Interacting Partner Detection_method PPI_type Lit_support PPI_score Source_databases AKT1 Affinity Capture-Western, Co-localization, proximity ligation assay physical, physical association 15856005, 22689577, 25241761 0.40 BioGRID, IntAct AURKA Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, protein kinase assay direct interaction, physical, physical association 17939994 0.54 BioGRID, IntAct BCL10 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 11113112, 14695475, 17213322, 19118383 0.35 BioGRID, IntAct BCL2 Affinity Capture-Western physical 22262057 NA BioGRID BIRC3 Co-localization, proximity ligation assay physical, physical association 25241761 0.40 BioGRID, IntAct BRAP Affinity Capture-Western physical 21670849 NA BioGRID BTRC Affinity Capture-Western physical 11158290, 19656241, 20797629 NA BioGRID C1QBP tandem affinity purification physical association 14743216 0.40 IntAct CASP8 Affinity Capture-Western physical 11002417 NA BioGRID CCAR2 tandem affinity purification physical association 14743216 0.40 IntAct CD40 Affinity Capture-MS, Affinity Capture-Western physical 20614026 NA BioGRID CDC37 Affinity Capture-Luminescence, Affinity Capture-MS, Co-purification, Reconstituted Complex, anti tag coimmunoprecipitation, tandem affinity purification association, physical, physical association 11864612, 14743216, 21903422, 25036637, 26496610 0.74 BioGRID, IntAct CDKN2A Affinity Capture-Western physical 20152798 NA BioGRID CHUK Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-fractionation, Co-localization, Co-purification, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, proximity ligation assay, tandem affinity purification association, physical, physical association 10733566, 10968790, 11057907, 11080499, 11585904, 11864612, 11971985, 12210728, 12244103, 12486103, 14743216, 16129692, 16286467, 16319058, 17693255, 20434986, 20932476, 21575199, 21784860, 21903422, 25241761, 25748427, 25852190, 28514442, 9346241, 9346484, 9346485, 9721103, 9751060, 9914500 0.94 BioGRID, IntAct, MINT CLTC Co-localization, proximity ligation assay, tandem affinity purification physical, physical association 14743216, 25241761 0.59 BioGRID, IntAct COMMD7 Affinity Capture-Western physical 26060140 NA BioGRID COPS3 Affinity Capture-Western, Two-hybrid physical 19656241, 23636414 NA BioGRID COPS4 Affinity Capture-Western, Two-hybrid physical 19656241 NA BioGRID COPS5 Affinity Capture-Western, Biochemical Activity, FRET, Two-hybrid physical 19656241, 23636414 NA BioGRID COPS7A Affinity Capture-Western, Two-hybrid physical 19656241 NA BioGRID CREBBP Affinity Capture-Western, Co-localization, Two-hybrid, affinity chromatography technology, proximity ligation assay association, physical, physical association 11971985, 14597638, 25241761 0.56 BioGRID, IntAct CSF2RA Co-localization, FRET, Reconstituted Complex, Two-hybrid, proximity ligation assay physical, physical association 12637324, 25241761 0.40 BioGRID, IntAct CSF2RB Two-hybrid physical 12637324 NA BioGRID CSNK1A1 anti bait coimmunoprecipitation association 19118383 0.35 IntAct CSNK2B Affinity Capture-Western physical 20797629 NA BioGRID CTNNB1 Affinity Capture-Western, Co-localization, Reconstituted Complex, proximity ligation assay physical, physical association 11527961, 25241761 0.40 BioGRID, IntAct CUEDC2 Affinity Capture-Western, Two-hybrid physical 18362886 NA BioGRID CUL1 Affinity Capture-Western physical 19656241 NA BioGRID CUL3 Affinity Capture-Western physical 19818716 NA BioGRID DHCR24 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 0.35 BioGRID, IntAct DPP4 Affinity Capture-Western physical 17287217 NA BioGRID DUSP1 Affinity Capture-Western physical 10022904 NA BioGRID EGLN3 Affinity Capture-Western, Reconstituted Complex physical 19786027, 23732909 NA