Gene Name	HGNC ID	COSMIC_MutID	Primary site	Primary histology	AA-Mutation	Mutation Type	Genomic Position	FATHMM prediction	FATHMM score	Literature evidence
MAPK1	6871	COSM4991465,	skin	carcinoma	p.Y358D	Substitution - Missense	22:21769215-21769215,	PATHOGENIC	0.99826	25589618
MAPK1	6871	COSM6929109,	central_nervous_system	glioma	p.H141Y	Substitution - Missense	22:21805921-21805921,	PATHOGENIC	0.99544	28481359
MAPK1	6871	COSM3552430,	urinary_tract	carcinoma	p.S142L	Substitution - Missense	22:21805917-21805917,	PATHOGENIC	0.99544	28481359
MAPK1	6871	COSM6912785,	breast	carcinoma	p.P176T	Substitution - Missense	22:21799095-21799095,	PATHOGENIC	0.99397	28481359
MAPK1	6871	COSM1172768,	penis	carcinoma	p.S246F	Substitution - Missense	22:21788376-21788376,	PATHOGENIC	0.99358	28481359
MAPK1	6871	COSM1172768,	NS	carcinoma	p.S246F	Substitution - Missense	22:21788376-21788376,	PATHOGENIC	0.99358	28481359
MAPK1	6871	COSM1172768,	NS	carcinoma	p.S246F	Substitution - Missense	22:21788376-21788376,	PATHOGENIC	0.99358	28481359
MAPK1	6871	COSM6921964,	prostate	carcinoma	p.R148H	Substitution - Missense	22:21805899-21805899,	PATHOGENIC	0.99269	28481359
MAPK1	6871	COSM6957643,	penis	carcinoma	p.C166R	Substitution - Missense	22:21799125-21799125,	PATHOGENIC	0.99157	28481359
MAPK1	6871	COSM6848077,	pleura	mesothelioma	p.I347L	Substitution - Missense	22:21769248-21769248,	PATHOGENIC	0.99143	26928227
MAPK1	6871	COSM6981970,	endometrium	carcinoma	p.E326K	Substitution - Missense	22:21769311-21769311,	PATHOGENIC	0.99049	28481359
MAPK1	6871	COSM6979966,	large_intestine	carcinoma	p.Q132E	Substitution - Missense	22:21805948-21805948,	PATHOGENIC	0.99008	28481359
MAPK1	6871	COSM6934067,	large_intestine	carcinoma	p.L134P	Substitution - Missense	22:21805941-21805941,	PATHOGENIC	0.98892	28481359
MAPK1	6871	COSM6913430,	urinary_tract	carcinoma	p.E349*	Substitution - Nonsense	22:21769242-21769242,	PATHOGENIC	0.98626	28481359
MAPK1	6871	COSM3308981,	urinary_tract	carcinoma	p.R135K	Substitution - Missense	22:21805938-21805938,	PATHOGENIC	0.98335	28481359
MAPK1	6871	COSM3308981,	cervix	carcinoma	p.R135K	Substitution - Missense	22:21805938-21805938,	PATHOGENIC	0.98335	28481359
MAPK1	6871	COSM3308981,	cervix	carcinoma	p.R135K	Substitution - Missense	22:21805938-21805938,	PATHOGENIC	0.98335	28481359
MAPK1	6871	COSM6976461,	central_nervous_system	glioma	p.G230E	Substitution - Missense	22:21788729-21788729,	PATHOGENIC	0.98154	28481359
MAPK1	6871	COSM6908905,	biliary_tract	carcinoma	p.I211V	Substitution - Missense	22:21788787-21788787,	PATHOGENIC	0.98057	28481359
MAPK1	6871	COSM6908905,	biliary_tract	carcinoma	p.I211V	Substitution - Missense	22:21788787-21788787,	PATHOGENIC	0.98057	28481359
MAPK1	6871	COSM6912629,	skin	carcinoma	p.E322A	Substitution - Missense	22:21772874-21772874,	PATHOGENIC	0.97705	28481359
MAPK1	6871	COSM6966595,	large_intestine	carcinoma	p.D318N	Substitution - Missense	22:21772887-21772887,	PATHOGENIC	0.97538	28481359
MAPK1	6871	COSM461148,	urinary_tract	carcinoma	p.E322K	Substitution - Missense	22:21772875-21772875,	PATHOGENIC	0.97522	28481359
MAPK1	6871	COSM461148,	upper_aerodigestive_tract	carcinoma	p.E322K	Substitution - Missense	22:21772875-21772875,	PATHOGENIC	0.97522	28481359
MAPK1	6871	COSM461148,	urinary_tract	carcinoma	p.E322K	Substitution - Missense	22:21772875-21772875,	PATHOGENIC	0.97522	28481359
