Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
INSR	6091	COSM6987494,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.?	Unknown	19:7119447-7119447,	PATHOGENIC	0.9979	28481359
INSR	6091	COSM6944418,	large_intestine	carcinoma	p.R1331C	Substitution - Missense	19:7117214-7117214,	PATHOGENIC	0.99416	28481359
INSR	6091	COSM6970158,	lung	carcinoma	p.E1123*	Substitution - Nonsense	19:7122881-7122881,	PATHOGENIC	0.99414	28481359
INSR	6091	COSM6932370,	lung	carcinoma	p.P997L	Substitution - Missense	19:7126607-7126607,	PATHOGENIC	0.99404	28481359
INSR	6091	COSM6940468,	urinary_tract	carcinoma	p.R372Q	Substitution - Missense	19:7174591-7174591,	PATHOGENIC	0.99392	28481359
INSR	6091	COSM6940468,	NS	malignant_melanoma	p.R372Q	Substitution - Missense	19:7174591-7174591,	PATHOGENIC	0.99392	28481359
INSR	6091	COSM6933311,	urinary_tract	carcinoma	p.E1123K	Substitution - Missense	19:7122881-7122881,	PATHOGENIC	0.99344	28481359
INSR	6091	COSM6962640,	upper_aerodigestive_tract	carcinoma	p.?	Unknown	19:7142815-7142815,	PATHOGENIC	0.99336	28481359
INSR	6091	COSM5609168,	skin	malignant_melanoma	p.S166F	Substitution - Missense	19:7267500-7267500,	PATHOGENIC	0.99274	26343386
INSR	6091	COSM6933455,	endometrium	carcinoma	p.T937M	Substitution - Missense	19:7132190-7132190,	PATHOGENIC	0.9925	28481359
INSR	6091	COSM6971146,	pancreas	carcinoma	p.G677R	Substitution - Missense	19:7163032-7163032,	PATHOGENIC	0.99245	28481359
INSR	6091	COSM5609158,	NS	malignant_melanoma	p.S784F	Substitution - Missense	19:7143007-7143007,	PATHOGENIC	0.99164	28481359
INSR	6091	COSM5609158,	skin	malignant_melanoma	p.S784F	Substitution - Missense	19:7143007-7143007,	PATHOGENIC	0.99164	26343386
INSR	6091	COSM5609158,	skin	malignant_melanoma	p.S784F	Substitution - Missense	19:7143007-7143007,	PATHOGENIC	0.99164	28481359
INSR	6091	COSM6968359,	breast	carcinoma	p.E894K	Substitution - Missense	19:7141679-7141679,	PATHOGENIC	0.99155	28481359
INSR	6091	COSM6975379,	urinary_tract	carcinoma	p.L1255P	Substitution - Missense	19:7119479-7119479,	PATHOGENIC	0.99062	28481359
INSR	6091	COSM6936929,	skin	carcinoma	p.E1338*	Substitution - Nonsense	19:7117193-7117193,	PATHOGENIC	0.98889	28481359
INSR	6091	COSM6920214,	lung	carcinoma	p.D1251H	Substitution - Missense	19:7119492-7119492,	PATHOGENIC	0.98878	28481359
INSR	6091	COSM6947009,	soft_tissue	malignant_fibrous_histiocytoma-pleomorphic_sarcoma	p.Q588*	Substitution - Nonsense	19:7166253-7166253,	PATHOGENIC	0.98842	28481359
INSR	6091	COSM6960422,	lung	carcinoma	p.W586G	Substitution - Missense	19:7166259-7166259,	PATHOGENIC	0.98836	28481359
INSR	6091	COSM6913887,	skin	malignant_melanoma	p.R208Q	Substitution - Missense	19:7267374-7267374,	PATHOGENIC	0.98771	28481359
INSR	6091	COSM6947385,	large_intestine	carcinoma	p.E544*	Substitution - Nonsense	19:7166385-7166385,	PATHOGENIC	0.98709	28481359
INSR	6091	COSM2728609,	central_nervous_system	glioma	p.P79S	Substitution - Missense	19:7267762-7267762,	PATHOGENIC	0.98708	28481359
INSR	6091	COSM4439707,	breast	carcinoma	p.T107M	Substitution - Missense	19:7267677-7267677,	PATHOGENIC	0.98708	28481359
INSR	6091	COSM2728609,	skin	carcinoma	p.P79S	Substitution - Missense	19:7267762-7267762,	PATHOGENIC	0.98708	28481359
INSR	6091	COSM2728584,	breast	carcinoma	p.P269L	Substitution - Missense	19:7184484-7184484,	PATHOGENIC	0.98677	28481359
INSR	6091	COSM3960682,	endometrium	carcinoma	p.G1366R	Substitution - Missense	19:7117109-7117109,	PATHOGENIC	0.98672	28481359
INSR	6091	COSM6221294,	large_intestine	carcinoma	p.T1058M	Substitution - Missense	19:7125368-7125368,	PATHOGENIC	0.98617	28481359
INSR	6091	COSM48429,	lung	carcinoma	p.G910V	Substitution - Missense	19:7132271-7132271,	PATHOGENIC	0.9851	18948947
INSR	6091	COSM48430,	lung	carcinoma	p.G386C	Substitution - Missense	19:7172402-7172402,	PATHOGENIC	0.98498	18948947
INSR	6091	COSM6974782,	large_intestine	carcinoma	p.E389*	Substitution - Nonsense	19:7172393-7172393,	PATHOGENIC	0.98498	28481359
