIC	0.92778	28481359
PPP6C	9323	COSM5799451,	endometrium	carcinoma	p.R111*	Substitution - Nonsense	9:125158289-125158289,	PATHOGENIC	0.9136	28481359
PPP6C	9323	COSM6980298,	lung	carcinoma	p.V10M	Substitution - Missense	9:125189691-125189691,	PATHOGENIC	0.90999	28481359
PPP6C	9323	COSM5521405,	NS	malignant_melanoma	p.P259S, p.R264C	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	23890154
PPP6C	9323	COSM5414957,	NS	malignant_melanoma	p.?, p.A136V, p.A138T, p.A138V, p.A212T, p.A218V, p.C51Y, p.G112R, p.G189R, p.G211R, p.G213D, p.G266R, p.L215P, p.M272T, p.P186S, p.P199L, p.P199S, p.R177L, p.R210*, p.R264C, p.S197L, p.T204I, p.T204N, p.T279I, p.T299L, p.T300I, p.T46I, p.V195I, p.V277I, p.V50M, p.W196*, p.W205*, p.W214*, p.W214R, p.W256*	Substitution - Missense, Substitution - Nonsense	Info_not_available	Info_not_available	Info_not_available	24336958
PPP6C	9323	COSM5413519,	skin	malignant_melanoma	p.R264C	Substitution - Missense	Info_not_available	Info_not_available	Info_not_available	25070294
PPP6C	9323	COSM6984202,	NS, biliary_tract, breast, large_intestine, prostate	carcinoma	p.F274fs*4, p.R140fs*12, p.R286W, p.R85fs*10, p.V162fs*7	Deletion - Frameshift, Substitution - Missense	9:125158353-125158368,	Info_not_available	Info_not_available	28481359