MAPK1	6871	COSM461148,	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	p.E322K	Substitution - Missense	22:21772875-21772875,	PATHOGENIC	0.97522	28481359
MAPK1	6871	COSM461148,	urinary_tract	carcinoma	p.E322K	Substitution - Missense	22:21772875-21772875,	PATHOGENIC	0.97522	28481359
MAPK1	6871	COSM461148,	upper_aerodigestive_tract	carcinoma	p.E322K	Substitution - Missense	22:21772875-21772875,	PATHOGENIC	0.97522	28481359
MAPK1	6871	COSM461148,	lung	carcinoma	p.E322K	Substitution - Missense	22:21772875-21772875,	PATHOGENIC	0.97522	28481359
MAPK1	6871	COSM461148,	lung	carcinoma	p.E322K	Substitution - Missense	22:21772875-21772875,	PATHOGENIC	0.97522	28481359
MAPK1	6871	COSM461148,	upper_aerodigestive_tract	carcinoma	p.E322K	Substitution - Missense	22:21772875-21772875,	PATHOGENIC	0.97522	28481359
MAPK1	6871	COSM461148,	upper_aerodigestive_tract	carcinoma	p.E322K	Substitution - Missense	22:21772875-21772875,	PATHOGENIC	0.97522	28481359
MAPK1	6871	COSM6911025,	lung	carcinoma	p.I227F	Substitution - Missense	22:21788739-21788739,	PATHOGENIC	0.96725	28481359
MAPK1	6871	COSM6964410,	large_intestine	carcinoma	p.D332N	Substitution - Missense	22:21769293-21769293,	PATHOGENIC	0.96531	28481359
MAPK1	6871	COSM6707733,	endometrium	carcinoma	p.R50*	Substitution - Nonsense	22:21807818-21807818,	PATHOGENIC	0.95814	28481359
MAPK1	6871	COSM4471756,	lung	carcinoma	p.P58L	Substitution - Missense	22:21807793-21807793,	PATHOGENIC	0.95	28481359
MAPK1	6871	COSM6946407,	large_intestine	carcinoma	p.R67I	Substitution - Missense	22:21807766-21807766,	PATHOGENIC	0.94852	28481359
MAPK1	6871	COSM6986835,	urinary_tract	carcinoma	p.D235E	Substitution - Missense	22:21788713-21788713,	PATHOGENIC	0.9445	28481359
MAPK1	6871	COSM6971608,	prostate	carcinoma	p.A2V	Substitution - Missense	22:21867436-21867436,	PATHOGENIC	0.83	28481359
MAPK1	6871	COSM6963570,	prostate	carcinoma	p.G10S	Substitution - Missense	22:21867413-21867413,	PATHOGENIC	0.82154	28481359
MAPK1	6871	COSM4135212,	soft_tissue	haemangioblastoma	p.Y43Y	Substitution - coding silent	22:21807837-21807837,	PATHOGENIC	0.81172	25589003
MAPK1	6871	COSM4135212,	soft_tissue	haemangioblastoma	p.Y43Y	Substitution - coding silent	22:21807837-21807837,	PATHOGENIC	0.81172	25589003
MAPK1	6871	COSM4135212,	soft_tissue	haemangioblastoma	p.Y43Y	Substitution - coding silent	22:21807837-21807837,	PATHOGENIC	0.81172	25589003
MAPK1	6871	COSM4135212,	soft_tissue	haemangioblastoma	p.Y43Y	Substitution - coding silent	22:21807837-21807837,	PATHOGENIC	0.81172	25589003
MAPK1	6871	COSM6976462,	central_nervous_system	glioma	p.P23S	Substitution - Missense	22:21867374-21867374,	PATHOGENIC	0.75694	28481359
MAPK1	6871	COSM6969537,	breast	carcinoma	p.I31M	Substitution - Missense	22:21867348-21867348,	PATHOGENIC	0.72893	28481359
MAPK1	6871	COSM6938072,	urinary_tract	carcinoma	p.G34D	Substitution - Missense	22:21867340-21867340,	NEUTRAL	0.40445	28481359
MAPK1	6871	COSM6983373,	prostate	carcinoma	p.N144K	Substitution - Missense	22:21805910-21805910,	NEUTRAL	0.38903	28481359
MAPK1	6871	COSM5020436,	soft_tissue	haemangioblastoma	p.A325A	Substitution - coding silent	22:21769312-21769312,	NEUTRAL	0.34745	25589003
MAPK1	6871	COSM6973722,	breast, large_intestine, urinary_tract	carcinoma	p.A6_A7delAA, p.A9T, p.C65fs*3, p.E33Q, p.N82fs*18	Deletion - Frameshift, Deletion - In frame, Insertion - Frameshift, Substitution - Missense	22:21867419-21867424,	Info_not_available	0.51584, .65173, Info_not_available	28481359