Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
YES1	12841	COSM6919051,	lung	carcinoma	p.R395L	Substitution - Missense	18:736915-736915,	PATHOGENIC	0.99664	28481359
YES1	12841	COSM6979814,	breast	carcinoma	p.S79L	Substitution - Missense	18:756592-756592,	PATHOGENIC	0.99609	28481359
YES1	12841	COSM6955247,	large_intestine	carcinoma	p.E534*	Substitution - Nonsense	18:724456-724456,	PATHOGENIC	0.99586	28481359
YES1	12841	COSM6934003,	skin	malignant_melanoma	p.S84L	Substitution - Missense	18:756577-756577,	PATHOGENIC	0.99577	28481359
YES1	12841	COSM4741841,	large_intestine	carcinoma	p.E290K	Substitution - Missense	18:743272-743272,	PATHOGENIC	0.99463	28481359
YES1	12841	COSM6982918,	skin	carcinoma	p.G284E	Substitution - Missense	18:743289-743289,	PATHOGENIC	0.99463	28481359
YES1	12841	COSM4741841,	skin	malignant_melanoma	p.E290K	Substitution - Missense	18:743272-743272,	PATHOGENIC	0.99463	28481359
YES1	12841	COSM6914080,	large_intestine	carcinoma	p.G383C	Substitution - Missense	18:736952-736952,	PATHOGENIC	0.99441	28481359
YES1	12841	COSM6968831,	lung	carcinoma	p.W270R	Substitution - Missense	18:743332-743332,	PATHOGENIC	0.99429	28481359
YES1	12841	COSM6913717,	central_nervous_system	glioma	p.A385T	Substitution - Missense	18:736946-736946,	PATHOGENIC	0.99339	28481359
YES1	12841	COSM6906826,	breast	carcinoma	p.D364H	Substitution - Missense	18:739782-739782,	PATHOGENIC	0.99321	28481359
YES1	12841	COSM6941613,	skin	malignant_melanoma	p.S44L	Substitution - Missense	18:756697-756697,	PATHOGENIC	0.99314	28481359
YES1	12841	COSM6931485,	urinary_tract	carcinoma	p.Q154E	Substitution - Missense	18:747930-747930,	PATHOGENIC	0.99252	28481359
YES1	12841	COSM6923691,	soft_tissue	gastrointestinal_stromal_tumour	p.K369*	Substitution - Nonsense	18:739767-739767,	PATHOGENIC	0.9921	28481359
YES1	12841	COSM6912335,	large_intestine	carcinoma	p.P334A	Substitution - Missense	18:742978-742978,	PATHOGENIC	0.99184	28481359
YES1	12841	COSM6912334,	large_intestine	carcinoma	p.S340C	Substitution - Missense	18:742959-742959,	PATHOGENIC	0.99184	28481359
YES1	12841	COSM6912336,	large_intestine	carcinoma	p.Q322E	Substitution - Missense	18:743014-743014,	PATHOGENIC	0.99184	28481359
YES1	12841	COSM6950772,	skin	malignant_melanoma	p.S197F	Substitution - Missense	18:745842-745842,	PATHOGENIC	0.99168	28481359
YES1	12841	COSM6935541,	endometrium	carcinoma	p.E271K	Substitution - Missense	18:743329-743329,	PATHOGENIC	0.99091	28481359
YES1	12841	COSM6980351,	breast	carcinoma	p.E483Q	Substitution - Missense	18:724609-724609,	PATHOGENIC	0.99036	28481359
YES1	12841	COSM6915180,	lung	carcinoma	p.P492Q	Substitution - Missense	18:724581-724581,	PATHOGENIC	0.98986	28481359
YES1	12841	COSM6959095,	bone	osteosarcoma	p.T348I	Substitution - Missense	18:742935-742935,	PATHOGENIC	0.98981	28481359
YES1	12841	COSM6977613,	breast	carcinoma	p.R105T	Substitution - Missense	18:751762-751762,	PATHOGENIC	0.98965	28481359
YES1	12841	COSM48846,	lung	carcinoma	p.W158L	Substitution - Missense	18:746049-746049,	PATHOGENIC	0.98926	18948947
YES1	12841	COSM49006,	lung	carcinoma	p.?	Unknown	18:751704-751704,	PATHOGENIC	0.98916	18948947
YES1	12841	COSM6976115,	upper_aerodigestive_tract	carcinoma	p.Q430*	Substitution - Nonsense	18:736811-736811,	PATHOGENIC	0.98848	28481359
YES1	12841	COSM6940532,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.P492S	Substitution - Missense	18:724582-724582,	PATHOGENIC	0.98843	28481359
YES1	12841	COSM6917082,	NS	carcinoma	p.V404L	Substitution - Missense	18:736889-736889,	PATHOGENIC	0.98787	28481359
YES1	12841	COSM6914646,	ovary	carcinoma	p.S65F	Substitution - Missense	18:756634-756634,	PATHOGENIC	0.98727	28481359
YES1	12841	COSM6944975,	lung	carcinoma	p.E8Q	Substitution - Missense	18:756806-756806,	PATHOGENIC	0.98706	28481359
YES1	12841	COSM6231778,	skin	malignant_melanoma	p.D109N	Substitution - Missense	18:751751-751751,	PATHOGENIC	0.98582	28481359
YES1	12841	COSM6944507,	endometrium	carcinoma	p.E103G	Substitution - Missense	18:751768-751768,	PATHOGENIC	0.98455	28481359
YES1	12841	COSM6984976,	large_intestine	carcinoma	p.R470Q	Substitution - Missense	18:732848-732848,	PATHOGENIC	0.9833	28481359