BioGRID EIF2AK2 Affinity Capture-Western physical 10848580 NA BioGRID ELP1 Affinity Capture-Western physical 9751059 NA BioGRID EPAS1 Affinity Capture-Western physical 26500060 NA BioGRID EPRS tandem affinity purification physical association 14743216 0.40 IntAct ERC1 Affinity Capture-Western, Co-purification physical 15218148, 20932476 NA BioGRID FAF1 Affinity Capture-Western, Reconstituted Complex physical 17684021 NA BioGRID FANCA Affinity Capture-Western, Co-purification, Two-hybrid physical 12210728 NA BioGRID FKBP4 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 21903422 0.35 BioGRID, IntAct FKBP5 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 21903422 0.35 BioGRID, IntAct FLNA tandem affinity purification physical association 14743216 0.40 IntAct FLNC Co-fractionation physical 22863883 NA BioGRID FOXO3 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 15084260, 25241761 NA BioGRID FOXO3 proximity ligation assay physical association 25241761 0.40 IntAct GLI1 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 26603838 NA BioGRID HIF1A Affinity Capture-Western physical 26500060 NA BioGRID HNRNPU Affinity Capture-Western physical 20797629 NA BioGRID HNRNPU tandem affinity purification physical association 14743216 0.40 IntAct HOMER3 Affinity Capture-Western, Two-hybrid physical 20693425 NA BioGRID HSP90AA1 Affinity Capture-Western, tandem affinity purification physical, physical association 14743216, 19786027 0.40 BioGRID, IntAct HSP90AB1 Co-localization, proximity ligation assay, tandem affinity purification physical, physical association 14743216, 25241761 0.59 BioGRID, IntAct HSPA1L tandem affinity purification physical association 14743216 0.40 IntAct HSPA5 tandem affinity purification physical association 14743216 0.40 IntAct HSPA8 tandem affinity purification physical association 14743216 0.40 IntAct HSPA9 tandem affinity purification physical association 14743216 0.40 IntAct HSPB1 Affinity Capture-Western physical 16840786 NA BioGRID HTT Biochemical Activity physical 20026656 NA BioGRID IFIT5 Affinity Capture-Western physical 26334375 NA BioGRID IKBKB Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Reconstituted Complex, anti tag coimmunoprecipitation, cosedimentation in solution, light scattering, molecular sieving, protein kinase assay, tandem affinity purification, x-ray crystallography direct interaction, phosphorylation reaction, physical, physical association 10807933, 11585904, 12709429, 12890679, 14743216, 16319058, 17079871, 17939994, 21423167, 23776406, 23792959, 24611898, 24912152, 25486864, 29111346, 9346485, 9721103, 9914500 0.87 BioGRID, IntAct IKBKE Affinity Capture-Western, Biochemical Activity physical 23453969, 9914500 NA BioGRID IKBKG Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-purification, Protein-peptide, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein array, protein kinase assay, pull down, tandem affinity purification, two hybrid, x-ray crystallography association, direct interaction, phosphorylation reaction, physical, physical association 10980203, 11057907, 11864612, 11971985, 12133833, 12459277, 12486103, 12612076, 14743216, 15184390, 15749833, 15802604, 16126728, 16129692, 16319058, 16497931, 16547522, 16583354, 16603398, 16611882, 16906147, 16938294, 17000764, 17363973, 17568778, 17693255, 17977820, 18037881, 18207244, 18266324, 18266467, 18450452, 18462684, 18583959, 18949366, 19365808, 19422324, 19656241, 19666608, 19706536, 19815509, 19820708, 19959994, 20098747, 20167598, 20368414, 20434986, 20932476, 21423167, 21455180, 21803029, 21903422, 22099304, 22605335, 22990857, 23104095, 23131831, 23506214, 23986494, 24240172, 24266532, 24469399, 24618592, 25286246, 25304104, 25400026, 25852190, 25979343, 26496610, 26500060, 27929056, 28249776, 