INSR	6091	COSM20533,	stomach	carcinoma	p.C228R	Substitution - Missense	19:7184608-7184608,	PATHOGENIC	0.98485	Info_not_available
INSR	6091	COSM20533,	stomach	carcinoma	p.C228R	Substitution - Missense	19:7184608-7184608,	PATHOGENIC	0.98485	Info_not_available
INSR	6091	COSM6983482,	large_intestine	carcinoma	p.V624A	Substitution - Missense	19:7163190-7163190,	PATHOGENIC	0.98434	28481359
INSR	6091	COSM6983864,	salivary_gland	carcinoma	p.P1199S	Substitution - Missense	19:7120684-7120684,	PATHOGENIC	0.98363	28481359
INSR	6091	COSM6935862,	central_nervous_system	glioma	p.G1223D	Substitution - Missense	19:7119575-7119575,	PATHOGENIC	0.98353	28481359
INSR	6091	COSM6942131,	skin	malignant_melanoma	p.P316S	Substitution - Missense	19:7184344-7184344,	PATHOGENIC	0.9835	28481359
INSR	6091	COSM5609172,	skin	malignant_melanoma	p.G607R	Substitution - Missense	19:7166196-7166196,	PATHOGENIC	0.98318	26343386
INSR	6091	COSM6976690,	central_nervous_system	glioma	p.T1215I	Substitution - Missense	19:7120635-7120635,	PATHOGENIC	0.98308	28481359
INSR	6091	COSM1003140,	skin	carcinoma	p.A1140V	Substitution - Missense	19:7122724-7122724,	PATHOGENIC	0.98281	28481359
INSR	6091	COSM6933423,	skin	malignant_melanoma	p.K956Q	Substitution - Missense	19:7128931-7128931,	PATHOGENIC	0.98279	28481359
INSR	6091	COSM6917053,	cervix	carcinoma	p.D562H	Substitution - Missense	19:7166331-7166331,	PATHOGENIC	0.98245	28481359
INSR	6091	COSM6932808,	lung	carcinoma	p.C239F	Substitution - Missense	19:7184574-7184574,	PATHOGENIC	0.9822	28481359
INSR	6091	COSM4425636,	lung	carcinoma	p.A402S	Substitution - Missense	19:7172354-7172354,	PATHOGENIC	0.98202	28481359
INSR	6091	COSM1003155,	lung	carcinoma	p.D985Y	Substitution - Missense	19:7126644-7126644,	PATHOGENIC	0.98191	28481359
INSR	6091	COSM6968998,	NS	carcinoma	p.E860K	Substitution - Missense	19:7141781-7141781,	PATHOGENIC	0.98191	28481359
INSR	6091	COSM6935045,	large_intestine	carcinoma	p.P987L	Substitution - Missense	19:7126637-7126637,	PATHOGENIC	0.98169	28481359
INSR	6091	COSM6984698,	lung	carcinoma	p.G333R	Substitution - Missense	19:7174709-7174709,	PATHOGENIC	0.98111	28481359
INSR	6091	COSM6913720,	central_nervous_system	glioma	p.G910S	Substitution - Missense	19:7132272-7132272,	PATHOGENIC	0.98109	28481359
INSR	6091	COSM6937235,	skin	carcinoma	p.R926Q	Substitution - Missense	19:7132223-7132223,	PATHOGENIC	0.98107	28481359
INSR	6091	COSM6686295,	large_intestine	carcinoma	p.R478H	Substitution - Missense	19:7170587-7170587,	PATHOGENIC	0.98036	28481359
INSR	6091	COSM6955830,	large_intestine	carcinoma	p.C1272Y	Substitution - Missense	19:7117390-7117390,	PATHOGENIC	0.97975	28481359
INSR	6091	COSM6930359,	urinary_tract	carcinoma	p.E1263Q	Substitution - Missense	19:7119456-7119456,	PATHOGENIC	0.97949	28481359
INSR	6091	COSM6929707,	skin	carcinoma	p.G365R	Substitution - Missense	19:7174613-7174613,	PATHOGENIC	0.97837	28481359
INSR	6091	COSM6948791,	skin	malignant_melanoma	p.?	Unknown	19:7184315-7184315,	PATHOGENIC	0.97829	28481359
INSR	6091	COSM6964621,	large_intestine	carcinoma	p.P1129L	Substitution - Missense	19:7122757-7122757,	PATHOGENIC	0.97756	28481359
INSR	6091	COSM6960077,	large_intestine	carcinoma	p.N633S	Substitution - Missense	19:7163163-7163163,	PATHOGENIC	0.97741	28481359
INSR	6091	COSM6922526,	large_intestine	carcinoma	p.E1315K	Substitution - Missense	19:7117262-7117262,	PATHOGENIC	0.97726	28481359
INSR	6091	COSM6935047,	central_nervous_system	glioma	p.V840I	Substitution - Missense	19:7142840-7142840,	PATHOGENIC	0.97724	28481359
INSR	6091	COSM6935047,	large_intestine	carcinoma	p.V840I	Substitution - Missense	19:7142840-7142840,	PATHOGENIC	0.97724	28481359
INSR	6091	COSM2728558,	pancreas	carcinoma	p.A402T	Substitution - Missense	19:7172354-7172354,	PATHOGENIC	0.97721	28481359
INSR	6091	COSM6948358,	lung	carcinoma	p.L678R	Substitution - Missense	19:7152924-7152924,	PATHOGENIC	0.9772	28481359
