Interacting Partner	Detection_method	PPI_type	Lit_support	PPI_score	Source_databases
GRB10	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, protein three hybrid, pull down, two hybrid	direct interaction, physical, physical association	10871840, 15664450, 19648926, 7479769, 8621530, 9006901, 9506989	0.40, 0.58	BioGRID, IntAct, MINT
GRB14	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, bioluminescence resonance energy transfer	physical, physical association	11726652, 16582879, 19648926, 24535599	0.40	BioGRID, IntAct, MINT
IRS1	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, two hybrid	association, direct interaction, physical, physical association	11606564, 11781100, 16582879, 17167487, 25667086, 7499194, 7935368, 8626379, 8662806	0.35, 0.70	BioGRID, IntAct, MINT
IRS2	Two-hybrid, pull down, two hybrid	direct interaction, physical, physical association	8626379, 8662806	0.53	BioGRID, IntAct, MINT
MAD2L1	imaging technique, two hybrid, two hybrid array, two hybrid prey pooling approach	physical association	9092546, 	0.46, 0.49	IntAct, MINT
PIK3R1	fluorescent resonance energy transfer, pull down	association, physical association	10500481, 11796522, 9593725	0.69	IntAct, MINT
PLCG1	Protein-peptide, coimmunoprecipitation, cross-linking study, fluorescence microscopy, pull down	colocalization, direct interaction, physical, physical association	11796522, 14568990, 22974441, 9593725	0.80	BioGRID, IntAct, MINT
PTPN1	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, bimolecular fluorescence complementation, bioluminescence resonance energy transfer, coimmunoprecipitation, filter binding, fluorescent resonance energy transfer, genetic interference, phosphatase assay, protein kinase assay, pull down, x-ray crystallography	association, colocalization, dephosphorylation reaction, direct interaction, phosphorylation reaction, physical, physical association	11163213, 11506178, 11579209, 11726652, 12237455, 12634852, 14722096, 15588987, 16271887, 16582879, 16926280, 17092689, 17159996, 17481567, 19029027, 21806020, 8702689, 8999839	0.44, 0.98	BioGRID, IntAct, MINT
PTPN11	Affinity Capture-Western, Reconstituted Complex, pull down	association, physical, physical association	7493946, 8135823, 9593725	0.56	BioGRID, IntAct, MINT
PTPN2	anti bait coimmunoprecipitation	physical association	15192089	0.40	IntAct, MINT
RASA1	Affinity Capture-Western, pull down	physical, physical association	1331107, 9593725	0.40	BioGRID, IntAct, MINT
RHOB	fluorescence microscopy	colocalization	14722096	0.27	IntAct, MINT
SH2B1	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, coimmunoprecipitation, two hybrid	association, physical, physical association	10594240, 15767667, 9742218	0.48	BioGRID, IntAct, MINT
SHC1	Reconstituted Complex, Two-hybrid, pull down, two hybrid	physical, physical association	10803466, 15629149, 7499194, 9593725	0.57	BioGRID, IntAct, MINT
STAT5B	Affinity Capture-Western, two hybrid	physical, physical association	12456798, 9428692	0.37	BioGRID, IntAct, MINT