28514442, 29111346, 9751060 0.44, 0.98 BioGRID, IntAct, MINT IQGAP1 tandem affinity purification physical association 14743216 0.40 IntAct IRAK1 Affinity Capture-Western physical 11096118, 18180283 NA BioGRID IRF3 cosedimentation through density gradient colocalization 21782231 0.35 IntAct IRS1 Affinity Capture-Western physical 12351658 NA BioGRID ITCH Affinity Capture-Western physical 26603838 NA BioGRID JUN Biochemical Activity physical 19656241 NA BioGRID KEAP1 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, pull down colocalization, physical, physical association 19818716, 20600852, 24127568, 24322982, 25926686, 27387502 0.61 BioGRID, IntAct KLHL21 Affinity Capture-Western, Reconstituted Complex physical 27387502 NA BioGRID LATS2 Affinity Capture-Western physical 25946971 NA BioGRID LYZ tandem affinity purification physical association 14743216 0.40 IntAct MACROD1 Affinity Capture-MS physical 25735744 NA BioGRID MALT1 Affinity Capture-Western, anti bait coimmunoprecipitation association, physical 19118383 0.35 BioGRID, IntAct MAP3K1 Affinity Capture-Western, Biochemical Activity, protein kinase assay phosphorylation reaction, physical 11057907, 16286467, 9819420 0.44 BioGRID, IntAct MAP3K11 Biochemical Activity physical 10713178 NA BioGRID MAP3K13 Affinity Capture-Western physical 12492477 NA BioGRID MAP3K14 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti tag coimmunoprecipitation, protein kinase assay, tandem affinity purification phosphorylation reaction, physical, physical association 10733566, 11278268, 14743216, 16286467, 28514442, 9346485, 9520446 0.71 BioGRID, IntAct MAP3K21 anti tag coimmunoprecipitation physical association 26859459 0.40 IntAct MAP3K3 tandem affinity purification physical association 14743216 0.40 IntAct MAP3K7 Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation physical, physical association 10807933, 17363905, 17363973, 18316610, 18456659, 20932476, 21331078, 24270572, 25946971, 26334375, 27387502 0.40 BioGRID, IntAct, MINT MAPK14 Affinity Capture-Western physical 20797629 NA BioGRID MARK3 anti bait coimmunoprecipitation physical association 17363905 0.40 IntAct, MINT MAVS Biochemical Activity, anti tag coimmunoprecipitation, cosedimentation through density gradient colocalization, physical, physical association 16177806, 21782231, 25636800 0.56 BioGRID, IntAct MEOX2 Affinity Capture-Western physical 20421348 NA BioGRID MTOR Affinity Capture-Western, Co-purification physical 18490760, 18519641 NA BioGRID MUC1 Affinity Capture-Western, Co-fractionation physical 18037881 NA BioGRID MYD88 anti tag coimmunoprecipitation association 16365431 0.35 IntAct MYH10 tandem affinity purification physical association 14743216 0.40 IntAct NAA20 Affinity Capture-Western, Biochemical Activity physical 19716809 NA BioGRID NCOA3 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-fractionation, Reconstituted Complex, coimmunoprecipitation physical, physical association 11971985, 16051665 0.40 BioGRID, IntAct NEDD4L Biochemical Activity physical 18981174 NA BioGRID NFKB1 Affinity Capture-Western, Biochemical Activity, Co-localization, protein kinase assay, proximity ligation assay phosphorylation reaction, physical, physical association 10469655, 11158290, 11297557, 11976329, 12482991, 25241761 0.72 BioGRID, IntAct NFKB2 tandem affinity purification physical association 14743216 0.40 IntAct NFKBIA Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, protein kinase assay, pull down, tandem affinity purification direct interaction, phosphorylation reaction, physical, physical association 11080499, 12054687, 12411322, 12486103, 12624112, 12709429, 12943667, 14743216, 15125833, 15125834, 15217903, 15218148, 15456896, 15919917, 16126728, 16286467, 16319058, 16365431, 16611882, 17079871, 