INSR	6091	COSM6984625,	endometrium	carcinoma	p.E124K	Substitution - Missense	19:7267627-7267627,	PATHOGENIC	0.97707	28481359
INSR	6091	COSM6954056,	skin	malignant_melanoma	p.V624M	Substitution - Missense	19:7163191-7163191,	PATHOGENIC	0.97706	28481359
INSR	6091	COSM6983040,	skin	carcinoma	p.G1253R	Substitution - Missense	19:7119486-7119486,	PATHOGENIC	0.97695	28481359
INSR	6091	COSM6974326,	central_nervous_system	glioma	p.A619D	Substitution - Missense	19:7166159-7166159,	PATHOGENIC	0.97695	28481359
INSR	6091	COSM6954118,	breast	carcinoma	p.D1344N	Substitution - Missense	19:7117175-7117175,	PATHOGENIC	0.97629	28481359
INSR	6091	COSM6937529,	lung	carcinoma	p.E1338G	Substitution - Missense	19:7117192-7117192,	PATHOGENIC	0.97621	28481359
INSR	6091	COSM1305281,	urinary_tract	carcinoma	p.S682L	Substitution - Missense	19:7152912-7152912,	PATHOGENIC	0.97482	28481359
INSR	6091	COSM1003146,	oesophagus	carcinoma	p.V1086M	Substitution - Missense	19:7125285-7125285,	PATHOGENIC	0.97419	28481359
INSR	6091	COSM6914927,	endometrium	carcinoma	p.V1059I	Substitution - Missense	19:7125366-7125366,	PATHOGENIC	0.97416	28481359
INSR	6091	COSM4541859,	lung	carcinoma	p.E1028K	Substitution - Missense	19:7125459-7125459,	PATHOGENIC	0.97416	28481359
INSR	6091	COSM6927507,	lung	carcinoma	p.Y1190C	Substitution - Missense	19:7120710-7120710,	PATHOGENIC	0.97253	28481359
INSR	6091	COSM6959264,	lung	carcinoma	p.D1259N	Substitution - Missense	19:7119468-7119468,	PATHOGENIC	0.97162	28481359
INSR	6091	COSM5020781,	soft_tissue	haemangioblastoma	p.T1099M	Substitution - Missense	19:7122952-7122952,	PATHOGENIC	0.97133	25589003
INSR	6091	COSM6971144,	pancreas	carcinoma	p.R1201Q	Substitution - Missense	19:7120677-7120677,	PATHOGENIC	0.97085	28481359
INSR	6091	COSM6935864,	central_nervous_system	glioma	p.P70L	Substitution - Missense	19:7267788-7267788,	PATHOGENIC	0.97028	28481359
INSR	6091	COSM6930677,	kidney	carcinoma	p.D569N	Substitution - Missense	19:7166310-7166310,	PATHOGENIC	0.97022	28481359
INSR	6091	COSM6930677,	kidney	carcinoma	p.D569N	Substitution - Missense	19:7166310-7166310,	PATHOGENIC	0.97022	28481359
INSR	6091	COSM6930677,	kidney	carcinoma	p.D569N	Substitution - Missense	19:7166310-7166310,	PATHOGENIC	0.97022	28481359
INSR	6091	COSM6913992,	lung	carcinoma	p.?	Unknown	19:7152928-7152928,	PATHOGENIC	0.96968	28481359
INSR	6091	COSM6986711,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.F905V	Substitution - Missense	19:7132287-7132287,	PATHOGENIC	0.96658	28481359
INSR	6091	COSM6911540,	endometrium	carcinoma	p.H1157R	Substitution - Missense	19:7122673-7122673,	PATHOGENIC	0.96654	28481359
INSR	6091	COSM6987085,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E71K	Substitution - Missense	19:7267786-7267786,	PATHOGENIC	0.96606	28481359
INSR	6091	COSM6953818,	skin	carcinoma	p.G1346R	Substitution - Missense	19:7117169-7117169,	PATHOGENIC	0.96551	28481359
INSR	6091	COSM6955258,	large_intestine	carcinoma	p.A848V	Substitution - Missense	19:7141816-7141816,	PATHOGENIC	0.96307	28481359
INSR	6091	COSM6939863,	liver	carcinoma	p.M1364V	Substitution - Missense	19:7117115-7117115,	PATHOGENIC	0.96276	28481359
INSR	6091	COSM6918742,	upper_aerodigestive_tract	carcinoma	p.L102M	Substitution - Missense	19:7267693-7267693,	PATHOGENIC	0.96161	28481359
INSR	6091	COSM6929191,	pleura	mesothelioma	p.S636F	Substitution - Missense	19:7163154-7163154,	PATHOGENIC	0.95983	28481359
INSR	6091	COSM6965754,	lung	carcinoma	p.S1001I	Substitution - Missense	19:7126595-7126595,	PATHOGENIC	0.95954	28481359
INSR	6091	COSM6965090,	breast	carcinoma	p.D852E	Substitution - Missense	19:7141803-7141803,	PATHOGENIC	0.95914	28481359
INSR	6091	COSM6932874,	breast	carcinoma	p.E690K	Substitution - Missense	19:7152889-7152889,	PATHOGENIC	0.95842	28481359
INSR	6091	COSM6975249,	NS	carcinoma	p.S810Y	Substitution - Missense	19:7142929-7142929,	PATHOGENIC	0.95839	28481359
