Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
PTPRB	9665	COSM142734,	skin	malignant_melanoma	p.P907L	Substitution - Missense	12:70569935-70569935,	PATHOGENIC	0.99812	19074898
PTPRB	9665	COSM3734679,	soft_tissue	angiosarcoma	p.?	Unknown	12:70544556-70544556,	PATHOGENIC	0.99594	24633157
PTPRB	9665	COSM142736,	skin	malignant_melanoma	p.S1704F	Substitution - Missense	12:70539638-70539638,	PATHOGENIC	0.99546	19074898
PTPRB	9665	COSM142748,	skin	malignant_melanoma	p.R1732*	Substitution - Nonsense	12:70538945-70538945,	PATHOGENIC	0.98811	19074898
PTPRB	9665	COSM142744,	skin	malignant_melanoma	p.T1334A	Substitution - Missense	12:70559403-70559403,	PATHOGENIC	0.98586	19074898
PTPRB	9665	COSM5989962,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.E1708Q	Substitution - Missense	12:70539627-70539627,	PATHOGENIC	0.9803	26648538
PTPRB	9665	COSM142740,	skin	malignant_melanoma	p.S877F	Substitution - Missense	12:70571112-70571112,	PATHOGENIC	0.97709	19074898
PTPRB	9665	COSM5749277,	genital_tract	germ_cell_tumour	p.R1965G	Substitution - Missense	12:70524549-70524549,	PATHOGENIC	0.96862	26956871
PTPRB	9665	COSM5749223,	genital_tract	germ_cell_tumour	p.Y142C	Substitution - Missense	12:70596228-70596228,	PATHOGENIC	0.9584	26956871
PTPRB	9665	COSM1513256,	soft_tissue	angiosarcoma	p.?	Unknown	12:70555869-70555869,	PATHOGENIC	0.94509	24633157
PTPRB	9665	COSM5749216,	genital_tract	germ_cell_tumour	p.V621M	Substitution - Missense	12:70581099-70581099,	PATHOGENIC	0.92893	26956871
PTPRB	9665	COSM142732,	skin	malignant_melanoma	p.S654F	Substitution - Missense	12:70576609-70576609,	PATHOGENIC	0.87964	19074898
PTPRB	9665	COSM142728,	skin	malignant_melanoma	p.S452I	Substitution - Missense	12:70590005-70590005,	PATHOGENIC	0.87929	19074898
PTPRB	9665	COSM142746,	skin	malignant_melanoma	p.W1340*	Substitution - Nonsense	12:70559383-70559383,	PATHOGENIC	0.85798	19074898
PTPRB	9665	COSM142726,	skin	malignant_melanoma	p.G199E	Substitution - Missense	12:70596057-70596057,	PATHOGENIC	0.81833	19074898
PTPRB	9665	COSM5702640,	autonomic_ganglia	neuroblastoma	p.W1241*	Substitution - Nonsense	12:70560727-70560727,	NEUTRAL	0.40578	27009842
PTPRB	9665	COSM1606581,	liver	carcinoma	p.Y1865Y	Substitution - coding silent	12:70534607-70534607,	NEUTRAL	0.35255	Info_not_available
PTPRB	9665	COSM142738,	skin	malignant_melanoma	p.R749K	Substitution - Missense	12:70572030-70572030,	NEUTRAL	0.26397	19074898
PTPRB	9665	COSM5749127,	testis	germ_cell_tumour	p.G210V	Substitution - Missense	12:70594700-70594700,	NEUTRAL	0.073	26956871
PTPRB	9665	COSM5989950,	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	p.G156E	Substitution - Missense	12:70596186-70596186,	NEUTRAL	0.0081	26648538
PTPRB	9665	COSM5546580,	skin	malignant_melanoma	p.?	Unknown	Info_not_available	Info_not_available	Info_not_available	24463458
PTPRB	9665	COSM3734677,	soft_tissue	angiosarcoma	p.E1535*, p.H1454fs*6, p.R633*, p.W575*	Substitution - Nonsense, Unknown	Info_not_available	Info_not_available	Info_not_available	24633157
PTPRB	9665	COSM142742,	skin	malignant_melanoma	p.I1063M, p.S452R	Substitution - Missense	12:70590004-70590004,	Info_not_available	0.55703, .67462	19074898