17363905, 18202307, 18375836, 18519641, 18593939, 18981174, 19196987, 19345327, 19959994, 20434986, 20449947, 20797629, 21399639, 21423167, 21765415, 22022389, 22037600, 22904686, 22990857, 23816567, 24469399, 24611898, 24618592, 24912152, 25595906, 25759022, 26221961, 26740240, 26802121, 27387502, 27497262, 28214532, 9346485, 9520446, 9689078, 9721103, 9751059, 9891086, 9914500 0.97 BioGRID, IntAct, MINT NFKBIB Affinity Capture-Western, Biochemical Activity, tandem affinity purification physical, physical association 14743216, 9346485, 9689078 0.40 BioGRID, IntAct NGFR Affinity Capture-Western physical 23017601 NA BioGRID NLRC5 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 20434986 0.52 BioGRID, IntAct NLRP2 Affinity Capture-Western physical 15456791 NA BioGRID NLRX1 Affinity Capture-Western physical 21703539 NA BioGRID PARP1 tandem affinity purification physical association 14743216 0.40 IntAct PELI1 Biochemical Activity physical 21204785 NA BioGRID PKM protein kinase assay phosphorylation reaction 24606918 0.44 IntAct PLK1 Biochemical Activity physical 18957422 NA BioGRID PPARG Protein-peptide physical 19596656 NA BioGRID PPM1B Affinity Capture-Western, Biochemical Activity physical 14585847 NA BioGRID PPP1CA Affinity Capture-Western physical 18362886, 18949366 NA BioGRID PPP1R15A Affinity Capture-Western physical 18362886 NA BioGRID PPP2CA Affinity Capture-Western, anti bait coimmunoprecipitation, coimmunoprecipitation, molecular sieving association, physical, physical association 16126728, 16129692 0.64 BioGRID, IntAct, MINT PPP2R3C Reconstituted Complex physical 20925653 NA BioGRID PRDX3 Affinity Capture-Western physical 12492477 NA BioGRID PRKCA Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 10022904 NA BioGRID PRKCB Co-localization, proximity ligation assay physical, physical association 25241761 0.40 BioGRID, IntAct PRKCD Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 10022904 NA BioGRID PRKCE Affinity Capture-Western, Biochemical Activity physical 23123196 NA BioGRID PRKCI Affinity Capture-Western, Reconstituted Complex physical 10022904 NA BioGRID PRKCQ Affinity Capture-Western physical 11120819, 15802604, 17363905, 20164171 NA BioGRID PRKDC Biochemical Activity physical 9632806 NA BioGRID PSG1 Affinity Capture-MS physical 28514442 NA BioGRID PYCARD Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy association, colocalization, physical 12486103 0.51 BioGRID, IntAct PYGL Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 21903422 0.35 BioGRID, IntAct RAN Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 0.35 BioGRID, IntAct RELA Affinity Capture-Western, Biochemical Activity, Co-localization, experimental interaction detection, protein kinase assay, proximity ligation assay phosphorylation reaction, physical, physical association 10521409, 12842894, 15489227, 16046471, 18519641, 22689577, 25241761 0.69 BioGRID, IntAct, MINT RICTOR Affinity Capture-Western, Reconstituted Complex physical 23872070 NA BioGRID RIPK1 Co-fractionation, Reconstituted Complex physical 10980203, 21606198 NA BioGRID ROCK1 Biochemical Activity physical 24240172 NA BioGRID RPS3 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay phosphorylation reaction, physical association 21399639 0.60 IntAct RPTOR Affinity Capture-Western physical 18519641, 23872070 NA BioGRID SASH1 Affinity Capture-Western physical 23776175 NA BioGRID SHARPIN Affinity Capture-Western, anti bait coimmunoprecipitation association, physical 21455180 0.35 BioGRID, IntAct SLC25A13 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 0.35 BioGRID, IntAct SLC25A22 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 0.35 BioGRID, IntAct SMARCC1 tandem affinity purification physical association 14743216 0.40 IntAct SMN1 Affinity Capture-Western