INSR	6091	COSM6938018,	urinary_tract	carcinoma	p.E207K	Substitution - Missense	19:7267378-7267378,	PATHOGENIC	0.95772	28481359
INSR	6091	COSM6948754,	biliary_tract	carcinoma	p.D1004G	Substitution - Missense	19:7126586-7126586,	PATHOGENIC	0.95699	28481359
INSR	6091	COSM2728444,	breast	carcinoma	p.R1128H	Substitution - Missense	19:7122760-7122760,	PATHOGENIC	0.95575	25850943
INSR	6091	COSM6979441,	NS	carcinoma	p.S727L	Substitution - Missense	19:7152777-7152777,	PATHOGENIC	0.95229	28481359
INSR	6091	COSM6976692,	central_nervous_system	glioma	p.P951S	Substitution - Missense	19:7128946-7128946,	PATHOGENIC	0.9517	28481359
INSR	6091	COSM1680561,	large_intestine	carcinoma	p.R1270C	Substitution - Missense	19:7117397-7117397,	PATHOGENIC	0.94881	28481359
INSR	6091	COSM6973630,	ovary	carcinoma	p.R1020G	Substitution - Missense	19:7125483-7125483,	PATHOGENIC	0.94681	28481359
INSR	6091	COSM6946780,	lung	carcinoma	p.V305I	Substitution - Missense	19:7184377-7184377,	PATHOGENIC	0.94449	28481359
INSR	6091	COSM6916111,	biliary_tract	carcinoma	p.E1300K	Substitution - Missense	19:7117307-7117307,	PATHOGENIC	0.94045	28481359
INSR	6091	COSM6924723,	large_intestine	carcinoma	p.T352M	Substitution - Missense	19:7174651-7174651,	PATHOGENIC	0.93805	28481359
INSR	6091	COSM6958387,	central_nervous_system	glioma	p.D491E	Substitution - Missense	19:7170547-7170547,	PATHOGENIC	0.93775	28481359
INSR	6091	COSM6958621,	pancreas	carcinoma	p.R279H	Substitution - Missense	19:7184454-7184454,	PATHOGENIC	0.9372	28481359
INSR	6091	COSM6964404,	large_intestine	carcinoma	p.S635P	Substitution - Missense	19:7163158-7163158,	PATHOGENIC	0.93565	28481359
INSR	6091	COSM3541199,	lung	carcinoma	p.E692K	Substitution - Missense	19:7152883-7152883,	PATHOGENIC	0.93438	28481359
INSR	6091	COSM6983920,	thyroid	carcinoma	p.D178G	Substitution - Missense	19:7267464-7267464,	PATHOGENIC	0.93387	28481359
INSR	6091	COSM6983565,	breast	carcinoma	p.E1325*	Substitution - Nonsense	19:7117232-7117232,	PATHOGENIC	0.93188	28481359
INSR	6091	COSM418721,	urinary_tract	carcinoma	p.M137I	Substitution - Missense	19:7267586-7267586,	PATHOGENIC	0.93058	28481359
INSR	6091	COSM6930361,	urinary_tract	carcinoma	p.D985H	Substitution - Missense	19:7126644-7126644,	PATHOGENIC	0.93046	28481359
INSR	6091	COSM6686309,	urinary_tract	carcinoma	p.R110W	Substitution - Missense	19:7267669-7267669,	PATHOGENIC	0.93009	28481359
INSR	6091	COSM6934929,	skin	malignant_melanoma	p.S112L	Substitution - Missense	19:7267662-7267662,	PATHOGENIC	0.92851	28481359
INSR	6091	COSM6986448,	lung	carcinoma	p.Q588H	Substitution - Missense	19:7166251-7166251,	PATHOGENIC	0.92799	28481359
INSR	6091	COSM6946000,	breast	carcinoma	p.P687Q	Substitution - Missense	19:7152897-7152897,	PATHOGENIC	0.92702	28481359
INSR	6091	COSM6686313,	endometrium	carcinoma	p.R1353W	Substitution - Missense	19:7117148-7117148,	PATHOGENIC	0.92644	28481359
INSR	6091	COSM6932968,	skin	carcinoma	p.P1360S	Substitution - Missense	19:7117127-7117127,	PATHOGENIC	0.92494	28481359
INSR	6091	COSM5609162,	skin	malignant_melanoma	p.F115F	Substitution - coding silent	19:7267652-7267652,	PATHOGENIC	0.92476	26343386
INSR	6091	COSM4766586,	large_intestine	carcinoma	p.R410Q	Substitution - Missense	19:7172329-7172329,	PATHOGENIC	0.92416	28481359
INSR	6091	COSM6948018,	large_intestine	carcinoma	p.R819H	Substitution - Missense	19:7142902-7142902,	PATHOGENIC	0.92377	28481359
INSR	6091	COSM6958302,	skin	malignant_melanoma	p.K981N	Substitution - Missense	19:7128854-7128854,	PATHOGENIC	0.92376	28481359
INSR	6091	COSM6958302,	skin	carcinoma	p.K981N	Substitution - Missense	19:7128854-7128854,	PATHOGENIC	0.92376	28481359
INSR	6091	COSM6961757,	stomach	carcinoma	p.N308T	Substitution - Missense	19:7184367-7184367,	PATHOGENIC	0.92355	28481359
INSR	6091	COSM6939344,	bone	chondrosarcoma	p.T557M	Substitution - Missense	19:7166345-7166345,	PATHOGENIC	0.91446	28481359
