Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
IKBKB	5960	COSM6851660,	breast	carcinoma	p.S267N	Substitution - Missense	8:42314429-42314429,	PATHOGENIC	0.99787	25591616
IKBKB	5960	COSM48872,	lung	carcinoma	p.E356*	Substitution - Nonsense	8:42316845-42316845,	PATHOGENIC	0.98323	18948947
IKBKB	5960	COSM5416031,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K171Q	Substitution - Missense	8:42306376-42306376,	PATHOGENIC	0.97173	25987724
IKBKB	5960	COSM4944024,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K171T	Substitution - Missense	8:42306377-42306377,	PATHOGENIC	0.97173	22891273
IKBKB	5960	COSM4944024,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K171T	Substitution - Missense	8:42306377-42306377,	PATHOGENIC	0.97173	22891273
IKBKB	5960	COSM4944023,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K171E	Substitution - Missense	8:42306376-42306376,	PATHOGENIC	0.96968	22891273
IKBKB	5960	COSM4944023,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K171E	Substitution - Missense	8:42306376-42306376,	PATHOGENIC	0.96968	22891273
IKBKB	5960	COSM4944023,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K171E	Substitution - Missense	8:42306376-42306376,	PATHOGENIC	0.96968	21881048
IKBKB	5960	COSM4944023,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K171E	Substitution - Missense	8:42306376-42306376,	PATHOGENIC	0.96968	22891273
IKBKB	5960	COSM4944023,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K171E	Substitution - Missense	8:42306376-42306376,	PATHOGENIC	0.96968	22891273
IKBKB	5960	COSM4944023,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K171E	Substitution - Missense	8:42306376-42306376,	PATHOGENIC	0.96968	22891273
IKBKB	5960	COSM4944023,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K171E	Substitution - Missense	8:42306376-42306376,	PATHOGENIC	0.96968	21881048
IKBKB	5960	COSM4944023,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.K171E	Substitution - Missense	8:42306376-42306376,	PATHOGENIC	0.96968	21881048
IKBKB	5960	COSM630,	breast	carcinoma	p.A360S	Substitution - Missense	8:42316857-42316857,	PATHOGENIC	0.93711	16959974
IKBKB	5960	COSM144951,	breast	carcinoma	p.E81Q	Substitution - Missense	8:42290196-42290196,	PATHOGENIC	0.93541	22302350
IKBKB	5960	COSM5416032,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E745D	Substitution - Missense	8:42330942-42330942,	NEUTRAL	0.27044	25987724
IKBKB	5960	COSM20642,	ovary	carcinoma	p.E348E	Substitution - coding silent	Info_not_available	Info_not_available	Info_not_available	Info_not_available