physical 28214532 NA BioGRID SQSTM1 fluorescence technology colocalization 19959994 0.35 IntAct, MINT SRC Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation association, physical 12645577, 12707358, 15456896, 15749833 0.35 BioGRID, IntAct STAP2 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical, physical association 16365431 0.62 BioGRID, IntAct STAT3 anti bait coimmunoprecipitation physical association 19345327 0.40 IntAct STK26 Affinity Capture-Western physical 25642822 NA BioGRID TAB1 Affinity Capture-Western physical 18316610 NA BioGRID TAB2 Biochemical Activity physical 21811235 NA BioGRID TAB3 Affinity Capture-Western physical 27497262 NA BioGRID TBK1 cosedimentation through density gradient colocalization 21782231 0.35 IntAct TFAP2C Two-hybrid, two hybrid array physical, physical association 21988832 0.37 BioGRID, IntAct TIMM50 tandem affinity purification physical association 14743216 0.40 IntAct TNF Affinity Capture-MS, Affinity Capture-Western physical 16603398, 20005846 NA BioGRID TNFAIP3 Affinity Capture-Western, Biochemical Activity, protein kinase assay phosphorylation reaction, physical 11594795, 21220427, 26649818 0.44 BioGRID, IntAct TNFRSF1A Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, proximity ligation assay physical, physical association 10755617, 11002417, 11821416, 18949366, 21331078, 21724995, 25241761 0.40 BioGRID, IntAct TNIK Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 22904686 0.50 BioGRID, IntAct TNIP2 Affinity Capture-Western physical 21784860 NA BioGRID TP53 Biochemical Activity, anti bait coimmunoprecipitation, protein kinase assay phosphorylation reaction, physical, physical association 19196987, 19883646 0.61 BioGRID, IntAct, MINT TP63 Affinity Capture-Western physical 20145131 NA BioGRID TP73 Affinity Capture-Western, Biochemical Activity, FRET physical 21482671 NA BioGRID TPX2 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 17939994 0.40 BioGRID, IntAct TRAF1 Affinity Capture-Western, FRET, Two-hybrid physical 12709429, 20856938 NA BioGRID TRAF2 Affinity Capture-Western, Co-localization, Reconstituted Complex, cosedimentation through density gradient, proximity ligation assay colocalization, physical, physical association 11359906, 18362886, 19150425, 20449947, 21782231, 23007157, 25241761, 27387502 0.56 BioGRID, IntAct TRAF3IP2 Affinity Capture-Western, Co-fractionation physical 10962033, 12943667, 24561578 NA BioGRID TRAF6 Affinity Capture-Western, cosedimentation through density gradient colocalization, physical 16920630, 21782231 0.35 BioGRID, IntAct TRAPPC9 Affinity Capture-Western physical 15951441 NA BioGRID TRIM21 Affinity Capture-Western, Biochemical Activity physical 19675099 NA BioGRID TRIM27 Affinity Capture-Western, Biochemical Activity physical 16393995 NA BioGRID TRIM40 Affinity Capture-Western physical 21474709 NA BioGRID TRPC4AP Affinity Capture-Western physical 14585990 NA BioGRID TSC1 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, protein kinase assay direct interaction, physical, physical association 17693255 0.61 BioGRID, IntAct TUBA3C tandem affinity purification physical association 14743216 0.40 IntAct TUBB tandem affinity purification physical association 14743216 0.40 IntAct TUBB2B tandem affinity purification physical association 14743216 0.40 IntAct TUBB4A tandem affinity purification physical association 14743216 0.40 IntAct TWIST1 Biochemical Activity physical 23375009 NA BioGRID UBC Reconstituted Complex physical 28190767 NA BioGRID USP18 Affinity Capture-Western physical 26240016 NA BioGRID USP4 Affinity Capture-Western physical 21331078 NA BioGRID VDAC1 cosedimentation through density gradient colocalization 21782231 0.35 IntAct ZC3H12A anti bait coimmunoprecipitation physical association 22037600 0.40 IntAct