INSR	6091	COSM6967237,	lung	carcinoma	p.K849N	Substitution - Missense	19:7141812-7141812,	PATHOGENIC	0.91416	28481359
INSR	6091	COSM6686311,	endometrium	carcinoma	p.V944M	Substitution - Missense	19:7132170-7132170,	PATHOGENIC	0.91299	28481359
INSR	6091	COSM6939630,	breast	carcinoma	p.G192D	Substitution - Missense	19:7267422-7267422,	PATHOGENIC	0.91265	28481359
INSR	6091	COSM6976449,	central_nervous_system	glioma	p.M65I	Substitution - Missense	19:7267802-7267802,	PATHOGENIC	0.91058	28481359
INSR	6091	COSM6918478,	urinary_tract	carcinoma	p.R398H	Substitution - Missense	19:7172365-7172365,	PATHOGENIC	0.90727	28481359
INSR	6091	COSM6918062,	large_intestine	carcinoma	p.V950I	Substitution - Missense	19:7128949-7128949,	PATHOGENIC	0.90432	28481359
INSR	6091	COSM6947337,	skin	carcinoma	p.L764F	Substitution - Missense	19:7143068-7143068,	PATHOGENIC	0.9043	28481359
INSR	6091	COSM6947337,	oesophagus	carcinoma	p.L764F	Substitution - Missense	19:7143068-7143068,	PATHOGENIC	0.9043	28481359
INSR	6091	COSM6935557,	endometrium	carcinoma	p.R813Q	Substitution - Missense	19:7142920-7142920,	PATHOGENIC	0.89468	28481359
INSR	6091	COSM6926005,	skin	malignant_melanoma	p.F533L	Substitution - Missense	19:7167981-7167981,	PATHOGENIC	0.89059	28481359
INSR	6091	COSM2728450,	large_intestine	carcinoma	p.R1053H	Substitution - Missense	19:7125383-7125383,	PATHOGENIC	0.88385	28481359
INSR	6091	COSM3729713,	skin	malignant_melanoma	p.E670K	Substitution - Missense	19:7163053-7163053,	PATHOGENIC	0.87685	26343386
INSR	6091	COSM6934426,	urinary_tract	carcinoma	p.Y976C	Substitution - Missense	19:7128870-7128870,	PATHOGENIC	0.87657	28481359
INSR	6091	COSM48428,	lung	carcinoma	p.G1346E	Substitution - Missense	19:7117168-7117168,	PATHOGENIC	0.87243	18948947
INSR	6091	COSM6938020,	urinary_tract	carcinoma	p.V200I	Substitution - Missense	19:7267399-7267399,	PATHOGENIC	0.86942	28481359
INSR	6091	COSM1305279,	prostate	carcinoma	p.G1080A	Substitution - Missense	19:7125302-7125302,	PATHOGENIC	0.86463	28481359
INSR	6091	COSM6940883,	lung	carcinoma	p.S1019A	Substitution - Missense	19:7125486-7125486,	PATHOGENIC	0.86094	28481359
INSR	6091	COSM1003173,	central_nervous_system	glioma	p.R603H	Substitution - Missense	19:7166207-7166207,	PATHOGENIC	0.85979	26487540
INSR	6091	COSM5609164,	skin	malignant_melanoma	p.Q276*	Substitution - Nonsense	19:7184464-7184464,	PATHOGENIC	0.84944	26343386
INSR	6091	COSM5609166,	skin	malignant_melanoma	p.P249S	Substitution - Missense	19:7184545-7184545,	PATHOGENIC	0.84242	26343386
INSR	6091	COSM6980054,	lung	carcinoma	p.S1297C	Substitution - Missense	19:7117316-7117316,	PATHOGENIC	0.84124	28481359
INSR	6091	COSM6942129,	skin	malignant_melanoma	p.P334L	Substitution - Missense	19:7174705-7174705,	PATHOGENIC	0.84005	28481359
INSR	6091	COSM6970601,	skin	malignant_melanoma	p.E1339K	Substitution - Missense	19:7117190-7117190,	PATHOGENIC	0.83804	28481359
INSR	6091	COSM5904001,	breast	carcinoma	p.P1299L	Substitution - Missense	19:7117309-7117309,	PATHOGENIC	0.81894	28481359
INSR	6091	COSM6911929,	lung	carcinoma	p.R506W	Substitution - Missense	19:7168062-7168062,	PATHOGENIC	0.81132	28481359
INSR	6091	COSM6911929,	lung	carcinoma	p.R506W	Substitution - Missense	19:7168062-7168062,	PATHOGENIC	0.81132	28481359
INSR	6091	COSM6952380,	large_intestine	carcinoma	p.K294N	Substitution - Missense	19:7184408-7184408,	PATHOGENIC	0.80416	28481359
INSR	6091	COSM6925408,	endometrium	carcinoma	p.R581Q	Substitution - Missense	19:7166273-7166273,	PATHOGENIC	0.79702	28481359
INSR	6091	COSM6925408,	NS	carcinoma	p.R581Q	Substitution - Missense	19:7166273-7166273,	PATHOGENIC	0.79702	28481359
INSR	6091	COSM312006,	lung	carcinoma	p.I1359I	Substitution - coding silent	19:7117128-7117128,	PATHOGENIC	0.77987	22941188
INSR	6091	COSM4082714,	urinary_tract	carcinoma	p.T320M	Substitution - Missense	19:7184331-7184331,	PATHOGENIC	0.75818	28481359
INSR	6091	COSM6985225,	endometrium	carcinoma	p.D248N	Substitution - Missense	19:7184548-7184548,	PATHOGENIC	0.75494	28481359