YES1	12841	COSM6980053,	lung	carcinoma	p.N401D	Substitution - Missense	18:736898-736898,	PATHOGENIC	0.98311	28481359
YES1	12841	COSM6957604,	penis	carcinoma	p.Q322P	Substitution - Missense	18:743013-743013,	PATHOGENIC	0.98303	28481359
YES1	12841	COSM6982957,	large_intestine	carcinoma	p.A148V	Substitution - Missense	18:747947-747947,	PATHOGENIC	0.98287	28481359
YES1	12841	COSM6932261,	skin	carcinoma	p.E125K	Substitution - Missense	18:748017-748017,	PATHOGENIC	0.98278	28481359
YES1	12841	COSM6922065,	soft_tissue	liposarcoma	p.S56G	Substitution - Missense	18:756662-756662,	PATHOGENIC	0.98223	28481359
YES1	12841	COSM6971175,	skin	adnexal_tumour	p.K353I	Substitution - Missense	18:742920-742920,	PATHOGENIC	0.98198	28481359
YES1	12841	COSM228200,	skin	carcinoma	p.S500F	Substitution - Missense	18:724557-724557,	PATHOGENIC	0.9816	28481359
YES1	12841	COSM6966397,	lung	carcinoma	p.K5E	Substitution - Missense	18:756815-756815,	PATHOGENIC	0.98112	28481359
YES1	12841	COSM6924782,	breast	carcinoma	p.E349K	Substitution - Missense	18:742933-742933,	PATHOGENIC	0.9808	28481359
YES1	12841	COSM6968146,	lung	carcinoma	p.H502L	Substitution - Missense	18:724551-724551,	PATHOGENIC	0.98026	28481359
YES1	12841	COSM6915720,	large_intestine	carcinoma	p.K353E	Substitution - Missense	18:742921-742921,	PATHOGENIC	0.97957	28481359
YES1	12841	COSM990024,	large_intestine	carcinoma	p.R117I	Substitution - Missense	18:751726-751726,	PATHOGENIC	0.97851	28481359
YES1	12841	COSM990024,	large_intestine	carcinoma	p.R117I	Substitution - Missense	18:751726-751726,	PATHOGENIC	0.97851	28481359
YES1	12841	COSM6968355,	breast	carcinoma	p.D514N	Substitution - Missense	18:724516-724516,	PATHOGENIC	0.97526	28481359
YES1	12841	COSM3146913,	large_intestine	carcinoma	p.R179Q	Substitution - Missense	18:745986-745986,	PATHOGENIC	0.97161	28481359
YES1	12841	COSM6920698,	urinary_tract	carcinoma	p.R199C	Substitution - Missense	18:745837-745837,	PATHOGENIC	0.96987	28481359
YES1	12841	COSM6944417,	large_intestine	carcinoma	p.R398W	Substitution - Missense	18:736907-736907,	PATHOGENIC	0.96866	28481359
YES1	12841	COSM5948366,	large_intestine	carcinoma	p.R487Q	Substitution - Missense	18:724596-724596,	PATHOGENIC	0.96718	28481359
YES1	12841	COSM5948366,	large_intestine	carcinoma	p.R487Q	Substitution - Missense	18:724596-724596,	PATHOGENIC	0.96718	28481359
YES1	12841	COSM6981599,	urinary_tract	carcinoma	p.R448W	Substitution - Missense	18:732915-732915,	PATHOGENIC	0.96579	28481359
YES1	12841	COSM6934198,	stomach	carcinoma	p.R117K	Substitution - Missense	18:751726-751726,	PATHOGENIC	0.96508	28481359
YES1	12841	COSM6967884,	lung	carcinoma	p.S77L	Substitution - Missense	18:756598-756598,	PATHOGENIC	0.96138	28481359
YES1	12841	COSM6912333,	large_intestine	carcinoma	p.S352L	Substitution - Missense	18:742923-742923,	PATHOGENIC	0.94918	28481359
YES1	12841	COSM6935542,	endometrium	carcinoma	p.T241A	Substitution - Missense	18:745711-745711,	PATHOGENIC	0.94853	28481359
YES1	12841	COSM6912337,	large_intestine	carcinoma	p.I304M	Substitution - Missense	18:743066-743066,	PATHOGENIC	0.9416	28481359
YES1	12841	COSM6961023,	kidney	carcinoma	p.L357I	Substitution - Missense	18:739803-739803,	PATHOGENIC	0.93373	28481359
YES1	12841	COSM4440509,	central_nervous_system	glioma	p.R278*	Substitution - Nonsense	18:743308-743308,	PATHOGENIC	0.93153	28481359
YES1	12841	COSM6919634,	central_nervous_system	glioma	p.A87P	Substitution - Missense	18:756569-756569,	PATHOGENIC	0.88167	28481359
YES1	12841	COSM6987503,	large_intestine	carcinoma	p.N20S	Substitution - Missense	18:756769-756769,	PATHOGENIC	0.86736	28481359
YES1	12841	COSM6909179,	prostate	carcinoma	p.S40*	Substitution - Nonsense	18:756709-756709,	PATHOGENIC	0.81398	28481359
YES1	12841	COSM6984622,	endometrium	carcinoma	p.R17K	Substitution - Missense	18:756778-756778,	PATHOGENIC	0.77279	28481359
YES1	12841	COSM6932967,	skin	carcinoma	p.V52G	Substitution - Missense	18:756673-756673,	NEUTRAL	0.0855	28481359
YES1	12841	COSM989973,	central_nervous_system, kidney, large_intestine, skin	carcinoma, glioma, malignant_melanoma	p.D454fs*12, p.G72K, p.H394fs*11, p.S187fs*1, p.T21fs*33	Deletion - Frameshift, Insertion - Frameshift, Substitution - Missense	18:756766-756767,	Info_not_available	Info_not_available	28481359