INSR	6091	COSM6940466,	urinary_tract	carcinoma	p.D1323N	Substitution - Missense	19:7117238-7117238,	PATHOGENIC	0.74679	28481359
INSR	6091	COSM6975381,	urinary_tract	carcinoma	p.S748*	Substitution - Nonsense	19:7150521-7150521,	PATHOGENIC	0.72172	28481359
INSR	6091	COSM2728556,	large_intestine	carcinoma	p.R413H	Substitution - Missense	19:7172320-7172320,	PATHOGENIC	0.71474	28481359
INSR	6091	COSM2728490,	urinary_tract	carcinoma	p.V854F	Substitution - Missense	19:7141799-7141799,	NEUTRAL	0.46529	28481359
INSR	6091	COSM2728490,	urinary_tract	carcinoma	p.V854F	Substitution - Missense	19:7141799-7141799,	NEUTRAL	0.46529	28481359
INSR	6091	COSM6686281,	skin	carcinoma	p.D247N	Substitution - Missense	19:7184551-7184551,	NEUTRAL	0.42854	28481359
INSR	6091	COSM4132752,	soft_tissue	haemangioblastoma	p.D546D	Substitution - coding silent	19:7166377-7166377,	NEUTRAL	0.35643	25589003
INSR	6091	COSM4132752,	soft_tissue	haemangioblastoma	p.D546D	Substitution - coding silent	19:7166377-7166377,	NEUTRAL	0.35643	25589003
INSR	6091	COSM4132752,	soft_tissue	haemangioblastoma	p.D546D	Substitution - coding silent	19:7166377-7166377,	NEUTRAL	0.35643	25589003
INSR	6091	COSM4132752,	soft_tissue	haemangioblastoma	p.D546D	Substitution - coding silent	19:7166377-7166377,	NEUTRAL	0.35643	25589003
INSR	6091	COSM4132752,	soft_tissue	haemangioblastoma	p.D546D	Substitution - coding silent	19:7166377-7166377,	NEUTRAL	0.35643	25589003
INSR	6091	COSM4132752,	soft_tissue	haemangioblastoma	p.D546D	Substitution - coding silent	19:7166377-7166377,	NEUTRAL	0.35643	25589003
INSR	6091	COSM4132752,	soft_tissue	haemangioblastoma	p.D546D	Substitution - coding silent	19:7166377-7166377,	NEUTRAL	0.35643	25589003
INSR	6091	COSM4132752,	soft_tissue	haemangioblastoma	p.D546D	Substitution - coding silent	19:7166377-7166377,	NEUTRAL	0.35643	25589003
INSR	6091	COSM4132752,	soft_tissue	haemangioblastoma	p.D546D	Substitution - coding silent	19:7166377-7166377,	NEUTRAL	0.35643	25589003
INSR	6091	COSM4132752,	soft_tissue	haemangioblastoma	p.D546D	Substitution - coding silent	19:7166377-7166377,	NEUTRAL	0.35643	25589003
INSR	6091	COSM5019943,	soft_tissue	haemangioblastoma	p.?	Unknown	19:7142813-7142813,	NEUTRAL	0.35067	25589003
INSR	6091	COSM2728494,	soft_tissue	haemangioblastoma	p.P792L	Substitution - Missense	19:7142983-7142983,	NEUTRAL	0.32405	25589003
INSR	6091	COSM1003197,	endometrium	carcinoma	p.V173M	Substitution - Missense	19:7267480-7267480,	NEUTRAL	0.28885	28481359
INSR	6091	COSM6919173,	urinary_tract	carcinoma	p.D766N	Substitution - Missense	19:7143062-7143062,	NEUTRAL	0.25521	28481359
INSR	6091	COSM6686307,	penis	carcinoma	p.E708K	Substitution - Missense	19:7152835-7152835,	NEUTRAL	0.22285	28481359
INSR	6091	COSM5609156,	skin	malignant_melanoma	p.I172I	Substitution - coding silent	19:7267481-7267481,	NEUTRAL	0.2041	26343386
INSR	6091	COSM6987610,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.R297W	Substitution - Missense	19:7184401-7184401,	NEUTRAL	0.20029	28481359
INSR	6091	COSM3757403,	soft_tissue	haemangioblastoma	p.Y1011Y	Substitution - coding silent	19:7125508-7125508,	NEUTRAL	0.19867	25589003
INSR	6091	COSM3757403,	soft_tissue	haemangioblastoma	p.Y1011Y	Substitution - coding silent	19:7125508-7125508,	NEUTRAL	0.19867	25589003
INSR	6091	COSM3757403,	soft_tissue	haemangioblastoma	p.Y1011Y	Substitution - coding silent	19:7125508-7125508,	NEUTRAL	0.19867	25589003
INSR	6091	COSM6934428,	urinary_tract	carcinoma	p.T790M	Substitution - Missense	19:7142989-7142989,	NEUTRAL	0.15881	28481359
INSR	6091	COSM5019875,	soft_tissue	haemangioblastoma	p.I881I	Substitution - coding silent	19:7141716-7141716,	NEUTRAL	0.156	25589003
INSR	6091	COSM6949534,	kidney	carcinoma	p.V772E	Substitution - Missense	19:7143043-7143043,	NEUTRAL	0.11226	28481359
INSR	6091	COSM5019857,	soft_tissue	haemangioblastoma	p.T731T	Substitution - coding silent	19:7152764-7152764,	NEUTRAL	0.1082	25589003
INSR	6091	COSM2728568,	urinary_tract	carcinoma	p.V362I	Substitution - Missense	19:7174622-7174622,	NEUTRAL	0.10485	28481359
INSR	6091	COSM2728568,	autonomic_ganglia	neuroblastoma	p.V362I	Substitution - Missense	19:7174622-7174622,	NEUTRAL	0.10485	28481359
INSR	6091	COSM2728534,	urinary_tract	carcinoma	p.G582C	Substitution - Missense	19:7166271-7166271,	NEUTRAL	0.09636	28481359
INSR	6091	COSM4001051,	soft_tissue	haemangioblastoma	p.L640L	Substitution - coding silent	19:7163143-7163143,	NEUTRAL	0.08696	25589003
INSR	6091	COSM4001051,	soft_tissue	haemangioblastoma	p.L640L	Substitution - coding silent	19:7163143-7163143,	NEUTRAL	0.08696	25589003
INSR	6091	COSM4001051,	soft_tissue	haemangioblastoma	p.L640L	Substitution - coding silent	19:7163143-7163143,	NEUTRAL	0.08696	25589003
INSR	6091	COSM4001051,	soft_tissue	haemangioblastoma	p.L640L	Substitution - coding silent	19:7163143-7163143,	NEUTRAL	0.08696	25589003
INSR	6091	COSM4001047,	soft_tissue	haemangioblastoma	p.H1085H	Substitution - coding silent	19:7125286-7125286,	NEUTRAL	0.08126	25589003
INSR	6091	COSM4001047,	soft_tissue	haemangioblastoma	p.H1085H	Substitution - coding silent	19:7125286-7125286,	NEUTRAL	0.08126	25589003
INSR	6091	COSM4001047,	soft_tissue	haemangioblastoma	p.H1085H	Substitution - coding silent	19:7125286-7125286,	NEUTRAL	0.08126	25589003
INSR	6091	COSM4001047,	soft_tissue	haemangioblastoma	p.H1085H	Substitution - coding silent	19:7125286-7125286,	NEUTRAL	0.08126	25589003
INSR	6091	COSM4001047,	soft_tissue	haemangioblastoma	p.H1085H	Substitution - coding silent	19:7125286-7125286,	NEUTRAL	0.08126	25589003
INSR	6091	COSM4001047,	soft_tissue	haemangioblastoma	p.H1085H	Substitution - coding silent	19:7125286-7125286,	NEUTRAL	0.08126	25589003
INSR	6091	COSM4001047,	soft_tissue	haemangioblastoma	p.H1085H	Substitution - coding silent	19:7125286-7125286,	NEUTRAL	0.08126	25589003
INSR	6091	COSM4001047,	soft_tissue	haemangioblastoma	p.H1085H	Substitution - coding silent	19:7125286-7125286,	NEUTRAL	0.08126	25589003
INSR	6091	COSM4001047,	soft_tissue	haemangioblastoma	p.H1085H	Substitution - coding silent	19:7125286-7125286,	NEUTRAL	0.08126	25589003
INSR	6091	COSM6915857,	skin	carcinoma	p.R1378W	Substitution - Missense	19:7117073-7117073,	NEUTRAL	0.0797	28481359
INSR	6091	COSM5020603,	soft_tissue	haemangioblastoma	p.N865N	Substitution - coding silent	19:7141764-7141764,	NEUTRAL	0.07305	25589003
INSR	6091	COSM5020603,	soft_tissue	haemangioblastoma	p.N865N	Substitution - coding silent	19:7141764-7141764,	NEUTRAL	0.07305	25589003
INSR	6091	COSM5019870,	soft_tissue	haemangioblastoma	p.A842A	Substitution - coding silent	19:7142832-7142832,	NEUTRAL	0.06495	25589003
INSR	6091	COSM5020913,	soft_tissue	haemangioblastoma	p.?	Unknown	19:7117415-7117415,	NEUTRAL	0.05204	25589003
INSR	6091	COSM5020913,	soft_tissue	haemangioblastoma	p.?	Unknown	19:7117415-7117415,	NEUTRAL	0.05204	25589003
INSR	6091	COSM5019324,	soft_tissue	haemangioblastoma	p.V206V	Substitution - coding silent	19:7267379-7267379,	NEUTRAL	0.04761	25589003
INSR	6091	COSM2728500,	large_intestine	carcinoma	p.V774M	Substitution - Missense	19:7143038-7143038,	NEUTRAL	0.04746	28481359
INSR	6091	COSM5019868,	soft_tissue	haemangioblastoma	p.T816T	Substitution - coding silent	19:7142910-7142910,	NEUTRAL	0.0395	25589003
INSR	6091	COSM5019338,	soft_tissue	haemangioblastoma	p.D261D	Substitution - coding silent	19:7184507-7184507,	NEUTRAL	0.03869	25589003
INSR	6091	COSM5019338,	soft_tissue	haemangioblastoma	p.D261D	Substitution - coding silent	19:7184507-7184507,	NEUTRAL	0.03869	25589003
INSR	6091	COSM5019338,	soft_tissue	haemangioblastoma	p.D261D	Substitution - coding silent	19:7184507-7184507,	NEUTRAL	0.03869	25589003
INSR	6091	COSM5019338,	soft_tissue	haemangioblastoma	p.D261D	Substitution - coding silent	19:7184507-7184507,	NEUTRAL	0.03869	25589003
INSR	6091	COSM5609170,	skin	malignant_melanoma	p.S810S	Substitution - coding silent	19:7142928-7142928,	NEUTRAL	0.02705	26343386
INSR	6091	COSM20399,	large_intestine	carcinoma	p.T1099T	Substitution - coding silent	19:7122951-7122951,	NEUTRAL	0.02509	Info_not_available
INSR	6091	COSM20399,	large_intestine	carcinoma	p.T1099T	Substitution - coding silent	19:7122951-7122951,	NEUTRAL	0.02509	Info_not_available
INSR	6091	COSM4001049,	soft_tissue	haemangioblastoma	p.P644P	Substitution - coding silent	19:7163129-7163129,	NEUTRAL	0.02351	25589003
INSR	6091	COSM4001049,	soft_tissue	haemangioblastoma	p.P644P	Substitution - coding silent	19:7163129-7163129,	NEUTRAL	0.02351	25589003
INSR	6091	COSM4001049,	soft_tissue	haemangioblastoma	p.P644P	Substitution - coding silent	19:7163129-7163129,	NEUTRAL	0.02351	25589003
INSR	6091	COSM4001049,	soft_tissue	haemangioblastoma	p.P644P	Substitution - coding silent	19:7163129-7163129,	NEUTRAL	0.02351	25589003
INSR	6091	COSM148469,	soft_tissue	haemangioblastoma	p.A550A	Substitution - coding silent	19:7166365-7166365,	NEUTRAL	0.01813	25589003
INSR	6091	COSM148469,	soft_tissue	haemangioblastoma	p.A550A	Substitution - coding silent	19:7166365-7166365,	NEUTRAL	0.01813	25589003
INSR	6091	COSM148469,	soft_tissue	haemangioblastoma	p.A550A	Substitution - coding silent	19:7166365-7166365,	NEUTRAL	0.01813	25589003
INSR	6091	COSM148469,	soft_tissue	haemangioblastoma	p.A550A	Substitution - coding silent	19:7166365-7166365,	NEUTRAL	0.01813	25589003
INSR	6091	COSM148469,	soft_tissue	haemangioblastoma	p.A550A	Substitution - coding silent	19:7166365-7166365,	NEUTRAL	0.01813	25589003
INSR	6091	COSM148469,	soft_tissue	haemangioblastoma	p.A550A	Substitution - coding silent	19:7166365-7166365,	NEUTRAL	0.01813	25589003
INSR	6091	COSM148469,	soft_tissue	haemangioblastoma	p.A550A	Substitution - coding silent	19:7166365-7166365,	NEUTRAL	0.01813	25589003
INSR	6091	COSM148469,	soft_tissue	haemangioblastoma	p.A550A	Substitution - coding silent	19:7166365-7166365,	NEUTRAL	0.01813	25589003
INSR	6091	COSM148469,	soft_tissue	haemangioblastoma	p.A550A	Substitution - coding silent	19:7166365-7166365,	NEUTRAL	0.01813	25589003
INSR	6091	COSM148469,	soft_tissue	haemangioblastoma	p.A550A	Substitution - coding silent	19:7166365-7166365,	NEUTRAL	0.01813	25589003
INSR	6091	COSM312008,	lung	carcinoma	p.A1340A	Substitution - coding silent	19:7117185-7117185,	NEUTRAL	0.00777	22941188
INSR	6091	COSM5020471,	soft_tissue	haemangioblastoma	p.?	Unknown	19:7163203-7163203,	NEUTRAL	0.00408	25589003
INSR	6091	COSM5020471,	soft_tissue	haemangioblastoma	p.?	Unknown	19:7163203-7163203,	NEUTRAL	0.00408	25589003
INSR	6091	COSM5020471,	soft_tissue	haemangioblastoma	p.?	Unknown	19:7163203-7163203,	NEUTRAL	0.00408	25589003
INSR	6091	COSM5020471,	soft_tissue	haemangioblastoma	p.?	Unknown	19:7163203-7163203,	NEUTRAL	0.00408	25589003
INSR	6091	COSM5017273,	kidney	carcinoma	p.L463fs*24	Deletion - Frameshift	19:7170632-7170632,	Info_not_available	Info_not_available	25401301
INSR	6091	COSM5025091,	breast	carcinoma	p.I1069fs*2	Deletion - Frameshift	19:7125312-7125336,	Info_not_available	Info_not_available	25850943
INSR	6091	COSM5611311,	skin	malignant_melanoma	p.Q588*, p.S929S	Substitution - Nonsense, Substitution - coding silent	19:7166253-7166254,	Info_not_available	0.59219, Info_not_available	26343386
INSR	6091	COSM6972054,	breast, large_intestine, lung, pancreas, skin, soft_tissue	carcinoma, liposarcoma, malignant_melanoma	p.E831*, p.G27V, p.G37S, p.L240fs*42, p.L977*, p.N309delN, p.P570F, p.R1343Q, p.V1265fs*16	Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Substitution - Missense, Substitution - Nonsense	19:7293812-7293812,	Info_not_available	0.54568, .60261, .64938, Info_not_available	28481359
INSR	6091	COSM5019266,	soft_tissue	haemangioblastoma	p.F669F, p.R1270H	Substitution - Missense, Substitution - coding silent	19:7163054-7163054,	Info_not_available	0.51513, .61896	25589003